Bhasin, M

Blake, P

Buettner, C

Burstein, R

Perry, C

The Journal of Headache and Pain

Harvard University - DASH 

 EHMTI-0354. Abnormal expression of gene transcripts linked toinflammatory response in the periosteum of chronic migrainepatients: implications to extracranial origin of headache  (Article begins on next page)The Harvard community has made this article openly available.Please share how this access benefits you. Your story matters.Citation Burstein, R, C Perry, P Blake, C Buettner, and M Bhasin. 2014.“EHMTI-0354. Abnormal expression of gene transcripts linkedto inflammatory response in the periosteum of chronic migrainepatients: implications to extracranial origin of headache.” TheJournal of Headache and Pain 15 (Suppl 1): K2.doi:10.1186/1129-2377-15-S1-K2.http://dx.doi.org/10.1186/1129-2377-15-S1-K2.Published Version doi:10.1186/1129-2377-15-S1-K2Accessed February 17, 2015 3:18:20 AM ESTCitable Link http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347501Terms of Use This article was downloaded from Harvard University's DASHrepository, and is made available under the terms and conditionsapplicable to Other Posted Material, as set forth athttp://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAAMEETING ABSTRACT Open AccessEHMTI-0354. Abnormal expression of genetranscripts linked to inflammatory response inthe periosteum of chronic migraine patients:implications to extracranial origin of headacheR Burstein1*, C Perry2, P Blake3, C Buettner4, M Bhasin5From 4th European Headache and Migraine Trust International Congress: EHMTIC 2014Copenhagen, Denmark. 18-21 September 2014IntroductionProgress in headache research suggests that migrainepathophysiology involves inherited abnormal brain func-tions and that the initiation of headache depends on flowof nociceptive signals that originate in pain-sensitive intra-and extra-cranial organs conveyed through peripheralnociceptors to central trigeminovascular neurons. Despitethis progress, little is known about the identity of the painfibers that mediate the initiation phase, or what activatesthem.AimsTo assess the extent of presence of inflammatory mole-cules in periosteum tissues that were taken from calvar-ial areas where the head hurts.MethodsWe compared number of copies of gene transcripts(mRNA) that encode proteins that play known roles ininflammatory and immune responses and number ofcopies of molecules that regulate the expression of thosegenes (miRNA) in periosteum tissues of 27 chronicmigraine (CM) patients and 17 control subjects.Results36/524 mRNAs and 27/726 miRNAs were differentiallyexpressed in the periosteum of CM patients compared tocontrol subjects. Of these, 25 genes were up-regulated (allencode proteins that facilitate inflammation) whereas11 were down-regulated (all encode proteins that suppressinflammation). Of the 27 post-transcripts, expression waslow for 11 (all regulate expression of pro-inflammatorygenes) and high for 16 (all regulate expression of anti-inflammatory genes) miRNA sequences.ConclusionThe findings suggest that the molecular environment inwhich periosteal pain fibers exist contain abnormal expres-sion of genes that promote inflammation; a condition thatis likely to lower their activation threshold, when symp-toms appear at the onset of an attack, or activate themchronically.Authors’ details1Anesthesia, Harvard Medical School, Boston, USA.2Surgery, MemorialHermann Northwest Hospital, Houston, USA.3Neurology, Memorial HermannNorthwest Hospital, Houston, USA.4Medicine, Harvard Medical School,Boston, USA.5Genomics Proteomics and Bioinformatics, Harvard MedicalSchool, Boston, USA.Published: 18 September 2014doi:10.1186/1129-2377-15-S1-K2Cite this article as: Burstein et al.: EHMTI-0354. Abnormal expression ofgene transcripts linked to inflammatory response in the periosteum ofchronic migraine patients: implications to extracranial origin ofheadache. The Journal of Headache and Pain 2014 15(Suppl 1):K2.1Anesthesia, Harvard Medical School, Boston, USAFull list of author information is available at the end of the articleBurstein et al. The Journal of Headache and Pain 2014, 15(Suppl 1):K2http://www.thejournalofheadacheandpain.com/content/15/S1/K2© 2014 Burstein et al; licensee Springer. This is an Open Access article distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction inany medium, provided the original work is properly cited.

EHMTI-0354. Abnormal expression of gene transcripts linked to inflammatory response in the periosteum of chronic migraine patients: implications to extracranial origin of headache

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EHMTI-0354. Abnormal expression of gene transcripts linked to inflammatory response in the periosteum of chronic migraine patients: implications to extracranial origin of headache

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