5,276 research outputs found

    Effects of staggered fermions and mixed actions on the scalar correlator

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    We provide the analytic predictions for the flavor non-singlet scalar correlator, which will enable determination of the scalar meson mass from the lattice scalar correlator. We consider simulations with 2+1 staggered sea quarks and staggered or chiral valence quarks. At small u/d masses the correlator is dominated by the bubble contribution, which is the intermediate state with two pseudoscalar mesons. We determine the bubble contribution within Staggered and Mixed Chiral Perturbation Theory. Its effective mass is smaller than the mass M_pi+M_eta, which is the lightest intermediate state in proper 2+1 QCD. The unphysical effective mass is a consequence of the taste breaking that makes possible the intermediate state with mass 2*M_pi. We find that the scalar correlator can be negative in the simulations with mixed quark actions if the sea and valence quark masses are tuned by matching the pion masses M_{val,val}=M_{pi_5}.Comment: 16 pages, 7 figure

    Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria

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    Background:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g. nontypeable Haemophilus influenzae [NTHi]) infection. However, the mechanisms underlying bacterial infections during AECOPD remain poorly understood. As neutrophilic inflammation including increased release of human neutrophil elastase (HNE) is a salient feature of AECOPD, we hypothesized that HNE impairs airway epithelial defense against NTHi by degrading airway epithelial host defense proteins such as short palate, lung, and nasal epithelium clone 1 (SPLUNC1).Methodology/Main Results:Recombinant human SPLUNC1 protein was incubated with HNE to confirm SPLUNC1 degradation by HNE. To determine if HNE-mediated impairment of host defense against NTHi was SPLUNC1-dependent, SPLUNC1 protein was added to HNE-treated primary normal human airway epithelial cells. The in vivo function of SPLUNC1 in NTHi defense was investigated by infecting SPLUNC1 knockout and wild-type mice intranasally with NTHi. We found that: (1) HNE directly increased NTHi load in human airway epithelial cells; (2) HNE degraded human SPLUNC1 protein; (3) Recombinant SPLUNC1 protein reduced NTHi levels in HNE-treated human airway epithelial cells; (4) NTHi levels in lungs of SPLUNC1 knockout mice were increased compared to wild-type mice; and (5) SPLUNC1 was reduced in lungs of COPD patients.Conclusions:Our findings suggest that SPLUNC1 degradation by neutrophil elastase may increase airway susceptibility to bacterial infections. SPLUNC1 therapy likely attenuates bacterial infections during AECOPD. © 2013 Jiang et al

    Arbitrary Waveform Generator for Quantum Information Processing with Trapped Ions

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    Atomic ions confined in multi-electrode traps have been proposed as a basis for scalable quantum information processing. This scheme involves transporting ions between spatially distinct locations by use of time-varying electric potentials combined with laser or microwave pulses for quantum logic in specific locations. We report the development of a fast multi-channel arbitrary waveform generator for applying the time-varying electric potentials used for transport and for shaping quantum logic pulses. The generator is based on a field-programmable gate array controlled ensemble of 16-bit digital-to-analog converters with an update frequency of 50 MHz and an output range of ±\pm10 V. The update rate of the waveform generator is much faster than relevant motional frequencies of the confined ions in our experiments, allowing diabatic control of the ion motion. Numerous pre-loaded sets of time-varying voltages can be selected with 40 ns latency conditioned on real-time signals. Here we describe the device and demonstrate some of its uses in ion-based quantum information experiments, including speed-up of ion transport and the shaping of laser and microwave pulses

    Electronic coupling between Bi nanolines and the Si(001) substrate: An experimental and theoretical study

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    Atomic nanolines are one dimensional systems realized by assembling many atoms on a substrate into long arrays. The electronic properties of the nanolines depend on those of the substrate. Here, we demonstrate that to fully understand the electronic properties of Bi nanolines on clean Si(001) several different contributions must be accounted for. Scanning tunneling microscopy reveals a variety of different patterns along the nanolines as the imaging bias is varied. We observe an electronic phase shift of the Bi dimers, associated with imaging atomic p-orbitals, and an electronic coupling between the Bi nanoline and neighbouring Si dimers, which influences the appearance of both. Understanding the interplay between the Bi nanolines and Si substrate could open a novel route to modifying the electronic properties of the nanolines.Comment: 6 pages (main), 2 pages (SI), accepted by Phys. Rev.

    I=2 pi-pi Scattering from Fully-Dynamical Mixed-Action Lattice QCD

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    We compute the I=2 pi-pi scattering length at pion masses of m_pi ~ 294, 348 and 484 MeV in fully-dynamical lattice QCD using Luscher's finite-volume method. The calculation is performed with domain-wall valence-quark propagators on asqtad-improved MILC configurations with staggered sea quarks at a single lattice spacing, b ~ 0.125 fm. Chiral perturbation theory is used to perform the extrapolation of the scattering length from lattice quark masses down to the physical value, and we find m_pi a_2 = -0.0426 +- 0.0006 +- 0.0003 +- 0.0018, in good agreement with experiment. The I=2 pi-pi scattering phase shift is calculated to be delta = -43 +- 10 +- 5 degrees at |p| ~ 544 MeV for m_pi ~ 484 MeV.Comment: 16 pages, 4 figure

    Chaotic sources and Percolation of strings

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    It is shown that different ways of interacting strings formed in high energy nucleus-nucleus collisions cause a different strength of the chaoticity parameter lambda of Bose-Einstein correlations. In particular, in the case of percolation of strings, lambda shows a peculiar dependence on the string density, very similar to the dependence of the fractional average cluster size. In both, the derivative on the string density is maximum at the critical point. The reasonable agreement with the existing experimental data indicates that percolation of strings can actually occurs.Comment: 11 pages, LaTeX, 3 eps figure

    Local Real-Space View of the Achiral 1TT-TiSe2_2 2 ×\times 2 ×\times 2 Charge Density Wave

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    The transition metal dichalcogenide 1TT-TiSe2_2 is a quasi-two-dimensional layered material undergoing a commensurate 2 ×\times 2 ×\times 2 charge density wave (CDW) transition with a weak periodic lattice distortion (PLD) below \approx 200 K. Scanning tunneling microscopy (STM) combined with intentionally introduced interstitial Ti atoms allows to go beyond the usual spatial resolution of STM and to intimately probe the three-dimensional character of the PLD. Furthermore, the inversion-symmetric, achiral nature of the CDW in the zz-direction is revealed, contradicting the claimed existence of helical CDW stacking and associated chiral order. This study paves the way to a simultaneous real-space probing of both charge and structural reconstructions in CDW compounds.Comment: 5 pages, 4 figure
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