746 research outputs found
A study of symmetry breaking in a relativistic Bose gas using the contraction algorithm
A relativistic Bose gas at finite density suffers from a sign problem that
makes direct numerical simulations not feasible. One possible solution to the
sign problem is to re-express the path integral in terms of Lefschetz thimbles.
Using this approach we study the relativistic Bose gas both in the symmetric
phase (low-density) and the spontaneously broken phase (high-density). In the
high-density phase we break explicitly the symmetry and determine the
dependence of the order parameter on the breaking. We study the relative
contributions of the dominant and sub-dominant thimbles in this phase. We find
that the sub-dominant thimble only contributes substantially when the explicit
symmetry breaking is small, a regime that is dominated by finite volume
effects. In the regime relevant for the thermodynamic limit, this contribution
is negligible.Comment: 12 pages, 6 figures, 1 tabl
Using guarding net to reduce regularly discarded invertebrates in trammel net fisheries operating on seagrass meadows (Posidonia oceanica) in Izmir Bay (Eastern Aegean Sea)
Prohibition of both beach and boat seines and trawl fishery along the İzmir Bay coasts in the Aegean Sea signifies intensive usage of gillnets and trammel nets, for catching red mullet (Mullus spp.) species in particular. Trials were realized between March 2009 and February 2010 with trammel nets in the areas on the boundaries of the sea grass (Posidonia oceanica) meadows in the Bay. Guarding net (selvedge) was attached to the lead line of experimental nets (Exp1-Exp2) - 36 and 40 mm inner panel. Differences for discard amounts between control group nets (C1-C2) (having the same inner panel as the experimental nets), used by commercial fishermen, and experimental nets are 54.7% for C1-Exp1 and 62.8% for C2-Exp2 (p<0.05). Use of nets with selvedge not only reduced regularly discarded invertebrates (Hexaplex trunculus, Bolinus brandaris, Maja spp.) in the region, but also avoided net damage caused by these species
Diabetic Foot Due to Anaphylactic Shock: A Case Report
Introduction: Diabetic foot is a clinical disorder, which is commonly seen in patients with diabetes mellitus. It is also the major cause of below knee amputation in the world. There are many underlying causes such as neuropathic, ischemic, and infectious causes for diabetic foot. Local or systemic complications may develop after snake bite.
Case Presentation: We reported a very rare case, involving a 78-year-old male admitted to the Emergency Department, who developed anaphylactic shock and diabetic foot after the snake bite.
Conclusions: Reviewing the literature, this is the second reported case of snake bite associated with diabetic foot
Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors
In humans, neuroligin-3 mutations are associated with autism, while in mice the corresponding mutations produce robust synaptic and behavioral changes. However, different neuroligin-3 mutations cause largely distinct phenotypes in mice, and no causal relationship links a specific synaptic dysfunction to a behavioral change. Using rotarod motor learning as a proxy for acquired repetitive behaviors in mice, we found that different neuroligin-3 mutations uniformly enhanced formation of repetitive motor routines. Surprisingly, neuroligin-3 mutations caused this phenotype not via changes in the cerebellum or dorsal striatum, but via a selective synaptic impairment in the nucleus accumbens/ventral striatum. Here, neuroligin-3 mutations increased rotarod learning by specifically impeding synaptic inhibition onto D1-dopamine receptor-expressing but not D2-dopamine receptor-expressing medium spiny neurons. Our data thus suggest that different autism-associated neuroligin-3 mutations cause a common increase in acquired repetitive behaviors by impairing a specific striatal synapse, and thereby provide a plausible circuit substrate for autism pathophysiology
Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors
In humans, neuroligin-3 mutations are associated with autism, while in mice the corresponding mutations produce robust synaptic and behavioral changes. However, different neuroligin-3 mutations cause largely distinct phenotypes in mice, and no causal relationship links a specific synaptic dysfunction to a behavioral change. Using rotarod motor learning as a proxy for acquired repetitive behaviors in mice, we found that different neuroligin-3 mutations uniformly enhanced formation of repetitive motor routines. Surprisingly, neuroligin-3 mutations caused this phenotype not via changes in the cerebellum or dorsal striatum, but via a selective synaptic impairment in the nucleus accumbens/ventral striatum. Here, neuroligin-3 mutations increased rotarod learning by specifically impeding synaptic inhibition onto D1-dopamine receptor-expressing but not D2-dopamine receptor-expressing medium spiny neurons. Our data thus suggest that different autism-associated neuroligin-3 mutations cause a common increase in acquired repetitive behaviors by impairing a specific striatal synapse, and thereby provide a plausible circuit substrate for autism pathophysiology
Perillyl alcohol in Solid Lipid Nanoparticles (SLN-PA): Cytotoxicity and antitumor potential in sarcoma 180 mice model
Cancer is a group of diseases characterized by the uncontrolled growth of cells. These cells invade organs and tissues by extension or direct dissemination and can spread to other regions of the body.
Nanomedicine offers many possibilities to prevent the spread of cancer tissue and help cure the disease.
In this work, solid lipid nanoparticles (SLN) were used to encapsulate perillyl alcohol (PA), a volatile
monoterpene with proven anticancer activity. Encapsulation of PA into SLN (SLN-PA) is expected to
promote controlled release, increase PA bioavailability, and impair the volatility of the monoterpene.
SLN-PA prepared by high-shear homogenization showed average particle diameter around 254 nm,
polydispersity index ~ 0.35, zeta potential ~ -14.7 mV, and encapsulation efficiency 84.6%. Scanning
electron microscope analysis revealed a decrease in crystallinity, suggesting the encapsulation of PA in
the SLN, confirming the spherical shape and the loading of the monoterpene in the SLN. In vitro cytotoxicity
assays against murine fibroblasts (L929) showed that SLN-PA in both treated doses did not
induce any cytotoxicity on non-tumoral cells. In vivo antitumor effect of the SLN-PA was evaluated in
sarcoma 180-transplanted mice. The in vivo results demonstrated a significant tumor inhibition rate of
51.76 and 54.49% via intraperitoneal application of SLN-PA at doses of 100 and 200 mg/kg/day (p <
0.05), respective when compared to the negative control (dimethyl sulfoxide). Adverse side effects of
SLN-PA were not noticed in the liver, the kidney, or spleen tissue. The developed SLN-PA can be
considered as a safe approach for site-specific antitumor effect in vivo, reinterpreting new nanoparticles-
based cancer therapy.This work was supported by the Banco do Nordeste (grant FUNDECI/2016.0015), Conselho Nacional
de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Apoio à Pesquisa e à Inovação
Tecnológica do Estado de Sergipe (Fapitec) and Coordenação de Aperfeiçoamento de Pessoal de Nível
Superior (CAPES). Eliana B. Souto would like to acknowledge the Portuguese Science and Technology
Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) for the project
UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersio
Diseño e implementación de un sistema domótico utilizando plataformas de desarrollo como controlador
Desarrolla un sistema domótico
inteligente adaptable a todo tipo de edificio para garantizar un mayor control y gestión
de las funciones de la vivienda.
Estudia el desarrollo de un sistema domótico gobernado por servidores locales y
plataformas de desarrollo comerciales como controladores, lo que permitirá la
autonomía del control de la vivienda tanto para las personas que carezcan de las
capacidades para realizarlo, como para aquellas que desean tener un mayor control
remoto, seguridad o comodidad en su viviend
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