Experimental validation of multiphase flow models and testing of multiphase flow meters: A critical review of flow loops worldwide

Around the world, research into multiphase flow is performed by scientists with hugely diverse backgrounds: physicists, mathematicians and engineers from mechanical, nuclear, chemical, civil, petroleum, environmental and aerospace disciplines. Multiphase flow models are required to investigate the co-current or counter-current flow of different fluid phases under a wide range of pressure and temperature conditions and in several different configurations. To compliment this theoretical effort, measurements at controlled experimental conditions are required to verify multiphase flow models and assess their range of applicability, which has given rise to a large number of multiphase flow loops around the world. These flow loops are also used intensively to test and validate multiphase flow meters, which are devices for the in-line measurement of multiphase flow streams without separation of the phases. However, there are numerous multiphase flow varieties due to differences in pressure and temperature, fluids, flow regimes, pipe geometry, inclination and diameter, so a flow loop cannot represent all possible situations. Even when experiments in a given flow loop are believed to be sufficiently exhaustive for a specific study area, the real conditions encountered in the field tend to be very different from those recreated in the research facility. This paper presents a critical review of multiphase flow loops around the world, highlighting the pros and cons of each facility with regard to reproducing and monitoring different multiphase flow situations. The authors suggest a way forward for new developments in this area

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

Background: During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma. Methods: E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin immunohistochemical expression were evaluated using a double score based on staining intensity and cellular localization. Results: Cytoplasmic E-cadherin and α/γ catenin staining were associated with a decrease in survival, cytoplasmic β-catenin was associated with advanced stage, and N-cadherin and vimentin expression were associated with poor differentiation and tumor relapse. On the basis of cancer cells, epithelial or mesenchymal morphological and immunophenotypic similarity we identified 4 main subgroups correlated with a transition to a more undifferentiated phenotype, which have a different pattern of relapse and survival. Conclusion: The negative prognostic role of epithelial-to-mesenchymal transition has been confirmed and a predictive role in glottic tumors has been suggested, leading us to propose epithelial-to-mesenchymal transition as an additional adverse feature in laryngeal carcinoma

Performance assessment of GPS/GLONASS single point positioning in an urban environment

In signal-degraded environments such as urban canyons and mountainous area, many GNSS signals are either blocked or strongly degraded by natural and artificial obstacles. In such scenarios standalone GPS is often unable to guarantee a continuous and accurate positioning due to lack (or the poor quality) of signals. The combination of different GNSSs could be a suitable approach to fill this gap, because the multi-constellation system guarantees an improved satellite availability compared to standalone GPS, thus providing enhanced accuracy, continuity and integrity of the positioning. The present GNSSs are GPS, GLONASS, Galileo and Beidou, but the latter two are still in the development phase. In this work GPS/GLONASS systems are combined for single point positioning and their performance are assessed for different configurations. Using GPS/GLONASS multi-constellation implies the addition of an additional unknown, i.e. the intersystem time scale offset, which requires a sacrifice of one measurement. Since the intersystem offset is quasi-constant over a short period, a pseudo-measurement can be introduced to compensate the sacrifice. The benefit after adding a pseudo-measurement has been demonstrated in a vehicular test

High redshift X-ray galaxy clusters. I. The impact of point sources on the cluster properties

The current generation of X-ray observatories like Chandra allows studies with very fine spatial details. It is now possible to resolve X-ray point sources projected into the cluster diffuse emission and exclude them from the analysis to estimate the ``correct'' X-ray observables. In order to verify the incidence of point sources on the cluster thermal emission and to evaluate the impact of their non-thermal emission on the determination of cluster properties, we used a sample of 18 high-z (0.25 < z < 1.01) clusters from the Chandra archive. We performed a detailed analysis of the cluster properties and compared the changes observed in the X-ray observables, like temperature and luminosity or their inter-relation, when one keeps the point sources in the analysis. The point sources projected into the cluster extended emission affect the estimates of cluster temperature or luminosity considerably (up to 13% and 17% respectively). These percentages become even larger for clusters with z > 0.7 where temperature and luminosity increase up to 24% and 22%, respectively. Thus the point sources should be removed to correctly estimate the cluster properties. However the inclusion of the point sources does not impact significantly the slope and normalization of the L-T relationship since for each cluster the correction to be applied to T and L produces a moderate shift in the L-T plane almost parallel to the best-fit of the ``correct'' L-T relation.Comment: 16 pages, 18 postscript figures. Accepted for publication in Astronomy & Astrophysic

Liquid loading in gas wells: experimental investigation of back pressure effects on the near-wellbore reservoir

A large-scale core-flooding experimental setup was designed and constructed to investigate the back pressure effects on transient flow through porous medium, and so mimic the physical process of liquid loading and reservoir response. Between initial and final steady-state flowing conditions, where inlet pressure was maintained at a constant level while initiating a transient pressure build up at the core sample end, an “U-shaped” temporal distribution of pore fluid pressure within the medium itself was observed, which is in direct contrast to the conventional reservoir pressure profile

