7 research outputs found
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt AH
- Abedi Vida
- Adams Hieab
- Adebajo OJ
- Adeoye AM
- Afzal S
- Ago Tetsuro
- Agunloye A
- Akinyemi J
- Akinyemi Rufus
- Akpa O
- Akpalu A
- Almgren P
- Alvarez-Sabin J
- Amin N
- Amouyel Philippe
- Anderson CD
- Anderson Christopher D.
- Aparicio HJ
- Arenillas JF
- Armasu SM
- Armstrong Nicole D.
- Arnett DK
- Arulogun O
- Attia J
- Ay H
- Bae Hee-Joon
- Bakker Mark K.
- Bammler TK
- Bartz Traci M.
- Bastarache Lisa
- Beiser AS
- Bell S
- Benavente OR
- Benn M
- Bennett David A.
- Berr C
- Bevan S
- Bis JC
- Bis Joshua C.
- Blay N
- Boerwinkle E
- Boncoraglio GB
- Bordes Constance
- Braekkan SK
- Brody JA
- Brouwers PJAM
- Brown RD
- Brumpton BM
- Buring JE
- Bustamante M
- Butterworth AS
- Børte Sigrid
- Cain Anael
- Campos F
- Camps-Renom P
- Caro Ilana
- Carrera C
- Carty CL
- Caso V
- Castillo J
- Chasman Daniel I.
- Chauhan Ganesh
- Chen JS
- Chen MH
- Chen Pei-Hsin
- Chen WM
- Chen YP
- Chen Zhengming
- Cheng YC
- Cho Kelly
- Choi SH
- Chong Michael R.
- Chowhan A
- Christensen Kaare
- Clarke R
- Cole John W.
- Collins R
- Correa A
- Cotlarciuc I
- Cruchaga Carlos
- Cullell N
- Curtze S
- Cushman M
- Cárcel-Márquez Jara
- Damrauer Scott M.
- Danesh J
- Dartigues JF
- de Andrade M
- de Bakker PIW
- de Cid R
- de Cid Rafael
- de Jager Phil L.
- de Jager PL
- de Kort PL
- de Laat KF
- de Leeuw FE
- de Leeuw Frank-Erik
- Debette Stephanie
- Delavaran H
- Deleuze JF
- Delgado P
- Delgado-Mederos R
- den Heijer T
- den Hoed M
- DeStefano AL
- Dhar R
- Diaz-Navarro R
- Dichgans Martin
- Dorr M
- Duan Q
- Ellekjaer H
- Endres Matthias
- Engelter ST
- Engstrom G
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Fakunle AG
- Falcone GJ
- Fernández-Cadenas Israel
- Ferreira LE
- Ferreira Leslie E.
- Fongang B
- Ford I
- Fornage Myriam
- Frantz S
- França Paulo H. C.
- Frazer KA
- Freijo M
- Frikke-Schmidt Ruth
- Fritsche LG
- Furie KL
- Gabrielsen ME
- Gallego-Fabrega C
- Gasca Natalie C.
- Gasca NC
- Geerlings MI
- Geerlings Mirjam I.
- Georgakis Marios K.
- Germain M
- Ghanbari M
- Gieger Christian
- Giese AK
- Giulianini F
- Gons RAR
- Gordon W
- Gottesman RF
- Grabe Hans J.
- Gravel S
- Gretarsdottir S
- Grewal RP
- Gudnason V
- Gudnason Vilmundur
- Guo Y
- Gurpreet WS
- Gustafsson S
- Habib Naomi
- Hachiya Tsuyoshi
- Haessler J
- Haeusler Karl Georg
- Hagen K
- Hamsten A
- Hansen JB
- Harris TB
- Hassan A
- Hata Jun
- Havulinna Aki S.
- He Jing
- He Yunye
- Heath AK
- Heath Alicia K.
- Heckbert SR
- Heit JA
- Heitsch L
- Heuch I
- Heuschmann Peter Ulrich
- Hill M
- Ho Yuk-Lam
- Holliday EG
- Hopewell Jemma C.
- Howard G
- Howson Joanna M. M.
- Hozawa A
- Hsu FC
- Huffman Jennifer E.
- Hveem K
- Hyacinth Hyacinth I.
- Ibanez L
- Ibrahim M
- Ikram MK
- Ikram Mohammad A.
- Ilinca A
- Ingelsson E
- Ingelsson M
- Inouye Michael
- Irvin Marguerite R.
- Irvin MR
- Iwasaki M
- Jackson RD
- Jacob Mina A.
- Jee Yon Ho
- Jenkins C
- Jensen GB
- Jeon Christina E.
- Jern Christina
- Jian XQ
- Jimenez-Conde J
- Johnson AD
- Johnson JA
- Jood K
- Jousilahti P
- Judy Renae L.
- Jukema J. Wouter
- Jung Keum J.
- JĂĽrgenson Tuuli
- Kabrhel C
- Kaffashian S
- Kalra L
- Kamanu Frederick K.
- Kamatani Yoichiro
- Kamouchi Masahiro
- Kamstrup PR
- Kanai M
- Kappelle LJ
- Keene Keith L.
- Kim BJ
- Kim J
- Kim Young Jin
- Kinnunen J
- Kissela BM
- Kitazono Takanari
- Kittner Steven J.
- Kjartansson O
- Kleindorfer DO
- Kleinschnitz C
- Kloss M
- Knol Maria J.
- Koido Masaru
- Komolafe M
- Konuma Takahiro
- Kooperberg C
- Koudstaal PJ
- Kraft P
- Krebs Kristi
- Kristoffersen ES
- Krupinski J
- Kubo M
- Kumar Amit
- Kõrv Janika
- Labovitz DL
- Lacaze Paul
- Lange LA
- Langefeld CD
- Langenberg C
- Lathrop G. Mark
- Launer Lenore J.
