Effect of beetroot juice supplementation on aerobic response during swimming

The beneficial effects of beetroot juice supplementation (BJS) have been tested during cycling, walking, and running. The purpose of the present study was to investigate whether BJS can also improve performance in swimmers. Fourteen moderately trained male master swimmers were recruited and underwent two incremental swimming tests randomly assigned in a pool during which workload, oxygen uptake (VO2), carbon dioxide production (VCO2), pulmonary ventilation (VE), and aerobic energy cost (AEC) of swimming were measured. One was a control swimming test (CSW) and the other a swimming test after six days of BJS (0.5l/day organic beetroot juice containing about 5.5 mmol of NO3 -). Results show that workload at anaerobic threshold was significantly increased by BJS as compared to the CSW test (6.3 ± 1 and 6.7 ± 1.1 kg during the CSW and the BJS test respectively). Moreover, AEC was significantly reduced during the BJS test (1.9 ± 0.5 during the SW test vs. 1.7 ± 0.3 kcal·kg-1·h-1 during the BJS test). The other variables lacked a statistically significant effect with BJS. The present investigation provides evidence that BJS positively affects performance of swimmers as it reduces the AEC and increases the workload at anaerobic threshold

Development and psychometric properties of a brief measure of subjective decision quality for breast cancer treatment

Abstract Background Breast cancer patients face several preference-sensitive treatment decisions. Feelings such as regret or having had inadequate information about these decisions can significantly alter patient perceptions of recovery and recurrence. Numerous objective measures of decision quality (e.g., knowledge assessments, values concordance measures) have been developed; there are far fewer measures of subjective decision quality and little consensus regarding how the construct should be assessed. The current study explores the psychometric properties of a new subjective quality decision measure for breast cancer treatment that could be used for other preference sensitive decisions. Methods 320 women aged 20–79 diagnosed with AJCC stage 0 – III breast cancer were surveyed at two cancer specialty centers. Decision quality was assessed with single items representing six dimensions: regret, satisfaction, and fit as well as perceived adequacy of information, time, and involvement. Women rated decision quality for their overall treatment experience and surgery, chemotherapy, and radiation decisions separately. Principle components was used to explore factor structure. After scales were formed, internal consistency was computed using Cronbach’s alpha. The association of each of the four final scales with patient characteristics scores was examined by Pearson correlation. Results For overall breast cancer treatment as well as surgery, chemotherapy, and radiation decisions, the six items yielded a single factor solution. Factor loadings of the six decision items were all above .45 across the overall and treatment-specific scales, with the exception of “Right for You” for chemotherapy and radiation. Internal consistency was 0.77, 0.85, 0.82, and 0.78 for the overall, surgery, chemotherapy, and radiation decision quality scales, respectively. Conclusions Our measure of subjective appraisal of breast cancer treatment decisions includes 5 related elements; regret and satisfaction as well as perceived adequacy of information, time, and involvement. Future research is needed to establish norms for the measure as is further psychometric testing, particularly to examine how it is associated with outcomes such as quality of life, psychological coping and objective decision quality.http://deepblue.lib.umich.edu/bitstream/2027.42/109727/1/12911_2014_Article_110.pd

Innate Immunity and Resistance to Tolerogenesis in Allotransplantation

The development of immunosuppressive drugs to control adaptive immune responses has led to the success of transplantation as a therapy for end-stage organ failure. However, these agents are largely ineffective in suppressing components of the innate immune system. This distinction has gained in clinical significance as mounting evidence now indicates that innate immune responses play important roles in the acute and chronic rejection of whole organ allografts. For instance, whereas clinical interest in natural killer (NK) cells was once largely confined to the field of bone marrow transplantation, recent findings suggest that these cells can also participate in the acute rejection of cardiac allografts and prevent tolerance induction. Stimulation of Toll-like receptors (TLRs), another important component of innate immunity, by endogenous ligands released in response to ischemia/reperfusion is now known to cause an inflammatory milieu favorable to graft rejection and abrogation of tolerance. Emerging data suggest that activation of complement is linked to acute rejection and interferes with tolerance. In summary, the conventional wisdom that the innate immune system is of little importance in whole organ transplantation is no longer tenable. The addition of strategies that target TLRs, NK cells, complement, and other components of the innate immune system will be necessary to eventually achieve long-term tolerance to human allograft recipients

