Polynuclear Complexes of Fumaric Acid Dihydrazide with Cu (II), Ni (II) and Co (II)

Metal chloride and metal sulphate complexes of fumaric acid dihydrazide (FZ) of the type MX2.FZ.H2O, [M = Cu (II), Ni (II), and X = Cl2 and 1/2 SO4] and NiX2.FZ.2H2O have been prepared. Coordination occurs though oxygen of the> C = O and nitrogen of the -NH2 of the hydrazide group. A polymeric octahedral structure for MCI2 complexes and sulphate bridged quadricoordinate structure for MS04 complexes has been proposed. TGA and DTA results are also reported

Complexes of Cu(II) & Hg(II) with 1,3-Diamino- & 1,4-Diamino- benzenes

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DEVELOPMENT OF SPECTROPHOTOMETRIC AND FLUOROMETRIC METHODS FOR ESTIMATION OF DARUNAVIR USING QBD APPROACH

Objective: The main objective of the present study is to develop newer simple, precise spectrophotometric and fluorometric methods of estimation for Darunavir using coupling agent O-pthaladehyde.Methods: The experimental work was designed for both spectroscopic and fluorometric method development and validation. The method is based on formation complex of Darunavir with O-pthaladehyde. QbD approach was applied by varying different parameters. These parameters were designed into Ishikawa diagram.Results: The complex Darunavir-Phthalaldehyde in methanol with 0.1 N HCl showed linearity for both spectrophotometric and fluorometric methods. The calibration curve by spectrophotometry is linear in concentration range of 2-22 µg/ml with regression coefficient (R2) = 0.998 at 355 nm and for fluorometry it is linear in concentration range of 0.5-5.0 ng/ml with regression coefficient (R2) = 0.999. This method was found to be rugged and robust in different testing criteria with % RSD less than 2. The limit of detection and limit of quantification was found to be 0.2 μg/ml and 0.8 μg/ml for a spectrophotometric method and 0.12 μg/ml and 0.43 μg/ml for fluorometric method respectively.Conclusion: Both methods were found to be precise with % RSD of less than 2. The % recovery of the spectrophotometric and fluorometric methods was found to be 101.04 %, 98.15 % respectively. In this way, the results of all validation parameter were within the limits as per International Conference on Harmonization guideline.Â

Observations on a bumper catch of oil sardine by Rampan nets in Goa

During the past decade Sardinella longiceps hascontributed about 30 to 50% of the total fish catchalong the Goa coast. The annual oil sardine landingsin Goa during the year 2015 and 2016 was 16,212and 24951 tons (t) respectively. There are 20 landingcentres on the South Goa district and 14 landingcentres in the North Goa district. At Pale LandingCentre (150 22" 017’ N 0730 52" 552’ E) fishing 20shoreseine (Rampan) units are engaged in fishing

Globalization and Public Health: An Examination of Cross-Border Health Issues

The rapid interconnection facilitated by globalization intensifies the dissemination of infectious diseases, posing substantial obstacles for public health systems globally. This paper utilizes a comparative methodology to analyze the impact of globalization on the dynamics of health issues that transcend national borders. It does so by closely examining two distinct pandemics: COVID-19 and the Nipah virus. Utilizing epidemiological data, public health policies, and scholarly literature, we examine the transmission patterns, susceptibilities, and strategies for addressing both viruses. By contrasting the easily transmissible and airborne characteristics of COVID-19 with the localized outbreaks and zoonotic source of the Nipah virus, we expose the varied difficulties presented by distinct cross-border health hazards. The main discovery we made emphasizes the contradictory connection between globalization and the readiness of public health. Interconnectedness not only speeds up the spread of viruses, but also promotes international collaboration in areas such as research, surveillance, and sharing of resources. We contend that effectively addressing cross-border health threats necessitates a nuanced comprehension of the dual nature of globalization, highlighting the importance of strong national health systems in conjunction with intensified global cooperation. This paper seeks to offer valuable insights to policymakers and public health professionals by analyzing the divergent cases of COVID-19 and Nipah virus. It aims to assist them in effectively managing the intricate relationship between globalization and health concerns that transcend national borders. We promote a proactive strategy that utilizes the advantages of international collaboration while enhancing local capacity to guarantee efficient readiness and reaction to forthcoming pandemics

Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling

The DNA damage response (DDR) ensures cellular adaptation to genotoxic insults. In the crowded environment of the nucleus, the assembly of productive DDR complexes requires multiple protein modifications. How the apical E1 ubiquitin activation enzyme UBA1 integrates spatially and temporally in the DDR remains elusive. Using a human cell-free system, we show that poly(ADP-ribose) polymerase 1 promotes the recruitment of UBA1 to DNA. We find that the association of UBA1 with poly(ADP-ribosyl)ated protein–DNA complexes is necessary for the phosphorylation replication protein A and checkpoint kinase 1 by the serine/threonine protein kinase ataxia-telangiectasia and RAD3-related, a prototypal response to DNA damage. UBA1 interacts directly with poly(ADP-ribose) via a solvent-accessible and positively charged patch conserved in the Animalia kingdom but not in Fungi. Thus, ubiquitin activation can anchor to poly(ADP-ribose)-seeded protein assemblies, ensuring the formation of functional ataxia-telangiectasia mutated and RAD3-related-signalling complexes

Preliminary Pharmacological Screening of Ethanolic Extract of Aristoochia indica on Nephrolithiasis Rat

The effect of ethanolic extract of Aristolochia indica was studied on experimentally induced nepharolithatic and urolithuasis in rats. Oxalate urolithiasis was produced by the addition of 0.75% ethylene glycol in the diet for a period for 30 days. Ethylene glycol treatment resulted in a significant increase in the levels of calcium and oxalate. Treatment of ethanolic extract of Aristolochia indica 100mg/kg body weight for 30 days revealed a dose –related effect in the reduction of lithogenic substances, following glycolic acid induced urolithiasis. Simultaneous oral treatment with at a dose of ethanolic extract of Aristolochia indica 100mg/kg for 30 days significantly reversed the ethylene glycol induced nepharolithiasis and urolithiasis. Presumably by preventing the urinary supersaturation of lithogenic substances. Especially of oxalate and calcium. These observation indicate that ethanolic extract of Aristolochia indica can play an important role in the prevention of disorders associated with kidney stone formation

DROM: Enabling Efficient and Effortless Malleability for Resource Managers

In the design of future HPC systems, research in resource management is showing an increasing interest in a more dynamic control of the available resources. It has been proven that enabling the jobs to change the number of computing resources at run time, i.e. their malleability, can significantly improve HPC system performance. However, job schedulers and applications typically do not support malleability due to the common belief that it introduces additional programming complexity and performance impact. This paper presents DROM, an interface that provides efficient malleability with no effort for program developers. The running application is enabled to adapt the number of threads to the number of assigned computing resources in a completely transparent way to the user through the integration of DROM with standard programming models, such as OpenMP/OmpSs, and MPI. We designed the APIs to be easily used by any programming model, application and job scheduler or resource manager. Our experimental results from two realistic use cases analysis, based on malleability by reducing the number of cores a job is using per node and jobs co-allocation, show the potential of DROM for improving the performance of HPC systems. In particular, the workload of two MPI+OpenMP neuro-simulators are tested, reporting improvement in system metrics, such as total run time and average response time, up to 8% and 48%, respectively.This work is partially supported by the Span- ish Government through Programa Severo Ochoa (SEV-2015-0493), by the Spanish Ministry of Science and Technology through TIN2015-65316-P project, by the Generalitat de Catalunya (contract 2017-SGR-1414) and from the European Union’s Horizon 2020 under grant agreement No 785907 (HBP SGA2)Peer ReviewedPostprint (author's final draft

