Reversible adsorption on a random site surface

We examine the reversible adsorption of hard spheres on a random site surface in which the adsorption sites are uniformly and randomly distributed on a plane. Each site can be occupied by one solute provided that the nearest occupied site is at least one diameter away. We use a numerical method to obtain the adsorption isotherm, i.e. the number of adsorbed particles as a function of the bulk activity. The maximum coverage is obtained in the limit of infinite activity and is known exactly in the limits of low and high site density. An approximate theory for the adsorption isotherms, valid at low site density, is developed by using a cluster expansion of the grand canonical partition function. This requires as input the number of clusters of adsorption site of a given size. The theory is accurate for the entire range of activity as long as the site density is less than about 0.3 sites per particle area. We also discuss a connection between this model and the vertex cover problem.Comment: 16 pages, 10 figure

The Isolation of an Actinomycetes-Like Organism from Root Canals

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67354/2/10.1177_00220345410200030301.pd

Evaluation of a multidisciplinary Tier 3 weight management service for adults with morbid obesity, or obesity and comorbidities, based in primary care

A multidisciplinary Tier 3 weight management service in primary care recruited patients with a body mass index ≥40 kg·m−2, or 30 kg·m−2 with obesity-related co-morbidity to a 1-year programme. A cohort of 230 participants was recruited and evaluated using the National Obesity Observatory Standard Evaluation Framework. The primary outcome was weight loss of at least 5% of baseline weight at 12 months. Diet was assessed using the two-item food frequency questionnaire, activity using the General Practice Physical Activity questionnaire and quality of life using the EuroQol-5D-5L questionnaire. A focus group explored the participants' experiences. Baseline mean weight was 124.4 kg and mean body mass index was 44.1 kg·m−2. A total of 102 participants achieved 5% weight loss at 12 months. The mean weight loss was 10.2 kg among the 117 participants who completed the 12-month programme. Baseline observation carried forward analysis gave a mean weight loss of 5.9 kg at 12 months. Fruit and vegetable intake, activity level and quality of life all improved. The dropout rate was 14.3% at 6 months and 45.1% at 1 year. Focus group participants described high levels of satisfaction. It was possible to deliver a Tier 3 weight management service for obese patients with complex co-morbidity in a primary care setting with a full multidisciplinary team, which obtained good health outcomes compared with existing services

Discovery of a Second Nova Eruption of V2487 Ophiuchi

A directed search for previously-undiscovered nova eruptions was conducted in the astronomical plate archives at Harvard College Observatory and Sonneberg Observatory. We found that an eruption of V2487 Oph (Nova Oph 1998) occurred on 1900 June 20. V2487 Oph was previously classified as a classical nova, which we identified as a probable recurrent nova based on its large expansion velocities and the presence of high excitation lines in the outburst spectrum. The event was recorded on Harvard plate AM 505, at a B magnitude of 10.27 +/- 0.11, which is near peak. The outburst can only be seen on one plate, but the image has a characteristic dumbbell shape (caused by a double exposure) that is identical to the other star images on the plate, and thus is not a plate defect. We conclude that this is in fact a previously-undiscovered nova outburst of V2487 Oph, confirming our prediction that it is a recurrent nova. We also examine the discovery efficiency for eruptions of the system and conclude that a randomly-timed outburst has, on average, a 30% chance of being discovered in the past century. Using this, we deduce a recurrence time for V2487 Oph of approximately 18 years, which implies that the next eruption is expected around 2016.Comment: 18 pages, 2 figures, to be published in the Astronomical Journa

Transient, unsettling and creative space: Experiences of liminality through the accounts of Chinese students on a UK-based MBA

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ The Author(s) 2009.This article explores the experiences of liminality through the accounts of Chinese students on a UK-based MBA programme. The transient nature of the MBA experience, as well as the international status of the Chinese student, is resonant with conceptualizations of liminality as ‘in between’ space. Based on semi-structured interviews with 20 MBA graduates who had subsequently returned to China with their qualification, we explored their perceptions of outcomes from the course and their experiences as international students on a programme imbued with western norms and values. Results support the unsettling yet creative implications of liminality, as well as the fragmented insecure nature of identities, as individuals pass through the MBA ‘rite of passage’ in terms of ‘becoming’ a manager and entering a new phase of career. Accounts suggest the creation of hierarchical structures within liminal space whereby Chinese students, through their positioning at the margin, have uncomfortable yet illuminating encounters with alterity. At the same time, they experience levels of ambiguity and uncertainty in the post-liminal phase of China-located employments, as new western-based managerial identities collide with dominant discourses of Chinese organization

An exploratory cluster randomised controlled trial of knowledge translation strategies to support evidence-informed decision-making in local governments (The KT4LG study)