- Laurie CC
- Le Grand Q
- Le Grand Quentin
- Lee JM
- Lee Keon-Joo
- Lee TH
- Lemmens R
- Lemmons R
- Leonard Hampton L.
- Lepik Kaido
- Levi CR
- Lewis Adam J.
- Lewis CM
- Leys D
- Li Jiang
- Li Liming
- Li LN
- Liaw Yi-Ching
- Liaw Yung-Po
- Liman Thomas
- Lin Kuang
- Lin WY
- Lind L
- Lindgren AG
- Lindgren CM
- Lindstrom S
- Linkohr B
- Lioutas V
- Liu YM
- Lledos M
- Llucia-Carol L
- Longstreth W. T.
- Lopez OL
- Lopez-Cancio E
- Lorentzen E
- Luijckx GJ
- Lv J
- MacDonald J
- Magi R
- Magnusson PK
- Maguire J
- Makoto H
- Malik Rainer
- Manichaikul Ani
- Markus Hugh S.
- Marston Nicholas A.
- Marti-Fabregas J
- Martinez-Majander N
- Martinsen AE
- Matsuda K
- Mayerhofer Ernst
- McArdle PF
- McCauley BM
- McDonough CW
- McKnight B
- Meitinger Thomas
- Melander O
- Menon V
- Meschia JF
- Metspalu A
- Milani Lili
- Millan M
- Millwood Iona Y.
- Minegishi N
- Mishra Aniket
- Mitchell Braxton D.
- Molina CA
- Montaner J
- Montellano Felipe A.
- Morange PE
- Morisaki Takayuki
- Morris AP
- Mosley Thomas H.
- Muino E
- Muller-Nurasyid M
- Munoz-Narbona L
- Murakami Y
- Nagai A
- Nalls Mike A.
- Namba Shinichi
- Nederkoorn PJ
- Nelis M
- Nielsen JB
- Niiranen Teemu J.
- Ninomiya Toshiharu
- Nordestgaard BG
- Nordestgaard Børge G.
- Norrving B
- Nygaard Marianne
- O'Donnell CJ
- O'Donnell Martin J.
- Obach V
- Obiako R
- Ogbole G
- Ogishima S
- Okada Yukinori
- Olalere A
- Onland-Moret N. Charlotte
- Onland-Moret NC
- Osaigbovo G
- Ovbiagele Bruce
- Owolabi L
- Owolabi Mayowa O.
- Pankow JS
- Pankratz N
- Parati EA
- Parodi Livia
- Paré Guillaume
- Pattee JW
- Peddareddygari LR
- Pedersen LM
- Pedersen NL
- Pera J
- Perola M
- Peters Annette
- Peto R
- Pezzini A
- Pileggi S
- Posner Daniel C.
- Pozarickij A
- Prasad Kameshwar
- Prats-Sanchez L
- Psaty Bruce M.
- Pulit SL
- Putaala J
- Puurunen MK
- Rabionet R
- Rannikmae K
- Reiner A
- Reiner AP
- Rexrode KM
- Riaz Moeen
- Riba-Llena I
- Ribases M
- Ribo M
- Rice K
- Rich Stephen S.
- Ridker Paul M.
- Rissanen Ina L.
- Rolfs A
- Romero JR
- Roquer J
- Rosand Jonathan
- Rosendaal FR
- Roshchupkin Gennady V.
- Ross OA
- Rost NS
- Rothwell PM
- Rotter Jerome I.
- Rudd AG
- Ruff Christian T.
- Ruigrok Ynte M.
- Rundek Tatjana
- Rutten-Jacobs L
- Sabatine Marc S.
- Sacco Ralph L.
- Saillour-Glenisson F
- Sakaue S
- Sale MM
- Saleheen Danish
- Salomaa Veikko
- Sandset Else Charlotte
- Sanghera DK
- Sapkota BR
- Sarfo FS
- Sargurupremraj M
- Sargurupremraj Muralidharan
- Sarin AP
- Sarju R
- Sarnowski C
- Sasaki Makoto
- Satizabal Claudia L.
- Satoh M
- Sattar N
- Sawada N
- Schmidt Carsten O.
- Schmidt D
- Schmidt R
- Schminke U
- Schnohr P
- Segura T
- Serrano-Heras G
- Seshadri Sudha
- Sharma P
- Shi Mingyang
- Shimizu Atsushi
- Shiroma EJ
- Sibolt G
- Sigurdsson A
- Sigurdsson S
- Simonsick Eleanor M.
- Skogholt AH
- Sloane Kelly L.
- Slowik A
- Smith A
- Smith EN
- Smith Nicholas L.
- Sobrino T
- Sobue K
- Soderholm M
- Soriano-Tarraga C
- Srinivasasainagendra Vinodh
- Stanne TM
- Stefansson K
- Stevens B
- Stine OC
- Stott DJ
- Strauch K
- Strbian Daniel
- Suchon P
- Sudlow CLM
- Sumoy L
- Sun Yan V.
- Sung YJ
- Sutoh Yoichi
- Takai T
- Tanaka H
- Tang WH
- Tanislav C
- Tanno Kozo
- Tatlisumak Turgut
- Taylor KD
- Teumer A
- Thijs VNS
- Thomas LF
- Thomassen Jesper Qvist
- Thorleifsson G
- Thorsteinsdottir U
- Tiainen M
- Tiedt Steffen
- Tiwari Hemant K.
- Tomppo Liisa
- Torres-Aguila Nuria P.
