Observed strategies in the freehand drawing of complex hierarchical diagrams

Chunk decomposition and assembly strategies have been found in the drawing of complex hierarchical diagrams (spe- cifically AVOW diagrams). Analysis of 40 diagrams pro- duced by five participants provided evidence for the strategies based on the duration of pauses between drawn elements. The strategies were initially discovered using a new visualiza- tion technique developed to allow the detailed examination of the sequential order of diagram drawing in conjunction with information about the durations of pauses associated with drawn elements

Monitoring ocean dumping with ERTS-1 data

The results of an analysis of ERTS-1 data for the New York Bight collected on 16 August 1972 are described. Results are presented which show acid-iron wastes, sewage sludge, suspended solids, and major water mass boundary features in the study area. The potential of satellite remote sensing for monitoring large scale events such as ocean dumping is discussed

Examining the Need for an Elementary/Middle to Secondary School Level Transition Plan for Students with Learning Disabilities

The need for a transition plan to ease the progression of students with learning disabilities from the elementary and middle school grades to the secondary environment was examined in this study. Surveys were distributed and completed by 30 special education teachers in grades 5-8, 10 special education-learning disabilities teachers in grades 9-10, and 42 regular education-content area teachers in one school system. In addition to demographic data on respondents, information was gathered on instruction and student ability in the areas of academic skills, academic support skills, and social/behavioral skills. The characteristics of current modes and levels of planning were also examined. The results of analyses of various dimensions suggest that low levels of planning and communication pertaining to student competencies and teacher expectations exist between regular education teachers at the secondary level and elementary/middle school special education teachers. A need for greater emphasis on academic support skills in the elementary and middle school special education classroom is indicated. In addition, the need and desire for increased levels of communication in the form of a structured plan is demonstrated

CTMC calculations of electron capture and ionization in collisions of multiply charged ions with elliptical Rydberg atoms

We have performed classical trajectory Monte Carlo (CTMC) studies of electron capture and ionization in multiply charged (Q=8) ion-Rydberg atom collisions at intermediate impact velocities. Impact parallel to the minor and to the major axis, respectively, of the initial Kepler electron ellipse has been investigated. The important role of the initial electron momentum distribution found for singly charged ion impact is strongly disminished for higher projectile charge, while the initial spatial distribution remains important for all values of Q studied.Comment: 3 pages, 5 figure

SAW Sensor for Fastener Failure Detection

The proof of concept for using surface acoustic wave (SAW) strain sensors in the detection of aircraft fastener failures is demonstrated. SAW sensors were investigated because they have the potential for the development of passive wireless systems. The SAW devices employed four orthogonal frequency coding (OFC) spread spectrum reflectors in two banks on a high temperature piezoelectric substrate. Three SAW devices were attached to a cantilever panel with removable side stiffeners. Damage in the form of fastener failure was simulated by removal of bolts from the side stiffeners. During testing, three different force conditions were used to simulate static aircraft structural response under loads. The design of the sensor, the panel arrangement and the panel testing results are reported. The results show that the sensors successfully detected single fastener failure at distances up to 54.6 cm from the failure site under loaded conditions

A CTMC study of collisions between protons and H2+H_2^+ molecular ions

We study numerically collisions between protons and $H_2^+$ molecular ions at intermediate impact energies by using the Classical Trajectory Monte Carlo method (CTMC). Total and differential cross sections are computed. The results are compared with: a) the standard one electron--two nucleon scattering, and b) the quantum mechanical treatment of the $H^{+} - H^{+}_{2}$ scattering.Comment: ReVTeX, 5 pages + 5 figs. (EPS) To be published in Physica Script

Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments

Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycle

The role of health determinants in the influenza vaccination uptake among older adults (65+): a scope review

Background: Although the burden of influenza infection is the highest in older adults, vaccination coverage remains low, despite this age group being more vulnerable than others. Aims: Given the current pandemic of SARS-CoV-2, it was the aim of this scope review to update knowledge on factors affecting seasonal influenza vaccine uptake among older adults to strengthen prevention approaches in the context of an overall burden of infectious diseases. Methods: We searched bibliographic databases from 2012 to 2019. All studies reviewed one or more social determinant of health listed by WHO, or factors affecting the decision-making process whether to accept influenza vaccine or not. Results: Overall, 44 studies were included, 41 determinants were extracted and summarized into six categories. Older age and constitutional factors including multiple chronic diseases as well as preventive lifestyle and frequent routine healthcare utilization positively affected vaccination uptake (VU). Living and working conditions are also researched determinants of influenza vaccine uptake. A small number of studies explored the role of social inclusion and system-based interventions. Discussion and conclusions: This scope review provides a comprehensive overview on factors affecting seasonal influenza vaccination uptake among older citizens. The review also clearly shows gaps for evidence on system-based level or political strategies to improve vaccination uptake

Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

DNA G-rich sequences are able to form four-stranded structures organized in stacked guanine tetrads. These structures, called G-quadruplexes, were found to have an important role in the regulation of oncogenes expression and became, for such a reason, appealing targets for anticancer drugs. Aiming at finding selective G-quadruplex binders, we have designed, synthesized and characterized a new water soluble Salen-like Schiff base ligand and its NiII and CuII metal complexes. UV-Vis, circular dichroism and FRET measurements indicated that the nickel complex can stabilize oncogene promoter G-quadruplexes with high selectivity, presenting no interactions with duplex DNA at all. The same compound exhibited dose-dependent cytotoxic activity in MCF-7 breast cancer cells when combined with lipofectamine as lipophilic carrier

De novo Renal Transplantation after Kaposi Sarcoma: Favorable Outcome in a Patient Receiving Sirolimus and Mycophenolate-Based Immunosuppression

Immunosuppressive treatment increases the risk of infection and malignancy in organ transplant recipients. We report on a 42-year-old male renal transplant recipient who lost his first graft after reduction of immunosuppressive treatment due to Kaposi sarcoma and who successfully underwent a second renal transplant 10 years later. The patient's current treatment consists of low-dose prednisone, and the two antiproliferative immunosuppressants mycophenolate mofetil and rapamycin. 4.5 years after his second transplant, the serum creatinine is 1 mg/dl and the patient has no signs of recurrent disease