Anisotropic Superparamagnetism of Monodispersive Cobalt-Platinum Nanocrystals

Based on the high-temperature organometallic route (Sun et al. Science 287, 1989 (2000)), we have synthesized powders containing CoPt_3 single crystals with mean diameters of 3.3(2) nm and 6.0(2) nm and small log-normal widths sigma=0.15(1). In the entire temperature range from 5 K to 400 K, the zero-field cooled susceptibility chi(T) displays significant deviations from ideal superparamagnetism. Approaching the Curie temperature of 450(10) K, the deviations arise from the (mean-field) type reduction of the ferromagnetic moments, while below the blocking temperature T_b, chi(T) is suppressed by the presence of energy barriers, the distributions of which scale with the particle volumes obtained from transmission electron microscopy (TEM). This indication for volume anisotropy is supported by scaling analyses of the shape of the magnetic absorption chi''(T,omega) which reveal distribution functions for the barriers being also consistent with the volume distributions observed by TEM. Above 200 K, the magnetization isotherms M(H,T) display Langevin behavior providing 2.5(1) mu_B per CoPt_3 in agreement with reports on bulk and thin film CoPt_3. The non-Langevin shape of the magnetization curves at lower temperatures is for the first time interpreted as anisotropic superparamagnetism by taking into account an anisotropy energy of the nanoparticles E_A(T). Using the magnitude and temperature variation of E_A(T), the mean energy barriers and 'unphysical' small switching times of the particles obtained from the analyses of chi''(T,omega) are explained. Below T_b hysteresis loops appear and are quantitatively described by a blocking model, which also ignores particle interactions, but takes the size distributions from TEM and the conventional field dependence of E_A into account.Comment: 12 pages with 10 figures and 1 table. Version accepted for publication in Phys. Rev. B . Two-column layou

A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex

Pyramidal cells (PCs) form the backbone of the layered structure of the neocortex, and plasticity of their synapses is thought to underlie learning in the brain. However, such long-term synaptic changes have been experimentally characterized between only a few types of PCs, posing a significant barrier for studying neocortical learning mechanisms. Here we introduce a model of synaptic plasticity based on data-constrained postsynaptic calcium dynamics, and show in a neocortical microcircuit model that a single parameter set is sufficient to unify the available experimental findings on long-term potentiation (LTP) and long-term depression (LTD) of PC connections. In particular, we find that the diverse plasticity outcomes across the different PC types can be explained by cell-type-specific synaptic physiology, cell morphology and innervation patterns, without requiring type-specific plasticity. Generalizing the model to in vivo extracellular calcium concentrations, we predict qualitatively different plasticity dynamics from those observed in vitro. This work provides a first comprehensive null model for LTP/LTD between neocortical PC types in vivo, and an open framework for further developing models of cortical synaptic plasticity.We thank Michael Hines for helping with synapse model implementation in NEURON; Mariana Vargas-Caballero for sharing NMDAR data; Veronica Egger for sharing in vitro data and for clarifications on the analysis methods; Jesper Sjöström for sharing in vitro data, helpful discussions, and feedback on the manuscript; Ralf Schneggenburger for helpful discussions and clarifications on the NMDAR calcium current model; Fabien Delalondre for helpful discussions; Francesco Casalegno and Taylor Newton for helpful discussion on model fitting; Daniel Keller for helpful discussions on the biophysics of synaptic plasticity; Natali Barros-Zulaica for helpful discussions on MVR modeling and generalization; Srikanth Ramaswamy, Michael Reimann and Max Nolte for feedback on the manuscript; Wulfram Gerstner and Guillaume Bellec for helpful discussions on synaptic plasticity modeling. This study was supported by funding to the Blue Brain Project, a research center of the École polytechnique fédérale de Lausanne, from the Swiss government’s ETH Board of the Swiss Federal Institutes of Technology. E.B.M. received additional support from the CHU Sainte-Justine Research Center (CHUSJRC), the Institute for Data Valorization (IVADO), Fonds de Recherche du Québec–Santé (FRQS), the Canada CIFAR AI Chairs Program, the Quebec Institute for Artificial Intelligence (Mila), and Google. R.B.P. and J.DF. received support from the Spanish “Ministerio de Ciencia e Innovación” (grant PGC2018-094307-B-I00). M.D. and I.S. were supported by a grant from the ETH domain for the Blue Brain Project, the Gatsby Charitable Foundation, and the Drahi Family Foundation