Supercritical multicomponent solvent coal extraction

The yield of organic extract from the supercritical extraction of coal with larger diameter organic solvents such as toluene is increased by use of a minor amount of from 0.1 to 10% by weight of a second solvent such as methanol having a molecular diameter significantly smaller than the average pore diameter of the coal

Demonstration of a partially automated assessment approach to create an individualised, open-ended modelling worksheet

\ua9 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Partially automated assessment is implemented via the ‘Printable worksheet’ mode in the Numbas e-assessment system to create a mathematical modelling worksheet which is individualised with random parameters but completed and marked as if it were a non-automated piece of coursework, preserving validity while reducing the risk of academic misconduct via copying and collusion. A simple modelling scenario is used for this demonstration. A cylindrical tank of water is draining through a small hole in its base, with the size of the tank, size of the hole and initial volume of water randomised so that the details are different for each student. Students are guided through deriving a model of the movement of water out of their version of the tank, asked to compute the expected time for it to empty and asked to discuss some aspects of the model and their findings in a discursive narrative report

Qubits as spectrometers of dephasing noise

We present a procedure for direct characterization of the dephasing noise acting on a single qubit by making repeated measurements of the qubit coherence under suitably chosen sequences of controls. We show that this allows a numerical reconstruction of the short time noise correlation function and that it can be combined with a series of measurements under free evolution to allow a characterization of the noise correlation function over many orders of magnitude range in timescale. We also make an analysis of the robustness and reliability of the estimated correlation functions. Application to a simple model of two uncorrelated noise fluctuators using decoupling pulse sequences shows that the approach provides a useful route for experimental characterization of dephasing noise and its statistical properties in a variety of condensed phase and atomic systems.Comment: 10 pages, 3 figure

Selected Mission Architectures For The Terrestrial Planet Finder (TPF): Large, Medium, and Small

Four teams incorporating scientists and engineers from more than 50 universities and 20 engineering firms have assessed techniques for detecting and characterizing terrestrial planets orbiting nearby stars. The primary conclusion from the effort of the past two years is that with suitable technology investment starting now, a mission to detect terrestrial planets around 150 nearby stars could be launched within a decade. Missions of smaller scale could carry out more modest programs capable of detecting and characterizing gas giant planets around tens of stars and of detecting terrestrial planets around the nearest stars

Efficient operation of a high-power X-band gyroklystron

Experimental studies of amplification in a two-cavity X-band gyroklystron are reported. The system utilizes a thermionic magnetron injection gun at voltages up to 440 kV and currents up to 190 A in 1-μs pulses. Optimum performance is achieved by tapering the magnetic-field profile. Peak powers of 20 MW in the TE01 mode at 9.87 GHz are measured with calibrated crystals and with methanol calorimetry. Resultant efficiencies are in excess of 31% and large-signal gains surpass 26 dB. The experimental results are in good agreement with simulated results from a partially self-consistent, nonlinear, steady-state code

Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD

Isomorphic classical molecular dynamics model for an excess electron in a supercritical fluid

Ring polymer molecular dynamics (RPMD) is used to directly simulate the dynamics of an excess electron in a supercritical fluid over a broad range of densities. The accuracy of the RPMD model is tested against numerically exact path integral statistics through the use of analytical continuation techniques. At low fluid densities, the RPMD model substantially underestimates the contribution of delocalized states to the dynamics of the excess electron. However, with increasing solvent density, the RPMD model improves, nearly satisfying analytical continuation constraints at densities approaching those of typical liquids. In the high density regime, quantum dispersion substantially decreases the self-diffusion of the solvated electron. In this regime where the dynamics of the electron is strongly coupled to the dynamics of the atoms in the fluid, trajectories that can reveal diffusive motion of the electron are long in comparison to $\beta\hbar$.Comment: 24 pages, 4 figure

The 2nd United Kingdom Extracellular Vesicle Forum Meeting Abstracts: 15 December 2015, Hadyn Ellis Building, Cardiff University

The UK Extracellular Vesicles (UKEV) Forum meetings were born of the realization that there were a number of UK laboratories studying extracellular vesicle biology and using similar techniques but without a regular national meeting dedicated to EVs at which to share their findings. This was compounded by the fact that many of these labs were working in different fields and thus networking and sharing of ideas and best practice was sometimes difficult. The first workshop was organized in 2013 by Dr Charlotte Lawson, under the auspices of the Society for Endocrinology, led to the founding of the UKEV Forum and the organization of a British Heart Foundation sponsored 1-day conference held in London in December 2014. Although growing in size every year, the central aims of these workshops have remained the same: to provide a forum for discussion and exchange of ideas, to allow young scientists to present their data in the form of short talks and poster presentations and to discuss their work with more established scientists in the field. Here we include the presented abstracts for the 2015 1-day conference hosted by Cardiff University. This meeting was attended by approximately 130 delegates throughout the United Kingdom, but also attended by delegates from Belgium, Netherlands, France, Ireland and other nations. The day composed of plenary presentations from Prof Matthias Belting, Lund University, Sweden and Dr Guillaume van Niel, Institut Curie, Paris together with 10 short presentations from submitted abstracts. The topics covered were broad, with sessions on Mechanisms of EV production, EVs in Infection, EVs in Cancer and in Blood and Characterizing EVs in Biological fluids. This hopefully gives a reflection of the range of EV-related studies being conducted currently in the UK. There were also 33 poster presentations equally broad in subject matter. The organizers are grateful to the Life Science Research Network Wales - a Welsh government-funding scheme that part-sponsored the conference. We are also grateful to commercial sponsors, and 3 paid-presentations are included in the abstracts. The UK EV Forum is expected to become an established annual event held at different Universities across the UK and continue to attract increasing delegate numbers and abstract submissions. We look forward to the next planned conference, which will be hosted by David Carter and his colleagues at Oxford Brookes University on 13th December 2016

Tip timing techniques for turbomachinery HCF condition monitoring

High Cycle Fatigue (HCF) has been established as the major common failure mode in the US Air Force large fleet of aero-engines. Corrective measures for this failure mode in themselves deliver additional technical, managerial and cost pressures. Two responses are in place to address this problem; risk mitigation through accelerated engine development fixes and technology transition through targeted and focussed R&D studies. It is the latter that is of interests and is discussed in this paper. Aero-engine blade vibrations of sufficient amplitude cause High Cycle Fatigue, which reduces blade life. In order to observe this vibration a non-intrusive monitoring system is sought. The vibration can be detected by measuring blade tip timing since in the presence of vibration the blade timing will differ slightly from the passing time calculated from rotor speed. Work done to investigate the suitability of a commercially available capacitance probe tip clearance measurement system for application as a non-intrusive turbomachinery blade tip timing measurement device is reported. Capacitance probe results are correlated with simultaneously measure strain gauge results and the performance of the capacitance system in measuring blade vibration is analysed. The growing interest in blade high cycle fatigue within the aerospace industry, and an approach to monitoring their condition are discussed as an extension to the above study. The suggested approach is based upon the tip-timing method, using non-contact optical probes located around the engine’s casing. Two current tip-timing techniques are suggested for the purpose. The techniques are summarised, the experimental validation of both methods outlined, and the approach taken to investigate the potential use as a condition monitoring tool described. The paper is concluded with a discussion of the future use of tiptiming as a condition monitoring tool