51 research outputs found

    Salivary molecular spectroscopy : a sustainable, rapid and non-invasive monitoring tool for diabetes mellitus during insulin treatment

    Get PDF
    Monitoring of blood glucose is an invasive, painful and costly practice in diabetes. Consequently, the search for a more cost-effective (reagent-free), non-invasive and specific diabetes monitoring method is of great interest. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used in diagnosis of several diseases, however, applications in the monitoring of diabetic treatment are just beginning to emerge. Here, we used ATR-FTIR spectroscopy to evaluate saliva of non-diabetic (ND), diabetic (D) and insulin-treated diabetic (D+I) rats to identify potential salivary biomarkers related to glucose monitoring. The spectrum of saliva of ND, D and D+I rats displayed several unique vibrational modes and from these, two vibrational modes were pre-validated as potential diagnostic biomarkers by ROC curve analysis with significant correlation with glycemia. Compared to the ND and D+I rats, classification of D rats was achieved with a sensitivity of 100%, and an average specificity of 93.33% and 100% using bands 1452 cm-1 and 836 cm-1, respectively. Moreover, 1452 cm-1 and 836 cm-1 spectral bands proved to be robust spectral biomarkers and highly correlated with glycemia (R2 of 0.801 and 0.788, P < 0.01, respectively). Both PCA-LDA and HCA classifications achieved an accuracy of 95.2%. Spectral salivary biomarkers discovered using univariate and multivariate analysis may provide a novel robust alternative for diabetes monitoring using a non-invasive and green technology

    L'Écho : grand quotidien d'information du Centre Ouest

    No full text
    30 octobre 19311931/10/30 (A60).Appartient à l’ensemble documentaire : PoitouCh

    Manipulating dissipative soliton ensembles in passively mode-locked fiber lasers

    Get PDF
    International audienceWe review our recent experimental and theoretical results addressing the dynamics of large numbers of solitons interacting in presence of a background in passively mode-locked erbium-doped fiber lasers. We first characterize experimentally the soliton rain complex dynamics, and then we focus on ordered soliton patterns. We report that, for suitable experimental parameters, a continuous wave can impose harmonic mode locking. Two levels of modeling for a mode-locked laser subjected to the external injection of a continuous wave are developed to support the latter observation. The first one is based on a scalar master equation, while the second one takes into account the mode-locking mechanism more accurately through a vectorial approach.</p

    Versatile and scalable pulse compression platform

    No full text
    International audienceWe report on a user-friendly sub-100 fs nonlinear pulse compression platform named FastLas. The compressor is based on gas fillable inhibited-coupling fibers and can be scaled over a large parameter-space of the input pulse. OCIS codes: 320.5520, 320.7140, 060.5295 1. Introduction Over the last two decades, ultra-short pulse (USP) lasers have witnessed a dramatic progress in their design, performance and in their applications. Nowadays, commercially available table-top lasers emitting pulses with duration of hundreds of femtosecond and milli-Joule energy have become a common place. Among the most representative of these USP lasers, we count Ti:Sapph laser emitting at around 800 nm for, Yb-based laser emitting around 1 µm, and Er-based laser emitting around 1.5 µm, and their frequency-doubled and tripled versions. Within this landscape, the laser pulse-duration is often larger than 100 fs, and achieving sub-100 fs pulse duration still remains a challenge. Among the limiting factors in pulse compression is the narrow gain-bandwidth of some lasers (e.g. Yb-based and Er-based lasers), which requires further spectral-broadening followed with a post-compression, and/or nonlinear compression. Furthermore, even with larger gain bandwidth lasers such as Ti:Sapph, complex setup are required for efficient dispersion compensation. Finally, the high sensitivity of current pulse-compression schemes to well defined parameter set of the input laser such as pulse energy, pulse duration, and wavelength, makes it extremely challenging to have efficient and scalable USP compressors. This situation is illustrated by state-of-the-art of Yb-based lasers. The latter offers a superior power-scaling, it can be operated in different operational modes, such as emitting from CW regime to 100 fs pulses with repetition rate from kHz to GHz repetition rate. Achieving sub-100 fs remains a challenging task despite the implementation of ingenious schemes to overpass this limitation [1]. In turn, this limits their impact in some of the emerging industrial applications where processing of some materials such as dielectric or semiconductor require 10-100 µJ level pulses with pulse-width below 300 fs. Here, we exploit the engineerable dispersion, the broadband transmission and high energy handling of Inhibted-Coupling guiding hollow-core photonic crystal fiber (IC-HCPCF) to propose a USP compression platform coined FastLas, which operates on energy range between few microjoules to hundred microjoules and efficient for a wide variety of wavelengths

    Biochemical and immunological characterization of p190-calmodulin complex from vertebrate brain: a novel calmodulin-binding myosin

    No full text
    Abstract. We have recently identified a novel 190-kD calmodulin-binding protein (p190) associated with the actinobased cytoskeleton from mammalian brain (Larson

    A Lower Serum Antioxidant Capacity as a Distinctive Feature for Women with HER2+ Breast Cancer: A Preliminary Study

