The risk linked to ionizing radiation: an alternative epidemiologic approach.

Radioprotection norms have been based on risk models that have evolved over time. These models show relationships between exposure and observed effects. There is a high level of uncertainty regarding lower doses. Recommendations have been based on the conservative hypothesis of a linear relationship without threshold value. This relationship is still debated, and the diverse observations do not allow any definitive conclusion. Available data are contradictory, and various interpretations can be made. Here we review an alternative approach for defining causation and reconciling apparently contradictory conclusions. This alternative epidemiologic approach is based on causal groups: Each component of a causal group is necessary but not sufficient for causality. Many groups may be involved in causality. Thus, ionizing radiation may be a component of one or several causal groups. This formalization reconciles heterogeneous observations but implies searching for the interactions between components, mostly between critical components of a causal profile, and, for instance, the reasons why specific human groups would not show any effect despite exposure, when an effect would be expected

Landbouw, Milieu, Natuur en Economie; Editie 2001/2002

Landbouw, Milieu, Natuur en Economie brengt op systematische wijze bij LEI beschikbare gegevens bijeen die van belang zijn voor discussies over milieu, natuur en economie in de agrarische sector. Deze gegevens zijn voor een belangrijk deel ontleend aan het Bedrijven-Informatienet van LEI. Op basis daarvan worden de ontwikkelingen rond de milieuthema's water, nutriënten, gewasbescherming, energie, agrarisch natuur- en landschapsbeheer, biologische landbouw en de grondmarkt beschreven. Milieu/Natuur/Economie/Landbouw/Tuinbouw/Nutriënten/Gewasbescherming/Water/Energie/ Biologische landbouw/Grondmark

Fixation locations when grasping partly occluded objects

When grasping an object, subjects tend to look at the contact positions of the digits (A. M. Brouwer, V. H. Franz, D. Kerzel, & K. R. Gegenfurtner, 2005; R. S. Johansson, G. Westling, A. Bäckström, & J. R. Flanagan, 2001). However, these contact positions are not always visible due to occlusion. Subjects might look at occluded parts to determine the location of the contact positions based on extrapolated information. On the other hand, subjects might avoid looking at occluded parts since no object information can be gathered there. To find out where subjects fixate when grasping occluded objects, we let them grasp flat shapes with the index finger and thumb at predefined contact positions. Either the contact position of the thumb or the finger or both was occluded. In a control condition, a part of the object that does not involve the contact positions was occluded. The results showed that subjects did look at occluded object parts, suggesting that they used extrapolated object information for grasping. Additionally, they preferred to look in the direction of the index finger. When the contact position of the index finger was occluded, this tendency was inhibited. Thus, an occluder does not prevent fixations on occluded object parts, but it does affect fixation locations especially in conditions where the preferred fixation location is occluded. © ARVO

Localization of quasiparticles in a disordered vortex

We study the diffusive motion of low-energy normal quasiparticles along the core of a single vortex in a dirty, type-II, s-wave superconductor. The physics of this system is argued to be described by a one-dimensional supersymmetric nonlinear sigma model, which differs from the sigma models known for disordered metallic wires. For an isolated vortex and quasiparticle energies less than the Thouless energy, we recover the spectral correlations that are predicted by random matrix theory for the universality class C. We then consider the transport problem of transmission of quasiparticles through a vortex connected to particle reservoirs at both ends. The transmittance at zero energy exhibits a weak localization correction reminiscent of quasi-one-dimensional metallic systems with symmetry index beta = 1. Weak localization disappears with increasing energy over a scale set by the Thouless energy. This crossover should be observable in measurements of the longitudinal heat conductivity of an ensemble of vortices under mesoscopic conditions. In the regime of strong localization, the localization length is shown to decrease by a factor of 8 as the quasiparticle energy goes to zero.Comment: 38 pages, LaTeX2e + epsf, 4 eps figures, one reference adde

Effect of the COVID-19 pandemic on clinical characteristics and outcomes of adult pneumococcal meningitis patients - a Dutch prospective nationwide cohort study.

PURPOSE To investigate clinical characteristics and outcomes of patients with pneumococcal meningitis during the COVID-19 pandemic. METHODS In a Dutch prospective cohort, risk factors and clinical characteristics of pneumococcal meningitis episodes occurring during the COVID-19 pandemic (starting March 2020) were compared with those from baseline and the time afterwards. Outcomes were compared with an age-adjusted logistic regression model. RESULTS We included 1,699 patients in 2006-2020, 50 patients in 2020-2021, and 182 patients in 2021-2023. After March 2020 relatively more alcoholism was reported (2006-2020, 6.1%; 2020-2021, 18%; 2021-2023, 9.7%; P = 0.002) and otitis-sinusitis was less frequently reported (2006-2020, 45%; 2020-2021, 22%; 2021-2023, 47%; P = 0.006). Other parameters, i.e. age, sex, symptom duration or initial C-reactive protein level, remained unaffected. Compared to baseline, lumbar punctures were more frequently delayed (on admission day, 2006-2020, 89%; 2020-2021, 74%; 2021-2022, 86%; P = 0.002) and outcomes were worse ('good recovery', 2020-2021, OR 0.5, 95% CI 0.3-0.8). CONCLUSION During the COVID-19 pandemic, we observed worse outcomes in patients with pneumococcal meningitis. This may be explained by differing adherence to restrictions according to risk groups or by reduced health care quality

Reflection of light from a disordered medium backed by a phase-conjugating mirror

