Is sirolimus a therapeutic option for patients with progressive pulmonary lymphangioleiomyomatosis?

<p>Abstract</p> <p>Background</p> <p>Lymphangioleiomyomatosis (LAM) is a rare lung disease characterised by progressive airflow obstruction. No effective medical treatment is available but therapy with sirolimus has shown some promise. The aim of this observational study was to evaluate sirolimus in progressive LAM.</p> <p>Methods</p> <p>Sirolimus (trough level 5 - 10 ng/ml) was administered to ten female patients (42.4 ± 11.9 years) with documented progression. Serial pulmonary function tests and six-minute-walk-distance (6-MWD) assessments were performed.</p> <p>Results</p> <p>The mean loss of FEV₁was -2.30 ± 0.52 ml/day before therapy and a significant mean gain of FEV₁of 1.19 ± 0.26 ml/day was detected during treatment (p = 0.001). Mean FEV₁and FVC at baseline were 1.12 ± 0.15 l (36.1 ± 4.5%pred.) and 2.47 ± 0.25 l (69.2 ± 6.5%pred.), respectively. At three and six months during follow-up a significant increase of FEV₁and FVC was demonstrated (3 months ΔFEV₁: 220 ± 82 ml, p = 0.024; 6 months ΔFEV₁: 345 ± 58 ml, p = 0.001); (3 months ΔFVC: 360 ± 141 ml, p = 0.031; 6 months ΔFVC: 488 ± 138 ml, p = 0.006). Sirolimus was discontinued in 3 patients because of serious recurrent lower respiratory tract infection or sirolimus-induced pneumonitis. No deaths and no pneumothoraces occurred during therapy.</p> <p>Conclusions</p> <p>Our data suggest that sirolimus might be considered as a therapeutic option in rapidly declining LAM patients. However, sirolimus administration may be associated with severe respiratory adverse events requiring treatment cessation in some patients. Moreover, discontinuation of sirolimus is mandatory prior to lung transplantation.</p

Academic and life satisfaction in Portuguese and Mozambican college students : a comparative study

Publicado em "ICERI2010 Proceedings, ISBN 978-84-614-2439-9"The social-cognitive model of well-being [1] has become an important framework to study satisfaction and adjustment in specific life contexts and in overall life [1] [2]. Taking into consideration this integrative perspective, this paper aims to understand and compare the process of academic satisfaction in European and Mozambican Portuguese speaking college students, and to draw implications for psycho educational interventions and research in those contexts. We present and discuss the results of the assessment of self-efficacy, goal progress, environmental supports, academic adjustment, positive affect and overall life satisfaction dimensions (AAQ; Academic Adjustment Questionnaire [1]), conducted with 305 students attending one public university and one public polytechnic institute in Portugal, and with 465 students attending one public university in Mozambique. A first study of the instrument in Portugal with higher education students [3] revealed values of internal consistency for the seven scales ranging between 0,75 and 0,88 (M =0, 84, SD = 5,00). In this study, the range of internal consistency coefficients (Cronbach alpha) were between 0,52 and 0,78 (M =0,67, SD = 9,5) for the Portuguese sample, and between 0,65 and 0,83 (M =0,75, SD = 5,4) for the African Mozambican sample. Moreover, in the Portuguese sample, positive correlations were registered between the dimensions of academic adjustment, positive affect and satisfaction with life in general. In the Mozambican sample, in turn, in general, moderate and positive correlations were obtained, statistically significant between all the dimensions of the academic adjustment that were evaluated. An analysis of the mean tells us that, in both samples, students tend to have moderate values on the dimensions of the academic adjustment model. The comparison test of means reveals significant differences between the two countries in the overall dimensions of academic adjustment, with the exception of the scale factors to stimulate the academic adjustment. Specifically, the Portuguese students obtain the highest values in the dimensions of self-confidence, overall adjustment, and satisfaction with life. The Mozambican students registered higher results on self- confidence to face academic barriers and progress in their academic goals. The results obtained also evidence that students from both countries perceive they have a support system and incentives in the academic and classroom environments. This is a dimension that is directly and indirectly correlated with academic adjustment, in both samples, which suggests the importance of socio-cognitive dimensions of adjustment to college

