Revisiting Charmless Hadronic B_{u,d} Decays in QCD Factorization

Within the framework of QCD factorization (QCDF), we consider two different types of power correction effects in order to resolve the CP puzzles and rate deficit problems with penguin-dominated two-body decays of B mesons and color-suppressed tree-dominated $\pi^0\pi^0$ and $\rho^0\pi^0$ modes: penguin annihilation and soft corrections to the color-suppressed tree amplitude. We emphasize that the electroweak penguin solution to the $B\to K\pi$ CP puzzle via New Physics is irrelevant for solving the CP and rate puzzles related to tree-dominated decays. While some channels e.g. $K^-\pi^+,K^-\rho^0,\pi^+\pi^-,\rho^\pm\pi^\mp$ need penguin annihilation to induce the correct magnitudes and signs for their CP violation, some other decays such as $B^-\to K^-\pi^0,\pi^-\eta, K^-\eta$ and $\bar B^0\to \bar K^{*0}\eta,\pi^0\pi^0$ require the presence of both power corrections to account for the measured CP asymmetries. In general, QCDF predictions for the branching fractions and direct CP asymmetries of $\bar B\to PP,VP,VV$ decays are in good agreement with experiment. The predictions of pQCD and soft-collinear effective theory are included for comparison.Comment: 51 pages, 1 figur

The Cost-Balanced Path Problem: A Mathematical Formulation and Complexity Analysis

This paper introduces a new variant of the Shortest Path Problem (SPP) called the Cost-Balanced Path Problem (CBPP). Various real problems can either be modeled as BCPP or include BCPP as a sub-problem. We prove several properties related to the complexity of the CBPP problem. In particular, we demonstrate that the problem is NP-hard in its general version, but it becomes solvable in polynomial time in a specific family of instances. Moreover, a mathematical formulation of the CBPP, as a mixed-integer programming model, is proposed, and some additional constraints for modeling real requirements are given. This paper validates the proposed model and its extensions with experimental tests based on random instances. The analysis of the results of the computational experiments shows that the proposed model and its extension can be used to model many real applications. Obviously, due to the problem complexity, the main limitation of the proposed approach is related to the size of the instances. A heuristic solution approach should be required for larger-sized and more complex instances

Precision Measurement of KS Meson Lifetime with the KLOE detector

Using a large sample of pure, slow, short lived K0 mesons collected with KLOE detector at DaFne, we have measured the KS lifetime. From a fit to the proper time distribution we find tau = (89.562 +- 0.029_stat +- 0.043_syst) ps. This is the most precise measurement today in good agreement with the world average derived from previous measurements. We observe no dependence of the lifetime on the direction of the Ks.Comment: 5 pages, 7 figure

A Constructive Heuristics and an Iterated Neighborhood Search Procedure to Solve the Cost-Balanced Path Problem

This paper presents a new heuristic algorithm tailored to solve large instances of an NP-hard variant of the shortest path problem, denoted the cost-balanced path problem, recently proposed in the literature. The problem consists in finding the origin–destination path in a direct graph, having both negative and positive weights associated with the arcs, such that the total sum of the weights of the selected arcs is as close to zero as possible. At least to the authors’ knowledge, there are no solution algorithms for facing this problem. The proposed algorithm integrates a constructive procedure and an improvement procedure, and it is validated thanks to the implementation of an iterated neighborhood search procedure. The reported numerical experimentation shows that the proposed algorithm is computationally very efficient. In particular, the proposed algorithm is most suitable in the case of large instances where it is possible to prove the existence of a perfectly balanced path and thus the optimality of the solution by finding a good percentage of optimal solutions in negligible computational time

Rainfall variability in southern Africa: drivers, climate change impacts and implications for agriculture

Southern Africa is characterised by a high degree of rainfall variability aff�ecting agriculture among other sectors. The focus of this study is to investigate such variability and to identify stable relationships with its potential drivers in the climate system. These relationships are used as the basis for the statistical downscaling of climate model (GCM) outputs. From the simulated rainfall, indices representative of growing season characteristics are computed with the fi�nal purpose of studying the implications on maize cropping under a future climate change scenario. The analysis uses generalized linear models (GLMs), which allow the investigation of the relationships between diff�erent components of the climate system (geographical and climatic drivers) simultaneously. Initially, the e�ffects of various climate indicators upon monthly regional (for all southern Africa) precipitation occurrences and amounts are characterised. Six climate factors are found to drive part of the rainfall variability in the region and their modelled e�ffect upon rainfall occurrences and amounts agrees broadly with previous studies. Among the retained indices, relative humidity and El Niño accounted for the highest degree of explained variability. The location and intensity of the jet stream is also found to have a statistically signi�ficant and physically meaningful e�ffect upon rainfall variability. Although e�ffective for the analysis of monthly regional precipitation, and used to investigate future regional projections, the models do not perform adequately at more local spatial scales such as station locations or few km grids. The same methodology is, therefore, applied to characterise daily precipitation variability at multiple locations within a smaller region. The small scale statistical models capture adequately the seasonal and annual rainfall structure in the area. Indeed, the observations can not be distinguished from the simulated time series. However, the simulated rainfall values tend to be slightly too high throughout the seasons, possibly due to the spatial correlation structure not completely appropriate for such a complex region. From the simulated rainfall sequences, seven growing season indices (including the onset and length of the growing season, proportion of rainy days and total precipitation during the growing season) are derived and their projected change investigated under a climate change scenario. There is little consensus between the 18 selected GCMs, regarding changes in growing season indices between two investigated periods in the 20th and 21st centuries. For the next couple of decades the dominant source of variation in the indices appears to be the natural rainfall variability. Such information should therefore be taken into account when planning adaptation and mitigation strategies. The research presented here emerges as the fi�rst comprehensive assessment of di�fferent climatic factors linked to southern Africa rainfall variability as well as the fi�rst attempt to evaluate the GLMs suitability for the generation of rainfall sequences for agricultural impact studies

A combinatorial approach to gene expression analysis: DNA microarrays.

