Thermodynamics of phantom black holes in Einstein-Maxwell-Dilaton theory

A thermodynamic analysis of the black hole solutions coming from the Einstein-Maxwell-Dilaton theory (EMD) in 4D is done. By consider the canonical and grand-canonical ensemble, we apply standard method as well as a recent method known as Geometrothermodynamics (GTD). We are particularly interested in the characteristics of the so called phantom black hole solutions. We will analyze the thermodynamics of these solutions, the points of phase transition and their extremal limit. Also the thermodynamic stability is analyzed. We obtain a mismatch of the between the results of the GTD method when compared with the ones obtained by the specific heat, revealing a weakness of the method, as well as possible limitations of its applicability to very pathological thermodynamic systems. We also found that normal and phantom solutions are locally and globally unstable, unless for certain values of the coupled constant of the EMD action. We also shown that the anti-Reissner-Nordstrom solution does not posses extremal limit nor phase transition points, contrary to the Reissner-Nordstrom case.Comment: 23 pages, version accepted for publication in Physical Review

Clinical, imaging and genetic analysis of double bilateral radix entomolaris

Background: Anatomy describes that first mandibular molars have two roots: 1 mesial, with 2 root canals, and 1 distal, with 1 root canal. The presence of three roots in these teeth is uncommon. Root anatomical variations have an impact, especially in endodontic, where the highest rates of nonsurgical treatment failures are due to the inability to identify and access roots and/or accessory canals. The aim of this research is to report a case of double three-rooted mandibular first molar through clinical, imaging and genetic analysis. Materials and methods: Using a panoramic radiography, the presence of three roots in teeth 36 and 46 was diagnosed in a female patient. Additionally, it was indicated a cone beam computed tomography. Moreover, leukocyte genomic DNA was obtained from a blood sample of the patient to determine her ethnicity through analysis of mitochondrial DNA haplogroups using polymerase chain reaction-length restriction fragment polymorphism (PCR-RFLP). Results: Both molars had three roots, 1 mesial (M), 1 distolingual (DL), also known as radix entomolaris (RE), and a distovestibular (DV). For both teeth, M root had 2 canals, and DV and DL roots presented just 1 canal. Mitochondrial DNA analysis determined presence of haplogroup C, corresponding to Amerindian ethnicity. Conclusions: The presence of RE is uncommon. This case report contributes to describe this rare anatomical variation. To our knowledge, this is the first molecular-genetic study applied to dental anatomy and gives basis to develop future research in the area

Método de obtención de mosto concentrado virgen de uva sin aditivos

En el presente trabajo se propone una metodología para la obtención de mosto concentrado de uva virgen sin la adición de aditivos químicos conservantes. Se definió el proceso general de preparación, concentración y conservación del mosto de uva. Se utilizaron tres variedades de uva procedentes de los viñedos del Centro Nacional Vitivinícola (CENAVIT) de Bolivia. Como resultado de los ensayos realizados se estableció una línea de elaboración de mostos concentrados vírgenes para la obtención de productos vitivinícolas alternativos.Fil: Chavez Reque, M.. Centro Nacional de Vitivinicultura; BoliviaFil: Tolaba, C.. Centro Nacional de Vitivinicultura; BoliviaFil: Moya Oporto, R.. Universidad San Simón; Bolivia. Universidad Univalle; BoliviaFil: Ferrero, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Siñeriz, Faustino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; ArgentinaFil: Lucca, Maria Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentin

Building an endangered language resource in the classroom: Universal dependencies for Kakataibo

In this paper, we launch a new Universal Dependencies treebank for an endangered language from Amazonia: Kakataibo, a Panoan language spoken in Peru. We first discuss the collaborative methodology implemented, which proved effective to create a treebank in the context of a Computational Linguistic course for undergraduates. Then, we describe the general details of the treebank and the language-specific considerations implemented for the proposed annotation. We finally conduct some experiments on part-of-speech tagging and syntactic dependency parsing. We focus on monolingual and transfer learning settings, where we study the impact of a Shipibo-Konibo treebank, another Panoan language resourc

