Strong and Efficient Baselines for Open Domain Conversational Question Answering

Unlike the Open Domain Question Answering (ODQA) setting, the conversational (ODConvQA) domain has received limited attention when it comes to reevaluating baselines for both efficiency and effectiveness. In this paper, we study the State-of-the-Art (SotA) Dense Passage Retrieval (DPR) retriever and Fusion-in-Decoder (FiD) reader pipeline, and show that it significantly underperforms when applied to ODConvQA tasks due to various limitations. We then propose and evaluate strong yet simple and efficient baselines, by introducing a fast reranking component between the retriever and the reader, and by performing targeted finetuning steps. Experiments on two ODConvQA tasks, namely TopiOCQA and OR-QuAC, show that our method improves the SotA results, while reducing reader's latency by 60%. Finally, we provide new and valuable insights into the development of challenging baselines that serve as a reference for future, more intricate approaches, including those that leverage Large Language Models (LLMs).Comment: Accepted to EMNLP 2023 Finding

Differential associations of APOE-epsilon 2 and APOE-epsilon 4 alleles with PET-measured amyloid-beta and tau deposition in older individuals without dementia

Purpose: To examine associations between the APOE-ε2 and APOE-ε4 alleles and core Alzheimer’s disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau PET in older individuals without dementia. Methods: We analyzed data from 462 ADNI participants without dementia who underwent Aβ ([18F]florbetapir or [18F]florbetaben) and tau ([18F]flortaucipir) PET, structural MRI, and cognitive testing. Employing APOE-ε3 homozygotes as the reference group, associations between APOE-ε2 and APOE-ε4 carriership with global Aβ PET and regional tau PET measures (entorhinal cortex (ERC), inferior temporal cortex, and Braak-V/VI neocortical composite regions) were investigated using linear regression models. In a subset of 156 participants, we also investigated associations between APOE genotype and regional tau accumulation over time using linear mixed models. Finally, we assessed whether Aβ mediated the cross-sectional and longitudinal associations between APOE genotype and tau. Results: Compared to APOE-ε3 homozygotes, APOE-ε2 carriers had lower global Aβ burden (βstd [95% confidence interval (CI)]: − 0.31 [− 0.45, − 0.16], p = 0.034) but did not differ on regional tau burden or tau accumulation over time. APOE-ε4 participants showed higher Aβ (βstd [95%CI]: 0.64 [0.42, 0.82], p < 0.001) and tau burden (βstd range: 0.27-0.51, all p < 0.006). In mediation analyses, APOE-ε4 only retained an Aβ-independent effect on tau in the ERC. APOE-ε4 showed a trend towards increased tau accumulation over time in Braak-V/VI compared to APOE-ε3 homozygotes (βstd [95%CI]: 0.10 [− 0.02, 0.18], p = 0.11), and this association was fully mediated by baseline Aβ. Conclusion: Our data suggest that the established protective effect of the APOE-ε2 allele against developing clinical AD is primarily linked to resistance against Aβ deposition rather than tau pathology

Properties of mm galaxies: Constraints from K-band blank fields

We have used the IRAM Plateau de Bure mm interferometer to locate with subarcsecond accuracy the dust emission of three of the brightest 1.2mm sources in the NTT Deep Field (NDF) selected from our 1.2mm MAMBO survey at the IRAM 30m telescope. We combine these results with deep B to K imaging and VLA interferometry. Strikingly, none of the three accurately located mm galaxies MMJ120546-0741.5, MMJ120539-0745.4, and MMJ120517-0743.1 has a K-band counterpart down to the faint limit of K>21.9. This implies that these three galaxies are either extremely obscured and/or are at very high redshifts (z>~4). We combine our results with literature data for 11 more (sub)mm galaxies that are identified with similar reliability. In terms of their K-band properties, the sample divides into three roughly equal groups: (i) undetected to K~22, (ii) detected in the near-infrared but not the optical and (iii) detected in the optical with the possibility of optical follow-up spectroscopy. We find a trend in this sample between near-infrared to submm and submm to radio spectral indices, which in comparison to spectral energy distributions (SEDs) of low redshift infrared luminous galaxies suggests that the most plausible primary factor causing the extreme near-infrared faintness of our objects is their high redshift. We show that the near-infrared to radio SEDs of the sample are inconsistent with SEDs that resemble local far-infrared cool galaxies with moderate luminosities, which were proposed in some models of the submm sky. We briefly discuss the implications of the results for our understanding of galaxy formation.Comment: aastex, 5 figures. Accepted by Ap

