Whale Safe Gillnets

A grant from the Virginia Sea Grant program to test some modified gillnets to find ways of fishing that would allow whales to break free from our fishing gear

Polynomial kernelization for removing induced claws and diamonds

A graph is called (claw,diamond)-free if it contains neither a claw (a $K_{1,3}$) nor a diamond (a $K_4$ with an edge removed) as an induced subgraph. Equivalently, (claw,diamond)-free graphs can be characterized as line graphs of triangle-free graphs, or as linear dominoes, i.e., graphs in which every vertex is in at most two maximal cliques and every edge is in exactly one maximal clique. In this paper we consider the parameterized complexity of the (claw,diamond)-free Edge Deletion problem, where given a graph $G$ and a parameter $k$, the question is whether one can remove at most $k$ edges from $G$ to obtain a (claw,diamond)-free graph. Our main result is that this problem admits a polynomial kernel. We complement this finding by proving that, even on instances with maximum degree $6$, the problem is NP-complete and cannot be solved in time $2^{o(k)}\cdot |V(G)|^{O(1)}$ unless the Exponential Time Hypothesis fai

Traumatic brain injury and NADPH oxidase: A deep relationship

Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world. TBI is characterized by primary damage resulting from the mechanical forces applied to the head as a direct result of the trauma and by the subsequent secondary injury due to a complex cascade of biochemical events that eventually lead to neuronal cell death. Oxidative stress plays a pivotal role in the genesis of the delayed harmful effects contributing to permanent damage. NADPH oxidases (Nox), ubiquitary membrane multisubunit enzymes whose unique function is the production of reactive oxygen species (ROS), have been shown to be a major source of ROS in the brain and to be involved in several neurological diseases. Emerging evidence demonstrates that Nox is upregulated after TBI, suggesting Nox critical role in the onset and development of this pathology. In this review, we summarize the current evidence about the role of Nox enzymes in the pathophysiology of TBI

Early prediction of Autism Spectrum Disorders through interaction analysis in home videos and explainable artificial intelligence

There is considerable discussion about the advantages and disadvantages of early ASD diagnosis. However, the development of easily understandable and administrable tools for teachers or caregivers in order to identify potentially alarming behaviours (red flags) is usually considered valuable even by scholars who are concerned with very early diagnosis. This study proposes an AI pre-screening tool with the aim of creating an easily administrable tool for non-competent observers useful to identify potentially alarming signs in pre-verbal interactions. The use of these features is evaluated using an explainable artificial intelligence algorithm to assess which of the proposed new interaction characteristics were more effective in classifying individuals with ASD vs. controls. We used a rating scale with three core sections - sensorimotor, behavioural, and emotional - each further divided into four items. By seeing home videos of children doing everyday activities, two experienced observers rated each of these items from 1 (highly typical interaction) to 8 (extremely atypical interaction). Then, a machine learning model based on XGBoost was developed for identifying ASD children. The classification obtained was interpreted through the use of SHAP explanations, obtaining an area under the receiver operating curve of 0.938 and 0.914 for the two observers, respectively. These results demonstrated the significance of early detection of body-related sensorimotor features

Experimental observation of nonlinear Thomson scattering

A century ago, J. J. Thomson showed that the scattering of low-intensity light by electrons was a linear process (i.e., the scattered light frequency was identical to that of the incident light) and that light's magnetic field played no role. Today, with the recent invention of ultra-high-peak-power lasers it is now possible to create a sufficient photon density to study Thomson scattering in the relativistic regime. With increasing light intensity, electrons quiver during the scattering process with increasing velocity, approaching the speed of light when the laser intensity approaches 10^18 W/cm^2. In this limit, the effect of light's magnetic field on electron motion should become comparable to that of its electric field, and the electron mass should increase because of the relativistic correction. Consequently, electrons in such high fields are predicted to quiver nonlinearly, moving in figure-eight patterns, rather than in straight lines, and thus to radiate photons at harmonics of the frequency of the incident laser light, with each harmonic having its own unique angular distribution. In this letter, we report the first ever direct experimental confirmation of these predictions, a topic that has previously been referred to as nonlinear Thomson scattering. Extension of these results to coherent relativistic harmonic generation may eventually lead to novel table-top x-ray sources.Comment: including 4 figure