    No full text
    The overexpression of HER2 in breast cancer (BC) can contribute to redox imbalance, which is related to damage and structural modification in many biomolecules. To the best of our knowledge, this is the first study that has investigated the infrared spectrum wavenumbers obtained by ATR-FTIR and their relationship with the levels of redox status markers such as reduced glutathione, superoxide dismutase (SOD), catalase, Ferric Reducing Antioxidant Power (FRAP), and protein carbonyl among women with HER2+ BC, HER2&minus; BC, and benign breast disease (BBD). The study was conducted with 25 women, 17 of whom were diagnosed with BC (6 HER2+ and 11 HER2&minus;) and 8 with BBD. Our results indicate HER2+ BC cases could be distinguished from HER2&minus; BC and BBD cases by their serum&rsquo;s antioxidant capacity [HER2+ BC vs. HER2&minus; BC (AUC = 0.818; specificity = 81.82%; sensitivity = 66.67%); HER2+ BC vs. BBD (AUC = 0.875; specificity = 75%; sensitivity = 83.33%)]. The changes in biochemical terms that occur in serum as a result of the scarcity of antioxidants are related to a peculiar fingerprint in the infrared spectrum obtained by ATR-FTIR. In the serum of women with BBD, the SOD enzyme level is the highest, and this characteristic allowed us to distinguish them from HER2&minus; BC. Finally, data regarding the serological antioxidant capacity of FRAP and the infrared spectrum by ATR-FTIR will allow us to assess biochemical changes that occur before clinical signs, indicating whether changes in therapy or interventions are necessary

    Impact of summer season on pre-hospital time delays in women and men undergoing primary percutaneous coronary intervention

    Full text link
    BACKGROUND Pre-hospital delays have been associated with poor outcomes in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). It is currently unknown how environmental variables affect treatment delays in these patients. METHODS AND RESULTS The association between environmental variables, time to treatment including transportation times and adverse in-hospital events was assessed in 1828 consecutive patients with STEMI undergoing primary PCI between 2010 and 2014 in the Montreal metropolitan area. Median[Q1;Q3] total ischemia time was significantly longer during summer season (April-September) as compared to winter season (October-March, 201[140;305] min vs 187[126;266] min, p = 0.022). This difference between seasons was due to a significant increase in median decision time to seek treatment for symptoms during summer (90[46;185] min vs 78[40;156], p = 0.004). The former peaked during July and August and was most pronounced in men. Hence, outside temperature and summer season were identified as strong predictors of prolonged decision time in patients with STEMI (p < 0.001 and p = 0.002, respectively). Transportation times slightly increased during winter season and snow fall, this difference, however, was not significant (p = 0.46). A significant increase in in-hospital adverse outcomes following primary PCI was observed during summer season as compared to winter season (7.2% vs 4.8%, p = 0.032). Accordingly, multivariate logistic regression models adjusted for baseline variables identified summer season as a strong predictor of periprocedural adverse events (OR 1.83, 95% CI 1.2-3.11, p = 0.037). CONCLUSION Contrary to our initial hypothesis, pre-hospital delays in patients with STEMI are considerably longer and associated with adverse in-hospital outcomes during summer season. Considering the consequences of global warming, it is imperative that educational efforts targeting patients' perception are implemented to counter treatment delays

    Análise de limiar anaeróbica no exercício resistido com cargas crescentes em atleta portador de poliomielite, suplementado com creatina e maltodextrina

    No full text
    Avaliar a cinética da lactatemia no exercício supino reto em portadores de poliomielite suplementados com creatina. Oito voluntários do gênero masculino com 37±7 anos e 67±6,8 Kg aparentemente saudáveis passaram por duas fases de testes: a) medição da carga máxima (CM); e teste de cargas crescentes no supino reto iniciando a 10% da CM com incremento de 10% a cada estágio b) repetição dos procedimentos da primeira fase após a suplementação. O tempo para cada estágio foi de 45 segundos, com 2 minutos de descanso. No período de descanso coletou-se o sangue. Os voluntários foram divididos em grupos (n=4), grupo suplementados com creatina + maltodextrina (GMC) e grupo suplementado com maltodextrina (GM). A dosagem de creatina foi 0,3 g/kg-1 de peso corporal. O limiar de lactato se manteve em 30% da CM depois da suplementação. Não houve diferença entre as concentrações de lactato no teste antes e após a suplementação no grupo GM (p=0.031 e r=0.99), e no grupo GMC (p=0.0045 e r=0.99). O limiar de lactato dos dois grupos após a suplementação não foram diferentes entre eles (p=0.031 e r=0.99). Entretanto observou-se que a suplementação para o grupo GMC aumentou 8,70% da CM (p< 0,05) e um estagio a mais. A cinética do lactato foi semelhante entre os dois grupos. Os resultados demonstram aumento de ganho de força e resistência, mas sem alteração no limiar de lactato pela suplementação de creatina e maltodextrina. (*) O presente trabalho atende às �Normas de Realização de Pesquisa em Seres Humanos�, Resolução n.º 196/196 do Conselho Nacional de Saúde. de 10/10/96 (BRASIL, 1996), tendo sido submetido e aprovado pelo Comitê de Ética em Pesquisa Envolvendo Seres Humanos, da Universidade Federal de Uberlândia, parecer n.º 009/2003
    • …
    corecore