A Keck High Resolution Spectroscopic Study of the Orion Nebula Proplyds

We present the results of spectroscopy of four bright proplyds in the Orion Nebula obtained at a velocity resolution of 6 km/s. After careful isolation of the proplyd spectra from the confusing nebular radiation, the emission line profiles are compared with those predicted by realistic dynamic/photoionization models of the objects. The spectral line widths show a clear correlation with ionization potential, which is consistent with the free expansion of a transonic, ionization-stratified, photoevaporating flow. Fitting models of such a flow simultaneously to our spectra and HST emission line imaging provides direct measurements of the proplyd size, ionized density and outflow velocity. These measurements confirm that the ionization front in the proplyds is approximately D-critical and provide the most accurate and robust estimate to date of the proplyd mass loss rate. Values of 0.7E-6 to 1.5E-6 Msun/year are found for our spectroscopic sample, although extrapolating our results to a larger sample of proplyds implies that 0.4E-6 Msun/year is more typical of the proplyds as a whole. In view of the reported limits on the masses of the circumstellar disks within the proplyds, the length of time that they can have been exposed to ionizing radiation should not greatly exceed 10,000 years - a factor of 30 less than the mean age of the proplyd stars. We review the various mechanisms that have been proposed to explain this situation, and conclude that none can plausibly work unless the disk masses are revised upwards by a substantial amount.Comment: 23 pages, 8 figures, uses emulateapj.sty, accepted for publication in The Astronomical Journal (scheduled November 1999

O PAPEL DO TIPO DE RESPOSTA NA FORMA DO CONTRASTE NEGATIVO OU DA INDUÇÃO POSITIVA EM RATOS

Rats may decrease (negative contrast) or increase (positive induction) their rate of responding for 1% sucrose reinforcement when 32% sucrose reinforcement is upcoming under different conditions. Previous research suggests that which effect occurs may depend on what motor response (i.e., licking vs. press a lever) isrequired to obtain the sucrose. The present study investigated this idea by having subjects make different responses in different halves of the session. Subjects either licked or pressed a lever for 1% sucrose reinforcement in the first half of the session. They then made the alternative response for 1% or 32% sucrose reinforcement, in different conditions, in the second half. In Experiment 1, both licking and lever pressing were operant responses. In Experiment 2, licking was strictly a consummatory response. Results showed that upcoming 32% sucrose tended to decrease responding for 1% sucrose in the first half of the session regardless of the response required in either half. Positive induction was never observed. The present results question whether type of motor response is a key factor in whether contrast or induction is observed. Instead, they suggest that the location that thesubstances are delivered and consumed is critical. Ultimately, understanding when one effect or the other will occur will enhance our understanding of eating-related behavior.Key words: negative contrast, positive induction, reinforcement, lever press, rat.Ratos podem diminuir (contraste negativo) ou aumentar (indução positiva) sua taxa de respostas reforçadas com solução de sacarose a 1% quando reforçamento com solução de sacarose a 32% é iminente, em diferentes condições. Pesquisa anterior sugere que o efeito que ocorrerá pode depender de qual resposta motora (lamber versus pressionar a barra, por exemplo) é requerida para obter a solução de sacarose. O presente estudo investigou esse problema fazendo os sujeitos emitirem respostas diferentes em cada uma das metades das sessões. Os sujeitos ou lambiam ou pressionavam uma barra e produziam reforçamento de solução de sacarose a 1% na primeira metade da sessão. Eles emitiam, então, a resposta alternativa, reforçada por solução de sacarose a 1% ou 32%, em condições diferentes, na segunda metade da sessão. No Experimento 1, ambos, lamber e pressionar a barra eram respostas operantes. No Experimento 2, lamber foi uma resposta estritamente consumatória. Os resultados mostraram que a solução de sacarose a 32% iminente tendeu a diminuir o responder por solução de sacarose a 1% na primeira metade da sessão, independentemente de qual era a resposta requerida na outra metade. Indução positiva nunca foi observada. Os resultados presentes questionam se o tipo de resposta motora seria um fator chave para a observação de contraste ou de indução, sugerindo, ao contrário, que o local em que as substâncias são liberadas e consumidas seja crítico. Compreender quando um efeito ou outro vai ocorrer aumentará nossa compreensão do comportamento relacionado com alimentar-se. Palavras-chave: Contraste negativo, indução positiva, reforçamento, pressão à barra, rato