- Touze E
- Traylor M
- Trompet Stella
- Trégouët David-Alexandre
- Tsugane S
- Tuladhar Anil Man
- Turman C
- Turnbull I
- Tybjærg-Hansen Anne
- Tzourio C
- Uitterlinden AG
- Ungethum K
- Uvere E
- Valdimarsson EM
- van der Laan SW
- van der Lee SJ
- van Dijk EJ
- van Dijk GW
- van Duijn CM
- van Norden AGW
- van Oostenbrugge RJ
- van Rooij FGW
- van Setten J
- van Vugt M
- van Vugt Marion
- Vaura Felix C.
- Verma SS
- Verma Stefali S.
- Vermeer SE
- Vibo Riina
- Visser MC
- Vives-Bauza C
- Vlieg AV
- Volker U
- Volzke H
- Vonk JMJ
- Wahab K
- Wakai K
- Walters M
- Walters Robin G.
- Wang C
- Wang L
- Wang RQ
- Wareham NJ
- Wassertheil-Smoller Sylvia
- Weir D
- Wennberg Patrik
- Wermer MJH
- Wiggins Kerri L.
- Willer CJ
- Williams SR
- Wilson JG
- Wilson Peter W. F.
- Winsvold Bendik Slagsvold
- Wolfe CDA
- Wong QN
- Woo Daniel
- Worrall Bradford B.
- Xu Huichun
- Yaffe K
- Yamaji T
- Yang Chaojie
- Yang CR
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu CQ
- Yusuf S
- Zand Ramin
- Zhou W
- Zonderman AB
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/12/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.</p
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt Anne H
- Aamodt Anne H
- Abedi Vida
- Adams Hieab
- Adebajo Olayinka J
- Adeoye Abiodun M
- Afzal Shoaib
- Ago Tetsuro
- Agunloye Atinuke
- Akinyemi Joshua
- Akinyemi Rufus
- Akpa Onoja
- Akpa Onoja
- Akpalu Albert
- Almgren Peter
- Alvarez-Sabin Jose
- Amin Najaf
- Amouyel Philippe
- Anderson Christopher D
- Anderson Christopher D
- Anderson Christopher D
- Aparicio Hugo J
- Arenillas Juan Francisco
- Armasu Sebastian M
- Armstrong Nicole D
- Arnett Donna K
- Arulogun Oyedunni
- Attia John
- Ay Hakan
- Bae Hee-Joon
- Bakker Mark K
- Bammler Theo K
- Bartz Traci M
- Bastarache Lisa
- Beiser Alexa S
- Beiser Alexa S
- Bell Steven
- Benavente Oscar R
- Benn Marianne
- Bennett David A
- Berr Claudine
- Bevan Steve
- Bis Joshua C
- Bis Joshua C
- Bis Joshua C
- Blay Natalia
- Boerwinkle Eric
- Boncoraglio Giorgio B
- Bordes Constance
- Borte Sigrid
- Braekkan Sigrid K
- Brody Jennifer A
- Brouwers Paul JAM
- Brown Robert D
- Brumpton Ben M
- Brumpton Ben M
- Buring Julie E
- Bustamante Mariana
- Butterworth Adam S
- Cain Anael
- Campos Francisco
- Camps-Renom Pol
- Carcel-Marquez Jara
- Caro Ilana
- Carrera Caty
- Carty Cara L
- Caso Valeria
- Castillo Jose
- Chasman Daniel I
- Chauhan Ganesh
- Chen Junshi
- Chen Junshi
- Chen Ming-Huei
- Chen Pei-Hsin
- Chen Wei Min
- Chen Wei-Min
- Chen Yiping
- Chen Zhengming
- Cheng Yu-Ching
- Cho Kelly
- Choi Seung Hoan
- Chong Michael R
- Chowhan Ayesha
- Christensen Kaare
- Clarke Robert
- Cole John W
- Collins Rory
- Correa Adolfo
- Cotlarciuc Ioana
- Cruchaga Carlos
- Cullell Natalia
- Curtze Sami
- Curtze Sami
- Cushman Mary
- Damrauer Scott M
- Danesh John
- Dartigues Jean-Francois
- de Andrade Mariza
- de Bakker Paul IW
- de Cid Rafael
- de Cid Rafael
- de Jager Phil L
- de Jager Phil L
- de Jager Phil L
- de Kort Paul L
- de Laat Karlijn F
- de Laat Karlijn F
- de Leeuw Frank-Erik
- de Leeuw Frank-Erik
- Debette Stephanie
- Delavaran Hossein
- Deleuze Jean-Francois
- Delgado Pilar
- Delgado Pilar
- Delgado-Mederos Raquel
- den Heijer Tom
- den Hoed Marcel
- DeStefano Anita L
- Dhar Rajat
- Diaz-Navarro Rosa
- Dichgans Martin
- Dorr Marcus
- Duan Qing
- Ellekjaer Hanne
- Endres Matthias
- Engelter Stefan T
- Engstrom Gunnar
- Esko Tonu
- Esko Tonu
- Evans Michele K
- Fairhurst-Hunter Zammy
- Fakunle Adekunle G
- Falcone Guido J
- Fernandez-Cadenas Israel
- Ferreira Leslie E
- Ferreira Leslie E
- Fongang Bernard
- Ford Ian
- Fornage Myriam
- Franca Paulo HC
- Frantz Stefan
- Frazer Kelly A
- Freijo Marimar
- Frikke-Schmidt Ruth
- Fritsche Lars G
- Furie Karen L
- Gabrielsen Maiken E
- Gabrielsen Maiken E
- Gallego-Fabrega Cristina
- Gallego-Fabrega Cristina
- Gasca Natalie C
- Gasca Natalie C
- Geerlings Mirjam I
- Geerlings Mirjam I
- Geerlings Mirjam I
- Georgakis Marios K
- Germain Marine
- Ghanbari Mohsen
- Gieger Christian
