Visual Analogue Scales: do they have a role in the measurement of preferences for health states?

Health state preference data are increasingly used to inform national health care resource allocation decisions. In such circumstances it is important to be confident that the data we provide to decision makers is fit for purpose. Whilst there are many unresolved issues in health state preference measurement, there are some areas of agreement on procedures that are inappropriate. The past ten years have seen the publication of a number of papers reporting substantive problems with the use of visual analogue scales to value health states. In this journal Torrance and colleagues reviewed this literature and concluded that Visual Analogue Scales have a limited but useful role in health state preference measurement. In this paper we critically review the arguments advanced by Torrance and colleagues and argue that it is increasingly clear that Visual Analogue Scales are not an appropriate method and that the time has come to accept that VAS should not be used for health state preference measurement

Ion-retarding lens improves the abundance sensitivity of tandem mass spectrometers

Ion-retarding lens which increases the abundance sensitivity of tandem magnetic-analyzer mass spectrometers measures isotopes of low abundance in mass positions adjacent to isotopes of high abundance. The lens increases the abundance sensitivity for isotopes lying farther from high abundance isotopes than the energy cutoff of the lens

NASCAP modelling computations on large optics spacecraft in geosynchronous substorm environments

The NASA Charging Analyzer Program (NASCAP) is used to evaluate qualitatively the possibility of such enhanced spacecraft contamination on a conceptual version of a large satellite. The evaluation is made by computing surface voltages on the satellite due to encounters with substorm environments and then computing charged particle trajectories in the electric fields around the satellite. Particular attention is paid to the possibility of contaminants reaching a mirror surface inside a dielectric tube because this mirror represents a shielded optical surface in the satellite model used. Deposition of low energy charged particles from other parts of the spacecraft onto the mirror was found to be possible in the assumed moderate substorm environment condition. In the assumed severe substorm environment condition, however, voltage build up on the inside and edges of the dielectric tube in which the mirror is located prevents contaminants from reaching the mirror surface

Prisons and Drugs: A global review of incarceration, drug use and drug services. Report 12

Prisons play an important role in drug policy. They are used to punish people who break drug laws and they also hold a large number of people who have experience of drug use and drug problems. They therefore have an important part to play in attempts to reduce the harm caused by drugs. Imprisonment itself can be seen as one type of harm, as it causes problems for prisoners and their families and creates a large financial burden for taxpayers. Theseharms and costs are difficult to calculate, but there is little evidence that large scale imprisonment of drug offenders has had the desired results in deterring drug use or reducing drug problems (Bewley- Taylor, Trace, & Stevens, 2005). In this paper, we examine the international prevalence of drug users, drug use and related problems in prisons and we report on the problems that are related to the issue of drugs in prison. We go on to examine the international guidelines and effective responses that have been developed in this area in the last decade. The paper is a review of the literature, based on a search of bibliographic databases, including Medline, PubMed, ISI as well as EMBASE and contacts with researchers and practitioners in the field up to January 2007

Provisional specification for satellite time in a geomagnetic environment

Satellites in geosynchronous orbit were experiencing operational anomalies. These anomalies are believed to be due to the environment charging the spacecraft surfaces to a point where discharges occur. In designing future satellites for long term operation at geosynchronous altitude, it is important that designers have a specification that will give the total time per year, the particle flux density and particle energies that their satellites can be expected to encounter in these substorm environmental conditions. The limited data currently available on the environmental conditions are used to generate the provisional specification given in this report

Charging characteristics of materials: Comparison of experimental results with simple analytical models

A one-dimensional model for charging of samples is used in conjunction with experimental data taken to develop material charging characteristics for silvered Teflon. These characteristics are then used in a one dimensional model for charging in space to examine expected response. Relative charging rates as well as relative charging levels for silvered Teflon and metal are discussed

Health state values for the HUI 2 descriptive system: results from a UK survey

This paper reports the results of a study to estimate a statistical health state valuation model for a revised version of the Health Utilities Index Mark 2, using Standard Gamble health state preference data. A sample of 51 health states were valued by a sample of the 198 members of the UK general population. Models are estimated for predicting health state valuations for all 8,000 states defined by the revised HUI2. The recommended model produces logical and significant coefficients for all levels of all dimensions in the HUI2. These coefficients appear to be robust across model specifications. This model performs well in predicting the observed health state values within the valuation sample and for a separate validation sample of health states. However, there are concerns over large prediction errors for two health states in the valuation sample. These problems must be balanced against concerns over the validity of using the VAS based health state valuation data of the original HUI2 valuation model.HUI2

Health State Values for the HUI 2 descriptive system: results from a UK survey

This paper reports the results of a study to estimate a statistical health state valuation model for a revised version of the Health Utilities Index Mark 2, using Standard Gamble health state preference data. A sample of 51 health states were valued by a sample of the 198 members of the UK general population. Models are estimated for predicting health state valuations for all 8,000 states defined by the revised HUI2. The recommended model produces logical and significant coefficients for all levels of all dimensions in the HUI2. These coefficients appear to be robust across model specifications. This model performs well in predicting the observed health state values within the valuation sample and for a separate validation sample of health states. However, there are concerns over large prediction errors for two health states in the valuation sample. These problems must be balanced against concerns over the validity of using the VAS based health state valuation data of the original HUI2 valuation model

Increasing vertical mixing to reduce Southern Ocean deep convection in NEMO3.4

Most CMIP5 (Coupled Model Intercomparison Project Phase 5) models unrealistically form Antarctic Bottom Water by open ocean deep convection in the Weddell and Ross seas. To identify the mechanisms triggering Southern Ocean deep convection in models, we perform sensitivity experiments on the ocean model NEMO3.4 forced by prescribed atmospheric fluxes. We vary the vertical velocity scale of the Langmuir turbulence, the fraction of turbulent kinetic energy transferred below the mixed layer, and the background diffusivity and run short simulations from 1980. All experiments exhibit deep convection in the Riiser-Larsen Sea in 1987; the origin is a positive sea ice anomaly in 1985, causing a shallow anomaly in mixed layer depth, hence anomalously warm surface waters and subsequent polynya opening. Modifying the vertical mixing impacts both the climatological state and the associated surface anomalies. The experiments with enhanced mixing exhibit colder surface waters and reduced deep convection. The experiments with decreased mixing give warmer surface waters, open larger polynyas causing more saline surface waters and have deep convection across the Weddell Sea until the simulations end. Extended experiments reveal an increase in the Drake Passage transport of 4 Sv each year deep convection occurs, leading to an unrealistically large transport at the end of the simulation. North Atlantic deep convection is not significantly affected by the changes in mixing parameters. As new climate model overflow parameterisations are developed to form Antarctic Bottom Water more realistically, we argue that models would benefit from stopping Southern Ocean deep convection, for example by increasing their vertical mixing