Salivary melatonin onset in youth at familial risk for bipolar disorder

Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR). Adolescent participants (n = 12) were a mean age 14 ± 2.3 years and included 8 females and 4 males. Saliva samples were collected under standardized condition light (red light) and following a 200 lux light exposure over two consecutive nights in a sleep laboratory. Red Light Melatonin onset (RLMO) was defined as saliva melatonin level exceeding the mean of the first 3 readings plus 2 standard deviations. Polysomnography was also completed during each night. HR youth, relative to LR, experienced a significantly earlier melatonin onset following 200 lux light exposure. Polysomnography revealed that LR youth, relative to HR, spent significantly more time in combined stages 3 and 4 (deep sleep) following red light exposure. Additionally, regardless of the group status (HR or LR), there was no significant difference in Red Light Melatonin Onset recorded at home or in the laboratory, implying its feasibility and reliability

The Evolution of Circumstellar Disks in Ophiuchus Binaries

Four Ophiuchus binaries, two Class I systems and two Class II systems, with separations of ~450-1100 AU, were observed with the Owens Valley Radio Observatory (OVRO) millimeter interferometer. In each system, the 3 mm continuum maps show dust emission at the location of the primary star, but no emission at the position of the secondary. This result is different from observations of less evolved Class 0 binaries, in which dust emission is detected from both sources. The nondetection of secondary disks is, however, similar to the dust distribution seen in wide Class II Taurus binaries. The combined OVRO results from the Ophiuchus and Taurus binaries suggest that secondary disk masses are significantly lower than primary disk masses by the Class II stage, with initial evidence that massive secondary disks are reduced by the Class I stage. Although some of the secondaries retain hot inner disk material, the early dissipation of massive outer disks may negatively impact planet formation around secondary stars. Masses for the circumprimary disks are within the range of masses measured for disks around single T Tauri stars and, in some cases, larger than the minimum mass solar nebula. More massive primary disks are predicted by several formation models and are broadly consistent with the observations. Combining the 3 mm data with previous 1.3 mm observations, the dust opacity power-law index for each primary disk is estimated. The opacity index values are all less than the scaling for interstellar dust, possibly indicating grain growth within the circumprimary disks

Social contexts of remission from DSM-5 alcohol use disorder in a high-risk sample

BACKGROUND: Measures of social context, such as marriage and religious participation, are associated with remission from alcohol use disorders (AUDs) in population-based and treatment samples, but whether these associations hold among individuals at high familial risk for AUD is unknown. This study tests associations of measures of social context and treatment with different types of remission from DSM-5 AUD in a high-risk sample. METHODS: Subjects were 686 relatives of probands (85.7% first-degree) who participated in a high-risk family study of alcohol dependence. All subjects met criteria for AUD at baseline and were re-interviewed 5 years later. Follow-up status was categorized as persistent AUD, high-risk drinking, remitted low-risk drinking, and abstinence. Social context measures were defined as stable or changing from baseline to follow-up, and their bivariate and multivariate associations with follow-up status were tested. RESULTS: At follow-up, 62.8% of subjects had persistent AUD, 6.4% were high-risk drinkers, 22.2% were remitted low-risk drinkers, and 8.6% were abstinent. Birth of first child during the interval was the only measure of social context associated with remitted low-risk drinking and was significant for women only. Abstinent remission was characterized by being stably separated or divorced for women, new marriage for both sexes, experiencing low levels of family support and high levels of friend support, and receiving treatment. High-risk drinkers were more likely than individuals with persistent AUD to have a stable number of children and to have been recently unemployed. CONCLUSIONS: The social contexts accompanying different types of remission in this high-risk sample resemble those found in population-based and clinical samples. Low-risk drinkers resemble natural remitters from population-based samples who change their drinking habits with life transitions. Abstainers resemble clinical samples in marital context, support from friends, and treatment. High-risk drinkers appear to continue to experience negative consequences of heavy drinking

Genome-wide association studies of the self-rating of effects of ethanol (SRE).

