Photo-detection using Bose-condensed atoms in a micro trap

A model of photo-detection using a Bose--Einstein condensate in an atom-chip based micro trap is analyzed. Atoms absorb photons from the incident light field, receive part of the photon momentum and leave the trap potential. Upon counting of escaped atoms within predetermined time intervals, the photon statistics of the incident light is mapped onto the atom-count statistics. Whereas traditional photo-detection theory treats the emission centers of photo electrons as distinguishable, here the centers of escaping atoms are condensed and thus indistinguishable atoms. From this an enhancement of the photon-number resolution as compared to the commonly known counting formula is derived.Comment: 11 pages, 5 figures; revised versio

Effects of Moringa oleifera and Brosimum alicastrum partial feed substitution in intramuscular fat and adipose tissues and on the expression of lipogenic genes of Mexican hairless pigs

The present study evaluated the effects of the inclusion of ground Moringa oleifera and Brosimum alicastrum leaf meal in the diet of Mexican hairless pigs (MHP) on the amount of intramuscular fat, subcutaneous fat, leg muscle (Biceps femoris) fat, loin muscle (Longissimus dorsi) fat, leg and back fat, and the expression of lipid metabolism genes. Hairless pigs are reared in the Mexican tropics and are characterised by their body and intramuscular fat accumulation. Eighteen male pigs fed for 82 d were randomly allotted to three experimental isoenergetic and isoproteic diets, where M. oleifera or B. alicastrum (six pigs per diet) replaced wheat bran. The diets used were a control diet, a diet with 10% M. oleifera leaf meal, and a diet with 10% ground B. alicastrum leaf meal. The M. oleifera diet decreased (P<0.05) the fat ratio in the Longissimus dorsi muscles, back fat, rib fat, total carcass fat, and the carcass fat: meat ratio. The B. alicastrum diet only decreased fat in the Biceps femoris muscle, back fat, and rib fat. Moringa oleifera and B. alicastrum diets also promoted the overexpression of mRNA from the stearoyl-CoA desaturase (SCD), fatty acid synthase (FASN), acetyl-CoA carboxylase alpha (ACACA), sterol regulatory element-binding protein 1 (SREBP1) and acyl carrier protein (ACP) lipogenic genes in the Biceps femoris muscle and leg fat (P<0.001). In addition, lower ACACA and SREBP1 mRNA expression in the Longissimus dorsi muscle and back fat (P<0.001) were related to the lower amount of fat in pigs fed M. oleifera and B. alicastrum. The inclusion of Moringa oleifera and Brosimum alicastrum meals 10% in the diet of the pig MHP reduces fat, this is an important finding because fat is abundant in this type of pig

Učinak praha avokada, suncokretova ulja te različitih omjera voluminozne i koncentrirane krme u obroku na unos hrane, probavljivost hrane i proizvodnost mladih ovnova

The objective of this study was to evaluate the inclusion of avocado flour and sunflower oil as energy sources in different proportions, as well as different forage:concentrate ratios on the productive performance and feed intake of male rams, and the in vitro dry matter digestibility, organic matter digestibility and gas production. The intake was measured in diets containing avocado flour or sunflower oil with 60% forage: 40% concentrate, and in diets with different forage:concentrate ratios and 10% inclusion of avocado flour or sunflower oil. The daily weight gain was registered for 84 days, the in vitro dry matter digestibility was determined at 48 h, and the in vitro gas production was evaluated at 72 h. The partial production of gas at 24 hours, raw protein, raw fat, and ash were used to estimate the metabolizable energy and organic matter digestibility. Low levels of avocado flour and sunflower oil in the diet showed the highest intake, in vitro dry matter digestibility and in vitro gas production. Daily weight gains were 0.28 kg in avocado flour and 0.30 kg in sunflower oil diets, both at 10% inclusion and 40% forage: 60% concentrate. The inclusion of high levels of avocado flour or forage in the diet decreased the feed intake of male sheep. The best avocado flour level was 10% with 40% forage: 60% concentrate.Cilj rada bio je istražiti utjecaj različitih omjera između praha avokada i suncokretova ulja kao izvora energije, te različitih omjera između voluminozne i koncentrirane krme u obroku na unos hrane i proizvodnost mladih ovnova. Osim toga, in vitro istražena je probavljivost suhe tvari, probavljivost organske tvari i proizvodnja plina. Unos hrane mjeren je u obrocima koji su sadržavali prah avokada ili suncokretovo ulje uz omjer između voluminozne i koncentrirane krme od 60:40% ili u obrocima sa različitim omjerom voluminozne i koncentrirane krme uz dodatak 10% praha avokada ili suncokretova ulja. Dnevni prirast bilježen je tijekom 84 dana. Probavljivost suhe tvari in vitro određivana je 48 h, a proizvodnja plina in vitro 72 h od uzimanja uzoraka. Za određivanje metaboličke energije i probavljivosti organske tvari korišteni su parcijalna proizvodnja plina 24-ti sat, sirovi protein, sirova mast i pepeo. Niske razine praha avokada i suncokretova ulja u obroku rezultirale su najvišim unosom hrane te najvišom in vitro probavljivošću suhe tvari i in vitro proizvodnjom plina. Dnevni prirast bio je 0,28 kg u životinja kojima je davano 10% praha avokada, 0,30 kg u životinja kojima je davano 10% suncokretova ulja, pri čemu je omjer voluminozne i koncentrirane krme iznosio 40:60%. Dodavanje visokih razina praha avokada ili voluminozne krme u obrok dovelo je do nižeg unosa hrane kod mladih ovnova pa je zaključeno da je najpovoljnija razina dodanog praha avokada 10% uz omjer voluminozne i koncentrirane krme 40:60%