Clinical global impression-severity score as a reliable measure for routine evaluation of remission in schizophrenia and schizoaffective disorders

Aims: This study aimed to compare the performance of Positive and Negative Syndrome Scale (PANSS) symptom severity criteria established by the Remission in Schizophrenia Working Group (RSWG) with criteria based on Clinical Global Impression (CGI) severity score. The 6-month duration criterion was not taken into consideration. Methods: A convenience sample of 112 chronic psychotic outpatients was examined. Symptomatic remission was evaluated according to RSWG severity criterion and to a severity criterion indicated by the overall score obtained at CGI-Schizophrenia (CGI-SCH) rating scale (≤3) (CGI-S). Results: Clinical remission rates of 50% and 49.1%, respectively, were given by RSWG and CGI-S, with a significant level of agreement between the two criteria in identifying remitted and non-remitted cases. Mean scores at CGI-SCH and PANSS scales were significantly higher among remitters, independent of the remission criteria adopted. Measures of cognitive functioning were largely independent of clinical remission evaluated according to both RSWG and CGI-S. When applying RSWG and CGI-S criteria, the rates of overall good functioning yielded by Personal and Social Performance scale (PSP) were 32.1% and 32.7%, respectively, while the mean scores at PSP scale differed significantly between remitted and non-remitted patients, independent of criteria adopted. The proportion of patients judged to be in a state of well-being on Social Well-Being Under Neuroleptics-Short Version scale (SWN-K) were, respectively, 66.1% and 74.5% among remitters according to RSWG and CGI-S; the mean scores at the SWN scale were significantly higher only among remitters according to CGI-S criteria. Conclusions: CGI severity criteria may represent a valid and user-friendly alternative for use in identifying patients in remission, particularly in routine clinical practic

LinguAPP: An m-Health Application for Teledentistry Diagnostics

An Android/iOS application for low-cost mobile devices to aid in dental diagnosis through questionnaire and photos is presented in this paper. The main purposes of our app lie in the ease of use even for nonexperienced users, in the limited hardware requirements that allow a wide diffusion, and in the possibility to modify the questionnaire for different pathologies. This tool was developed in about a month at the beginning of the COVID-19 (SARS-CoV-2) pandemic and is still in use in Italy to allow support to patients without going to the hospital, if not strictly necessary

Active TB screening among homeless people attending soup kitchens in Verona (Italy)

BACKGROUND: The hard-to-reach populations, including the homeless, are particularly vulnerable to the development of active tuberculosis. According to the World Health Organization, tuberculosis rates among the homeless in industrialized Countries are up to 20 times higher if compared with the general population, representing a relevant public health problem. The aim of our study was to describe the results of an active tuberculosis screening applied in order to find out suspected active TB cases among the homeless in Verona.METHODS: As part of a partnership between the non-profit association Medici per la Pace and one of the Local Health Units of Veneto Region (ULSS 9 Scaligera) in 2018, a tuberculosis screening, based on thoracic radiographs, was offered to the homeless guests of two Verona's soup kitchens.RESULT: The studied population included 139 people, and three cases of suspected active tuberculosis, all in males, were observed. Among these, two received a diagnostic confirmation of active tuberculosis (a prevalence of 1.44% - CI: 0,17 - 5,1). Moreover, radiographic patterns of tuberculosis aftermaths were found in six additional subjects.CONCLUSION: Interventions specifically dedicated to hard-to-reach populations, can be useful in identifying tuberculosis active cases and controlling the disease in low tuberculosis burden countries. In particular, the active research of subjects, the screening carried out with mobile X-ray, and also the constant caring of the patients with active disease, could be the right method to keep under control this relevant public health problem

Collagen gene variants and anterior cruciate ligament rupture in Italian athletes: a preliminary report

