1,431 research outputs found
Utilization of fish trash for increasing yield and quality of milk in cattle
The difference between cost of milk production and Its telling price Is very thin and Is
getting thinner due to cumulative increase in cattle food prices on one side and limitations on
marketing price of milk on the other. Possible utilization of trash fish converted to liquid silage
a* a part of cattle food resulting In Increased yield of milk and fat concern are discussed in
this paper. The development of silage and field trials on milking catties were carried out by
Gujarat Fisheries Aquatic Sciences Research Institute, Okha
Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202
CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at approximately equal rates. However, the subsequent 17,20 carbon–carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17α-hydroxypregnenlone (OHPREG) versus 17α-hydroxyprogesterone (OHPROG). Here we show that the identity of the residue at position 202 in human CYP17A1, thought to form a hydrogen bond with the A-ring alcohol substituent on the pregnene- nucleus, is a key driver of this enzyme’s native preference for OHPREG. Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. In a series of resonance Raman experiments, it was observed that, in contrast with the case for the wild-type protein, in the mutant the 17α alcohol of OHPROG tends to form a H-bond with the proximal rather than terminal oxygen of the oxy–ferrous complex. When OHPREG was a substrate, the mutant enzyme was found to have a H-bonding interaction with the proximal oxygen that is substantially weaker than that of the wild type. These results demonstrate that a single-point mutation in the active site pocket of CYP17A1, even when far from the heme, has profound effects on steroidogenic selectivity in androgen biosynthesis
Structural and magnetic properties of an InGaAs/FeSi superlattice in cylindrical geometry
The structure and the magnetic properties of an InGaAs/Fe3Si superlattice in
a cylindrical geometry are investigated by electron microscopy techniques,
x-ray diffraction and magnetometry. To form a radial superlattice, a
pseudomorphic InGaAs/Fe3As bilayer has been released from its substrate
self-forming into a rolled-up microtube. Oxide-free interfaces as well as areas
of crystalline bonding are observed and an overall lattice mismatch between
succeeding layers is determined. The cylindrical symmetry of the final radial
superlattice shows a significant effect on the magnetization behavior of the
rolled-up layers
A review of clinical decision-making: Models and current research
Aims and objectives: The aim of this paper was to review the current literature with respect to clinical decision-making models and the educational application of models to clinical practice. This was achieved by exploring the function and related research of the three available models of clinical decision making: information processing model, the intuitive-humanist model and the clinical decision making model.
Background: Clinical decision-making is a unique process that involves the interplay between knowledge of pre-existing pathological conditions, explicit patient information, nursing care and experiential learning. Historically, two models of clinical decision making are recognised from the literature; the information processing model and the intuitive-humanist model. The usefulness and application of both models has been examined in relation the provision of nursing care and care related outcomes. More recently a third model of clinical decision making has been proposed. This new multidimensional model contains elements of the information processing model but also examines patient specific elements that are necessary for cue and pattern recognition.
Design: Literature review
Methods: Evaluation of the literature generated from MEDLINE, CINAHL, OVID, PUBMED and EBESCO systems and the Internet from 1980 – November 2005
Tension Dynamics and Linear Viscoelastic Behavior of a Single Semiflexible Polymer Chain
We study the dynamical response of a single semiflexible polymer chain based
on the theory developed by Hallatschek et al. for the wormlike-chain model. The
linear viscoelastic response under oscillatory forces acting at the two chain
ends is derived analytically as a function of the oscillation frequency . We
shall show that the real part of the complex compliance in the low frequency
limit is consistent with the static result of Marko and Siggia whereas the
imaginary part exhibits the power-law dependence +1/2. On the other hand, these
compliances decrease as the power law -7/8 for the high frequency limit. These
are different from those of the Rouse dynamics. A scaling argument is developed
to understand these novel results.Comment: 23 pages, 6 figure
Experimental Investigation on the Deformation Response of Hybrid 3D Woven Composites
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97059/1/AIAA2012-1572.pd
Creation of the CMB spectrum: precise analytic solutions for the blackbody photosphere
The blackbody spectrum of CMB was created in the blackbody photosphere at
redshifts z>2x10^6. At these early times, the Universe was dense and hot enough
that complete thermal equilibrium between baryonic matter (electrons and ions)
and photons could be established. Any perturbation away from the blackbody
spectrum was suppressed exponentially. New physics, for example annihilation
and decay of dark matter, can add energy and photons to CMB at redshifts z>10^5
and result in a Bose-Einstein spectrum with a non-zero chemical potential
(). Precise evolution of the CMB spectrum around the critical redshift of
z~2x10^6 is required in order to calculate the -type spectral distortion
and constrain the underlying new physics. Although numerical calculation of
important processes involved (double Compton process, comptonization and
bremsstrahlung) is not difficult, analytic solutions are much faster and easier
to calculate and provide valuable physical insights. We provide precise (better
than 1%) analytic solutions for the decay of , created at an earlier
epoch, including all three processes, double Compton, Compton scattering on
thermal electrons and bremsstrahlung in the limit of small distortions. This is
a significant improvement over the existing solutions with accuracy ~10% or
worse. We also give a census of important sources of energy injection into CMB
in standard cosmology. In particular, calculations of distortions from
electron-positron annihilation and primordial nucleosynthesis illustrate in a
dramatic way the strength of the equilibrium restoring processes in the early
Universe. Finally, we point out the triple degeneracy in standard cosmology,
i.e., the and distortions from adiabatic cooling of baryons and
electrons, Silk damping and annihilation of thermally produced WIMP dark matter
are of similar order of magnitude (~ 10^{-8}-10^{-10})
Experimental investigation of few-nucleon dynamics at medium energies
An experiment, with unpolarized deuteron beam of 160 MeV impinging on liquid hydrogen and liquid deuterium targets, was carried out using BINA detector at KVI, in Groningen, the Netherlands. Data were collected for the purpose of obtaining high precision differential cross-section for the deuteron break-up reaction. The elastic scattering data were also collected alongside. We present here the methods applied in analysis of data collected in the backward part of the detector
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