New spatial mechanisms for the kinematic analysis of the tibiotalar joint

In virtually unloaded conditions, the tibiotalar (ankle) joint behaves as a single degree-of-freedom system, and two fibres within the calcaneal-fibular and tibio-calcaneal ligaments remain nearly isometric throughout the flexion arc. A relevant theoretical model also showed that three articular surfaces and two ligaments act together as a mechanism to control the passive kinematics. Two equivalent spatial parallel mechanisms were formulated, with ligament fibres assumed isometric and articulating surfaces assumed rigid, either as three sphere-plane contacts, or as a single spherical pair. Predicted and measured motion in three specimens compared fairly well. Important enhancement of this previous work is here presented, with more accurate experimental data, more anatomical model surfaces, and a more robust mathematical model

A Deep Learning Approach to Ancient Egyptian Hieroglyphs Classification

Nowadays, advances in Artificial Intelligence (AI), especially in machine and deep learning, present new opportunities to build tools that support the work of specialists in areas apparently far from the information technology field. One example of such areas is that of ancient Egyptian hieroglyphic writing. In this study, we explore the ability of different convolutional neural networks (CNNs) to classify pictures of ancient Egyptian hieroglyphs coming from two different datasets of images. Three well-known CNN architectures (ResNet-50, Inception-v3 and Xception) were taken into consideration and trained on the available images. The paradigm of transfer learning was tested as well. In addition, modifying the architecture of one of the previous networks, we developed a specifically dedicated CNN, named Glyphnet, tailoring its complexity to our classification task. Performance comparison tests were carried out and Glyphnet showed the best performances with respect to the other CNNs. In conclusion, this work shows how the ancient Egyptian hieroglyphs identification task can be supported by the deep learning paradigm, laying the foundation for information tools supporting automatic documents recognition, classification and, most importantly, the language translation task

Comparing Radiotherapy Patient Flows in England and Italy

Research into radiotherapy patient flows in England and Italy investigated the degree of self-sufficiency in related service areas across each country. The respective results showed very different patterns, with there apparently being greater patient flow and less self-sufficiency for services in Italy, compared to England. However, close inspection suggested the results were not strictly comparable, despite the data, methodology and analyses being similar and entirely fitting in both cases. The respective studies were consequently compared for a range of criteria: how radiotherapy services are commissioned and provided; cultural expectations; base area definitions; data used; analyses undertaken; and research results. It was found that direct comparisons could not necessarily be drawn because cultural, conceptual, organisational and systemic factors in the delivery of services within each country influenced the results. Therefore, such factors should be taken into account when comparing health services in different countries, particularly in respect of patient flows and service self-sufficiency

Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion

Dopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectornized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of DA antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and DA actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of DA through D-2 receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of DA through D, receptors and in other part by inhibition of stimulatory action of DA through D2 receptors

Massive measurements of 5G exposure in a town: methodology and results

We target the problem of performing a large set of measurements over the territory to characterize the exposure from a 5G deployment. Since using a single Spectrum Analyzer (SA) is not practically feasible (due to the limited battery duration), in this work we adopt an integrated approach, based on the massive measurement of 5G metrics with a 5G smartphone, followed by a detailed analysis done with the SA and an ElectroMagnetic Field (EMF) meter in selected locations. Results, obtained over a real territory covered by 5G signal, reveal that 5G exposure is overall very limited for most of measurement locations, both in terms of field strength (up to 0.7 [V/m]) and as share w.r.t. other wireless technologies (typically lower than 15%). Moreover, our approach allows easily spotting measurement outliers, e.g., due to the exploitation of Dynamic Spectrum Sharing (DSS) techniques between 4G and 5G. In addition, the exposure metrics collected with the smartphone are overall a good proxy of the total exposure measured over the whole 5G channel. Moreover, the sight conditions and the distance from 5G base station play a great role in determining the level of exposure. Finally, a maximum of 130 [W] of power radiated by a 5G base station is estimated in the scenario under consideration

In utero protein restriction causes growth delay and alters sperm parameters in adult male rats