The microarray technology is based on analytical tools that parallelize the quantitative and qualitative analysis of nucleic acids, proteins and tissue sections one of its more recent evolutions-. By miniaturizing the size of the reaction and sensing area, microarrays allow to assess at the activity of thousands of genes in a given tissue or cell line at once in a rapid and quantitative way, and to carry out serial comparative tests in multiple samples. These tools, that stem from the innovations resulting from the technological improvements and knowledge arising from the genome sequencing projects, can be considered as a combinatorial technique that can rapidly provide significant information about complex cellular pathways and processes within one or few ‘‘mass scale’’ and comprehensive testing of a biological sample’s composition

Vacuum Properties of Mesons in a Linear Sigma Model with Vector Mesons and Global Chiral Invariance

We present a two-flavour linear sigma model with global chiral symmetry and vector and axial-vector mesons. We calculate pion-pion scattering lengths and the decay widths of scalar, vector, and axial-vector mesons. It is demonstrated that vector and axial-vector meson degrees of freedom play an important role in these low-energy processes and that a reasonable theoretical description requires globally chirally invariant terms other than the vector meson mass term. An important question for meson vacuum phenomenology is the quark content of the physical scalar f0(600) and a0(980) mesons. We investigate this question by assigning the quark-antiquark sigma and a0 states of our model with these physical mesons. We show via a detailed comparison with experimental data that this scenario can describe all vacuum properties studied here except for the decay width of the sigma, which turns out to be too small. We also study the alternative assignment f0(1370) and a0(1450) for the scalar mesons. In this case the decay width agrees with the experimental value, but the pion-pion scattering length $a_{0}^{0}$ is too small. This indicates the necessity to extend our model by additional scalar degrees of freedom.Comment: 22 pages, 6 figure

Measurement of the η→3π0\eta\to 3\pi^{0} slope parameter α\alpha with the KLOE detector

We present a measurement of the slope parameter $\alpha$ for the $\eta\to 3\pi^{0}$ decay, with the KLOE experiment at the DA$\Phi$NE $\phi$-factory, based on a background free sample of $\sim$ 17 millions $\eta$ mesons produced in $\phi$ radiative decays. By fitting the event density in the Dalitz plot we determine \alpha = -0.0301 \pm 0.0035\,stat\;_{-0.0035}^{+0.0022}\,syst\,. The result is in agreement with recent measurements from hadro- and photo-production experiments.Comment: 14 pages, 11 figure

Study of the process e+e- -> omega pi0 in the phi-meson mass region with the KLOE detector

We have studied the e+e- -> omegapi0 cross section in the sqrt(s) interval 1000-1030 MeV using the pi+pi-pi0pi0 and pi0pi0gamma final states with a sample of ~600 pb^-1 collected with the KLOE detector at DAFNE. By fitting the observed interference pattern around M_phi for both final states, we extract the ratio of the decay widths Gamma(omega->pi0gamma)/Gamma(omega->pi+pi-pi0) = 0.0897 +- 0.0016 and derive the branching fractions BR(omega -> pi+pi-pi0)= (90.24 +- 0.19)%, BR(omega -> pi0gamma) = (8.09 +- 0.14)%. The parameters describing the e+e- -> omegapi0 reaction around M_\phi are also used to extract the branching fraction for the OZI and G-parity violating phi -> omegapi0 decay: BR(phi->omegapi0) = (4.4 +- 0.6)x10^-5.Comment: 12 Pages, 4 figures, submitted to Physics Letter

An NF-kB site in the 5'-untraslated leader region of the Human Immunodeficiency virus type 1 enhances the viral expression in response to NF-kB-activating stimuli.

The 5'-untranslated leader region of human immunodeficiency virus, type 1 (HIV-1), includes a complex array of putative regulatory elements whose role in the viral expression is not completely understood. Here we demonstrate the presence of an NF-κB-responsive element in the trans- activation response (TAR) region of HIV-1 that confers the full induction of HIV-1 long terminal repeat (LTR) in response to NF-κB-activating stimuli, such as DNA alkylating agents, phorbol 12-myristate 13-acetate, and tumor necrosis factor-α. The TAR NF-κB site GGGAGCTCTC spans from positions +31 to +40 and cooperates with the NF-κB enhancer upstream of the TATA box in the NF-κB-mediated induction of HIV-1 LTR. The conclusion stems from the following observations: (i) deletion of the two NF-κB sites upstream of the TATA box reduces, but does not abolish, the HIV-1 LTR activation by NF-κB inducers; (ii) deletion or base pair substitutions of the TAR NF-κB site significantly reduce the HIV-1 LTR activation by NF-κB inducers; (iii) deletions of both the NF-κB sites upstream of the TATA box and the TAR NF- κB site abolish the activation of HIV-1 LTR in response to NF-κB inducers. Moreover, the p50·p65 NF-κB complex binds to the TAR NF-κB sequence and trans-activates the TAR NF-κB-directed expression. The identification of an additional NF-κB site in the HIV-1 LTR points to the relevance of NF-κB factors in the HIV-1 life cycle