- Giese Anne-Katrin
- Giese Anne-Katrin
- Giulianini Franco
- Gons Rob AR
- Gordon William
- Gottesman Rebecca F
- Gottesman Rebecca F
- Gottesman Rebecca F
- Grabe Hans J
- Gravel Simon
- Gretarsdottir Solveig
- Grewal Raji P
- Gudnason Vilmundur
- Gudnason Vilmundur
- Guo Yu
- Gurpreet Wander S
- Gustafsson Stefan
- Habib Naomi
- Hachiya Tsuyoshi
- Haessler Jeffrey
- Haessler Jeffrey
- Haeusler Karl Georg
- Hagen Knut
- Hamsten Anders
- Hansen John-Bjarne
- Harris Tamara B
- Hassan Ahamad
- Hata Jun
- Havulinna Aki S
- He Jing
- He Yunye
- Heath Alicia K
- Heath Alicia K
- Heckbert Susan R
- Heit John A
- Heitsch Laura
- Heuch Ingrid
- Heuschmann Peter Ulrich
- Hill Michael
- Ho Yuk-Lam
- Holliday Elizabeth G
- Hopewell Jemma C
- Howard George
- Howson Joanna MM
- Hozawa Atsushi
- Hsu Fang-Chi
- Huffman Jennifer E
- Hveem Kristian
- Hveem Kristian
- Hyacinth Hyacinth I
- Ibanez Laura
- Ibrahim Manal
- Ikram Mohammad A
- Ikram Mohammad K
- Ilinca Andreea
- Ingelsson Erik
- Ingelsson Martin
- Inouye Michael
- Irvin Marguerite R
- Irvin Marguerite R
- Irvin Marguerite R
- Iwasaki Motoki
- Jackson Rebecca D
- Jackson Rebecca D
- Jacob Mina A
- Jee Yon Ho
- Jenkins Carolyn
- Jensen Gorm B
- Jeon Christina E
- Jern Christina
- Jian Xueqiu
- Jimenez-Conde Jordi
- Johnson Andrew D
- Johnson Julie A
- Jood Katarina
- Jousilahti Pekka
- Judy Renae L
- Jukema J Wouter
- Jung Keum Ji
- Jurgenson Tuuli
- Kabrhel Christopher
- Kaffashian Sara
- Kalra Lalit
- Kamanu Frederick K
- Kamatani Yoichiro
- Kamouchi Masahiro
- Kamstrup Pia R
- Kanai Masahiro
- Kappelle L Jaap
- Keene Keith L
- Kim Bong-Jo
- Kim Bong-Jo
- Kim Jihye
- Kim Young Jin
- Kinnunen Janne
- Kissela Brett M
- Kitazono Takanari
- Kittner Steven J
- Kjartansson Olafur
- Kleindorfer Dawn O
- Kleinschnitz Christoph
- Kleinschnitz Christoph
- Kloss Manja
- Knol Maria J
- Koido Masaru
- Komolafe Morenikeji
- Konuma Takahiro
- Kooperberg Charles
- Kooperberg Charles
- Kooperberg Charles
- Korv Janika
- Koudstaal Peter J
- Kraft Peter
- Krebs Kristi
- Kristoffersen Espen S
- Krupinski Jerzy
- Kubo Michiaki
- Kumar Amit
- Labovitz Daniel L
- Lacaze Paul
- Lange Leslie A
- Langefeld Carl D
- Langenberg Claudia
- Lathrop G Mark
- Launer Lenore J
- Laurie Cathy C
- Le Grand Quentin
- Le Grand Quentin
- Le Grand Quentin
- Lee Jin-Moo
- Lee Keon-Joo
- Lee Tsong-Hai
- Lemmens Robin
- Lemmons Robin
- Leonard Hampton L
- Lepik Kaido
- Levi Christopher R
- Lewis Adam J
- Lewis Cathryn M
- Leys Didier
- Li Jiang
- Li Liming
- Li Linxin
- Liaw Yi-Ching
- Liaw Yung-Po
- Liman Thomas
- Lin Kuang
- Lin Wei-Yu
- Lind Lars
- Lindgren Arne G
- Lindgren Cecilia M
- Lindstrom Sara
- Linkohr Birgit
- Lioutas Vasileios
- Liu Yong Mei
- Lledos Miquel
- Llucia-Carol Laia
- Longstreth WT
- Lopez Oscar L
- Lopez-Cancio Elena
- Lorentzen Erik
- Luijckx Gert-Jan
- Lv Jun
- MacDonald James
- Magi Reedik
- Magnusson Patrik K
- Maguire Jane
- Makoto Hirata
- Malik Rainer
- Manichaikul Ani
- Markus Hugh S
- Marston Nicholas A
- Marti-Fabregas Joan
- Martinez-Majander Nicolas
- Martinsen Amy E
- Matsuda Koichi
- Mayerhofer Ernst
- McArdle Patrick F
- McCauley Bryan M
- McDonough Caitrin W
- McKnight Barbara
- Meitinger Thomas
- Melander Olle
- Menon Vilas
- Menon Vilas
- Meschia James F
- Metspalu Andres
- Milani Lili
- Millan Monica
- Millwood Iona Y
- Minegishi Naoko
- Mishra Aniket
- Mitchell Braxton D
- Molina Carlos A
- Montaner Joan
- Montellano Felipe A
- Morange Pierre-Emmanuel
- Morisaki Takayuki
- Morris Andrew P
- Mosley Thomas H
- Muino Elena
- Muller-Nurasyid Martina
- Munoz-Narbona Lucia
- Murakami Yoishinori
- Nagai Akiko
- Nagai Akiko
- Nalls Mike A
- Namba Shinichi
- Nederkoorn Paul J
- Nederkoorn Paul J
- Nelis Mari
- Nielsen Jonas B
- Nielsen Jonas B
- Niiranen Teemu J
- Ninomiya Toshiharu
- Nordestgaard Borge G
- Nordestgaard Borge G
- Norrving Bo
- Nygaard Marianne
- O'Donnell Chris J
- O'Donnell Martin J
- Obach Victor
- Obiako Reginald
- Ogbole Godwin
- Ogishima Soichi
- Okada Yukinori
- Olalere Abimbola
