51 research outputs found
Classical Scattering for a driven inverted Gaussian potential in terms of the chaotic invariant set
We study the classical electron scattering from a driven inverted Gaussian
potential, an open system, in terms of its chaotic invariant set. This chaotic
invariant set is described by a ternary horseshoe construction on an
appropriate Poincare surface of section. We find the development parameters
that describe the hyperbolic component of the chaotic invariant set. In
addition, we show that the hierarchical structure of the fractal set of
singularities of the scattering functions is the same as the structure of the
chaotic invariant set. Finally, we construct a symbolic encoding of the
hierarchical structure of the set of singularities of the scattering functions
and use concepts from the thermodynamical formalism to obtain one of the
measures of chaos of the fractal set of singularities, the topological entropy.Comment: accepted in Phy. Rev.
Phase-Space Volume of Regions of Trapped Motion: Multiple Ring Components and Arcs
The phase--space volume of regions of regular or trapped motion, for bounded
or scattering systems with two degrees of freedom respectively, displays
universal properties. In particular, sudden reductions in the phase-space
volume or gaps are observed at specific values of the parameter which tunes the
dynamics; these locations are approximated by the stability resonances. The
latter are defined by a resonant condition on the stability exponents of a
central linearly stable periodic orbit. We show that, for more than two degrees
of freedom, these resonances can be excited opening up gaps, which effectively
separate and reduce the regions of trapped motion in phase space. Using the
scattering approach to narrow rings and a billiard system as example, we
demonstrate that this mechanism yields rings with two or more components. Arcs
are also obtained, specifically when an additional (mean-motion) resonance
condition is met. We obtain a complete representation of the phase-space volume
occupied by the regions of trapped motion.Comment: 19 pages, 17 figure
Self-pulsing effect in chaotic scattering
We study the quantum and classical scattering of Hamiltonian systems whose
chaotic saddle is described by binary or ternary horseshoes. We are interested
in parameters of the system for which a stable island, associated with the
inner fundamental periodic orbit of the system exists and is large, but chaos
around this island is well developed. In this situation, in classical systems,
decay from the interaction region is algebraic, while in quantum systems it is
exponential due to tunneling. In both cases, the most surprising effect is a
periodic response to an incoming wave packet. The period of this self-pulsing
effect or scattering echoes coincides with the mean period, by which the
scattering trajectories rotate around the stable orbit. This period of rotation
is directly related to the development stage of the underlying horseshoe.
Therefore the predicted echoes will provide experimental access to topological
information. We numerically test these results in kicked one dimensional models
and in open billiards.Comment: Submitted to New Journal of Physics. Two movies (not included) and
full-resolution figures are available at http://www.cicc.unam.mx/~mejia
Metastatic seminoma treated with either single agent carboplatin or cisplatin-based combination chemotherapy: a pooled analysis of two randomised trials
The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo
Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects. Microfilariae are produced by long-lived adult parasites, which also release a suite of excretory-secretory products that have recently been subject to in-depth proteomic analysis. Surprisingly, the most abundant secreted protein of adult Brugia malayi is triose phosphate isomerase (TPI), a glycolytic enzyme usually associated with the cytosol. We now show that while TPI is a prominent target of the antibody response to infection, there is little antibody-mediated inhibition of catalytic activity by polyclonal sera. We generated a panel of twenty-three anti-TPI monoclonal antibodies and found only two were able to block TPI enzymatic activity. Immunisation of jirds with B. malayi TPI, or mice with the homologous protein from the rodent filaria Litomosoides sigmodontis, failed to induce neutralising antibodies or protective immunity. In contrast, passive transfer of neutralising monoclonal antibody to mice prior to implantation with adult B. malayi resulted in 60–70% reductions in microfilarial levels in vivo and both oocyte and microfilarial production by individual adult females. The loss of fecundity was accompanied by reduced IFNγ expression by CD4+ T cells and a higher proportion of macrophages at the site of infection. Thus, enzymatically active TPI plays an important role in the transmission cycle of B. malayi filarial parasites and is identified as a potential target for immunological and pharmacological intervention against filarial infections
Measuring Cosmic Rays with the RadMap Telescope on the International Space Station
The RadMap Telescope is a new radiation-monitoring instrument operating in the U.S. Orbital
Segment (USOS) of the International Space Station (ISS). The instrument was commissioned in
May 2023 and will rotate through four locations inside American, European, and Japanese modules
over a period of about six months. In some locations, it will take data alongside operational,
validated detectors for a cross-check of measurements. RadMap’s central detector is a finely
segmented tracking calorimeter that records detailed depth-dose data relevant to studies of the
radiation exposure of the ISS crew. It is also able to record particle-dependent energy spectra of
cosmic-ray nuclei with energies up to several hundred MeV per nucleon. A unique feature of the
detector is its ability to track nuclei with omnidirectional sensitivity at an angular resolution of two
degrees. In this contribution, we present the design and capabilities of the RadMap Telescope and
give an overview of the instrument’s commissioning on the ISS
