1,261 research outputs found
Vanishing Fe 3d orbital moments in single-crystalline magnetite
We show detailed magnetic absorption spectroscopy results of an in situ
cleaved high quality single crystal of magnetite. In addition the experimental
setup was carefully optimized to reduce drift, self absorption, and offset
phenomena as far as possible. In strong contradiction to recently published
data, our observed orbital moments are nearly vanishing and the spin moments
are quite close to the integer values proposed by theory. This very important
issue supports the half metallic full spin polarized picture of magnetite.Comment: 7 pages, 4 figure
Deriving a Provisional Tolerable Intake for Intravenous Exposure to Silver Nanoparticles Released from Medical Devices
Silver nanoparticles (AgNP) are incorporated into medical devices for their anti-microbial characteristics. The potential exposure and toxicity of AgNPs is unknown due to varying physicochemical particle properties and lack of toxicological data. The aim of this safety assessment is to derive a provisional tolerable intake (pTI) value for AgNPs released from blood-contacting medical devices. A literature review of in vivo studies investigating critical health effects induced from intravenous (i. v.) exposure to AgNPs was evaluated by the Annapolis Accords principles and Toxicological Data Reliability Assessment Tool (ToxRTool). The point of departure (POD) was based on an i. v. 28-day repeated AgNP (20 nm) dose toxicity study reporting an increase in relative spleen weight in rats with a 5% lower confidence bound of the benchmark dose (BMDL05) of 0.14 mg/kg bw/day. The POD was extrapolated to humans by a modifying factor of 1,000 to account for intraspecies variability, interspecies differences and lack of long-term toxicity data. The pTI for long-term i. v. exposure to 20 nm AgNPs released from blood-contacting medical devices was 0.14 μg/kg bw/day. This pTI may not be appropriate for nanoparticles of other physicochemical properties or routes of administration. The methodology is appropriate for deriving pTIs for nanoparticles in general
Characterization of SCC\u3cem\u3emec \u3c/em\u3e Instability in Methicillin-Resistant \u3cem\u3eStaphylococcus aureus \u3c/em\u3e Affecting Adjacent Chromosomal Regions, Including the Gene for Staphylococcal Protein A \u3cem\u3e(spa)\u3c/em\u3e
Staphylococcal cassette chromosome mec (SCCmec) represents a sequence of clear clinical and diagnostic importance in staphylococci. At a minimum the chromosomal cassette contains the mecA gene encoding PBP2a but frequently also includes additional antibiotic resistance genes (e.g., ermA and aadC; macrolide and aminoglycoside resistance, respectively). Certain regions within SCCmec elements are hot spots for sequence instability due to cassette-specific recombinases and a variety of internal mobile elements. SCCmec changes may affect not only cassette stability but the integrity of adjacent chromosomal sequences (e.g., the staphylococcal protein A gene; spa). We investigated SCCmec stability in methicillin-resistant Staphylococcus aureus (MRSA) strains carrying one of four SCCmec types cultured in the absence of antimicrobial selection over a 3-month period. SCCmec rearrangements were first detected in cefoxitin-susceptible variants after 2 months of passage, and most commonly showed precise excision of the SCCmec element. Sequence analysis after 3 months revealed both precise SCCmec excision and a variety of SCCmec internal deletions, some including extensive adjacent chromosomal loss, including spa. No empty cassettes (i.e., loss of just mecA from SCCmec) were observed among the variants. SCCmec stability was influenced both by internal mobile elements (IS431) as well as the host cell environment. Genotypically similar clinical isolates with deletions in the spa gene were also included for purposes of comparison. The results indicate a role for host-cell influence and the IS431 element on SCCmec stability
Editorial: New insights and updates on the molecular epidemiology and antimicrobial resistance of MRSA in humans in the whole-genome sequencing era
[No abstract available
Magnetic coupling in highly-ordered NiO/Fe3O4(110): Ultrasharp magnetic interfaces vs. long-range magnetoelastic interactions
We present a laterally resolved X-ray magnetic dichroism study of the
magnetic proximity effect in a highly ordered oxide system, i.e. NiO films on
Fe3O4(110). We found that the magnetic interface shows an ultrasharp
electronic, magnetic and structural transition from the ferrimagnet to the
antiferromagnet. The monolayer which forms the interface reconstructs to
NiFe2O4 and exhibits an enhanced Fe and Ni orbital moment, possibly caused by
bonding anisotropy or electronic interaction between Fe and Ni cations. The
absence of spin-flop coupling for this crystallographic orientation can be
explained by a structurally uncompensated interface and additional
magnetoelastic effects
Nitrate reductase activity in the subsurface waters of the Peru Current
In March 1976 and 1977, nitrate reductase, nitrate, nitrite, and oxygen were measured between depths of 30 and 250m in the subsurface waters overlying the Peruvian continental shelf and shelf edge at 15S latitude. Oxygen concentrations of less than 1 ml/1 began between 20 and 30m in both years. The oxygen deficient waters extended to the bottom on the shelf and to 440m at the shelf edge...
The Emendation Eorle (Heruli) in Beowulf, Line 6a: Setting the Poem in “The Named Lands of the North”
A defence of the emendation of eorl to Eorle 'Heruli' in Beowulf 6a
Emergence of Oxacillin Resistance in Stealth Methicillin-Resistant \u3cem\u3eStaphylococcus aureus \u3c/em\u3eDue to \u3cem\u3emecA \u3c/em\u3eSequence Instability
Staphylococcus aureus strains that possess a mecA gene but are phenotypically susceptible to oxacillin and cefoxitin (OS-MRSA) have been recognized for over a decade and are a challenge for diagnostic laboratories. The mechanisms underlying the discrepancy vary from isolate to isolate. We characterized seven OS-MRSA clinical isolates of six different spa types from six different states by whole-genome sequencing to identify the nucleotide sequence changes leading to the OS-MRSA phenotype. The results demonstrated that oxacillin susceptibility was associated with mutations in regions of nucleotide repeats within mecA. Subinhibitory antibiotic exposure selected for secondary mecA mutations that restored oxacillin resistance. Thus, strains of S. aureus that contain mecA but are phenotypically susceptible can become resistant after antibiotic exposure, which may result in treatment failure. OS-MRSA warrant follow-up susceptibility testing to ensure detection of resistant revertants
Element-Specific Depth Profile of Magnetism and Stoichiometry at the La0.67Sr0.33MnO3/BiFeO3 Interface
Depth-sensitive magnetic, structural and chemical characterization is
important in the understanding and optimization of novel physical phenomena
emerging at interfaces of transition metal oxide heterostructures. In a
simultaneous approach we have used polarized neutron and resonant X-ray
reflectometry to determine the magnetic profile across atomically sharp
interfaces of ferromagnetic La0.67Sr0.33MnO3 / multiferroic BiFeO3 bi-layers
with sub-nanometer resolution. In particular, the X-ray resonant magnetic
reflectivity measurements at the Fe and Mn resonance edges allowed us to
determine the element specific depth profile of the ferromagnetic moments in
both the La0.67Sr0.33MnO3 and BiFeO3 layers. Our measurements indicate a
magnetically diluted interface layer within the La0.67Sr0.33MnO3 layer, in
contrast to previous observations on inversely deposited layers. Additional
resonant X-ray reflection measurements indicate a region of an altered Mn- and
O-content at the interface, with a thickness matching that of the magnetic
diluted layer, as origin of the reduction of the magnetic moment.Comment: 13 pages, 4 figures, supplemental material include
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