Porcine colonization of the Americas: a 60k SNP story.

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A commercial line probe assay for the rapid detection of rifampicin resistance in Mycobacterium tuberculosis: a systematic review and meta-analysis

BACKGROUND: Mycobacterium tuberculosis is a leading cause of death worldwide. In multi-drug resistant tuberculosis (MDR-TB) infectiousness is frequently prolonged, jeopardizing efforts to control TB. The conventional tuberculosis drug susceptibility tests are sensitive and specific, but they are not rapid. The INNO-LiPA Rif. TB (® )(LiPA) is a commercial line probe assay designed to rapidly detect rifampicin resistance, a marker of MDR-TB. Although LiPA has shown promising results, its overall accuracy has not been systematically evaluated. METHODS: We did a systematic review and meta-analysis to evaluate the accuracy of LiPA for the detection of rifampicin-resistant tuberculosis among culture isolates and clinical specimens. We searched Medline, Embase, Web of Science, BIOSIS, and Google Scholar, and contacted authors, experts and the manufacturer. Fifteen studies met our inclusion criteria. Of these, 11 studies used culture isolates, one used clinical specimens, and three used both. We used a summary receiver operating characteristic (SROC) curve and Q* index to perform meta-analysis and summarize diagnostic accuracy. RESULTS: Twelve of 14 studies that applied LiPA to isolates had sensitivity greater than 95%, and 12 of 14 had specificity of 100%. The four studies that applied LiPA directly to clinical specimens had 100% specificity, and sensitivity that ranged between 80% and 100%. The SROC curve had an area of 0.99 and Q* of 0.97. CONCLUSION: LiPA is a highly sensitive and specific test for the detection of rifampicin resistance in culture isolates. The test appears to have relatively lower sensitivity when used directly on clinical specimens. More evidence is needed before LiPA can be used to detect MDR-TB among populations at risk in clinical practice

Salud de los trabajadores

Actividad física y su relación con los factores de riesgo cardiovascular de carteros chilenosAnálisis de resultados: riesgos psicosociales en el trabajo Suceso-Istas 21 en Cesfam QuellónAusentismo laboral por enfermedades oftalmológicas, Chile 2009Brote de diarreas por norovirus, posterremoto-tsunami, Constitución, Región del MauleCalidad de vida en profesionales de la salud pública chilenaCaracterización del reposo laboral en personal del SSMN durante el primer semestre de 2010Concentración de nicotina en pelo en trabajadores no fumadores expuestos a humo de tabaco ambientalCondiciones de trabajo y bienestar/malestar docente en profesores de enseñanza media de SantiagoDisfunción auditiva inducida por exposición a xilenoErgonomía aplicada al estudio del síndrome de dolor lumbar en el trabajoEstimación de la frecuencia de factores de riesgo cardiovascular en trabajadores de una empresa mineraExposición a plaguicidas inhibidores de la acetilcolinesterasa en Colombia, 2006-2009Factores de riesgo y daños de salud en conductores de una empresa peruana de transporte terrestre, 2009Las consecuencias de la cultura en salud y seguridad ocupacional en una empresa mineraPercepción de cambios en la práctica médica y estrategias de afrontamientoPercepción de la calidad de vida en la Universidad del BiobíoPesos máximos aceptables para tareas de levantamiento manual de carga en población laboral femeninaRiesgo coronario en trabajadores mineros según la función de Framingham adaptada para la población chilenaTrastornos emocionales y riesgo cardiovascular en trabajadores de la salu

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p<0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p<0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding

Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study

OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required