4,972 research outputs found

    Knots and Classical 3-Geometries

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    It has been conjectured by Rovelli that there is a correspondence between the space of link classes of a Riemannian 3-manifold and the space of 3-geometries (on the same manifold). An exact statement of his conjecture will be established and then verified for the case when the 3-manifold is compact, orientable and closed.Comment: 14p. type-set in AmS-TeX version 2.

    Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons.

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    Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to regulate the transcription of CREB target genes. Here we investigate the long-distance retrograde transport of CRTC1 in hippocampal neurons. We show that local elevations in calcium, triggered by activation of glutamate receptors and L-type voltage-gated calcium channels, initiate active, dynein-mediated retrograde transport of CRTC1 along microtubules. We identify a nuclear localization signal within CRTC1, and characterize three conserved serine residues whose dephosphorylation is required for nuclear import. Domain analysis reveals that the amino-terminal third of CRTC1 contains all of the signals required for regulated nucleocytoplasmic trafficking. We fuse this region to Dendra2 to generate a reporter construct and perform live-cell imaging coupled with local uncaging of glutamate and photoconversion to characterize the dynamics of stimulus-induced retrograde transport and nuclear accumulation

    A multiple-cut analytic center cutting plane method for semidefinite feasibility problems

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    10.1137/S1052623400370503SIAM Journal on Optimization1241126-114

    Measurement of the lifetime of the 7s2S1/27s^2S_{1/2} state in atomic cesium using asynchronous gated detection

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    We report a measurement of the lifetime of the cesium 7s2S1/27s\,^2S_{1/2} state using time-correlated single-photon counting spectroscopy in a vapor cell. We excite the atoms using a Doppler-free two-photon transition from the 6s2S1/26s\,^2S_{1/2} ground state, and detect the 1.47μ\mum photons from the spontaneous decay of the 7s2S1/27s\,^2S_{1/2} to the 6p2P3/26p\,^2P_{3/2} state. We use a gated single photon detector in an asynchronous mode, allowing us to capture the fluorescence profile for a window much larger than the detector gate length. Analysis of the exponential decay of the photon count yields a 7s2S1/27s\,^2S_{1/2} lifetime of 48.28±\pm0.07ns, an uncertainty of 0.14%. These measurements provide sensitive tests of theoretical models of the Cs atom, which play a central role in parity violation measurements.Comment: 5 pages, 5 figures, 2 table

    A model for an inland port in Australia

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    This paper examines the role of an inland port particular to the outer regions of Melbourne, Australia. In this study, it has been experienced that the broad use of terminology, in the Melbourne context, has been a stumbling block. In its particular context, this has provided the impetus for the development of a model for an inland port that is unambiguous. It is clear from international examples that such a development acts as a significant potential nucleus for regional economic growth, but the lack of a facilitated discussion is an impediment. This model is offered as a facilitator and a useful tool in the construction of a common understanding

    Tidal signals in ocean-bottom magnetic measurements of the Northwestern Pacific: observation versus prediction

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    Motional induction in the ocean by tides has long been observed by both land and satellite measurements of magnetic fields. While these signals are weak (∼10 nT) when compared to the main magnetic field, their persistent nature makes them important for consideration during geomagnetic field modelling. Previous studies have reported several discrepancies between observations and numerical predictions of the tidal magnetic signals and those studies were inconclusive of the source of the error. We address this issue by (1) analysing magnetometer data from ocean-bottom stations, where the low-noise and high-signal environment is most suitable for detecting the weak tidal magnetic signals, (2) by numerically predicting the magnetic field with a spatial resolution that is 16times higher than the previous studies and (3) by using four different models of upper-mantle conductivity. We use vector magnetic data from six ocean-bottom electromagnetic (OBEM) stations located in the Northwestern Pacific Ocean. The OBEM tidal amplitudes were derived using an iteratively re-weighted least-squares (IRLS) method and by limiting the analysis of lunar semidiurnal (M2), lunar elliptic semidinurnal (N2) and diurnal (O1) tidal modes to the night-time. Using a 3-D electromagnetic induction solver and the TPX07.2 tidal model, we predict the tidal magnetic signal. We use earth models with non-uniform oceans and four 1-D mantle sections underneath taken from Kuvshinov and Olsen, Shimizu etal. and Baba etal. to compare the effect of upper-mantle conductivity. We find that in general, the predictions and observations match within 10-70 per cent across all the stations for each of the tidal modes. The median normalized percent difference (NPD) between observed and predicted amplitudes for the tidal modes M2, N2 and O1 were 15 per cent, 47 per cent and 98 per cent, respectively, for all the stations and models. At the majority of stations, and for each of the tidal modes, the higher resolution (0.25°×0.25°) modelling gave amplitudes consistently closer to the observations than the lower resolution (1°×1°) modelling. The difference in lithospheric resistance east and west of the Izu-Bonin trench system seems to be affecting the model response and observations in the O1 tidal mode. This response is not seen in the M2 and N2 modes, thereby indicating that the O1 mode is more sensitive to lithospheric resistanc

    A Pragmatic Evaluation of Distance Vector Proactive Routing in MANETs via Open Space Real-World Experiments

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    Mobile Ad hoc Networks constitute a promising and fast developing technology that could significantly enhance user freedom. The flexibility provided by such networks is accompanied by unreliability due to notably dynamic conditions that render routing quite problematic. For that reason, the research community has proposed multiple protocols claimed to address this issue, however, only few have been tested via real experiments, while even fewer have reached maturity to become readily available to end users. The main purpose of this paper is to pragmatically evaluate a promising, complete, and finalized MANET protocol via real-world experimentation in open space environment. The considered protocol, with the acronym B.A.T.M.A.N, which is based on distance vector proactive routing, was tested in different networking scenarios that revealed its ability to satisfactorily handle traffic under different conditions

    On the Nesterov-Todd Direction in Semidefinite Programming

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    On the Nesterov-Todd Direction in Semidefinite Programmin

    Binding of Basic Dyes by the Algae, Chara aspera

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    Non-living biomass of the algae Chara aspera is capable of binding two basic dyes, methylene blue and basic blue 3, from aqueous solution. Factors such as dye concentration, contact time, sorbent dosage and pH of solution were studied. Maximum sorption capacities of the algae for methylene blue and basic blue 3 are 139.4 and 17.8 mg/g, respectively, as determined from the Langmuir isothenns
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