- Onland-Moret N Charlotte
- Onland-Moret N Charlotte
- Onland-Moret N Charlotte
- Osaigbovo Godwin
- Ovbiagele Bruce
- Owolabi Lukman
- Owolabi Mayowa O
- Pankow James S
- Pankratz Nathan
- Parati Eugenio A
- Pare Guillaume
- Parodi Livia
- Pattee Jack W
- Peddareddygari Leema Reddy
- Pedersen Linda M
- Pedersen Nancy L
- Pera Joanna
- Perola Markus
- Peters Annette
- Peto Richard
- Pezzini Alessandro
- Pileggi Silvana
- Posner Daniel C
- Pozarickij Alfred
- Prasad Kameshwar
- Prats-Sanchez Luis
- Psaty Bruce M
- Pulit Sara L
- Putaala Jukka
- Puurunen Marja K
- Rabionet Raquel
- Rannikmae Kristiina
- Reiner Alexander
- Reiner Alexander P
- Rexrode Kathryn M
- Riaz Moeen
- Riba-Llena Iolanda
- Ribases Marta
- Ribo Marc
- Rice Kenneth
- Rich Stephen S
- Ridker Paul M
- Rissanen Ina L
- Rolfs Arndt
- Romero Jose R
- Roquer Jaume
- Rosand Jonathan
- Rosendaal Frits R
- Roshchupkin Gennady V
- Ross Owen A
- Rost Natalia S
- Rothwell Peter M
- Rotter Jerome I
- Rudd Anthony G
- Ruff Christian T
- Ruigrok Ynte M
- Rundek Tatjana
- Rutten-Jacobs Loes
- Sabatine Marc S
- Sacco Ralph L
- Saillour-Glenisson Florence
- Sakaue Saori
- Sale Michele M
- Saleheen Danish
- Salomaa Veikko
- Sandset Else Charlotte
- Sanghera Dharambir K
- Sapkota Bishwa R
- Sarfo Fred S
- Sargurupremraj Muralidharan
- Sargurupremraj Muralidharan
- Sarin Antti-Pekka
- Sarju Ralhan
- Sarnowski Chloe
- Sasaki Makoto
- Satizabal Claudia L
- Satoh Mamoru
- Sattar Naveed
- Sawada Norie
- Schmidt Carsten O
- Schmidt Dan
- Schmidt Reinhold
- Schminke Ulf
- Schnohr Peter
- Schnohr Peter
- Segura Tomas
- Serrano-Heras Gemma
- Seshadri Sudha
- Sharma Pankaj
- Shi Mingyang
- Shimizu Atsushi
- Shiroma Eric J
- Sibolt Gerli
- Sigurdsson Asgeir
- Sigurdsson Sigurdur
- Simonsick Eleanor M
- Skogholt Anne H
- Sloane Kelly L
- Slowik Agnieszka
- Smith Albert
- Smith Erin N
- Smith Nicholas L
- Sobrino Tomas
- Sobue Kenji
- Soderholm Martin
- Soriano-Tarraga Carolina
- Srinivasasainagendra Vinodh
- Stanne Tara M
- Stefansson Kari
- Stevens Becky
- Stine O Colin
- Stott David J
- Strauch Konstantin
- Strbian Daniel
- Suchon Pierre
- Sudlow Cathie LM
- Sumoy Lauro
- Sun Yan V
- Sung Yun Ju
- Sutoh Yoichi
- Takai Takako
- Tanaka Hideo
- Tang Weihong
- Tanislav Christian
- Tanno Kozo
- Tatlisumak Turgut
- Taylor Kent D
- Taylor Kent D
- Teumer Alexander
- Thijs Vincent NS
- Thomas Laurent F
- Thomassen Jesper Qvist
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tiainen Marjaana
- Tiedt Steffen
- Tiwari Hemant K
- Tomppo Liisa
- Torres-Aguila Nuria P
- Touze Emmanuel
- Traylor Matthew
- Tregouet David-Alexandre
- Trompet Stella
- Tsugane Shoichiro
- Tuladhar Anil Man
- Turman Constance
- Turnbull Iain
- Tybjaerg-Hansen Anne
- Tzourio Christophe
- Uitterlinden Andre G
- Ungethum Kathrin
- Uvere Ezinne
- Valdimarsson Einar M
- van der Laan Sander W
- van der Lee Sven J
- van Dijk Ewoud J
- van Dijk Ewoud J
- van Dijk Gert W
- van Duijn Cornelia M
- van Hylckama Vlieg Astrid
- van Norden Anouk GW
- van Oostenbrugge Robert J
- van Rooij Frank GW
- van Setten Jessica
- van Setten Jessica
- van Vugt Marion
- van Vugt Marion
- Vaura Felix C
- Verma Shefali S
- Verma Shefali S
- Vermeer Sarah E
- Vibo Riina
- Visser Marieke C
- Vives-Bauza Cristofol
- Volker Uwe
- Volzke Henry
- Vonk Jet MJ
- Wahab Kolawole
- Wakai Kenji
- Walters Matthew
- Walters Robin G
- Wang Chen
- Wang Lu
- Wang Ruiqi
- Wareham Nicholas J
- Wassertheil-Smoller Sylvia
- Weir David
- Wennberg Patrik
- Wermer Marieke JH
- Wiggins Kerri L
- Willer Cristen J
- Williams Stephen R
- Wilson James G
- Wilson Peter WF
- Winsvold Bendik Slagsvold
- Wolfe Charles DA
- Wong Quenna
- Woo Daniel
- Worrall Bradford B
- Xu Huichun
- Yaffe Kristine
- Yamaji Taiki
- Yang Chaojie
- Yang Chengran
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu Canqing
- Yusuf Salim
- Zand Ramin
- Zhou Wei
- Zonderman Alan B
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries
Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
- Author
- Abdelhamid N.