This is a theoretical study of the interplay of optical phase-conjugation and multiple scattering. We calculate the intensity of light reflected by a phase-conjugating mirror when it is placed behind a disordered medium. We compare the results of a fully phase-coherent theory with those from the theory of radiative transfer. Both methods are equivalent if the dwell time \tau_{dwell} of a photon in the disordered medium is much larger than the inverse of the frequency shift 2\Delta\omega acquired at the phase-conjugating mirror. When \tau_{dwell} \Delta\omega < 1, in contrast, phase coherence drastically affects the reflected intensity. In particular, a minimum in the dependence of the reflectance on the disorder strength disappears when \Delta\omega is reduced below 1/\tau_{dwell}. The analogies and differences with Andreev reflection of electrons at the interface between a normal metal and a superconductor are discussed.Comment: 27 pages RevTeX with 11 figures included with psfi

Effect of inelastic scattering on parametric pumping

Pumping of charge in phase-coherent mesoscopic systems due to the out-of-phase modulation of two parameters has recently found considerable interest. We investigate the effect of inelastic processes on the adiabatically pumped current through a two terminal mesoscopic sample. We find that the loss of coherence does not suppress the pumped charge but rather an additional physical mechanism for an incoherent pump effect comes into play. In a fully phase incoherent system the pump effect is similar to a rectification effect

Temperature dependence of spin-orbit torques across the magnetic compensation point in a ferrimagnetic TbCo alloy film

The temperature dependence of spin-orbit torques (SOTs) and spin-dependent transport parameters is measured in bilayer Ta/TbCo ferrimagnetic alloy films with bulk perpendicular magnetic anisotropy. We find that the dampinglike (DL)-SOT effective field diverges as temperature is swept through the magnetic compensation temperature (T[subscript M]), where the net magnetization vanishes due to the opposing contributions from the Tb and Co sublattices. We show that DL-SOT scales with the inverse of the saturation magnetization (M[subscript s]), whereas the spin-torque efficiency is independent of the temperature-dependent M [subscript s]. Our findings provide insight into spin transport mechanisms in ferrimagnets and highlight low-M [subscript s] rare-earth/transition-metal alloys as promising candidates for SOT device applications.National Science Foundation (U.S.) (NSF-ECCS-1408172

Acute flaccid myelitis and Guillain-Barre syndrome in children:A comparative study with evaluation of diagnostic criteria

BACKGROUND AND PURPOSE: Differentiation between acute flaccid myelitis (AFM) and Guillain–Barré syndrome (GBS) can be difficult, particularly in children. Our objective was to improve the diagnostic accuracy by giving recommendations based on a comparison of clinical features and diagnostic criteria in children with AFM or GBS. METHODS: A cohort of 26 children with AFM associated with enterovirus D68 was compared to a cohort of 156 children with GBS. The specificity of the Brighton criteria, used for GBS diagnosis, was evaluated in the AFM cohort and the specificity of the Centers for Disease Control and Prevention (CDC) AFM diagnostic criteria in the GBS cohort. RESULTS: Children with AFM compared to those with GBS had a shorter interval between onset of weakness and nadir (3 vs. 8 days, p < 0.001), more often had asymmetric limb weakness (58% vs. 0%, p < 0.001), and less frequently had sensory deficits (0% vs. 40%, p < 0.001). In AFM, cerebrospinal fluid leukocyte counts were higher, whereas protein concentrations were lower. Spinal cord lesions on magnetic resonance imaging were only found in AFM patients. No GBS case fulfilled CDC criteria for definite AFM. Of the AFM cases, 8% fulfilled the Brighton criteria for GBS, when omitting the criterion of excluding an alternate diagnosis. CONCLUSIONS: Despite the overlap in clinical presentation, we found distinctive early clinical and diagnostic characteristics for differentiating AFM from GBS in children. Diagnostic criteria for AFM and GBS usually perform well, but some AFM cases may fulfill clinical diagnostic criteria for GBS. This underlines the need to perform diagnostic tests early to exclude AFM in children suspected of atypical GBS

Analysis of multivariate stochastic signals sampled by on-line particle analyzers: Application to the quantitative assessment of occupational exposure to NOAA in multisource industrial scenarios (MSIS)

In multisource industrial scenarios (MSIS) coexist NOAA generating activities with other productive sources of airborne particles, such as parallel processes of manufacturing or electrical and diesel machinery. A distinctive characteristic of MSIS is the spatially complex distribution of aerosol sources, as well as their potential differences in dynamics, due to the feasibility of multi-task configuration at a given time. Thus, the background signal is expected to challenge the aerosol analyzers at a probably wide range of concentrations and size distributions, depending of the multisource configuration at a given time. Monitoring and prediction by using statistical analysis of time series captured by on-line particle analyzersin industrial scenarios, have been proven to be feasible in predicting PNC evolution provided a given quality of net signals (difference between signal at source and background). However the analysis and modelling of non-consistent time series, influenced by low levels of SNR (Signal-Noise Ratio) could build a misleading basis for decision making. In this context, this work explores the use of stochastic models based on ARIMA methodology to monitor and predict exposure values (PNC). The study was carried out in a MSIS where an case study focused on the manufacture of perforated tablets of nano-TiO2 by cold pressing was performed.Research carried out by projects SCAFFOLD and EHS Advance were made possible thanks to funding from European Commission through FP7 (GA 319092) and Basque Country Government through ETORTEK Programme