Alterações nas capacidades motoras Bbsicas, em idosos institucionalizados submetidos à prática de actividade física

Dissertação apresentado à Escola Superior de Educação do Instituto Politécnico de Castelo Branco com vista à obtenção do grau de Mestre em Actividade Física na Especialidade de Gerontomotricidade.Com o presente estudo pretendia-se conhecer, da forma mais aprofundada possível, a aptidão física funcional dos idosos institucionalizados a frequentarem aulas de actividade física, verificando se as habilidades motoras básicas sofriam variações consoante o género, a faixa etária e frequência semanal da aula. A nossa amostra consistiu num grupo de 32 idosos, com mais de 65 anos, do distrito de Castelo Branco, dos quais 24 eram mulheres e 8 eram homens. Estes foram ainda divididos por duas faixas etárias, uma que compreendia os idosos dos 65 aos 75 anos e outra que englobou os idosos com mais de 75 anos. Cada participante realizou um conjunto de testes baseados na bateria de testes de Rikli e Jones (1999). Para o tratamento dos dados recorremos ao programa informático SPSS versão 16 para Windows. A pesquisa colocou em evidência as diferenças nas habilidades motoras básicas com a prática de actividade física

Evaluation of an in-house molecular HIV-1 test to assess mother-to-child HIV-1 transmission in Angola (the APEHC cohort)

Poster presented at the 17th Annual International Meeting of the Institute of Human Virology. Baltimore, 27-30 September 2015"Mother-to-child-transmission (MTCT) rate has decreased sharply in recent years in most of the sub-Saharan Africa, however 220,000 children acquired HIV-1 in 2014. PCR detection of proviral DNA is the most sensitive method for early infant diagnosis (EID) of HIV-1 infection. Commercial kits are available but they have poor sensitivity with divergent non-B subtypes and high costs (≈30€ per test) which limit their use in resource-limited settings. The HIV-1 epidemic in Angola is driven by highly divergent strains of all group M subtypes, except B, as well as multiple recombinant forms (CRFs and URFs) making EID a challenge in this setting. The aim of this study was to develop and validate a qualitative, inexpensive and sensitive “inhouse” HIV-1 EID assay on heel prick dried blood spots (DBS) from infants of the Hospital da Divina Providência (HDP) in Luanda, Angola and determine the current HIV-1 MTCT rate in the Angolan PErinatal HIV Cohort (APEHC)."Fundação para a Ciência e a Tecnologia - Portugal ; European Unio

Dilemmas of girls and women in engineering: a study in Portugal

The reason that girls and women withdraw from science and technology education and careers has been a universal concern in the social sciences. This study investigated how gendered constructions of identity are translated into the barriers and fears that female students and professional women experience in decision-making about their careers. We conducted interviews with 63 girls and 39 women in academic and professional engineering careers, focusing on their interpersonal relationships with boys and men in their school and occupational engineering settings, respectively. Participant discourse highlighted the difficulties women face when managing the antagonistic discourses of femininity and masculinity in a social environment in which they are frequently forced to submit to hegemonic masculinity. The consequences of women’s differing discourses about the “masculine world” and the “feminine world” are discussed, and some strategies for creating more equalitarian relational environments in school and work settings are discussed.Fundação para a Ciência e a Tecnologia (FCT

Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caused by human adenovirus serotype 3 and a new 7/3 recombinant strain

Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004.Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and virus isolation. Most(96%) isolates were classified as being of subspecies B1. Phylogenetic analysis of fiber and hexon gene sequences revealed that most infants were infected with AdV serotype 3 (AdV3) strains. Infants attending one nursery harbored a new recombinant strain containing an AdV serotype 7 hexon and serotype 3 fiber (AdV7/3). Both the AdV3 and the AdV7/3 strains caused fatal infections. Two different serotype 3 strains were circulating in Lisbon in 2004, and the new AdV7/3 recombinant type originated from only one of those strains. These results demonstrate that recombination leads to the emergence of new adenovirus strains with epidemic and lethal potentialThis research was funded by DGE of the European Commission (for the research project entitled Genomic inventory, forensic markers, and assessment of potential therapeutic and vaccine targets for viruses relevant in biological crime and terrorism, grant SSPE-CT-2005-022639 RIVIGENE