- Abdul Rahman D.
- Abdul-Saheb M.
- Abreu P.
- Abroskina M.
- Abu Ahmad F.
- Accassat S.
- Acciaresi M.
- Adami A.
- Ahmad N.
- Ahmed F.
- Alberto Hawkes M.
- Alemseged F.
- Ali A.
- Altavilla R.
- Alwis L.
- Amarenco P.
- Amaro S.
- Amaya Sanchez L. E.
- Amelia Pinto A.
- Ameriso S. F.
- Ameriso Sebastian F
- Amin H.
- Amino T.
- Amjad A. K.
- Anagnostou E.
- Andersen G.
- Anderson C.
- Anderson D. C.
- Andrea Falco M.
- Andres Mackinnon F.
- Andreu D.
- Androulakis M.
- Angel Gamero M.
- Angel Saredo G.
- Angeles Diaz R.
- Angels Font M.
- Anticoli S.
- Arauz Gongora A. A.
- Arauz A.
- Araya P.
- Arenillas Lara J. F.
- Arias Rivas S.
- Arnold M.
- Augustin S.
- Avelar W.
- Azevedo E.
- Babikian V.
- Bacellar A.
- Badalyan K.
- Bae H. J.
- Baez Martinez E. M.
- Bagelmann H.
- Bailey P.
- Bak Z.
- Baker M.
- Balazs A.
- Baldaranov D.
- Balogun I.
- Balueva T.
- Bangdiwala Shrikant
- Bankuti Z.
- Bar M.
- Baranowska A.
- Bardutzky J.
- Barker Trejo S.
- Barlinn J.
- Baronnet F.
- Barroso C.
- Barteys M.
- Bartolottiova T.
- Barulin A.
- Bas M.
- Bashir S.
- Basile V.
- Bathe-Peters R.
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- Batista C.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with aspirin among patients with PFO enrolled in the NAVIGATE ESUS trial. Methods: NAVIGATE ESUS was a double-blinded, randomised, phase 3 trial done at 459 centres in 31 countries that assessed the efficacy and safety of rivaroxaban versus aspirin for secondary stroke prevention in patients with ESUS. For this prespecified subgroup analysis, cohorts with and without PFO were defined on the basis of transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE). The primary efficacy outcome was time to recurrent ischaemic stroke between treatment groups. The primary safety outcome was major bleeding, according to the criteria of the International Society of Thrombosis and Haemostasis. The primary analyses were based on the intention-to-treat population. Additionally, we did a systematic review and random-effects meta-analysis of studies in which patients with cryptogenic stroke and PFO were randomly assigned to receive anticoagulant or antiplatelet therapy. Findings: Between Dec 23, 2014, and Sept 20, 2017, 7213 participants were enrolled and assigned to receive rivaroxaban (n=3609) or aspirin (n=3604). Patients were followed up for a mean of 11 months because of early trial termination. PFO was reported as present in 534 (7·4%) patients on the basis of either TTE or TOE. Patients with PFO assigned to receive aspirin had a recurrent ischaemic stroke rate of 4·8 events per 100 person-years compared with 2·6 events per 100 person-years in those treated with rivaroxaban. Among patients with known PFO, there was insufficient evidence to support a difference in risk of recurrent ischaemic stroke between rivaroxaban and aspirin (hazard ratio [HR] 0·54; 95% CI 0·22–1·36), and the risk was similar for those without known PFO (1·06; 0·84–1·33; pinteraction=0·18). The risks of major bleeding with rivaroxaban versus aspirin were similar in patients with PFO detected (HR 2·05; 95% CI 0·51–8·18) and in those without PFO detected (HR 2·82; 95% CI 1·69–4·70; pinteraction=0·68). The random-effects meta-analysis combined data from NAVIGATE ESUS with data from two previous trials (PICSS and CLOSE) and yielded a summary odds ratio of 0·48 (95% CI 0·24–0·96; p=0·04) for ischaemic stroke in favour of anticoagulation, without evidence of heterogeneity. Interpretation: Among patients with ESUS who have PFO, anticoagulation might reduce the risk of recurrent stroke by about half, although substantial imprecision remains. Dedicated trials of anticoagulation versus antiplatelet therapy or PFO closure, or both, are warranted. Funding: Bayer and Janssen
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
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- Zhussupov B.
- Zimmermann E.
