197 research outputs found
Twin stars as probes of the nuclear equation of state: effects of rotation through the PSR J0952-0607 pulsar and constraints via the tidal deformability from the GW170817 event
In agreement with the constantly increasing gravitational wave events, new
aspects of the internal structure of compact stars can be considered. A
scenario in which a first order transition takes place inside these stars is of
particular interest as it can lead, under conditions, to a third
gravitationally stable branch (besides white dwarfs and neutron stars), the
twin stars. The new branch yields stars with the same mass as normal compact
stars but quite different radii. In the present work, we focus on hybrid stars
undergone a hadron to quark phase transition near their core and how this new
stable configuration arises. Emphasis is to be given on the aspects of the
phase transition and its parametrization in two different ways, namely with
Maxwell and Gibbs construction. We systematically study the gravitational mass,
the radius, and the tidal deformability, and we compare them with the
predictions of the recent observation by LIGO/VIRGO collaboration, the GW170817
event, along with the mass and radius limits, suggesting possible robust
constraints. Moreover, we extent the study in order to include rotation effects
on the twin stars configurations. The recent discovery of the fast rotating
supermassive pulsar PSR J0952-0607 triggered the effort to constrain the
equation of state and moreover to examine possible predictions related to the
phase transition in dense nuclear matter. We pay special attention to relate
the PSR J0952-0607 pulsar properties with the twin stars predictions and mainly
to explore the possibility that the existence of such a massive object would
rule out the existence of twin stars. Finally, we discuss the constraints on
the radius and mass of the recently observed compact object within the
supernova remnant HESS J1731-347. The estimations implies that this object is
either the lightest neutron star known, or a star with a more exotic equation
of state.Comment: 16 pages, 17 figure
Constraints for the X17 boson from compacts objects observations
We investigate the hypothetical X17 boson on neutron stars and Quark Stars
(QSs) using various hadronic Equation of States (EoSs) with phenomenological or
microscopic origin. Our aim is to set realistic constraints on its coupling
constant and the mass scaling, with respect to causality and various possible
upper mass limits and the dimensionless tidal deformability . In
particular, we pay special attention on two main phenomenological parameters of
the X17, the one is related to the coupling constant that it has
with hadrons or quarks and the other with the in-medium effects through the
regulator . Both are very crucial concerning the contribution on
the total energy density and pressure. In the case of considering the X17 as a
carrier of nuclear force in Relativistic Mean Field (RMF) theory, an admixture
into vector boson segment was constrained by 20\% and 30\%. In our
investigation, we came to the general conclusion that the effect of the
hypothetical X17 both on neutron and QSs constrained mainly by the causality
limit, which is a specific property of each EoS. Moreover, it depends on the
interplay between the main two parameters that is the interaction coupling
and the in-medium effects regulator . These effects
are more pronounced in the case of QSs concerning all the bulk properties.Comment: 12 pages, 14 figures, 2 table
PAM-4 and duobinary direct modulation of a hybrid InP/SOI DFB laser for 40 Gb/s transmission over 2 km single mode fiber
We demonstrate 40 Gb/s PAM-4 and Duobinary direct modulation of a heterogeneously integrated InP on SOI DFB laser. Transmission measurement was performed using a 2 km NZ-DSF with a PRBS 2(15) and 1.5 V-pp swing voltage
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.
OBJECTIVE: For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms. METHODS: We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-free populations are associated overall when combined with stroke populations. RESULTS: There were no associations at genome-wide significance with WMHV in stroke patients. All previously reported genome-wide significant associations with WMHV in community populations shared direction of effect in stroke patients. In a meta-analysis of the genome-wide significant and suggestive loci (p < 5 Ă 10(-6)) from community populations (15 single nucleotide polymorphisms in total) and from stroke patients, 6 independent loci were associated with WMHV in both populations. Four of these are novel associations at the genome-wide level (rs72934505 [NBEAL1], p = 2.2 Ă 10(-8); rs941898 [EVL], p = 4.0 Ă 10(-8); rs962888 [C1QL1], p = 1.1 Ă 10(-8); rs9515201 [COL4A2], p = 6.9 Ă 10(-9)). CONCLUSIONS: Genetic associations with WMHV are shared in otherwise healthy individuals and patients with stroke, indicating common genetic susceptibility in cerebral small vessel disease
Data Descriptor: Ash leaf metabolomes reveal differences between trees tolerant and susceptible to ash dieback disease
CMS was funded by the âNornexâ project jointly by UK BBSRC (BBS/E/J/000CA5323) and DEFRA and a BBSRC Tools and Resources grant (BB/N021452/1) awarded to M.G. and D.J.S
The diagnostic value of ultrasonography-derived edema of the temporal artery wall in giant cell arteritis: a second meta-analysis
