2,118 research outputs found
Tumores en ganado ovino sacrificado en matadero
Trabajo presentado al: XL Congreso Nacional y el XVI Congreso Internacional de la Sociedad Española de Ovinotecnia y Caprinotecnia. (Castellón de la Plana, España, 16-18 septiembre 2015).Peer Reviewe
A methodological proposal and tool support for the HL7 standards compliance in the development of health information systems
Health information systems are increasingly complex, and their development is presented as a challenge for software development companies offering quality, maintainable and interoperable products. HL7 (Health level 7) International, an international non-profit organization, defines and maintains standards related to health information systems. However, the modelling languages proposed by HL7 are far removed from standard languages and widely known by software engineers. In these lines, NDT is a software development methodology that has a support tool called NDT-Suite and is based, on the one hand, on the paradigm of model-driven engineering and, on the other hand, in UML that is a widely recognized standard language. This paper proposes an extension of the NDT methodology called MoDHE (Model Driven Health Engineering) to offer software engineers a methodology capable of modelling health information systems conforming to HL7 using UML domain models
The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene
CHD8 is a chromatin remodeling ATPase of the SNF2 family. We found that depletion of CHD8 impairs cell proliferation. In order to identify CHD8 target genes, we performed a transcriptomic analysis of CHD8-depleted cells, finding out that CHD8 controls the expression of cyclin E2 (CCNE2) and thymidylate synthetase (TYMS), two genes expressed in the G1/S transition of the cell cycle. CHD8 was also able to co-activate the CCNE2 promoter in transient transfection experiments. Chromatin immunoprecipitation experiments demonstrated that CHD8 binds directly to the 5′ region of both CCNE2 and TYMS genes. Interestingly, both RNA polymerase II (RNAPII) and CHD8 bind constitutively to the 5′ promoter-proximal region of CCNE2, regardless of the cell-cycle phase and, therefore, of the expression of CCNE2. The tandem chromodomains of CHD8 bind in vitro specifically to histone H3 di-methylated at lysine 4. However, CHD8 depletion does not affect the methylation levels of this residue. We also show that CHD8 associates with the elongating form of RNAPII, which is phosphorylated in its carboxy-terminal domain (CTD). Furthermore, CHD8-depleted cells are hypersensitive to drugs that inhibit RNAPII phosphorylation at serine 2, suggesting that CHD8 is required for an early step of the RNAPII transcription cycle
Nonlinear field theories during homogeneous spatial dilation
The effect of a uniform dilation of space on stochastically driven nonlinear
field theories is examined. This theoretical question serves as a model problem
for examining the properties of nonlinear field theories embedded in expanding
Euclidean Friedmann-Lema\^{\i}tre-Robertson-Walker metrics in the context of
cosmology, as well as different systems in the disciplines of statistical
mechanics and condensed matter physics. Field theories are characterized by the
speed at which they propagate correlations within themselves. We show that for
linear field theories correlations stop propagating if and only if the speed at
which the space dilates is higher than the speed at which correlations
propagate. The situation is in general different for nonlinear field theories.
In this case correlations might stop propagating even if the velocity at which
space dilates is lower than the velocity at which correlations propagate. In
particular, these results imply that it is not possible to characterize the
dynamics of a nonlinear field theory during homogeneous spatial dilation {\it a
priori}. We illustrate our findings with the nonlinear Kardar-Parisi-Zhang
equation
Carbon and oxygen in HII regions of the Magellanic Clouds: abundance discrepancy and chemical evolution
We present C and O abundances in the Magellanic Clouds derived from deep
spectra of HII regions. The data have been taken with the Ultraviolet-Visual
Echelle Spectrograph at the 8.2-m VLT. The sample comprises 5 HII regions in
the Large Magellanic Cloud (LMC) and 4 in the Small Magellanic Cloud (SMC). We
measure pure recombination lines (RLs) of CII and OII in all the objects,
permitting to derive the abundance discrepancy factors (ADFs) for O^2+, as well
as their O/H, C/H and C/O ratios. We compare the ADFs with those of other HII
regions in different galaxies. The results suggest a possible metallicity
dependence of the ADF for the low-metallicity objects, but more uncertain for
high-metallicity objects. We compare nebular and B-type stellar abundances and
we find that the stellar abundances agree better with the nebular ones derived
from collisionally excited lines (CELs). Comparing these results with other
galaxies we observe that stellar abundances seem to agree better with the
nebular ones derived from CELs in low-metallicity environments and from RLs in
high-metallicity environments. The C/H, O/H and C/O ratios show almost flat
radial gradients, in contrast with the spiral galaxies where such gradients are
negative. We explore the chemical evolution analysing C/O vs. O/H and comparing
with the results of HII regions in other galaxies. The LMC seems to show a
similar chemical evolution to the external zones of small spiral galaxies and
the SMC behaves as a typical star-forming dwarf galaxy.Comment: Accepted for publication in MNRAS, 17 pages, 11 figures, 8 table
Thiol Chlorination with N-Chlorosuccinimide: HCl-Catalyzed Release of Molecular Chlorine and the Dichotomous Effects of Water
El proyecto Flying Challenge, una experiencia de interconexión universidad-empresa utilizando mentoría entre iguales
Congreso Universitario de Innovación Educativa En las Enseñanzas Técnicas, CUIEET (26º. 2018. Gijón
Zinc nitride thin films: Basic properties and applications
A. Redondo-Cubero, M. Gómez-Castaño, C. García Núñez, M. Domínguez, L. Vázquez, J. L. Pau , "Zinc nitride thin films: basic properties and applications", Oxide-based Materials and Devices VIII, Proc. SPIE 10105, 101051B (24 February 2017); doi: 10.1117/12.2253044. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibitedProceedings of VIII Oxide-based Materials and Devices Conference (San Francisco, California, United States)Zinc nitride films can be deposited by radio frequency magnetron sputtering using a Zn target at substrate temperatures lower than 250°C. This low deposition temperature makes the material compatible with flexible substrates. The asgrown layers present a black color, polycrystalline structures, large conductivities, and large visible light absorption. Different studies have reported about the severe oxidation of the layers in ambient conditions. Different compositional, structural and optical characterization techniques have shown that the films turn into ZnO polycrystalline layers, showing visible transparency and semi-insulating properties after total transformation. The oxidation rate is fairly constant as a function of time and depends on environmental parameters such as relative humidity or temperature. Taking advantage of those properties, potential applications of zinc nitride films in environmental sensing have been studied in the recent years. This work reviews the state-of-the-art of the zinc nitride technology and the development of several devices such as humidity indicators, thin film (photo)transistors and sweat monitoring sensors.This research is supported by the MINECO (CTQ2014-53334-C2-2-R) and Comunidad de Madrid (NANOAVANSENS ref. S2013/MIT-3029). ARC acknowledges Ramón y Cajal program (under contract number RYC-2015-18047
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