The Grizzly, March 3, 2016

UC Reveals Plans for Semester in Philly, New Coffee Shop • Professor Romano Elected to National Book Critics Circle • Business Students Win Competition in Philadelphia • Relay for Life Gets Ready • International Perspective: Cultural Differences in Driving Practices • Falling in Love with Ursinus\u27 Unique History • Ping Pong Club Bounces Back • Using the Present to Prepare for the Future • Opinions: New Barbie Figures are Anti-Progressive; UC Second-Ever Musical Wows Audience • Freshman Phenom • Baseball Ready to Slug Awayhttps://digitalcommons.ursinus.edu/grizzlynews/1685/thumbnail.jp

The Grizzly, September 24, 2015

CIE Professors Lend a Hand at Columbia U. • As Rush Week Ends, Greek Numbers Defy Expectations • Getting Back on Track • Healthy Addition: HEP Welcomes Rugby Coach to Faculty Lineup • Improving the Higher Education Experience • UC Student Trains Service Dog on Campus • Students Work with College Communications Office • Main Street Life: Upperclassmen Debate Housing\u27s Pros and Cons • Opinions: The Visit Rates 5 / 10; Extra-curricular Options for Students • Going Pro : Symposium on Sports Business and the Entrepreneurial Mindset Comes to Ursinus • Looking to Three-peathttps://digitalcommons.ursinus.edu/grizzlynews/1671/thumbnail.jp

Filaggrin Genotype Determines Functional and Molecular Alterations in Skin of Patients with Atopic Dermatitis and Ichthyosis Vulgaris

BACKGROUND: Several common genetic and environmental disease mechanisms are important for the pathophysiology behind atopic dermatitis (AD). Filaggrin (FLG) loss-of-function is of great significance for barrier impairment in AD and ichthyosis vulgaris (IV), which is commonly associated with AD. The molecular background is, however, complex and various clusters of genes are altered, including inflammatory and epidermal-differentiation genes. OBJECTIVE: The objective was to study whether the functional and molecular alterations in AD and IV skin depend directly on FLG loss-of-function, and whether FLG genotype determines the type of downstream molecular pathway affected. METHODS AND FINDINGS: Patients with AD/IV (n = 43) and controls (n = 15) were recruited from two Swedish outpatient clinics and a Swedish AD family material with known FLG genotype. They were clinically examined and their medical history recorded using a standardized questionnaire. Blood samples and punch biopsies were taken and trans-epidermal water loss (TEWL) and skin pH was assessed with standard techniques. In addition to FLG genotyping, the STS gene was analyzed to exclude X-linked recessive ichthyosis (XLI). Microarrays and quantitative real-time PCR were used to compare differences in gene expression depending on FLG genotype. Several different signalling pathways were altered depending on FLG genotype in patients suffering from AD or AD/IV. Disease severity, TEWL and pH follow FLG deficiency in the skin; and the number of altered genes and pathways are correlated to FLG mRNA expression. CONCLUSIONS: We emphasize further the role of FLG in skin-barrier integrity and the complex compensatory activation of signalling pathways. This involves inflammation, epidermal differentiation, lipid metabolism, cell signalling and adhesion in response to FLG-dependent skin-barrier dysfunction