Space tug propulsion system failure mode, effects and criticality analysis

For purposes of the study, the propulsion system was considered as consisting of the following: (1) main engine system, (2) auxiliary propulsion system, (3) pneumatic system, (4) hydrogen feed, fill, drain and vent system, (5) oxygen feed, fill, drain and vent system, and (6) helium reentry purge system. Each component was critically examined to identify possible failure modes and the subsequent effect on mission success. Each space tug mission consists of three phases: launch to separation from shuttle, separation to redocking, and redocking to landing. The analysis considered the results of failure of a component during each phase of the mission. After the failure modes of each component were tabulated, those components whose failure would result in possible or certain loss of mission or inability to return the Tug to ground were identified as critical components and a criticality number determined for each. The criticality number of a component denotes the number of mission failures in one million missions due to the loss of that component. A total of 68 components were identified as critical with criticality numbers ranging from 1 to 2990

When groups help and when groups harm: origins, developments, and future directions of the 'social cure' perspective of group dynamics

A substantial literature supports the important role that social group memberships play in enhancing health. While the processes through which group memberships constitute a ‘Social Cure’ are becoming increasingly well-defined, the mechanisms through which these groups contribute to vulnerability and act as a ‘Social Curse’ are less understood. We present an overview of the Social Cure literature, and then go beyond this to show how the processes underpinning the health benefits of group membership can also negatively affect individuals through their absence. First, we provide an overview of early Social Cure research. We then describe later research concerning the potential health benefits of identifying with multiple groups, before moving on to consider the ‘darker side’ of the Social Cure by exploring how intra-group dynamics can foster Curse processes. Finally, we synthesise evidence from both the Cure and Curse literatures to highlight the complex interplay between these phenomena, and how they are influenced by both intra- and inter-group processes. We conclude by considering areas we deem vital for future investigation within the discipline

Palynofacies classification of the depositional elements of confined turbidite systems : Examples from the Gres d'Annot, SE France

Acknowledgements We thank BG Brasil for financial support for this project and permission to publish. BG Group is a wholly owned subsidiary of Royal Dutch Shell. McArthur is grateful to the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for the scholarship 049/2012. The Agência Nacional do Petróleo (ANP) are thanked for supporting this project. Massimo Zecchin is thanked for handling this paper and Roberto Tinterri is thanked for his constructive review, in addition to an anonymous reviewer.Peer reviewedPostprin

Evaluation and exploration of a social prescribing initiative: study protocol

Attention is being given to healthcare initiatives with the potential to save money and improve lives. One example is Social Prescribing (SP), which supports patients whose ill-health is exacerbated by loneliness. While evidence has accumulated attesting to SP’s efficacy, one limitation has been the lack of a theoretical framework, which limits understanding of how tackling loneliness improves health. In our evaluation of an SP pathway, we adopt a 'Social Cure' approach, which posits that social relations affect health. Our study will evaluate the efficacy of the pathway and determine the extent to which group processes are responsible for health improvements

Progress in the development of a biopesticide for the structural treatment of grain stores

Chemical insecticides are used to protect stored grain from infestation by stored product insects and mites. In the UK only a limited number of products are available for application and there are concerns about safety, pest resistance and environmental impact of these conventional pesticides. Biological control offers an alternative to the use of chemical insecticides. The potential for biological control of storage pests in the UK using an insect-specific fungus, Beauveria bassiana, to treat the structure of the stores, has previously been established. However, this study also highlighted areas where improvements were needed; specifically to improve the uptake of the fungal conidia by the pests and to improve their germination and penetration into the pests. In addition it was necessary to ensure that potential formulations had a good shelf-life and to develop a mass production method to consistently produce high quality fungal conidia. A four year project has recently been completed examining these  areas in detail. The work has concentrated on two different fungal isolates of B. bassiana, both of which were found from insects in UK grain stores. Optimisation of production methods, formulation and delivery systems has resulted in prototype formulations that exhibit good viability over periods up to one year and that have good efficacy against a range of storage insect pests under conditions that are likely to be found in UK grain stores. Pilot scale trials using three species of stored product beetle have shown that significant levels of control can be achieved. An overview of the key findings is presented. The study has made a significant contribution to the development of a biopesticide as a structural treatment for grain storage areas in the UK.Keywords: Biological control; Beauveria bassiana; Oryzaephilus surinamensis; Structural treatment; Biopesticid

Decision and Discovery in Defining “Disease”