Gastric Outlet Obstruction in a Patient with Bouveret's Syndrome: a Case Report

BACKGROUND: Gallstone ileus accounts for 1% to 4% of cases of mechanical bowel obstruction, but may be responsible for up to 25% of cases in older age groups. In non-iatrogenic cases, gallstone migration occurs after formation of a biliary-enteric fistula. In fewer than 10% of patients with gallstone ileus, the impacted gallstones are located in the pylorus or duodenum, resulting in gastric outlet obstruction, known as Bouveret's syndrome. CASE PRESENTATION: We report an 86-year-old female who was admitted to hospital with a 10-day history of persistent vomiting and prostration. She was in hypovolemic shock at the time of arrival in the emergency department. Investigations revealed a gallstone in the duodenal bulb and a cholecystoduodenal fistula. She underwent surgical gastrolithotomy. Unfortunately, she died of aspiration pneumonia on the fourth postoperative day. CONCLUSION: This case shows the importance of considering Bouveret's syndrome in the differential diagnosis of gastric outlet obstruction, especially in the elderly, even in patients with no previous history of gallbladder disease

Traumatic brain injury and NADPH oxidase: A deep relationship

Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world. TBI is characterized by primary damage resulting from the mechanical forces applied to the head as a direct result of the trauma and by the subsequent secondary injury due to a complex cascade of biochemical events that eventually lead to neuronal cell death. Oxidative stress plays a pivotal role in the genesis of the delayed harmful effects contributing to permanent damage. NADPH oxidases (Nox), ubiquitary membrane multisubunit enzymes whose unique function is the production of reactive oxygen species (ROS), have been shown to be a major source of ROS in the brain and to be involved in several neurological diseases. Emerging evidence demonstrates that Nox is upregulated after TBI, suggesting Nox critical role in the onset and development of this pathology. In this review, we summarize the current evidence about the role of Nox enzymes in the pathophysiology of TBI

Association of Intestinal Malrotation and Bochdalek Hernia in an Adult: a Case Report

Background Late presentations of congenital diaphragmatic hernia are rare and differ from the classic neonatal presentation. The association with other congenital malformations in children, mainly intestinal malrotation, is well documented. The diagnosis of this association in adults is very rare, and depends on a high degree of suspicion. Case presentation We report a case of a 50-year-old female Caucasian patient with a previous history of intestinal malrotation diagnosed in adolescence and treated conservatively. She was referred to the hospital with signs and symptoms of intestinal obstruction. The patient undertook computed tomography that confirmed small bowel obstruction with no obvious cause, and a right subphrenic abscess with right empyema was also present. An exploratory laparotomy was performed that revealed an intestinal malrotation associated with a right gangrenous and perforated Bochdalek hernia. Resection of the affected small bowel, closure of the Bochdalek foramen and the Ladd procedure were carried out. Conclusion This case shows a rare association of two rare conditions in adults, and highlights the challenge in reaching the diagnosis and management options

A systematic review of risk of HIV transmission through biting or spitting: implications for policy.

OBJECTIVES: The perceived threat of HIV transmission through spitting and biting is evidenced by the increasing use of "spit hoods" by Police Forces in the UK. In addition, a draft parliamentary bill has called for increased penalties for assaults on emergency workers, citing the risk of communicable disease transmission as one justification. We aimed to review literature relating to the risk of HIV transmission through biting or spitting. METHODS: A systematic literature search was conducted using Medline, Embase and Northern Lights databases and conference websites using search terms relating to HIV, AIDS, bite, spit and saliva. Inclusion and exclusion criteria were applied to identified citations. We classified plausibility of HIV transmission as low, medium, high or confirmed based on pre-specified criteria. RESULTS: A total of 742 abstracts were reviewed, yielding 32 articles for full-text review and 13 case reports/series after inclusion and exclusion criteria had been applied. There were no reported cases of HIV transmission related to spitting and nine cases identified following a bite, in which the majority occurred between family (six of nine), in fights involving serious wounds (three of nine), or to untrained first-aiders placing fingers in the mouth of someone having a seizure (two of nine). Only four cases were classified as highly plausible or confirmed transmission. None related to emergency workers and none were in the UK. CONCLUSIONS: There is no risk of transmitting HIV through spitting, and the risk through biting is negligible. Post-exposure prophylaxis is not indicated after a bite in all but exceptional circumstances. Policies to protect emergency workers should be developed with this evidence in mind

The Firefighter Problem: A Structural Analysis

We consider the complexity of the firefighter problem where b>=1 firefighters are available at each time step. This problem is proved NP-complete even on trees of degree at most three and budget one (Finbow et al.,2007) and on trees of bounded degree b+3 for any fixed budget b>=2 (Bazgan et al.,2012). In this paper, we provide further insight into the complexity landscape of the problem by showing that the pathwidth and the maximum degree of the input graph govern its complexity. More precisely, we first prove that the problem is NP-complete even on trees of pathwidth at most three for any fixed budget b>=1. We then show that the problem turns out to be fixed parameter-tractable with respect to the combined parameter "pathwidth" and "maximum degree" of the input graph