Flow of the Coarse Grained Free Energy for Crossover Phenomena

The critical behaviour of a system of two coupled scalar fields in three dimensions is studied within the formalism of the effective average action. The fixed points of the system are identified and the crossover between them is described in detail. Besides the universal critical behaviour, the flow of the coarse grained free energy also describes the approach to scaling.Comment: 18 pages, latex, 4 figures appended as uuencoded fil

An Analysis of Verbal Abuse Directed at Certified Registered Nurse Anesthetists

The concept of a healthy workplace environment is one that does not tolerate verbal abusiveness. Recent literature indicates that verbally abusive behavior may cause increased levels of stress, increased probability of errors, and feelings of frustration and powerlessness. Roy\u27s Adaptation Model was used as the conceptual framework. There is a lack of research looking at incidence, frequency, and the impact of verbal abuse with respect to the CRNA (Certified Registered Nurse Anesthetist) population. One hundred seventy eight CRNA\u27s from an upper Midwestern state in the United States that were mailed questionnaires, 115 were returned and statistically analyzed for this study. The analysis of the data included frequency distributions and Chi-Square test for independence. Eighty-seven (76%) CRNA\u27s reported experiencing some form of verbal abuse in the past six months of their practice and 67 (77%) respondants reported physician was the most common perpetrator. Over half of the CRNA\u27s who indicated an experience of verbal abuse in the past six months did not officially report any episodes. There was no significant correlation between demographic variables and the reporting of verbal abuse. The study concludes with recommendations for nursing practice, education, and further research

Risk attribution of Campylobacter infection by age group using exposure modelling

Knowledge on the relative importance of alternative sources of human campylobacteriosis is important in order to implement effective disease prevention measures. The objective of this study was to assess the relative importance of three key exposure pathways (travelling abroad, poultry meat, pet contact) for different patient age groups in Switzerland. With a stochastic exposure model data on Campylobacter incidence for the years 2002-2007 were linked with data for the three exposure pathways and the results of a case-control study. Mean values for the population attributable fractions (PAF) over all age groups and years were 27% (95% CI 17-39) for poultry consumption, 27% (95% CI 22-32) for travelling abroad, 8% (95% CI 6-9) for pet contact and 39% (95% CI 25-50) for other risk factors. This model provided robust results when using data available for Switzerland, but the uncertainties remained high. The output of the model could be improved if more accurate input data are available to estimate the infection rate per exposure. In particular, the relatively high proportion of cases attributed to ‘other risk factors' requires further attentio

f-scLVM: scalable and versatile factor analysis for single-cell RNA-seq.

Single-cell RNA-sequencing (scRNA-seq) allows studying heterogeneity in gene expression in large cell populations. Such heterogeneity can arise due to technical or biological factors, making decomposing sources of variation difficult. We here describe f-scLVM (factorial single-cell latent variable model), a method based on factor analysis that uses pathway annotations to guide the inference of interpretable factors underpinning the heterogeneity. Our model jointly estimates the relevance of individual factors, refines gene set annotations, and infers factors without annotation. In applications to multiple scRNA-seq datasets, we find that f-scLVM robustly decomposes scRNA-seq datasets into interpretable components, thereby facilitating the identification of novel subpopulations

Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements

Multivitamin/multimineral complexes are the most common dietary supplements. Unlike minerals in foods that are incorporated in bioorganic structures, minerals in dietary supplements are typically in an inorganic form. These minerals can catalyze the generation of free radicals, thereby oxidizing antioxidants during digestion. Here we examine the ability of a matrix consisting of an amino acid and non-digestible oligosaccharide (AAOS) to blunt metal-catalyzed oxidations. Monitoring of ascorbate radical generated by copper shows that ascorbate is oxidized more slowly with the AAOS matrix than with copper sulfate. Measurement of the rate of oxidation of ascorbic acid and Trolox® by catalytic metals confirmed the ability of AAOS to slow these oxidations. Similar results were observed with iron-catalyzed formation of hydroxyl radicals. When compared to traditional forms of minerals used in supplements, we conclude that the oxidative loss of antioxidants in solution at physiological pH is much slower when AAOS is present