Complete loop quantization of a dimension 1+2 Lorentzian gravity theory

De Sitter Chern-Simons gravity in D = 1 + 2 spacetime is known to possess an extension with a Barbero-Immirzi like parameter. We find a partial gauge fixing which leaves a compact residual gauge group, namely SU(2). The compacticity of the residual gauge group opens the way to the usual LQG quantization techniques. We recall the exemple of the LQG quantization of SU(2) CS theory with cylindrical space topology, which thus provides a complete LQG of a Lorentzian gravity model in 3-dimensional space-time.Comment: Loops11 - Madrid - 2011 (4 pages, Latex

High density polyethylene and polystyrene microplastics as vectors of Triclosan towards marine invertebrates: signals of reduced bioreactivity

Triclosan (TCS) is an emerging contaminant used as a preservative for its antifungal and bactericidal properties. Previous studies have showed different capacity of TCS sorption depending on the MP type, which was related to their physicochemical properties. As a part of the general objective to evaluate the capacity of polyethylene(PE) and polystyrene (PS) microplastics as TCS vectors in marine environments, the marine bivalve Mytilus galloprovincialis was used as a model organism to evaluate effects on immune function after in vivo co-exposure. Acute TCS spill scenario in the presence/absence of microplastics in the surrounding water was simulated under laboratory conditions. Mussels were simultaneously exposed to one type of weathered microplastics (PE or PS) and a high TCS concentration during 72 hours. In general, a decrease in lysosomal membrane stability was observed with all treatments compared to the control after three days, with most treatments resulting in moderate cell stress in mussels. A overall decrease in phagocytic efficiency was also observed in all treated mussels compared to the control mussels, the only exception being mussels individually exposed to PE, where a slight but not statistically significant increase was detected. No differences were observed between treatments in extracellular lysozyme activity and oxyradicals production. In general, mussels co-exposed to TCS+PE and TCS+PS showed effects on immune function that were lower than or comparable to those observed with individual exposures to TCS, PE and PS. Based on the results of this study, an additive effect on immune function derived from the co-exposure of TCS+PE and TCS+PS microplastics can be discarded. However, a weak antagonistic effect is suggested, potentially due to a reduction in their bioreactivity as a consequence of the adsorption of TCS to the surface of the ingested microplastics. The comparison of the results of bioaccumulation of TCS in mussels between the individual treatments and treatments with co-exposure to TCS, which are currently being analyzed, will help to strengthen or refute this hypothesis

Serial clinical and echocardiographic evaluation in children with Marfan syndrome