The level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for effects is genetically influenced and predicts higher risks for heavy drinking and alcohol problems. We conducted genome-wide association study (GWAS) in the African-American (COGA-AA, N = 1527 from 309 families) and European-American (COGA-EA, N = 4723 from 956 families) subsamples of the Collaborative Studies on the Genetics of Alcoholism (COGA) for two SRE scores: SRE-T (average of first five times of drinking, the period of heaviest drinking, and the most recent 3 months of consumption) and SRE-5 (the first five times of drinking). We then meta-analyzed the two COGA subsamples (COGA-AA + EA). Both SRE-T and SRE-5 were modestly heritable (h2 : 21%-31%) and genetically correlated with alcohol dependence (AD) and DSM-IV AD criterion count (rg : 0.35-0.76). Genome-wide significant associations were observed (SRE-T: chromosomes 6, rs140154945, COGA-EA P = 3.30E-08 and 11, rs10647170, COGA-AA+EA P = 3.53E-09; SRE-5: chromosome13, rs4770359, COGA-AA P = 2.92E-08). Chromosome 11 was replicated in an EA dataset from the National Institute on Alcohol Abuse and Alcoholism intramural program. In silico functional analyses and RNA expression analyses suggest that the chromosome 6 locus is an eQTL for KIF25. Polygenic risk scores derived using the COGA SRE-T and SRE-5 GWAS predicted 0.47% to 2.48% of variances in AD and DSM-IV AD criterion count in independent datasets. This study highlights the genetic contribution of alcohol response phenotypes to the etiology of alcohol use disorders

Eculizumab as rescue therapy for atypical hemolytic uremic syndrome with normal platelet count

Item does not contain fulltextBACKGROUND: Atypical hemolytic uremic syndrome (aHUS) in childhood is a rare disease with frequent progression to end-stage renal disease and a high recurrence after kidney transplantation. Eculizumab, a humanized monoclonal antibody that binds to complement protein C5, may be beneficial in the treatment of aHUS. CASE-DIAGNOSIS/TREATMENT: A 6-year-old girl developed aHUS with only slightly elevated C3d (4.4%), no mutations in complement factors, and no antibodies against factor H. Plasma exchange treatment was successful initially, until aHUS recurred. After reinitiating plasma exchange, normalization of the platelet count and improvement of hemolysis occurred, but renal function worsened. Renal function then improved dramatically promptly after the switch to eculizumab. CONCLUSIONS: This case demonstrates that platelet count is not always a reliable marker for improvement of aHUS and that eculizumab can prevent dialysis in plasma-resistant aHUS patients.1 juli 201

Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression

Abstract Background Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and stressful life events affecting the risk for depression, others report a main effect of 5-HTTLPR variation on depression, while others find no evidence for either a main or interaction effect. Meta-analyses of multiple studies have also reached differing conclusions. Methods/Design To improve understanding of the combined roles of 5-HTTLPR variation and stress in the development of depression, we are conducting a meta-analysis of multiple independent datasets. This coordinated approach utilizes new analyses performed with centrally-developed, standardized scripts. This publication documents the protocol for this collaborative, consortium-based meta-analysis of 5-HTTLPR variation, stress, and depression. Study eligibility criteria: Our goal is to invite all datasets, published or unpublished, with 5-HTTLPR genotype and assessments of stress and depression for at least 300 subjects. This inclusive approach is to minimize potential impact from publication bias. Data sources: This project currently includes investigators from 35 independent groups, providing data on at least N = 33,761 participants. The analytic plan was determined prior to starting data analysis. Analyses of individual study datasets will be performed by the investigators who collected the data using centrally-developed standardized analysis scripts to ensure a consistent analytical approach across sites. The consortium as a group will review and interpret the meta-analysis results. Discussion Variation in 5-HTTLPR is hypothesized to moderate the response to stress on depression. To test specific hypotheses about the role of 5-HTTLPR variation on depression, we will perform coordinated meta-analyses of de novo results obtained from all available data, using variables and analyses determined a priori. Primary analyses, based on the original 2003 report by Caspi and colleagues of a GxE interaction will be supplemented by secondary analyses to help interpret and clarify issues ranging from the mechanism of effect to heterogeneity among the contributing studies. Publication of this protocol serves to protect this project from biased reporting and to improve the ability of readers to interpret the results of this specific meta-analysis upon its completion.http://deepblue.lib.umich.edu/bitstream/2027.42/112319/1/12888_2013_Article_1474.pd

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases

Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of patients with dermatological disorders such as atopic dermatitis, psoriasis and vitiligo. This glucocorticoid is characterized by high lipophilicity, high glucocorticoid receptor binding and activation, and a rapid metabolic turnover in skin. Although skin blanching following fluticasone propionate exceeds that of corticosteroids of medium strength, several clinical trials demonstrate a low potential for cutaneous and systemic side-effects, even in difficult-to-treat areas like the face, the eyelids and intertriginous areas. Even among paediatric patients with atopic dermatitis, fluticasone propionate proved to be safe and effective. These pharmacological and clinical properties are reflected by the high therapeutic index of this glucocorticoid