The 3D soft X-ray cluster-AGN cross-correlation function in the ROSAT NEP survey

X-ray surveys facilitate investigations of the environment of AGNs. Deep Chandra observations revealed that the AGNs source surface density rises near clusters of galaxies. The natural extension of these works is the measurement of spatial clustering of AGNs around clusters and the investigation of relative biasing between active galactic nuclei and galaxies near clusters.The major aims of this work are to obtain a measurement of the correlation length of AGNs around clusters and a measure of the averaged clustering properties of a complete sample of AGNs in dense environments. We present the first measurement of the soft X-ray cluster-AGN cross-correlation function in redshift space using the data of the ROSAT-NEP survey. The survey covers 9x9 deg^2 around the North Ecliptic Pole where 442 X-ray sources were detected and almost completely spectroscopically identified. We detected a >3sigma significant clustering signal on scales s<50 h70^-1 Mpc. We performed a classical maximum-likelihood power-law fit to the data and obtained a correlation length s_0=8.7+1.2-0.3 h_70-1 Mpc and a slope gamma=1.7$^+0.2_-0.7 (1sigma errors). This is a strong evidence that AGNs are good tracers of the large scale structure of the Universe. Our data were compared to the results obtained by cross-correlating X-ray clusters and galaxies. We observe, with a large uncertainty, that the bias factor of AGN is similar to that of galaxies.Comment: 4 pages, 2 figure, proceedings of the Conference "At the edge of the Universe", Sintra Portugal, October 2006. To be published on the Astronomical Society of the Pacific Conference Series (ASPCS

Design of a LNA in the frequency band 1.8-2.2GHz in 0.13μm CMOS Technology

The subject of this work is a low noise amplifier (LNA), operating in the frequency range 1.8-2.1GHz. The CMOS 0.13μm technology is used in respect to the low cost of the final device. Among the specifications, a variable gain and an adjustable working frequency are required. In particular, four different working modes are provided: 1.8, 1.9 and 2.1GHz high gain and 2.1GHz low gain. The amplifier is designed to be used as first stage of a receiver for mobile telephony. For this reason low power consumption is taken into consideration (low supply voltage and low drain currents). A simple digital circuit, integrated on-chip, is used to select the operating mode of the LNA by means of two input pins. A Noise figure of 1dB is obtained with a supply voltage of 0.8V

Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy?

Dupuytren's contracture (DC) is a benign fibro-proliferative disease of the hand causing fibrotic nodules and fascial cords which determine debilitating contracture and deformities of fingers and hands. The present study was designed to characterize pro-inflammatory cytokines and growth factors involved in the pathogenesis, progression and recurrence of this disease, in order to find novel targets for alternative therapies and strategies in controlling DC. The expression of pro-inflammatory cytokines and of growth factors was detected by immunohistochemistry in fibrotic nodules and normal palmar fascia resected respectively from patients affected by DC and carpal tunnel syndrome (CTS; as negative controls). Reverse transcription (RT)-PCR analysis and immunofluorescence were performed to quantify the expression of transforming growth factor (TGF)-β1, interleukin (IL)-1β and vascular endothelial growth factor (VEGF) by primary cultures of myofibroblasts and fibroblasts isolated from Dupuytren's nodules. Histological analysis showed high cellularity and high proliferation rate in Dupuytren's tissue, together with the presence of myofibroblastic isotypes; immunohistochemical staining for macrophages was completely negative. In addition, a strong expression of TGF-β1, IL-1β and VEGF was evident in the extracellular matrix and in the cytoplasm of fibroblasts and myofibroblasts in Dupuytren's nodular tissues, as compared with control tissues. These results were confirmed by RT-PCR and by immunofluorescence in pathological and normal primary cell cultures. These preliminary observations suggest that TGF-β1, IL-1β and VEGF may be considered potential therapeutic targets in the treatment of Dupuytren's disease (DD)

The ROSAT North Ecliptic Pole Survey: The Optical Identifications

The X-ray data around the North Ecliptic Pole (NEP) of the ROSAT All Sky Survey have been used to construct a contiguous area survey consisting of a sample of 445 individual X-ray sources above a flux of ~2x10^-14 erg cm^-2 s^-1 in the 0.5-2.0 keV energy band. The NEP survey is centered at RA (2000) = 18h 00m, DEC(2000) = +66deg 33arcmin and covers a region of 80.7 sq. deg at a moderate Galactic latitude of b = 29.8deg. Hence, the NEP survey is as deep and covers a comparable solid angle to the ROSAT serendipitous surveys, but is also contiguous. We have identified 99.6% of the sources and determined redshifts for the extragalactic objects. In this paper we present the optical identifications of the NEP catalog of X-ray sources including basic X-ray data and properties of the sources. We also describe with some detail the optical identification procedure. The classification of the optical counterparts to the NEP sources is very similar to that of previous surveys, in particular the Einstein Extended Medium Sensitivity Survey (EMSS). The main constituents of the catalog are active galactic nuclei (~49%), either type 1 or type 2 according to the broadness of their permitted emission lines. Stellar counterparts are the second most common identification class (~34%). Clusters and groups of galaxies comprise 14%, and BL Lacertae objects 2%. One non-AGN galaxy, and one planetary nebula have also been found. The NEP catalog of X-ray sources is a homogeneous sample of astronomical objects featuring complete optical identification.Comment: Accepted for publication in the ApJS; 33 pages including 12 postscript figures and 3 tables; uses emulateapj.sty. On-line source catalog at http://www.eso.org/~cmullis/research/nep-catalog.htm

Correlation Redistribution by Causal Horizons

The Minkowski vacuum $|0\rangle_M$, which for an inertial observer is devoid of particles, is treated as a thermal bath by Rindler observers living in a single Rindler wedge, as a result of the discrepancy in the definition of positive frequency between the two classes of observers and a strong entanglement between degrees of freedom in the left and right Rindler wedges. We revisit, in the context of a free scalar Klein-Gordon field, the problem of quantification of the correlations between an inertial observer Alice and left/right Rindler observes Rob/AntiRob. We emphasize the analysis of informational quantities, like the locally accessible and locally inaccessible information, and a closely associated entanglement measure, the entanglement of formation. We conclude that, with respect to the correlation structure probed by inertial observers alone, the introduction of a Rindler observer gives rise to a correlation redistribution which can be quantified by the entanglement of formation.Comment: 9 pages, 7 figure