This version (May 17, 2005) was published in its final form as: Schwartz PH. Decision and discovery in defining 'disease'. In: Kincaid H, McKitrick J, editors. Establishing medical reality: essays in the metaphysics and epistemology of biomedical science. Dordrecht: Springer; 2007. p. 47-63. http://dx.doi.org/10.1007/1-4020-5216-2_5The debate over how to analyze the concept of disease has often centered on the question of whether to include a reference to values, in particular the ‘disvalue’of diseases, or whether to avoid such notions. ‘Normativists,’such as King ([1954], 1981) and Culver and Gert (1982) emphasize the undesirability of diseases, while ‘Naturalists,’ most prominently Christopher Boorse (1977, 1987, 1997), instead require just the presence of biological dysfunction. The debate between normativism and naturalism often deteriorates into stalemate, with each side able to point out significant problems with the other. It starts to look as if neither approach can work. In this paper, I argue that the standoff stems from deeply questionable assumptions that have been used to formulate the opposing positions and guide the debate. In the end, I propose an alternative set of guidelines that offer a more constructive way to devise and compare theories

Double deletion of Panx1 and Panx3 affects skin and bone but not hearing

Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a wide variety of tissues including the skin, bone, and cochlea. To date, the use of single knock-out mouse models of both Panx1 and Panx3 have demonstrated their roles in skin development, bone formation, and auditory phenotypes. Due to sequence homology between Panx1 and Panx3, when one Panx is ablated from germline, the other may be upregulated in a compensatory mechanism to maintain tissue homeostasis and function. To evaluate the roles of Panx1 and Panx3 in the skin, bone, and cochlea, we created the first Panx1/Panx3 double knock-out mouse model (dKO). These mice had smaller litters and reduced body weight compared to wildtype controls. The dKO dorsal skin had decreased epidermal and dermal area as well as decreased hypodermal area in neonatal but not in older mice. In addition, mouse skull shape and size were altered, and long bone length was decreased in neonatal dKO mice. Finally, auditory tests revealed that dKO mice did not exhibit hearing loss and were even slightly protected against noise-induced hearing damage at mid-frequency regions. Taken together, our findings suggest that Panx1 and Panx3 are important at early stages of development in the skin and bone but may be redundant in the auditory system. Key messages Panx double KO mice had smaller litters and reduced body weight. dKO skin had decreased epidermal and dermal area in neonatal mice. Skull shape and size changed plus long bone length decreased in neonatal dKO mice. dKO had no hearing loss and were slightly protected against noise-induced damage

Interactive video games to reduce paediatric procedural pain and anxiety: a systematic review and meta-analysis

Background: Procedural pain and anxiety in children can be poorly controlled, leading to significant short- and long-term sequelae, such as longer procedure times or future healthcare avoidance. Caregiver anxiety can exacerbate these effects. We aimed to evaluate the effect of interactive video game interventions on children's procedural pain and anxiety, including the effect of different types of video games on those outcomes. Methods: We conducted a systematic review and meta-analysis of the effectiveness of interactive video games compared with standard care in children (0–18 yr) undergoing painful procedures. We searched the databases MEDLINE, Embase, and PsycINFO. We conducted random-effects meta-analysis using ‘R’ of children's procedural pain and anxiety and caregivers' anxiety. Results: Of 2185 studies screened, 36 were eligible (n=3406 patients). Studies commonly involved venous access (33%) or day surgery (31%). Thirty-four studies were eligible for meta-analyses. Interactive video games appear to reduce children's procedural pain (standardised mean difference [SMD]=–0.43; 95% confidence interval [CI]: –0.67 to –0.20), anxiety (SMD=0.61; 95% CI: –0.88 to –0.34), and caregivers' procedural anxiety (SMD=–0.31; 95% CI: –0.58 to –0.04). We observed no difference between preparatory and distracting games, or between virtual reality and non-virtual reality games. We also observed no difference between interactive video games compared with standard care for most medical outcomes (e.g. procedure length), except a reduced need for restraint. Studies reported minimal adverse effects and typically had high intervention acceptability and satisfaction. Conclusions: Our findings support introducing easily available video games, such as distraction-based conventional video games, into routine practice to minimise paediatric procedural pain and child/caregiver anxiety

Healthcare provision inside immigration removal centres: a social identity analysis of trust, legitimacy and disengagement

The stressors of immigration detention and negative host country experiences make effective access to health care vital for migrant detainees, but little is known regarding the health experiences of this populations and the barriers to healthcare access. The present research investigates immigration detainees’ experiences of health‐related help‐seeking in the distressing and stigmatised environment of UK immigration removal centres (IRCs), as well as staff members’ experiences of providing help. Semi‐structured interviews were conducted with 40 detainees and 21 staff and analysed using theoretical thematic analysis guided by the social identity approach. The findings indicate that the practical constraints on help provision (e.g. lack of time and resources, the unpredictable nature of detention) are exacerbated by the complex and conflictual intergroup relationships within which these helping transactions occur. These transactions are negatively affected by stigma, mutual distrust and reputation management concerns, as well as detainees’ feelings of powerlessness and confusion around eligibility to receive health care. Some detainees argued that the help ignores the systematic inequalities associated with their detainee status, thereby making it fundamentally inappropriate and ineffective. The intergroup context (of inequality and illegitimacy) shapes the quality of helping transactions, care experiences and health service engagement in groups experiencing chronic low status, distress and uncertainty