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(1,2). This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories
Aspergillosis
- Author
- A Akkoyunlu
- A Charneau
- A Cueva
- A Gonzalez-Mendoza
- A Hauptmann
- A Krasnitz
- A Lara
- A Lucet
- A McDiarmid
- A Navarro-Blasco
- A Redmond
- A Sartory
- A Savage
- A Toigo
- A Weiner
- AB Kelly
- AB Mangiaracine
- AC Mayer
- AE Greer
- AE Rodin
- AE Steele
- AEW Gregson
- AF Naji
- AG Heppleston
- AG Oettlé
- AG Smith
- AGA Heffernan
- AH Henderson
- AH Henderson
- AH Henderson
- AJ Hertzog
- AJ Paradis
- AJ Stolow
- AJ Vadala
- AM Fisher
- AM Saunders
- AO Bech
- ASM Zijden Van Der
- AT Henrici
- B Gerstl
- B Turhan
- BA Sayle
- Baum
- BF Agbayani
- BF Fetter
- BF Nesbitt
- BH Ramsey
- BJ Wilson
- BJ Wilson
- BN Pittenger
- British Tuberculosis Association
- BS Fine
- BS Fine
- BS Fine
- BS Fine
- BS Fine
- C Ceni
- C Cramer
- C Friedman
- C Nicolle
- C Robin
- C Sanchez-Freijo
- C Thom
- C Thom
- CE Pena
- CF Ross
- CH Burnett
- CH Burnett
- CH Burnett
- CH Burnett
- CJ Arkle
- CL Graves
- CLN Robinson
- CT Ambrose
- CW Emmons
- CW Emmons
- CW Emmons
- D Fernandez-Luna
- D Harmer
- D Janke
- D Janke
- D Mackenzie
- D Rifkind
- DB Louria
- DD Buttrick
- DE Comings
- DEB Powell
- DG Cogan
- DG Scarpelli
- Dieulafoy
- DR Iriarte
- DV Pecora
- E Bodin
- E Breton Le
- E Cornet
- E Delikat
- E Deslongchamp
- E Gaucher
- E Leon-Antoni De
- E Marsalek
- E Moniz
- E Pinoy
- E Pinoy
- EA Porta
- EA Riley
- EA Stuart
- EB Hendrick
- EB Tilden
- Editorial
- EE Mays
- EE McKee
- EF Wahl
- EF Wahl
- EJ Autels Des
- EJ Levin
- EJ Whalen
- EL Schmidt
- EM Rau
- EP Cawley
- ER Harrell
- ER Pons
- ER Wybel
- ES Bereston
- ES Bereston
- ES Bereston
- ES Bereston
- ES Levy
- ET Peer
- EW Chick
- EW Chick
- F Batt
- F Dickens
- F Dévé
- F Montreuil
- F Siebenmann
- F Vellios
- FA Kingery
- FH Young
- FP Hoover
- FP Mackie
- FR Schechter
- FT Sluyter
- FT Wolf
- FW Shaw
- G Arnaud
- G Bader
- G Brounst
- G Fresenius
- G Guillain
- G Hildick-Smith
- G Rueda
- G Saubermann
- G SĂ©gretain
- G SĂ©gretain
- G Vantrappen
- Garcia-Trivino
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1971
- Field of study
Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
- Author
- A Adami
- A Ali
- A Amelia Pinto
- A Arauz
- A Bacellar
- A Balazs
- A Baranowska
- A Barulin
- A Beinlich
- A Belkin
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- A Irina Aniculaesei
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- Scott E Kasner
- SD Berkowitz
- SE Kasner
- SE Ta Wil
- Sebastian F Ameriso
- SF Ameriso
- Shrikant Bangdiwala
- SI Sohn
- SJ Connolly
- SM Garcia Sanchez
- Smer
- Sondergaard
- Steven R Messé
- Stuart J Connolly
- T Amino
- T Balueva
- T Bartolottiova
- T Bicsak
- T Black
- T Chen
- T Christensen
- T Duman
- T Field
- T Gregorio
- T Hayashi
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- T Kuwashiro
- T Largo
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- T Milling
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- Veronica Olavarria
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- W Xiong
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- X Wang
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- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt Anne H.
- Aamodt Anne H.
- Abedi Vida
- Adams Hieab
- Adebajo Olayinka J.
- Adeoye Abiodun M.
- Afzal Shoaib
- Ago Tetsuro
- Agunloye Atinuke
- Akinyemi Joshua
- Akinyemi Rufus
- Akpa Onoja
- Akpa Onoja
- Akpalu Albert
- Almgren Peter
- Alvarez-Sabin Jose
- Amin Najaf
- Amouyel Philippe
- Anderson Christopher D.
- Anderson Christopher D.
- Anderson Christopher D.
- Aparicio Hugo J.
- Arenillas Juan Francisco
- Armasu Sebastian M.
- Armstrong Nicole D.
- Arnett Donna K.
- Arulogun Oyedunni
- Attia John
- Ay Hakan
- Bae Hee-Joon
- Bakker Mark K.
- Bammler Theo K.
- Bartz Traci M.
- Bastarache Lisa
- Beiser Alexa S.
- Beiser Alexa S.
- Bell Steven
- Benavente Oscar R.
- Benn Marianne
- Bennett David A.
- Berr Claudine
- Bevan Steve
- Bis Joshua C.
- Bis Joshua C.
- Bis Joshua C.
- Blay Natalia
- Boerwinkle Eric
- Boncoraglio Giorgio B.
- Bordes Constance
- Borte Sigrid
- Braekkan Sigrid K.
- Brody Jennifer A.
- Brouwers Paul J. A. M.
- Brown Robert D., Jr.
- Brumpton Ben M.
- Brumpton Ben M.
- Buring Julie E.
- Bustamante Mariana
- Butterworth Adam S.