<p>Abstract</p> <p>Background</p> <p>Recent studies have supported the concept of "fetal programming" which suggests that during the intrauterine development the fetus may be programmed to develop diseases in adulthood. The possible effects of <it>in utero </it>protein restriction on sexual development of rat male offspring were evaluated in the present study.</p> <p>Methods</p> <p><it>Pregnant </it>Wistar rats were divided into two experimental groups: one group treated with standard chow (SC, n = 8, 17% protein) and the other group treated with hypoproteic chow (HC, n = 10, 6% protein) throughout gestation. After gestation the two experimental groups received standard chow. To evaluate the possible late reproductive effects of <it>in utero </it>protein restriction, the male offspring of both groups were assessed at different phases of sexual development: prepubertal (30 days old); peripubertal (60 days old); adult (90 days old). Student's t-test and Mann-Whitney test were utilized. Differences were considered significant when p < 0.05.</p> <p>Results</p> <p>We found that <it>in utero </it>protein restriction reduced the body weight of male pups on the first postnatal day and during the different sexual development phases (prepubertal, peripubertal and adult). During adulthood, Sertoli cell number, sperm motility and sperm counts in the testis and epididymal cauda were also reduced in HC. Furthermore, the numbers of sperm presenting morphological abnormalities and cytoplasmic drop retention were higher in HC.</p> <p>Conclusions</p> <p>In conclusion, <it>in utero </it>protein restriction, under these experimental conditions, causes growth delay and alters male reproductive-system programming in rats, suggesting impairment of sperm quality in adulthood.</p

Magnetic field turbulence in the solar wind at sub-ion scales: in situ observations and numerical simulations

We investigate the transition of the solar wind turbulent cascade from MHD to sub-ion range by means of a detail comparison between in situ observations and hybrid numerical simulations. In particular we focus on the properties of the magnetic field and its component anisotropy in Cluster measurements and hybrid 2D simulations. First, we address the angular distribution of wave-vectors in the kinetic range between ion and electron scales by studying the variance anisotropy of the magnetic field components. When taking into account the single-direction sampling performed by spacecraft in the solar wind, the main properties of the fluctuations observed in situ are also recovered in our numerical description. This result confirms that solar wind turbulence in the sub-ion range is characterized by a quasi-2D gyrotropic distribution of k-vectors around the mean field. We then consider the magnetic compressibility associated with the turbulent cascade and its evolution from large-MHD to sub-ion scales. The ratio of field-aligned to perpendicular fluctuations, typically low in the MHD inertial range, increases significantly when crossing ion scales and its value in the sub-ion range is a function of the total plasma beta only, as expected from theoretical predictions, with higher magnetic compressibility for higher beta. Moreover, we observe that this increase has a gradual trend from low to high beta values in the in situ data; this behaviour is well captured by the numerical simulations. The level of magnetic field compressibility that is observed in situ and in the simulations is in fairly good agreement with theoretical predictions, especially at high beta, suggesting that in the kinetic range explored the turbulence is supported by low-frequency and highly-oblique fluctuations in pressure balance, like kinetic Alfv\'en waves or other slowly evolving coherent structures.Comment: Manuscript submitted to Frontiers Astronomy and Space Sciences, Research Topic: Improving the Understanding of Kinetic Processes in Solar Wind and Magnetosphere: From CLUSTER to MM

Natural Formulations Based on Olea europaea L. Fruit Extract for the Topical Treatment of HSV-1 Infections

In the present study, a hydroxytyrosol-rich Olea europaea L. fruit extract (OFE) was added to three thoroughly green formulations—hydrogel, oleogel, and cream—in order to evaluate their antiviral activity against HSV-1. The extract was characterized by different analytical techniques, i.e., FT-IR, XPS, and TGA. HPLC analyses were carried out to monitor the content and release of hydroxytyrosol in the prepared formulations. The total polyphenol content and antioxidant activity were investigated through Folin–Ciocâlteu’s reagent, DPPH, and ABTS assays. The ability of the three formulations to convey active principles to the skin was evaluated using a Franz cell, showing that the number of permeated polyphenols in the hydrogel (272.1 ± 1.8 GAE/g) was significantly higher than those in the oleogel and cream (174 ± 10 and 179.6 ± 2 GAE/g, respectively), even if a negligible amount of hydroxytyrosol crossed the membrane for all the formulations. The cell viability assay indicated that the OFE and the three formulations were not toxic to cultured Vero cells. The antiviral activity tests highlighted that the OFE had a strong inhibitory effect against HSV-1 with a 50% inhibitory concentration (IC50) at 25 µg/mL, interfering directly with the viral particles. Among the three formulations, the hydrogel exhibited the highest antiviral activity also against the acyclovir-resistant strain