In vitro activity of a new 'higher-lactam' antibacterial agent LY 193239

In vitro activity ofthe new bicyclic pyrazolidinone LY 193239 (Eli Lilly) was evaluated against 52 clinical isolates of Haemophilus influenzae (4 were β-lactamase producers), 32 Enterococcus faecalis, 14 Neisseria gonorrhoeae (1 β-lactamasepositive) and 19 Neisseria meningitidis. Activity was best against Neisseria spp. and H. influenzae, including penicillinase- producing strains. Results of the time-kill study against a non-enzyme-mediated penicillin resistant strain of N. meningitidis indicate that exposure to an antibacterial concentration four times the minimal inhibitory concentration was bactericidal. E. faecalis was insensitive

Cardiovascular disease and nutrition: The use of food-based dietary guidelines for prevention in Africa

There is no doubt that morbidity and mortality from cardiovascular disease (CVD) are increasing in many African countries. Research and implementation of public health nutrition programmes in the developed world have shown that CVD can be prevented by dietary interventions. The objectives of this paper are to (i) review the relationships between diet and CVD; (ii) review the possible contribution of the nutrition transition, which is associated with economic development and “modernisation” to CVD in Africa; (iii) identify barriers and challenges plus assessing the opportunities available to steer the nutrition transition into a more positive direction; and (iv) show how ideal nutrient intakes can be translated into appropriate food based dietary guidelines (FBDGs) and how to apply these for prevention and management of CVDs. This should result in appropriate recommendations for diets that will be country-specific, affordable, culturally acceptable and based on available, traditional and indigenous foods. It is concluded that all health professionals should be sensitised, informed, trained and/or educated to apply FBDGs in a way that will motivate the public or patients to follow healthier diets for primary, secondary and tertiary prevention and treatment of CVD

The Determination of 11B/10B and 87Sr/86Sr Isotope Ratios by Quadrupole-Based ICP-MS for the Fingerprinting of South African Wine

The 11B/10B and 87Sr/86Sr isotope ratios in wines and soils of four major South African wine-producing regions have been determined by quadrupole-based ICP-MSin order to establish a fingerprint for origin verification of the wines. The 11B/10B isotope ratio was found to be a useful tool to distinguish among the wines of the selected wine regions. In addition, the use of B isotope ratios together with elemental concentrations of selected indicator elements as independent variables in a linear discriminant analysis procedure was shown to be a highly successful method to classify wine according to geographical origin. A good correlation between the B and Sr isotope ratios in wine and its provenance soil was found. Both wine and soil samples were prepared using microwave-assisted digestion followed by the isolation of boron and strontium from the sample matrix through element-specific ion exchange. Isotope ratio measurements with good precision, ~0.1 % RSD, for both boron and strontium have been obtained. The 87Sr/86Sr ratio showed limited potential as an indicator of provenance in the wine-producing regions included in this study, since the wines of only one region could be distinguished from the others.Keywords: Boron Isotope Ratio, Strontium Isotope Ratio, ICP-MS, Wine Analysis, Fingerprinting, Provenance Determinatio

A clinical and molecular investigation of two South African families with Simpson-Golabi-Behmel syndrome

Background. Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked recessive overgrowth syndrome manifesting primarily in boys and characterised by macrosomia, distinctive facial features and multiple congenital abnormalities. Although this rare condition is thought to be underdiagnosed, making a diagnosis is important as affected boys have a 7.5% risk of developing visceral tumours and surveillance is warranted. Mutations in GPC3 are found in up to 70% of boys affected with SGBS.Objectives. A clinical and molecular investigation of two boys with SGBS, probands B and S, and their mothers. Documentation of the clinical phenotype could assist with diagnosis in affected boys and will lead to early initiation of tumour surveillance.Methods. Hospital folders were reviewed and clinical consultations arranged for both probands and their mothers. Molecular investigations initially searched for whole-exon deletions in GPC3 followed by gene sequencing.Results. The clinical phenotype of both probands was consistent with that previously reported in the literature. The main features pointing towards the diagnosis were macrosomia, coarse facial features and macroglossia with a midline groove in the tongue. Proband B developed a Wilms tumour. He was found to have a novel mutation causing a premature stop codon.Conclusions. This research represents the first published report of SGBS in South Africa. Early recognition and confirmation of this condition is important in order to institute tumour surveillance and assist families with accurate recurrence risks

Unidentified Galactic High-Energy Sources as Ancient Pulsar Wind Nebulae in the light of new high energy observations and the new code

In a Pulsar Wind Nebula (PWN), the lifetime of inverse Compton (IC) emitting electrons exceeds the lifetime of its progenitor pulsar (as well as its shell-type remnant), but it also exceeds the age of those that emit via synchrotron radiation. Therefore, during its evolution, the PWN can remain bright in IC so that its GeV-TeV gamma-ray flux remains high for timescales much larger (for 10^5 - 10^6 yrs) than the pulsar lifetime and the X-ray PWN lifetime. In this scenario, the magnetic field in the cavity induced by the wind of the progenitor star plays a crucial role. This scenario is in line with the discovery of several unidentified or "dark" sources in the TeV gamma-ray band without X-ray counterparts; and it is also finding confirmation in the recent discoveries at GeV gamma rays. Moreover, these consequences could be also important for reinterpreting the detection of starburst galaxies in the TeV gamma-ray band when considering a leptonic origin of the gamma-ray signal. Both theoretical aspects and their observational proofs will be discussed, as well as the first results of our new modeling code.Comment: Proceedings of the 5th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma2012