- Cain Anael
- Campos Francisco
- Camps-Renom Pol
- Carcel-Marquez Jara
- Caro Ilana
- Carrera Caty
- Carty Cara L.
- Caso Valeria
- Castillo Jose
- Chasman Daniel I.
- Chauhan Ganesh
- Chen Junshi
- Chen Junshi
- Chen Ming-Huei
- Chen Pei-Hsin
- Chen Wei Min
- Chen Wei-Min
- Chen Yiping
- Chen Zhengming
- Cheng Yu-Ching
- Cho Kelly
- Choi Seung Hoan
- Chong Michael R.
- Chowhan Ayesha
- Christensen Kaare
- Clarke Robert
- Cole John W.
- Collins Rory
- Correa Adolfo
- Cotlarciuc Ioana
- Cruchaga Carlos
- Cullell Natalia
- Curtze Sami
- Curtze Sami
- Cushman Mary
- Damrauer Scott M.
- Danesh John
- Dartigues Jean-Francois
- de Andrade Mariza
- de Bakker Paul I. W.
- de Cid Rafael
- de Cid Rafael
- de Jager Phil L.
- de Jager Phil L.
- de Jager Phil L.
- de Kort Paul L.
- de Laat Karlijn F.
- de Laat Karlijn F.
- de Leeuw Frank-Erik
- de Leeuw Frank-Erik
- Debette Stephanie
- Delavaran Hossein
- Deleuze Jean-Francois
- Delgado Pilar
- Delgado Pilar
- Delgado-Mederos Raquel
- den Heijer Tom
- den Hoed Marcel
- DeStefano Anita L.
- Dhar Rajat
- Diaz-Navarro Rosa
- Dichgans Martin
- Dorr Marcus
- Duan Qing
- Ellekjaer Hanne
- Endres Matthias
- Engelter Stefan T.
- Engstrom Gunnar
- Esko Tonu
- Esko Tonu
- Evans Michele K.
- Fairhurst-Hunter Zammy
- Fakunle Adekunle G.
- Falcone Guido J.
- Fernandez-Cadenas Israel
- Ferreira Leslie E.
- Ferreira Leslie E.
- Fongang Bernard
- Ford Ian
- Fornage Myriam
- Franca Paulo H. C.
- Frantz Stefan
- Frazer Kelly A.
- Freijo Marimar
- Frikke-Schmidt Ruth
- Fritsche Lars G.
- Furie Karen L.
- Gabrielsen Maiken E.
- Gabrielsen Maiken E.
- Gallego-Fabrega Cristina
- Gallego-Fabrega Cristina
- Gasca Natalie C.
- Gasca Natalie C.
- Geerlings Mirjam I.
- Geerlings Mirjam I.
- Geerlings Mirjam I.
- Georgakis Marios K.
- Germain Marine
- Ghanbari Mohsen
- Gieger Christian
- Giese Anne-Katrin
- Giese Anne-Katrin
- Giulianini Franco
- Gons Rob A. R.
- Gordon William
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- Grabe Hans J.
- Gravel Simon
- Gretarsdottir Solveig
- Grewal Raji P.
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- Gudnason Vilmundur
- Guo Yu
- Gurpreet Wander S.
- Gustafsson Stefan
- Habib Naomi
- Hachiya Tsuyoshi
- Haessler Jeffrey
- Haessler Jeffrey
- Haeusler Karl Georg
- Hagen Knut
- Hamsten Anders
- Hansen John-Bjarne
- Harris Tamara B.
- Hassan Ahamad
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- Havulinna Aki S.
- He Jing
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- Heath Alicia K.
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- Hsu Fang-Chi
- Huffman Jennifer E.
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- Hyacinth Hyacinth I.
- Ibanez Laura
- Ibrahim Manal
- Ikram Mohammad A.
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- Ilinca Andreea
- Ingelsson Erik
- Ingelsson Martin
- Inouye Michael
- Irvin Marguerite R.
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- Iwasaki Motoki
- Jackson Rebecca D.
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- Jenkins Carolyn
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- Jian Xueqiu
- Jimenez-Conde Jordi
- Johnson Andrew D.
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- Jousilahti Pekka
- Judy Renae L.
- Jukema J. Wouter
- Jung Keum Ji
- Jurgenson Tuuli
- Kabrhel Christopher
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- Kamouchi Masahiro
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- Kanai Masahiro
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- Kim Bong-Jo
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- Kinnunen Janne
- Kissela Brett M.
- Kitazono Takanari
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- Kleindorfer Dawn O.
- Kleinschnitz Christoph
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- Kloss Manja
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- Koido Masaru
- Komolafe Morenikeji
- Konuma Takahiro
- Kooperberg Charles
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- Korv Janika
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- Kristoffersen Espen S.
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- Kubo Michiaki
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- Leys Didier
- Li Jiang
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- Wahab Kolawole
- Wakai Kenji
- Walters Matthew
- Walters Robin G.
- Wang Chen
- Wang Lu
- Wang Ruiqi
- Wareham Nicholas J.
- Wassertheil-Smoller Sylvia
- Weir David
- Wennberg Patrik
- Wermer Marieke J. H.
- Wiggins Kerri L.
- Willer Cristen J.
- Williams Stephen R.
- Wilson James G.
- Wilson Peter W. F.
- Winsvold Bendik Slagsvold
- Wolfe Charles D. A.
- Wong Quenna
- Woo Daniel
- Worrall Bradford B.
- Xu Huichun
- Yaffe Kristine
- Yamaji Taiki
- Yang Chaojie
- Yang Chengran
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu Canqing
- Yusuf Salim
- Zand Ramin
- Zhou Wei
- Zonderman Alan B.
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study