Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering

Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering would ameliorate these deficits. Bilateral uterine vessel ligation (Restricted) or sham (Control) surgery was performed on day 18 of gestation. Males and females were investigated at day 20 of gestation (E20), 1 (PN1), 7 (PN7) and 35 (PN35) days postnatally. A separate cohort of Control and Restricted pups were cross-fostered onto a different Control or Restricted mother and examined at PN7. In both sexes, peroxisome proliferator-activated receptor (PPAR)-&gamma; coactivator-1&alpha; (PGC-1&alpha;), cytochrome c oxidase subunits 3 and 4 (COX III and IV) and myogenic regulatory factor 4 expression increased from late gestation to postnatal life, whereas mitochondrial transcription factor A, myogenic differentiation 1 (MyoD), myogenin and insulin-like growth factor I (IGF-I) decreased. Foetal growth restriction increased MyoD mRNA in females at PN7, whereas in males IGF-I mRNA was higher at E20 and PN1. Cross-fostering Restricted pups onto a Control mother significantly increased COX III mRNA in males and COX IV mRNA in both sexes above controls with little effect on other genes. Developmental age appears to be a major factor regulating skeletal muscle mitochondrial and developmental genes, with growth restriction and cross-fostering having only subtle effects. It therefore appears that reductions in adult mitochondrial biogenesis markers likely develop after weaning.<br /

Millennial scale control of European climate by the North Atlantic Oscillation from 12,500 BP: the Asiul speleothem record

Contemporary climate in Europe is strongly influenced by the North Atlantic Oscillation (NAO), the atmospheric pressure dipole between Iceland and the Azores1. Under positive NAO conditions winter storm tracks associated with the Atlantic Westerly Jet (AWJ) migrate northwards, leading to wetter and warmer winter conditions in north-western Europe and dry conditions in southern Europe; including the Iberian Peninsula. Under the negative NAO phase, storm tracks weaken and shift southwards reversing the pattern1. Existing proxy records of the NAO suggest that this atmospheric process only began to dominate European climate at approximately 8000 years BP, related to the final breakup of the Laurentide ice shelf2. However, here we present evidence of precipitation changes from a high-resolution speleothem δ18O record from northern Iberia, which indicates NAO-like forcing extending throughout the Holocene and into the Younger Dryas (YD) at 12,500 years BP. These variations in precipitation delivery relate to an underlying millennial scale cycle in NAO dynamics. The speleothem δ18O is strongly correlated to existing records of North Atlantic Ocean ice rafted debris (IRD)3, indicating an NAO-like connection with oceanic circulation during the Holocene2. These large-scale atmospheric processes have dramatically influenced the delivery of precipitation to northern Iberia and may have played a decisive role in environmental and human development in the region, throughout the Holocene

North Atlantic forcing of moisture delivery to Europe throughout the Holocene

Century-to-millennial scale fluctuations in precipitation and temperature are an established feature of European Holocene climates. Changes in moisture delivery are driven by complex interactions between ocean moisture sources and atmospheric circulation modes, making it difficult to resolve the drivers behind millennial scale variability in European precipitation. Here, we present two overlapping decadal resolution speleothem oxygen isotope (δ18O) records from a cave on the Atlantic coastline of northern Iberia, covering the period 12.1–0 ka. Speleothem δ18O reveals nine quasi-cyclical events of relatively wet-to-dry climatic conditions during the Holocene. Dynamic Harmonic Regression modelling indicates that changes in precipitation occurred with a ~1500 year frequency during the late Holocene and at a shorter length during the early Holocene. The timing of these cycles coincides with changes in North Atlantic Ocean conditions, indicating a connectivity between ocean conditions and Holocene moisture delivery. Early Holocene climate is potentially dominated by freshwater outburst events, whilst ~1500 year cycles in the late Holocene are more likely driven by changes internal to the ocean system. This is the first continental record of its type that clearly demonstrates millennial scale connectivity between the pulse of the ocean and precipitation over Europe through the entirety of the Holocene

CONSERT suggests a change in local properties of 67P/Churyumov-Gerasimenko's nucleus at depth

International audienceAfter the successful landing of Philae on the nucleus of 67P/Churyumov-Gerasimenko, the Rosetta mission provided the first opportunity of performing measurements with the CONSERT tomographic radar in November 2014. CONSERT data were acquired during this first science sequence. They unambiguously showed that propagation through the smaller lobe of the nucleus was achieved. Aims. While the ultimate objective of the CONSERT radar is to perform the tomography of the nucleus, this paper focuses on the local characterization of the shallow subsurface in the area of Philae’s final landing site, specifically determining the possible presence of a permittivity gradient below the nucleus surface.Methods. A number of electromagnetic simulations were made with a ray-tracing code to parametrically study how the gradient of the dielectric constant in the near-subsurface affects the ability of CONSERT to receive signals.Results. At the 90 MHz frequency of CONSERT, the dielectric constant is a function of porosity, composition, and temperature. The dielectric constant values considered for the study are based on observations made by the other instruments of the Rosetta mission, which indicate a possible near-surface gradient in physical properties and on laboratory measurements made on analog samples. Conclusions. The obtained simulated data clearly show that if the dielectric constant were increasing with depth, it would have prevented the reception of signal at the CONSERT location during the first science sequence. We conclude from our simulations that the dielectric constant most probably decreases with depth

Zitterbewegung of electrons in graphene in a magnetic field

Electric current and spacial displacement due to trembling motion [Zitterbewegung (ZB)] of electrons in graphene in the presence of an external magnetic field are described. Contributions of both inequivalent $K$ points in the Brillouin zone of graphene are considered. It is shown that, when the electrons are prepared in the form of wave packets, the presence of a quantizing magnetic field $B$ has very important effects on ZB. (1) For $B\neq 0$ the ZB oscillations are permanent, for B=0 they are transient. (2) For $B\neq 0$ many ZB frequencies appear, for B=0 only one frequency is at work. (3) For $B\neq 0$ both interband and intraband (cyclotron) frequencies contribute to ZB, for B=0 there are no intraband frequencies. (4) Magnetic field intensity changes not only the ZB frequencies but the entire character of ZB spectrum. An emission of electromagnetic dipole radiation by the trembling electrons is proposed and described. It is argued that graphene in a magnetic field is a promising system for an experimental observation of Zitterbewegung.Comment: 9 pages, 8 figure

Adolescence and the next generation

Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today\u27s adolescents, the largest cohort in human history, will yield great dividends for future generations