The Co-movement of housing sales and housing prices : empirics and theory

March 1, 200

R-Silsesquioxane-Based Network Polymers by Fluoride Catalyzed Synthesis: An Investigation of Cross-Linker Structure and Its Influence on Porosity

Silsesquioxane-based networks are an important class of materials that have many applications where high thermal/oxidative stability and porosity are needed simultaneously. However, there is a great desire to be able to design these materials for specialized applications in environmental remediation and medicine. To do so requires a simple synthesis method to make materials with expanded functionalities. In this article, we explore the synthesis of R-silsesquioxane-based porous networks by fluoride catalysis containing methyl, phenyl and vinyl corners (R-Si(OEt)) combined with four different bis-triethoxysilyl cross-linkers (ethyl, ethylene, acetylene and hexyl). Synthesized materials were then analyzed for their porosity, surface area, thermal stability and general structure. We found that when a specified cage corner (i.e., methyl) is compared across all cross-linkers in two different solvent systems (dichloromethane and acetonitrile), pore size distributions are consistent with cross-linker length, pore sizes tended to be larger and π-bond-containing cross-linkers reduced overall microporosity. Changing to larger cage corners for each of the cross-linkers tended to show decreases in overall surface area, except when both corners and cross-linkers contained π-bonds. These studies will enable further understanding of post-synthesis modifiable silsesquioxane networks

How a fungus shapes biotechnology: 100 years of Aspergillus niger research

In 1917, a food chemist named James Currie made a promising discovery: any strain of the filamentous mould Aspergillus niger would produce high concentrations of citric acid when grown in sugar medium. This tricarboxylic acid, which we now know is an intermediate of the Krebs cycle, had previously been extracted from citrus fruits for applications in food and beverage production. Two years after Currie’s discovery, industrial-level production using A. niger began, the biochemical fermentation industry started to flourish, and industrial biotechnology was born. A century later, citric acid production using this mould is a multi-billion dollar industry, with A. niger additionally producing a diverse range of proteins, enzymes and secondary metabolites. In this review, we assess main developments in the field of A. niger biology over the last 100 years and highlight scientific breakthroughs and discoveries which were influential for both basic and applied fungal research in and outside the A. niger community. We give special focus to two developments of the last decade: systems biology and genome editing. We also summarize the current international A. niger research community, and end by speculating on the future of fundamental research on this fascinating fungus and its exploitation in industrial biotechnology.DFG, 325093850, Open Access Publizieren 2017 - 2018 / Technische Universität Berli

Chulmun Neolithic Intensification, Complexity, and Emerging Agriculture in Korea

Emergence of complex society in prehistoric Korea has long been understood as a socioeconomic corollary of its Bronze Age agriculture (1300–300 b.c. ). Archaeological data accumulated in recent years, however, point to the contrary. By around 3500 b.c. Korea’s Neolithic society had gone beyond foraging and collecting and become a society of the middle ground. It became increasingly sedentary and began food production, initially at a low level, as it sought to secure critical resources through logistic strategies. It also increasingly utilized storage as a mechanism of risk and wealth management. Gradually intensifying subsistence strategies that combined hunting, fishing, gathering, mobile horticulture, and storage mechanism, enabled Korea’s Chulmun Neolithic society to maintain its sociopolitical and economic stability over a period of several millennia. The intensification increased during the Late Neolithic with emerging mixed crop farming and mass-capture of marine resources. Post-Neolithic florescence of rice-based agriculture and the revolutionary societal elaboration during and beyond the Bronze Age were direct outcomes of socioeconomic foundations laid by the indigenous Korean hunter-fisher-gatherer-cultivators during the Chulmun Neolithic

Thermally Stable Fluorogenic Zn(II) Sensor Based on a Bis(benzimidazole)pyridine-Linked Phenyl-Silsesquioxane Polymer

A 2,6-bis(2-benzimidazolyl) pyridine-linked silsesquioxane-based semi-branched polymer was synthesized, and its photophysical and metal-sensing properties have been investigated. The polymer is thermally stable up to 285 °C and emits blue in both solid and solution state. The emission of the polymer is sensitive to pH and is gradually decreased and quenched upon protonation of the linkers. The initial emission color is recoverable upon deprotonation with triethylamine. The polymer also shows unique spectroscopic properties in both absorption and emission upon long-term UV irradiation, with red-shifted absorption and emission not present in a simple blended system of phenylsilsesquioxane and linker, suggesting that a long-lived energy transfer or charge separated state is present. In addition, the polymer acts as a fluorescence shift sensor for Zn(II) ions, with red shifts observed from 464 to 528 nm, and reversible binding by the introduction of a competitive ligand such as tetrahydrofuran. The ion sensing mechanism can differentiate Zn(II) from Cd(II) by fluorescence color shifts, which is unique because they are in the same group of the periodic table and possess similar chemical properties. Finally, the polymer system embedded in a paper strip acts as a fluorescent chemosensor for Zn(II) ions in solution, showing its potential as a solid phase ion extractor

Layer-specific developmentally precise axon targeting of transient Suppressed-by-Contrast retinal ganglion cells (tSbC RGCs)

The mouse retina encodes diverse visual features in the spike trains of \u3e40 retinal ganglion cell (RGC) types. Each RGC type innervates a specific subset of the \u3e50 retinorecipient brain areas. Our catalog of RGC types and feature representations is nearing completion. Yet, we know little about where specific RGC types send their information. Furthermore, the developmental strategies by which RGC axons choose their targets and pattern their terminal arbors remain obscure. Here, we identify a genetic intersection