<p>Abstract</p> <p>Background</p> <p>Ultrasonography of temporal arteries is not commonly used in the approach of patients with suspected giant cell arteritis (GCA) in clinical practice. A meta-analysis of primary studies available through April 2004 concluded that ultrasonography could indeed be helpful in diagnosing GCA. We specifically re-examined the diagnostic value of the ultrasonography-derived halo sign, a dark hypoechoic circumferential thickening around the artery lumen, indicating vasculitic wall edema, in GCA.</p> <p>Methods</p> <p>Original, prospective studies in patients with suspected GCA that examined ultrasonography findings of temporal arteries using the ACR 1990 classification criteria for GCA as reference standard, published through 2009, were identified. Only eight studies involving 575 patients, 204 of whom received the final diagnosis of GCA, fulfilled technical quality criteria for ultrasound. Weighted sensitivity and specificity estimates of the halo sign were assessed, their possible heterogeneity was investigated and pooled diagnostic odds ratio was determined.</p> <p>Results</p> <p>Unilateral halo sign achieved an overall sensitivity of 68% (95% CI, 0.61-0.74) and specificity of 91% (95% CI, 0.88-0.94) for GCA. The values of inconsistency coefficient (I<sup>2</sup>) of both sensitivity and specificity of the halo sign, showed significant heterogeneity concerning the results between studies. Pooled diagnostic odds ratio, expressing how much greater the odds of having GCA are for patients with halo sign than for those without, was 34 (95% CI, 8.21-138.23). Diagnostic odds ratio was further increased to 65 (95% CI, 17.86-236.82) when bilateral halo signs were present (sensitivity/specificity of 43% and 100%, respectively). In both cases, it was found that DOR was constant across studies.</p> <p>Conclusion</p> <p>Temporal artery edema demonstrated as halo sign should be always looked for in ultrasonography when GCA is suspected. Providing that currently accepted technical quality criteria are fulfilled, halo sign's sensitivity and specificity are comparable to those of autoantibodies used as diagnostic tests in rheumatology. Validation of revised GCA classification criteria which will include the halo sign may be warranted.</p
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.
OBJECTIVE: For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms. METHODS: We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community populations are also associated in stroke patients. Having established that genetic associations are shared between the 2 populations, we performed a meta-analysis testing which associations with WMHV in stroke-free populations are associated overall when combined with stroke populations. RESULTS: There were no associations at genome-wide significance with WMHV in stroke patients. All previously reported genome-wide significant associations with WMHV in community populations shared direction of effect in stroke patients. In a meta-analysis of the genome-wide significant and suggestive loci (p < 5 Ă 10(-6)) from community populations (15 single nucleotide polymorphisms in total) and from stroke patients, 6 independent loci were associated with WMHV in both populations. Four of these are novel associations at the genome-wide level (rs72934505 [NBEAL1], p = 2.2 Ă 10(-8); rs941898 [EVL], p = 4.0 Ă 10(-8); rs962888 [C1QL1], p = 1.1 Ă 10(-8); rs9515201 [COL4A2], p = 6.9 Ă 10(-9)). CONCLUSIONS: Genetic associations with WMHV are shared in otherwise healthy individuals and patients with stroke, indicating common genetic susceptibility in cerebral small vessel disease.Funding for collection, genotyping, and analysis of stroke samples was provided by Wellcome Trust Case Control Consortium-2, a functional genomics grant from the Wellcome Trust (DNA-Lacunar), the Stroke Association (DNA-lacunar), the Intramural Research Program of National Institute of Ageing (Massachusetts General Hospital [MGH] and Ischemic Stroke Genetics Study [ISGS]), National Institute of Neurological Disorders and Stroke (Siblings With Ischemic Stroke Study, ISGS, and MGH), the American Heart Association/Bugher Foundation Centers for Stroke Prevention Research (MGH), Deane Institute for Integrative Study of Atrial Fibrillation and Stroke (MGH), National Health and Medical Research Council (Australian Stroke Genetics Collaborative), and Italian Ministry of Health (Milan). Additional support for sample collection came from the Medical Research Council, National Institute of Health Research Biomedical Research Centre and Acute Vascular Imaging Centre (Oxford), Wellcome Trust and Binks Trust (Edinburgh), and Vascular Dementia Research Foundation (Munich). MT is supported by a project grant from the Stroke Association (TSA 2013/01). HSM is supported by an NIHR Senior Investigator award. HSM and SB are supported by the NIHR Cambridge University Hospitals Comprehensive Biomedical Research Centre. VT and RL are supported by grants from FWO Flanders. PR holds NIHR and Wellcome Trust Senior Investigator Awards. PAS is supported by an MRC Fellowship. CMLâs research is supported by the National Institute for Health Research Biomedical Research Centre (BRC) based at Guy's and St Thomas' NHS Foundation Trust and King's College London, and the BRC for Mental Health at South London and Maudsley NHS Foundation Trust and Kingâs College London.âThis is the final version of the article. It first appeared from Wolters Kluwer via http://dx.doi.org/10.1212/WNL.000000000000226
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