OBJECTIVE: To describe the clinical cardiac manifestations and temporal evolution of Marfan syndrome in children; to estimate the incidence of annuloaortic ectasia and mitral valve prolapse; and to evaluate tolerability and efficacy of beta-blockers in these patients. METHODS: During one year, 21children with Marfan syndrome underwent serial clinical and echocardiographic examinations. Echocardiograms assessed: the presence of mitral valve prolapse, aortic root diameter, mitral and aortic valves regurgitation, and aortic enlargement during beta-blocker therapy. Eleven patients had two measurements of the aortic root taken one year apart. RESULTS: The children were asymptomatic throughout the study. Mitral prolapse was found in 11 (52%) children. Annuloaortic ectasia occurred in 16 (76%) patients and found to be mild in 42.8%, moderate in 9.5%, and severe in 23.8%. One of these patients underwent aortic valve replacement and repair of the ascending aorta by the Bentall-De Bono technique, with good results. Heart rate decreased by 13.6% (from 85 to 73 bpm; p < 0.009) with the use of beta-blockers; however, aortic root diameter increased by 1.4 mm/year (p<0.02). One child could not be given beta-blockers due to bronchial asthma, and no significant side effects were observed in the remaining children, including one who also had bronchial asthma. CONCLUSION: The children remained asymptomatic throughout the study, the use of beta-blockers led to a significant decrease in heart rate, and no significant adverse effects were observed. Contrary to the literature, incidence of annuloaortic ectasia was high among the study population, greater than that of mitral valve prolapse, even during beta-blocker therapy.OBJETIVO: Descrever a apresentação clínica cardiológica e a evolução temporal, estimar a incidência de ectasia ânulo-aórtica e de prolapso da valva mitral, e avaliar a tolerância e a efetividade dos betabloqueadores em crianças com síndrome de Marfan. MÉTODOS: Foram submetidas a exame clínico e ecocardiográfico seriado, durante um ano, 21 crianças com síndrome de Marfan. No ecocardiograma foram analisados: presença de prolapso mitral, diâmetro da raiz aórtica, refluxos das valvas mitral e aórtica, e o crescimento dos diâmetros aórticos na vigência de betabloqueadores. Em 11 pacientes foi possível obter duas medidas da raiz aórtica no intervalo de um ano. RESULTADOS: Durante o estudo as crianças não apresentaram sintomas. Prolapso mitral foi encontrado em 11 (52%) crianças. Ectasia ânulo-aórtica ocorreu em 16 (76%) pacientes, sendo de grau discreto em 42,8%, moderado em 9,5%, e importante em 23,8%. Um desses pacientes foi submetido com sucesso à cirurgia de Bentall DeBono. Com o uso de betabloqueador a freqüência cardíaca diminuiu 13,6% (de 85 para 73 bpm; p < 0,009), mas houve um crescimento da raiz aórtica de 1,4 mm/ano (p < 0,02). Uma criança não pôde receber betabloqueador em razão de asma brônquica, e não foram observados efeitos colaterais significativos nas outras crianças, incluindo uma com asma brônquica. CONCLUSÃO: Os resultados obtidos sugerem que, no período observado, as crianças permaneceram assintomáticas, o uso de betabloqueadores diminuiu significativamente a freqüência cardíaca e não se acompanhou de efeitos adversos significativos. Ao contrário da literatura, a incidência de ectasia ânulo-aórtica foi elevada e maior do que a de prolapso valvar mitral, tendo crescimento mesmo na vigência de uso eficaz de betabloqueador.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

Quantization of Lorentzian 3d Gravity by Partial Gauge Fixing

D = 2+1 gravity with a cosmological constant has been shown by Bonzom and Livine to present a Barbero-Immirzi like ambiguity depending on a parameter. We make use of this fact to show that, for positive cosmological constant, the Lorentzian theory can be partially gauge fixed and reduced to an SU(2) Chern-Simons theory. We then review the already known quantization of the latter in the framework of Loop Quantization for the case of space being topogically a cylinder. We finally construct, in the same setting, a quantum observable which, although non-trivial at the quantum level, corresponds to a null classical quantity.Comment: Notation defect fixed on pages 5 (bottom) and 6 (around Eqs. 3.1)-- 19 pages, Late

Immunotherapy with CD25/CD71-allodepleted T cells to improve T-cell reconstitution after matched unrelated donor hematopoietic stem cell transplant: a randomized trial

BACKGROUND AND AIMS: Delayed immune reconstitution is a major challenge after matched unrelated donor (MUD) stem cell transplant (SCT). In this randomized phase 2 multi-center trial, Adoptive Immunotherapy with CD25/71 allodepleted donor T cells to improve immunity after unrelated donor stem cell transplant (NCT01827579), the authors tested whether allodepleted donor T cells (ADTs) can safely be used to improve immune reconstitution after alemtuzumab-based MUD SCT for hematological malignancies. METHODS: Patients received standard of care or up to three escalating doses of ADTs generated through CD25+/CD71+ immunomagnetic depletion. The primary endpoint of the study was circulating CD3+ T-cell count at 4 months post-SCT. Twenty-one patients were treated, 13 in the ADT arm and eight in the control arm. RESULTS: The authors observed a trend toward improved CD3+ T-cell count at 4 months in the ADT arm versus the control arm (230/µL versus 145/µL, P = 0.18), and three ADT patients achieved normal CD3+ T-cell count at 4 months (>700/µL). The rates of significant graft-versus-host disease (GVHD) were comparable in both cohorts, with grade ≥2 acute GVHD in seven of 13 and four of eight patients and chronic GVHD in three of 13 and three of eight patients in the ADT and control arms, respectively. CONCLUSIONS: These data suggest that adoptive transfer of ADTs is safe, but that in the MUD setting the benefit in terms of T-cell reconstitution is limited. This approach may be of more use in the context of more rigorous T-cell depletion