Toward the total synthesis of spirastrellolide A. Part 3: Intelligence gathering and preparation of a ring-expanded analogue

Different methods for the formation of the C.25–C.26 bond of spirastrellolide A (1) are evaluated that might qualify for the end game of the projected total synthesis, with emphasis on metathetic ways to forge the macrocyclic frame

Sistema de produção do milho safrinha em Mato Grosso do Sul.

bitstream/item/65388/1/29901.pdfOrganizado por Gessi Ceccon e Luiz Alberto Staut; Palestra

Manejo de espécies forrageiras em consórcio com milho safrinha.

O propósito deste documento é fornecer algumas informações sobre o cultivo consorciado de milho com espécies forrageiras dos gêneros Urochloa e Panicum, de forma a proporcionar maiores subsídios na tomada de decisão quanto à adoção deste sistema visando a sustentabilidade de sistemas produtivos de grãos e de carne/leite, pela utilização do componente forrageiro em duplo propósito para fornecer forragem no período de maior escassez de alimento e, ainda, viabilizar o SPD pelo resíduo depositado na superfície do solo.Editado por: Germani Concenço, Gessi Ceccon

Manejo de espécies forrageiras em consórcio com milho safrinha.

O propósito deste documento é fornecer algumas informações sobre o cultivo consorciado de milho com espécies forrageiras dos gêneros Urochloa e Panicum, de forma a proporcionar maiores subsídios na tomada de decisão quanto à adoção deste sistema visando a sustentabilidade de sistemas produtivos de grãos e de carne/leite, pela utilização do componente forrageiro em duplo propósito para fornecer forragem no período de maior escassez de alimento e, ainda, viabilizar o SPD pelo resíduo depositado na superfície do solo.Editado por: Germani Concenço, Gessi Ceccon

Normative data for optic disc vertical cup-to-disc ratio and intraocular pressure in London 2012 competitors and support teams

Background / Aims The aims of this study were to identify normative values in vertical cup-to-disc ratio (CDR) and intraocular pressure (IOP) measurements in a unique sample of competitors and non-competitors at London 2012 according to continents and geographical sub-regions and find a suitable tool for mapping results across the world. Methods Data from all patients seen in the eye clinic for the London 2012 Olympic and Paralympic Games were used in this study. Patients were categorized into countries using the United Nations Geographical Sub-regions classification. All patients underwent a full optometric eye examination and clinical details including cup-to-disc ratio were recorded. Intraocular pressures were also recorded via non contact methods using the Topcon TRK-1P. Data was analyzed using R statistical software and SPSS. Continent and sub-continent level choropleth maps were produced using GGPlot2 package. Results Our study used a sample of 2,077 patients for analysis. The mean age across all the continents ranged from 43.44 years in the Americas to 47.11 years in Europe with an overall mean age of 45.12 (SD = 13.62 years). A CDR was recorded in 1,566 right eyes (OD). A Games-Howell post-hoc test revealed that Africa had statistically significantly larger CDRs (0.34 +/- 0.16) than both Europe (0.29 +/- 0.12, p = 0.00) and Asia (0.31, 0.15, p = 0.04) in this unique sample. In addition, within geographical sub-regions, Western Africa had statistically larger CDRs (0.36 +/- 0.18) than Western Asia (0.27 +/- 0.14, p = 0.02), Eastern Europe (0.29 +/- 0.12, p = 0.01) and Northern Europe (0.29 +/- 0.13, p = 0.03). A total of 1,621 IOP measurements were recorded for the right eye (OD). A Tukey post-hoc test revealed that Oceania had statistically lower IOPs (15.45 +/- 2.57) than Europe (16.93 +/- 2.98, p = 0.01), Asia (16.95 +/- 2.80, p = 0.01), the Americas (16.53 +/- 2.73, p = 0.02) and Africa (16.41 +/- 3.17, p = 0.05).Within geographical sub-regions, Northern Africa had statistically significantly lower IOPs (15.85 +/- 2.92) than Western Africa (17.18 +/- 2.97, p = 0.02), Western Asia (17.58 +/- 2.83, p = 0.04) and Eastern Europe (17.10 +/- 3.06, p = 0.02). Finally, our study found that competitors had significantly smaller CDRs (U = 66583.50, p = 0.01).and lower IOPs than noncompetitors (U = 79544.50, p = 0.01). Conclusions This is the first study to map out cup-to-disc ratio and intraocular pressure in a unique sample of competitors and non-competitors at London 2012 by continent and geographical sub-regions. The authors hope that this data may have benefits globally and that data from future Olympic and Paralympic Games can be added to this information to produce larger, more comprehensive data sets in the future

Integração lavoura-pecuária-floresta. 1. Estruturação dos sistemas de integração lavoura-pecuária.

Sistemas de Produção; Sistemas de integração lavoura-pecuária; Pastagens anuais em sucessão às culturas de verão; Rotação de pastagem em áreas de lavoura; Rotação de culturas anuais em áreas de pastagens; ILP com rotação parcial de lavoura ou pecuária; ILP na agricultura familiar; Sistema integrado de produção; Investimentos necessários: estruturais, animais, adequações do solo , cercas, aguadas, máquinas e equipamentos, unidade de manejo, identificação dos animais,necessidade de pessoal e conhecimento; Oportunidades proporcionadas pela iLP; Da pecuária para a lavoura; Da lavoura para a pecuária; Consequência da interação entre ambas, Para o produtor.bitstream/item/58600/1/DOC2011110.pd

High performance liquid chromatographic determination of 2-furaldehyde and 5-hydroxymethyl-2-furaldehyde in processes citrus juices

The occurrence of 2-furaldehyde (F) and 5-hydroxymethyl-2-furaldehyde (HMF) in processed citrus juices is an indication of quality deterioration. A close relationship between flavor changes and F content exists, while HMF can give rise to browning reactions. Both F and HMF are formed during heat processing or storage at improper temperatures. The detection of these compounds becomes more and more important as aseptic processing and packaging of citrus juices are becoming widespread. Aseptic packaging allows higher temperatures during distribution and storage to be employed without microbial spoilage, but off-flavors develop as citrus products are exposed to these conditions. In this paper a method of determination by high performance liquid chromatography (HPLC) is described. The method is based on the formation of the 2,4-dinitrophenylhydrazones of carbonyl compounds and subsequent reversed-phase separation of these derivatives. Derivatization is carried out by utilizing an acidic solution of 2,4-dinitrophenylhydrazine in acetonitrile. Precipitation of the derivatives of carbonyl compounds is thus avoided, and direct injection of the sample into the HPLC system is allowed. The determination offers a high specificity and a detection limit of the order of 10-8 mol/l for both analytes. Recoveries from an orange juice spiked at different levels are quantitative. Reproducibility data are presented