Numerical simulations of composite supernova remnants for small σ\sigma pulsar wind nebulae

Composite supernova remnants consist of a pulsar wind nebula located inside a shell-type remnant. The presence of a shell has implications on the evolution of the nebula, although the converse is generally not true. The purpose of this paper is two-fold. The first aim is to determine the effect of the pulsar's initial luminosity and spin-down rate, the supernova ejecta mass, and density of the interstellar medium on the evolution of a spherically-symmetric, composite supernova remnant expanding into a homogeneous medium. The second aim is to investigate the evolution of the magnetic field in the pulsar wind nebula when the the composite remnant expands into a non-uniform interstellar medium. The Euler conservation equations for inviscid flow, together with the magnetohydrodynamic induction law in the kinematic limit, are solved numerically for a number of scenarios where the ratio of magnetic to particle energy is $\sigma < 0.01$. The simulations in the first part of the paper is solved in a one-dimensional configuration. In the second part of the paper, the effect of an inhomogeneous medium on the evolution is studied using a two-dimensional, axis-symmetric configuration

Institutionalizing diversity and inclusion engaged marketing (DIEM) for multicultural marketplace wellbeing

Within an institutional theory framework, this paper identifies three interconnected fields of the marketing institution – research, education, and practice – that contribute to advancing the diversity and inclusion discourse in promoting multicultural marketplace wellbeing. Conducting three studies, one in each field and across contexts in three continents, we identify barriers that inhibit effective implementation of diversity and inclusion initiatives in today’s multicultural marketplaces. These barriers exist within and across fields and pertain to cultural-cognitive (shared meanings), normative (normative factors), and regulatory (rules and systems) pillars supporting the existence or transformation of institutions. From our research findings, we provide specific guidance for institutional work within marketing’s fields and policy developments needed to advance diversity and inclusion engaged marketing (DIEM) for enhancing multicultural marketplace wellbeing

Functional foods with added plant sterols for treatment of hypercholesterolaemia and prevention of ischaemic heart disease

Background. A spread with added plant sterols, Pro-activ, is marketed in South Africa as an adjunct to low-fat diets for lowering of total and low-density lipoprotein (LDL) cholesterol concentrations and to decrease risk of ischaemic heart disease (IHD). Objectives. The need for this functional food in South Africa, its efficacy, safety and target market, are evaluated in this review. Results. The high, and probably increasing incidence of hypercholesterolaemia and cardiovascular disease in South Africa motivates the need for appropriate functional foods. There is convincing evidence in the literature that an average daily intake of about 2 g plant sterols in about 20 g of spread significantly lowers total and LDL cholesterol concentrations by approximately 10 - 15%, without influencing high-density lipoprotein (HDL) cholesterol and triglyceride concentrations. There is some concern about the effects on absorption of lipid-soluble vitamins and pro-vitamins, but safety tests lasting for up to 3 years found no serious adverse effects. Conclusions. The target market for this spread should be nonpregnant, non-lactating adults with hypercholesterolaemia and/or increased risk of IHD. If it is considered for use in hypercholesterolaemic children, fat-soluble vitamin status should be monitored. It is recommended that post-marketing surveillance should be established to determine long-term effects and safety

Why a contextual approach to professional development?

One of the peculiarities of the literature on academic professional development with regard to teaching is its a-political nature. It pays insufficient attention to issues of equity, and to how privilege, geographical location, class and ethnicity influence the way that staff in higher education learn to teach. This is surprising, or paradoxical, given the strong world-wide concern for widening participation and student success in higher education. The approaches towards professional academic development have been dominated by literature from the global North, which does not take into account conditions in resource-constrained environments. We contend that literature from these Southern environments enrich the international body of literature. Thus there is a need for scholarly writing on learning to teach in higher education, which takes a specifically social, contextual and relational approach and which considers these within resource-rich as well as resource-constrained environments

Brokering intercultural relations in the rainbow nation: introducing intercultural marketing

This paper considers the role of marketing in building intercultural relations in superdiverse, post-colonial societies, using post-apartheid South Africa as a case study. Drawing on neo-institutional theory, we analyze South African advertising campaigns to determine how marketing brokers intercultural relations by legitimizing social meanings conveyed through nation-building ideologies and consumers’ lived experiences. We examine whether marketing outputs align with stages of Rainbow Nation-building strategies and types of consumers’ lived experiences of South Africa’s superdiversity. We then derive a conceptualization of intercultural marketing, which we characterize as an approach focused on brokering meanings of convivial intercultural engagement and collective development of societal welfare goals. We contribute to macromarketing theory, directing attention to the important brokering role marketing has, in bridging conceptions of reconciliatory social development held by public policy makers and by societies’ populations. By conceptualizing intercultural marketing, its goals and tools, we contribute to multiculturally-sensitive marketing research and practice advancement