Serving children: the impact of poverty on children's experiences of services

This study arose from the identification of a gap in knowledge and corresponding need for the development of a better contemporary understanding of children's experiences of poverty. Focusing on children aged 10 - 14 years, the study aimed to provide a perspective on the lives of children and young people affected by poverty in Scotland through comparing the experiences of children living in poverty with those more economically advantaged

Student attitudes regarding the educational value and welfare implications in the use of model eyes and live dogs in teaching practical fundus examination: evaluation of responses from 40 students

This study sought to document student opinions on the educational value and welfare implications of use of artificial model eyes and live dogs in the training of veterinary students in examination of the canine fundus. Forty students who had undertaken a practical class on canine fundoscopy involving both use of artificial model eyes and live dogs were asked to complete a short questionnaire using a Likert scale to gauge their opinion on whether the use of live dogs and artificial eyes was very valuable (scoring 2), valuable (1), a neutral response (0), not particularly valuable (-1) or not at all valuable (-2) and to write a free text response on their views of the educational value and welfare implications of using artificial model eyes or live dogs in training for ophthalmic examination of the canine ocular fundus. Likert responses were 1.84±0.37 for using live greyhounds and 0.58±0.79 for using simulator eyes (p<0.0001). Thematic analysis of the written responses showed that while the artificial eyes were considered somewhat valuable in initial training, the live dogs were significantly preferred for their realism and the opportunity to examine the eye while handling a live animal. In conclusion, while model eyes are valuable initial training in use of the ophthalmoscope for funduscopic examination, students consider that examining the eye in the live dog is significantly more valuable and that the welfare of dogs thus used is not in their view unduly compromised

Inter-Session Repeatability of Marker-Less Motion Capture of Treadmill Running Gait

Twenty-one experienced runners completed three treadmill running sessions on different days. Each session consisted of three consecutive 2 min trials at self-selected speeds (RPE = 3, 5, and 7). An eight-camera marker-less motion capture system and instrumented pressure treadmill (TM) collected data over the final ~25 s at each speed. Lower extremity joint angles (ankle, knee, and hip) and segmental angles (pelvis and trunk) were computed for each trial with foot contact and toe off being kinematically determined. Spatiotemporal metrics (ground contact time, step length, and cadence) were measured via TM and compared to their kinematically derived counterparts. All spatiotemporal metrics demonstrated excellent agreement (ICCs \u3e 0.98). Both intra-trial and inter-session variability, averaged across the entire running cycle, for all lower extremity joint angles in all planes were low (intra-trial: sagittal = 2.0°, frontal = 1.2°, and transverse = 1.9°; inter-session: sagittal = 1.4°, frontal = 0.8°, and transverse = 1.3°). Discrete measures of lower extremity joint and segmental angles were evaluated for inter-session reliability at foot contact, toe off, and peak value during the stance phase. On average, discrete measures demonstrated good reliability (ICCsagittal = 0.85, ICCfrontal = 0.83, and ICCtransverse = 0.77) with average standard error of measurement \u3c 1°. Marker-less motion capture reliably measured treadmill running kinematics in a group of runners demonstrating heterogenous foot strike patterns (13 rearfoot strike and 8 non-rearfoot strike) across a range of speeds (2.67–4.44 m/s)

Metabolic Efficiency and Mechanics of Walking On Sloped Terrain

Researchers have spent considerable time studying the mechanics and energy expenditure associated with human walking. These studies are generally conducted on flat treadmill surfaces despite the fact that people do not only walk on flat surfaces; they climb and move on different slopes every day, whether it be in the forest for a rugged hike or along the smooth floors of a shopping mall. From stairs to hillsides, we climb slopes every day, yet we have very little information on how our body does this, or how efficient we are at slope walking with regard to metabolic cost. Evidence leads us to believe there is a relation between the steepness of the slope and at what slope a person switches to “forefoot” walking – walking up on the toes or ball of the foot – rather than flat-footed walking. It is proposed that this switch may change the behavior of the muscles in the calf resulting in a change in efficiency. Our study will focus on the degree of slope required to cause this “forefoot” switch as well as its connection to lower limb length and the evolution of human body proportions. Subjects will climb sloped treadmill at different degrees of steepness while motion capture models are created and metabolic energy consumption is recorded. With this, we will investigate how pressures from the environment on human skeletons and muscles may have influenced human evolution, as well as further the knowledge and understanding related to human movement

Regional specialization within the human striatum for diverse psychological functions

