15 research outputs found
Lake-size dependency of wind shear and convection as controls on gas exchange
High-frequency physical observations from 40 temperate lakes were used to examine the relative contributions of wind shear (u*) and convection (w*) to turbulence in the surface mixed layer. Seasonal patterns of u* and w* were dissimilar; u* was often highest in the spring, while w * increased throughout the summer to a maximum in early fall. Convection was a larger mixed-layer turbulence source than wind shear (u */w*-1 for lakes* and w* differ in temporal pattern and magnitude across lakes, both convection and wind shear should be considered in future formulations of lake-air gas exchange, especially for small lakes. © 2012 by the American Geophysical Union.Jordan S. Read, David P. Hamilton, Ankur R. Desai, Kevin C. Rose, Sally MacIntyre, John D. Lenters, Robyn L. Smyth, Paul C. Hanson, Jonathan J. Cole, Peter A. Staehr, James A. Rusak, Donald C. Pierson, Justin D. Brookes, Alo Laas, and Chin H. W
Canopy-wake dynamics and wind sheltering effects on Earth surface fluxes
The atmospheric boundary layer adjustment at the abrupt transition from a canopy (forest) to a flat surface (land or water) is investigated in a wind tunnel experiment. Detailed measurements examining the effect of canopy turbulence on flow separation, reduced surface shear stress andwake recovery are compared to data for the classical case of a solid backward-facing step. Results provide new insights into the interpretation for flux estimation by eddy-covariance and flux gradient methods and for the assessment of surface boundary conditions in turbulence models of the atmospheric boundary layer in complex landscapes and over water bodies affected by canopy wakes. The wind tunnel results indicate that the wake of a forest canopy strongly affects surface momentum flux within a distance of 35-100 times the step or canopy height, and mean turbulence quantities require distances of at least 100 times the canopy height to adjust to the new surface. The near-surface mixing length in the wake exhibits characteristic length scales of canopy flows at the canopy edge, of the flow separation in the near wake and adjusts to surface layer scaling in the far wake. Components of the momentum budget are examined individually to determine the impact of the canopy wake. The results demonstrate why a constant flux layer does not form until far downwind in the wake. An empirical model for surface shear stress distribution from a forest canopy to a clearing or lake is proposed
Experimental study of the impact of large-scale wind farms on landâatmosphere exchanges
Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor.
Rhabdomyosarcomas are the most frequent malignant soft tissue tumors of childhood; however, because current multimodality treatments fail to improve the poor survival rate of children with metastatic rhabdomyosarcoma, new treatments are required. We previously identified the gamma-subunit of the fetal acetylcholine receptor (fAChR) as a specific cell surface target in rhabdomyosarcoma. Here, we engineered human T lymphocytes to express chimeric receptors composed of the antigen-binding domain of a human anti-fAChR antibody joined to the signaling domain of the human T-cell receptor zeta-chain. The interaction of fAChRzeta-transduced T cells with fAChR-positive rhabdomyosarcoma cell lines, but not with fAChR-negative control cells, induced T-cell activation characterized by strong secretion of IFN-gamma and delayed lysis of tumor cells. Importantly, we found that in six of six rhabdomyosarcoma patients, chemotherapy increased fAChR expression on residual tumor cells in vivo. Our observations suggest that these fully human chimeric fAChRzeta-transduced T cells, which should be well tolerated by the patient, have potential use in vivo both as a primary treatment for rhabdomyosarcoma and as a complementary approach to eradicate residual tumor cells after chemotherapy
Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor.
Rhabdomyosarcomas are the most frequent malignant soft tissue tumors of childhood; however, because current multimodality treatments fail to improve the poor survival rate of children with metastatic rhabdomyosarcoma, new treatments are required. We previously identified the gamma-subunit of the fetal acetylcholine receptor (fAChR) as a specific cell surface target in rhabdomyosarcoma. Here, we engineered human T lymphocytes to express chimeric receptors composed of the antigen-binding domain of a human anti-fAChR antibody joined to the signaling domain of the human T-cell receptor zeta-chain. The interaction of fAChRzeta-transduced T cells with fAChR-positive rhabdomyosarcoma cell lines, but not with fAChR-negative control cells, induced T-cell activation characterized by strong secretion of IFN-gamma and delayed lysis of tumor cells. Importantly, we found that in six of six rhabdomyosarcoma patients, chemotherapy increased fAChR expression on residual tumor cells in vivo. Our observations suggest that these fully human chimeric fAChRzeta-transduced T cells, which should be well tolerated by the patient, have potential use in vivo both as a primary treatment for rhabdomyosarcoma and as a complementary approach to eradicate residual tumor cells after chemotherapy
Analytical Model for Mean Flow and Fluxes of Momentum and Energy in Very Large Wind Farms
Tree line advance reduces mixing and oxygen concentrations in arctic-alpine lakes through wind sheltering and organic carbon supply
Oxygen depletion in lake bottom waters has adverse impacts on ecosystem health including decreased water quality from release of nutrients and reduced substances from sediments, and the reduction of fish growth and reproduction. Depletion occurs when oxygen is consumed during decomposition of organic matter, and oxygen replenishment is limited by water column stratification. Arctic-alpine lakes are often well mixed and oxygenated, but rapid climate change in these regions is an important driver of shifts in catchment vegetation that could affect the mixing and oxygen dynamics of lakes. Here, we analyze high-resolution time series of dissolved oxygen concentration and temperature profiles in 40 Swedish arctic-alpine lakes across the tree line ecotone. The lakes stratified for 1-125 days, and during stratification, near-bottom dissolved oxygen concentrations changed by -0.20 to +0.15 mg L-1 day(-1), resulting in final concentrations of 1.1-15.5 mg L-1 at the end of the longest stratification period. Structural equation modeling revealed that lakes with taller shoreline vegetation relative to lake area had higher dissolved organic carbon concentrations and oxygen consumption rates, but also lower wind speeds and longer stratification periods, and ultimately, lower near-bottom dissolved oxygen concentrations. We use an index of shoreline canopy height and lake area to predict variations among our study lakes in near-bottom dissolved oxygen concentrations at the end of the longest stratification period (R-2 = 0.41). Upscaling this relationship to 8392 Swedish arctic-alpine lakes revealed that near-bottom dissolved oxygen concentrations drop below 3, 5, and 7 mg L-1 in 15%, 32%, and 53% of the lakes and that this proportion is sensitive (5%-22%, 13%-45%, and 29%-69%) to hypothetical tree line shifts observed in the past century or reconstructed for the Holocene (+/- 200 m elevation; +/- 0.5 degrees latitude). Assuming space-for-time substitution, we predict that tree line advance will decrease near-bottom dissolved oxygen concentrations in many arctic-alpine lakes
Automatic detection of perforator vessels using infrared thermography in reconstructive surgery
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Automated calculation of surface energy fluxes with high-frequency lake buoy data
Lake Heat Flux Analyzer is a program used for calculating the surface energy fluxes in lakes according to established literature methodologies. The program was developed in MATLAB for the rapid analysis of high-frequency data from instrumented lake buoys in support of the emerging field of aquatic sensor network science. To calculate the surface energy fluxes, the program requires a number of input variables, such as air and water temperature, relative humidity, wind speed, and short-wave radiation. Available outputs for Lake Heat Flux Analyzer include the surface fluxes of momentum, sensible heat and latent heat and their corresponding transfer coefficients, incoming and outgoing long-wave radiation. Lake Heat Flux Analyzer is open source and can be used to process data from multiple lakes rapidly. It provides a means of calculating the surface fluxes using a consistent method, thereby facilitating global comparisons of high-frequency data from lake buoys