several studies have investigated the role of genetics in anterior cruciate ligament (ACL) rupture, often returning conflicting results. the present pilot study aimed to analyze the association between six Single Nucleotide Polymorphisms (SNPs) (rs1800012; rs12722; rs13946; rs240736; rs970547; and rs4870723, located on the COL1A1, COL5A1, COL12A1, and COL14A1 genes), and ACL rupture, among Italian athletes. A hypothesis-driven association study was conducted. In total, 181 male and female athletes (n = 86 injured; n = 96 non-injured) were genotyped for the prioritized variants. All polymorphisms were genotyped using PCR RFLP, with the only exception being the rs1800012 on the COL1A1 gene, which was detected using MTPA PCR. The allele frequency distribution fell within the worldwide range. Despite the evident population variability, no selective pressure signals were recorded using PBS analysis. No significant difference was detected between the cases and controls for any of the SNPs (rs1800012; rs13946; rs240736; rs970547, and rs4870723) included in the analyses (p > 0.008, Bonferroni-adjusted for multiple comparisons). Moreover, no significant differences were found when males and females were assessed separately. Further investigations based on a larger sample size are needed, in order to draw solid conclusions for the influence between collagen genes and ACL rupture

Mechatronic face mask anti covid-19 to remotely record cardiorespiratory variables in farm’s workers engaged in jobs at high risk of infection

The most frequent prodromes of COVID-19 infection are fever, signs of respiratory diseases, cough and shortness of breath. Nevertheless, it is not infrequent that patients with COVID-19 also show cardiac symptoms. So, it is of importance to detect the prodromal symptoms of the COVID-19 infection in order to be able to make a diagnosis as quickly as possible to provide the immediate insertion of the infected people in isolation/therapy protocols. Here is presented a prototype of a smart face mask, named AG47-SmartMask that, in addition to the function of both an active and passive anti COVID-19 filter by an electro-heated filter brought to a minimum temperature of 38°C, it also allows the continuous monitoring of numerous cardio-pulmonary variables. Several specific sensors are incorporated into the mask to assess the inside mask temperature from which synchronous waving with the breathing was acquired the breath frequency, relative humidity, air pressure together and end tidal carbon dioxide percentage, and an auricular assessment of the body temperature, the heart rate and the percentage of oxygen saturation of haemoglobin. Sensors are embedded within an advanced ICT platform. To validate the AG47-SmartMask tool, were engaged twenty seven Farm’s workers of a vegetable packaging chain and they dressed the face mask device to simulate, while working, both tachypnea and cough, and the AG47-SmartMask faithfully quantified the simulated dyspnoic events

Strengthening the sustainability of European food chains through quality and procurement policies

International audienceBackgroundThe nexus of agri-food and sustainability in economic development has recently attracted the interest of policymakers, as global challenges like climate change and food security are revisited and reassessed. The critical role of food production in economic development has been emphasized through targeted agricultural quality policies. Many developed countries worldwide, including EU member states, have introduced food quality policies that could support sustainability.Scope and approachThis paper combines knowledge obtained by several groups in a broad EU study and the reflections on policy-related results by EU-stakeholders, streamlined by a Delphi analysis. Current work presents research-based policy recommendations and statements on various quality schemes, introductory inferred from expert opinions throughout Europe, gauged through a modified policy Delphi framework.Key findings and conclusionsA roadmap of policy and practical proposals have been identified for all key stakeholders involved in these initiatives, implying the need to reshape the supply chain dynamics to continuously improve producers, processors, retailers, and consumers within the EU and definitively worldwide. Furthermore, implementing a holistic approach considering environmental and socio-economic features can improve the effectiveness of EU food quality policies

Cardiodynamic adjustments in skilled civil aircraft pilots while unexpected emergency conditions appeared during a simulated flight within a homemade Airbus A300 cockpit

To highlight which cardiodynamic adjustments take place in civil aircraft pilots when unexpected mechanical accidents occur while they are in flight, in 8 skilled pilots we detected the mean blood arterial pressure (MAP) and heart rate (HR) while a unexpected failing of one engine occurred when they were engaged in a simulated flight with a homemade Airbus A300 cockpit. Comparing these two cardiovascular variables in a simulated flight test, just as when the accident happened, together with the values assessed in a simulated control flight without accidents, by the non-parametric Wilcoxon test for paired data it has been found a significant increase of MAP's median (+ 20.3%, P = 0.008) without significant increase in HR one. However, in several tested pilots this sudden MAP increase tended to progressively recover baseline values while simulating the flight despite the event triggering this functional response was still present. We concluded that the cardiovascular apparatus of skilled aircraft civil pilots adapts in such a way of sudden respond to unexpected emergency conditions by adjusting mean arterial blood pressure for adequate blood flow to limb muscles, and this happens without a concomitant tachycardia response in order to maintain an optimal mechanical/metabolic efficiency of the heart