Decades of animal and human neuroimaging research have identified distinct, but overlapping, striatal zones, which are interconnected with separable corticostriatal circuits, and are crucial for the organization of functional systems. Despite continuous efforts to subdivide the human striatum based on anatomical and resting-state functional connectivity, characterizing the different psychological processes related to each zone remains a work in progress. Using an unbiased, data-driven approach, we analyzed large-scale coactivation data from 5,809 human imaging studies. We (i) identified five distinct striatal zones that exhibited discrete patterns of coactivation with cortical brain regions across distinct psychological processes and (ii) identified the different psychological processes associated with each zone. We found that the reported pattern of cortical activation reliably predicted which striatal zone was most strongly activated. Critically, activation in each functional zone could be associated with distinct psychological processes directly, rather than inferred indirectly from psychological functions attributed to associated cortices. Consistent with well-established findings, we found an association of the ventral striatum (VS) with reward processing. Confirming less well-established findings, the VS and adjacent anterior caudate were associated with evaluating the value of rewards and actions, respectively. Furthermore, our results confirmed a sometimes overlooked specialization of the posterior caudate nucleus for executive functions, often considered the exclusive domain of frontoparietal cortical circuits. Our findings provide a precise functional map of regional specialization within the human striatum, both in terms of the differential cortical regions and psychological functions associated with each striatal zone

What Should Be Done To Tackle Ghostwriting in the Medical Literature?

Background to the debate: Ghostwriting occurs when someone makes substantial contributions to a manuscript without attribution or disclosure. It is considered bad publication practice in the medical sciences, and some argue it is scientific misconduct. At its extreme, medical ghostwriting involves pharmaceutical companies hiring professional writers to produce papers promoting their products but hiding those contributions and instead naming academic physicians or scientists as the authors. To improve transparency, many editors' associations and journals allow professional medical writers to contribute to the writing of papers without being listed as authors provided their role is acknowledged. This debate examines how best to tackle ghostwriting in the medical literature from the perspectives of a researcher, an editor, and the professional medical writer

The purpose of peer review in the case of an open-access publication

First scientific journals were simply a way of informing colleagues about new research findings. In due course, they started filtering out unreasonable claims, and introduced a peer-review system. The purpose of peer reviewing changed with time. Since the middle of the past century, commercial publishers have owned a large number of scientific journals and as a result, the marketable value of a submitted manuscript has become an increasingly important factor in publishing decisions. Recently some publishers have developed business schemes which may stop this tendency. In the case of an open-access publication, the marketable value of a manuscript is not the primary consideration, since access to the research is not being sold. This innovation challenges scientists to re-consider the purpose of peer review. This editorial indicates some of the commonly used criteria for publication that consequently should receive less or little emphasis under the open-access model

Recent Advances in Understanding the Structure and Properties of Amorphous Oxide Semiconductors

Amorphous oxide semiconductors (AOSs)--ternary or quaternary oxides of post-transition metals such as In-Sn-O, Zn-Sn-O, or In-Ga-Zn-O–have been known for a decade and have attracted a great deal of attention as they possess several technological advantages, including low-temperature large-area deposition, mechanical flexibility, smooth surfaces, and high carrier mobility that is an order of magnitude larger than that of amorphous silicon (a-Si:H). Compared to their crystalline counterparts, the structure of AOSs is extremely sensitive to deposition conditions, stoichiometry, and composition, giving rise to a wide range of tunable optical and electrical properties. The large parameter space and the resulting complex deposition--structure--property relationships in AOSs make the currently available theoretical and experimental research data rather scattered and the design of new materials difficult. In this work, the key properties of several In-based AOSs are studied as a function of cooling rates, oxygen stoichiometry, cation composition, or lattice strain. Based on a thorough comparison of the results of ab initio modeling, comprehensive structural analysis, accurate property calculations, and systematic experimental measurements, a four-dimensional parameter space for AOSs is derived, serving as a solid foundation for property optimization in known AOSs and for design of next-generation transparent amorphous semiconductors

Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease)

The neuronal ceroid lipofuscinoses are a group of lysosomal storage disorders that comprise the most common, genetically heterogeneous, fatal neurodegenerative disorders of children. They are characterised by childhood onset, visual failure, epileptic seizures, psychomotor retardation and dementia. CLN3 disease, also known as Batten disease, is caused by autosomal recessive mutations in the CLN3 gene, 80–85% of which are a ~1 kb deletion. Currently no treatments exist, and after much suffering, the disease inevitably results in premature death. The aim of this study was to generate a zebrafish model of CLN3 disease using antisense morpholino injection, and characterise the pathological and functional consequences of Cln3 deficiency, thereby providing a tool for future drug discovery. The model was shown to faithfully recapitulate the pathological signs of CLN3 disease, including reduced survival, neuronal loss, retinopathy, axonopathy, loss of motor function, lysosomal storage of subunit c of mitochondrial ATP synthase, and epileptic seizures, albeit with an earlier onset and faster progression than the human disease. Our study provides proof of principle that the advantages of the zebrafish over other model systems can be utilised to further our understanding of the pathogenesis of CLN3 disease and accelerate drug discovery