Background: Childhood overweight and obesity is the most prevalent and, arguably, politically complex child health problem internationally. Governments, communities and industry have important roles to play, and are increasingly expected to deliver an evidence-informed system-wide prevention program. However, efforts are impeded by a lack of organisational access to and use of research evidence. This study aims to identify feasible, acceptable and ideally, effective knowledge translation (KT) strategies to increase evidence-informed decision making in local governments, within the context of childhood obesity prevention as a national policy priority.Methods/Design: This paper describes the methods for KT4LG, a cluster randomised controlled trial which is exploratory in nature, given the limited evidence base and methodological advances. KT4LG aims to examine a program of KT strategies to increase the use of research evidence in informing public health decisions in local governments. KT4LG will also assess the feasibility and acceptability of the intervention. The intervention program comprises a facilitated program of evidence awareness, access to tailored research evidence, critical appraisal skills development, networking and evidence summaries and will be compared to provision of evidence summaries alone in the control program. 28 local governments were randomised to intervention or control, using computer generated numbers, stratified by budget tertile (high, medium or low). Questionnaires will be used to measure impact, costs, and outcomes, and key informant interviews will be used to examine processes, feasibility, and experiences. Policy tracer studies will be included to examine impact of intervention on policies within relevant government policy documents.Discussion: Knowledge translation intervention studies with a focus on public health and prevention are very few in number. Thus, this study will provide essential data on the experience of program implementation and evaluation of a system-integrated intervention program employed within the local government public health context. Standardised programs of system, organisational and individual KT strategies have not been described or rigorously evaluated. As such, the findings will make a significant contribution to understanding whether a facilitated program of KT strategies hold promise for facilitating evidence-informed public health decision making within complex multisectoral government organisations.<br /

Infrared Properties of Cataclysmic Variables from 2MASS: Results from the 2nd Incremental Data Release

Because accretion-generated luminosity dominates the radiated energy of most cataclysmic variables, they have been ``traditionally'' observed primarily at short wavelengths. Infrared observations of cataclysmic variables contribute to the understanding of key system components that are expected to radiate at these wavelengths, such as the cool outer disk, accretion stream, and secondary star. We have compiled the J, H, and Ks photometry of all cataclysmic variables located in the sky coverage of the 2 Micron All Sky Survey (2MASS) 2nd Incremental Data Release. This data comprises 251 systems with reliably identified near-IR counterparts and S/N > 10 photometry in one or more of the three near-IR bands.Comment: 2 pages, including 1 figure. To appear in the proceedings of The Physics of Cataclysmic Variables and Related Objects, Goettingen, Germany. For our followup ApJ paper (in press), also see http://www.ctio.noao.edu/~hoard/research/2mass/index.htm

Evaluation of live attenuated Streptococcus pneumoniae vaccine strains on the epithelial response to colonisation using a human challenge model

Background: Streptococcus pneumoniae frequently colonises the human nasopharynx but causes over 500,000 deaths each year from Pneumonia, Sepsis and Meningitis. Nasopharyngeal carriage is required for transmission and is a pre-requisite for disease. The conjugate polysaccharide vaccines have proven effective in decreasing disease. However, replacement of vaccine serotypes with non-vaccine types in carriage threatens the future of the vaccines’ efficiency. Using an Experimental Human Pneumococcal Challenge model (EHPC) and epithelial cell culture models, we have previously shown that pneumococcal colonisation involves both direct epithelial association and micro-invasion, inducing innate immunity and clearance without overt disease. Repeated challenge in the EHPC with the same strain decreases subsequent carriage efficiency and diminishes transmission potential and/or progression to disease, suggesting active mucosal immunity in the nasopharynx. Methods and materials: We have generated live attenuated strains of 6B S. pneumoniae (AS1 and AS2) that have double virulence deletions and cannot revert to cause disease. Here, we have explored the hypothesis that despite their attenuation in a mouse model of disease, these attenuated strains retain their ability to invade the epithelium and induce epithelial-derived innate immunity in humans. Colonisation were measured by confocal microscopy and microbiology density by CFU counts. Epithelial activation was measured by flow cytometry, ELISA and RNAseq. Results: We found that both mutants colonised the human nasopharynx and formed epithelial associations with microinvasion in the EHPC model. In vitro, both mutants adhered, invaded and transmigrated across the epithelium 4-fold less than wild type. However, both mutants still resulted in secretion of IL-8, IL-6 and ICAM-1 secretion and barrier integrity was maintained. PCA analyses revealed that epithelial transcriptomic responses between wild type and the mutants generally overlapped, indicating overall similar stimulation of signaling pathways following exposure. Conclusion: The results reveal that attenuation of these pneumococcal strains has not led to loss of their ability to elicit amucosal immune/inflammatory response. This approach provides an exciting new pipeline for the development and testing of novel vaccines. The application of these attenuated strains in the EHPC also has the potential to provide important new knowledge on the mechanisms behind bacterial clearance, transmission and disease progression during colonisation