Medicines review in the elderly

Poster presented at the Pharmaceutical Care Network Europe (PCNE) Working Symposium: Medication review, Drug-related problems, Standards and Guidelines, 2014, Sliema (Malta)Egas Moniz - Cooperativa de Ensino Superior CRL; Ordem dos Farmacêuticos

Brassica oleracea var. costata: comparative study on organic acids and biomass production with other cabbage varieties

BACKGROUND: A study was undertaken to evaluate the effect of agronomic practices, harvesting time and leaf age on the organic acid composition and biomass production of Brassica oleracea L. var. costata DC (tronchuda cabbage). Samples were cultivated under eight different fertilisation regimes (two levels each of nitrogen, boron and sulfur, an organic fertiliser and no fertiliser) and collected at three different times. RESULTS: Principal component analysis of the data indicated significant differences. Three principal components with an eigenvalue higher than one accounted for 79.0% of the total variance of the data set. Samples obtained with conventional fertilisation were characterised by the highest values of fresh weight. External leaves showed higher total organic acid and malic acid contents than internal leaves,while the latterwere characterised by higher proportions of citric acid. For consecutive harvests, total organic acid concentration decreased in both external and internal leaves. CONCLUSION: The use of a conventional fertilisation regime (nitrogen, boron or sulfur) improved the growth of B. oleracea var. costata without affecting its organic acid profile. However, for consecutive harvests, total organic acid concentration was observed to decrease independently of the agronomic practices tested. Leaf age influenced the quantitative composition of organic acids.FC

Determinants of the Use of Health and Fitness Mobile Apps by Patients With Asthma: Secondary Analysis of Observational Studies

Background: Health and fitness apps have potential benefits to improve self-management and disease control among patients with asthma. However, inconsistent use rates have been reported across studies, regions, and health systems. A better understanding of the characteristics of users and nonusers is critical to design solutions that are effectively integrated in patients' daily lives, and to ensure that these equitably reach out to different groups of patients, thus improving rather than entrenching health inequities. Objective: This study aimed to evaluate the use of general health and fitness apps by patients with asthma and to identify determinants of usage. Methods: A secondary analysis of the INSPIRERS observational studies was conducted using data from face-to-face visits. Patients with a diagnosis of asthma were included between November 2017 and August 2020. Individual-level data were collected, including age, gender, marital status, educational level, health status, presence of anxiety and depression, postcode, socioeconomic level, digital literacy, use of health services, and use of health and fitness apps. Multivariate logistic regression was used to model the probability of being a health and fitness app user. Statistical analysis was performed in R. Results: A total of 526 patients attended a face-to-face visit in the 49 recruiting centers and 514 had complete data. Most participants were ≤40 years old (66.4%), had at least 10 years of education (57.4%), and were in the 3 higher quintiles of the socioeconomic deprivation index (70.1%). The majority reported an overall good health status (visual analogue scale [VAS] score>70 in 93.1%) and the prevalence of anxiety and depression was 34.3% and 11.9%, respectively. The proportion of participants who reported using health and fitness mobile apps was 41.1% (n=211). Multivariate models revealed that single individuals and those with more than 10 years of education are more likely to use health and fitness mobile apps (adjusted odds ratio [aOR] 2.22, 95%CI 1.05-4.75 and aOR 1.95, 95%CI 1.12-3.45, respectively). Higher digital literacy scores were also associated with higher odds of being a user of health and fitness apps, with participants in the second, third, and fourth quartiles reporting aORs of 6.74 (95%CI 2.90-17.40), 10.30 (95%CI 4.28-27.56), and 11.52 (95%CI 4.78-30.87), respectively. Participants with depression symptoms had lower odds of using health and fitness apps (aOR 0.32, 95%CI 0.12-0.83). Conclusions: A better understanding of the barriers and enhancers of app use among patients with lower education, lower digital literacy, or depressive symptoms is key to design tailored interventions to ensure a sustained and equitable use of these technologies. Future studies should also assess users' general health-seeking behavior and their interest and concerns specifically about digital tools. These factors may impact both initial engagement and sustained use.info:eu-repo/semantics/publishedVersio