New constraints on the cosmic mid-infrared background using TeV gamma-ray astronomy

Very high energy gamma-ray data obtained by CAT and HEGRA from active galactic nucleus Mkn 501 are used to constrain the cosmic Mid-Infrared background. While the entire infrared and submillimeter spectrum shape based on models has been fixed and the density scaled as a whole in previous studies, recent measures on the low and high energy infrared background are extensively used in this paper. In this original approach, the infrared distribution is only varied in the unexplored 3.5-100 microns region. With conservative hypothesis on the intrinsic spectra of Mkn 501, an upper limit of 4.7 nW.m-2.sr-1 between 5 and 15 microns is derived, which is very close to the lower limit inferred from deep ISOCAM cosmological surveys at 15 microns. This result is shown to be independent of the exact density of the lambda < 3.5 microns and lambda > 100 microns infrared distribution within the uncertainties of the measurements. Moreover, the study presented here rules out a complete extragalactic origin for the 60 microns excess found by Finkbeiner et al. (2000).Comment: Accepted for publication by A&

NeAT: a Nonlinear Analysis Toolbox for Neuroimaging

NeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely based on linear models. NeAT provides a wide range of statistical and machine learning non-linear methods for model estimation, several metrics based on curve fitting and complexity for model inference and a graphical user interface (GUI) for visualization of results. We illustrate its usefulness on two study cases where non-linear effects have been previously established. Firstly, we study the nonlinear effects of Alzheimer’s disease on brain morphology (volume and cortical thickness). Secondly, we analyze the effect of the apolipoprotein APOE-ε4 genotype on brain aging and its interaction with age. NeAT is fully documented and publicly distributed at https://imatge-upc.github.io/neat-tool/

Alginate electrodeposition onto three-dimensional porous Co-Ni films as drug delivery platform

Three-dimensional porous Co-Ni films/alginate hybrid materials have been successfully prepared by electrodeposition to be used as a steerable magnetic device for drug delivery. Firstly, 3D porous Co-Ni films were prepared as substrates for the subsequent electrodeposition of the alginate biopolymer. Cyclic voltammetry, galvanostatic and potentiostatic studies were performed to establish the best conditions to obtain porous Co-Ni films. The electrochemical experiments were carried out in an electrolyte containing the metal salts and ammonium chloride at low pHs. In a second stage, the electrochemical deposition of alginate as a biocompatible polymer drug delivery carrier was performed. The characteristics of the alginate matrix were investigated in terms of electrochemical properties, morphology and drug release. The hybrid material obtained showed soft-magnetic behavior and drug release indicating its suitability to be used as a steerable magnetic drug delivery device

Planck pre-launch status: HFI beam expectations from the optical optimisation of the focal plane

Planck is a European Space Agency (ESA) satellite, launched in May 2009, which will map the cosmic microwave background anisotropies in intensity and polarisation with unprecedented detail and sensitivity. It will also provide full-sky maps of astrophysical foregrounds. An accurate knowledge of the telescope beam patterns is an essential element for a correct analysis of the acquired astrophysical data. We present a detailed description of the optical design of the High Frequency Instrument (HFI) together with some of the optical performances measured during the calibration campaigns. We report on the evolution of the knowledge of the pre-launch HFI beam patterns when coupled to ideal telescope elements, and on their significance for the HFI data analysis procedure

FIRBACK Source Counts and Cosmological Implications

FIRBACK is a one of the deepest surveys performed at 170 microns with ISOPHOT onboard ISO, and is aimed at the study of cosmic far infrared background sources. About 300 galaxies are detected in an area of four square degrees, and source counts present a strong slope of 2.2 on an integral "logN-logS" plot, which cannot be due to cosmological evolution if no K-correction is present. The resolved sources account for less than 10% of the Cosmic Infrared Background at 170 microns. In order to understand the nature of the sources contributing to the CIB, and to explain deep source counts at other wavelengths, we have developed a phenomenological model, which constrains in a simple way the luminosity function evolution with redshift, and fits all the existing deep source counts from the mid-infrared to the submillimetre range. Images, materials and papers available on the FIRBACK web: http://wwwfirback.ias.u-psud.fr wwwfirback.ias.u-psud.frComment: proceedings of "ISO Surveys of a Dusty Universe", eds. D. Lemke, M. Stickel, K. Wilke, Ringberg, 8-12 Nov 1999, to appear in Springer 'Lecture Notes of Physics'. 8 pages, 7 eps figures, .sty include