Macrophage origin limits functional plasticity in helminth-bacterial co-infection
Rapid reprogramming of the macrophage activation phenotype is considered important in the defense against consecutive infection with diverse infectious agents. However, in the setting of persistent, chronic infection the functional importance of macrophage-intrinsic adaptation to changing environments vs. recruitment of new macrophages remains unclear. Here we show that resident peritoneal macrophages expanded by infection with the nematode Heligmosomoides polygyrus bakeri altered their activation phenotype in response to infection with Salmonella enterica ser. Typhimurium in vitro and in vivo. The nematode-expanded resident F4/80high macrophages efficiently upregulated bacterial induced effector molecules (e.g. MHC-II, NOS2) similarly to newly recruited monocyte-derived macrophages. Nonetheless, recruitment of blood monocyte-derived macrophages to Salmonella infection occurred with equal magnitude in co-infected animals and caused displacement of the nematode-expanded, tissue resident-derived macrophages from the peritoneal cavity. Global gene expression analysis revealed that although nematode-expanded resident F4/80high macrophages made an anti-bacterial response, this was muted as compared to newly recruited F4/80low macrophages. However, the F4/80high macrophages adopted unique functional characteristics that included enhanced neutrophil-stimulating chemokine production. Thus, our data provide important evidence that plastic adaptation of MΦ activation does occur in vivo, but that cellular plasticity is outweighed by functional capabilities specific to the tissue origin of the cell
Surgically generated aerosol and mitigation strategies: combined use of irrigation, respirators and suction massively reduces particulate matter aerosol
Background
Aerosol is a health risk to theatre staff. This laboratory study quantifies the reduction in particulate matter aerosol concentrations produced by electrocautery and drilling when using mitigation strategies such as irrigation, respirator filtration and suction in a lab environment to prepare for future work under live OR conditions.
Methods
We combined one aerosol-generating procedure (monopolar cutting or coagulating diathermy or high-speed diamond- or steel-tipped drilling of cadaveric porcine tissue) with one or multiple mitigation strategies (instrument irrigation, plume suction and filtration using an FFP3 respirator filter) and using an optical particle counter to measure particulate matter aerosol size and concentrations.
Results
Significant aerosol concentrations were observed during all aerosol-generating procedures with concentrations exceeding 3 × 106 particles per 100 ml. Considerable reductions in concentrations were observed with mitigation. In drilling, suction, FFP3 filtration and wash alone respectively reduced aerosol by 19.3–31.6%, 65.1–70.8% and 97.2 to > 99.9%. The greatest reduction (97.38 to > 99.9%) was observed when combining irrigation and filtration. Coagulating diathermy reduced concentrations by 88.0–96.6% relative to cutting, but produced larger particles. Suction alone, and suction with filtration reduced aerosol concentration by 41.0–49.6% and 88.9–97.4% respectively. No tested mitigation strategies returned aerosol concentrations to baseline.
Conclusion
Aerosol concentrations are significantly reduced through the combined use of filtration, suction and irrigation. Further research is required to characterise aerosol concentrations in the live OR and to find acceptable exposure limits, and in their absence, to find methods to further reduce exposure to theatre staff
Neighborhood deprivation and biomarkers of health in Britain: The mediating role of the physical environment
Background: Neighborhood deprivation has been consistently linked to poor individual health outcomes; however, studies exploring the mechanisms involved in this association are scarce. The objective of this study was to investigate whether objective measures of the physical environment mediate the association between neighborhood socioeconomic deprivation and biomarkers of health in Britain. Methods: We linked individual-level biomarker data from Understanding Society: The UK Household Longitudinal Survey (2010-2012) to neighborhood-level data from different governmental sources. Our outcome variables were forced expiratory volume in 1 s (FEV1%; n=16,347), systolic blood pressure (SBP; n=16,846), body mass index (BMI; n=19,417), and levels of C-reactive protein (CRP; n=11,825). Our measure of neighborhood socioeconomic deprivation was the Carstairs index, and the neighborhood-level mediators were levels of air pollutants (sulphur dioxide [SO2], particulate matter [PM10], nitrogen dioxide [NO2], and carbon monoxide [CO]), green space, and proximity to waste and industrial facilities. We fitted a multilevel mediation model following a multilevel structural equation framework in MPlus v7.4, adjusting for age, gender, and income. Results: Residents of poor neighborhoods and those exposed to higher pollution and less green space had worse health outcomes. However, only SO2exposure significantly and partially mediated the association between neighborhood socioeconomic deprivation and SBP, BMI, and CRP. Conclusion: Reducing air pollution exposure and increasing access to green space may improve population health but may not decrease health inequalities in Britain
Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage
Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown. We found that Ym1 and Ym2 induced the accumulation of neutrophils through the expansion of γδ T cell populations that produced interleukin 17 (IL-17). While BRP-39 did not influence neutrophilia, it was required for IL-17 production in γδ T cells, which suggested that regulation of IL-17 is an inherent feature of mouse CLPs. Analysis of a nematode infection model, in which the parasite migrates through the lungs, revealed that the IL-17 and neutrophilic inflammation induced by Ym1 limited parasite survival but at the cost of enhanced lung injury. Our studies describe effector functions of CLPs consistent with innate host defense traits of the chitinase family
- …