Health surveillance and geography: Theoretical and methodological potential

Objectives: To contribute to constructing recognition methodologies in the field by means of secondary data on objects and their forms, namely conditions of action and means of existence of human endeavor; to contribute to health surveillance through the incorporation of particular geographic characteristics; to relate concepts and categories of the territorialization process of health surveillance practices

The convergence of radiation and immunogenic cell death signaling pathways.

Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms, including apoptosis, necrosis, mitotic catastrophe (MC), autophagy, and senescence, which may occur concurrently. When considering tumor cell death in the context of an organism, an emerging body of evidence suggests there is a reciprocal relationship in which radiation stimulates the immune system, which in turn contributes to tumor cell kill. As a result, traditional measurements of radiation-induced tumor cell death, in vitro, fail to represent the extent of clinically observed responses, including reductions in loco-regional failure rates and improvements in metastases free and overall survival. Hence, understanding the immunological responses to the type of radiation-induced cell death is critical. In this review, the mechanisms of radiation-induced tumor cell death are described, with particular focus on immunogenic cell death (ICD). Strategies combining radiotherapy with specific chemotherapies or immunotherapies capable of inducing a repertoire of cancer specific immunogens might potentiate tumor control not only by enhancing cell kill but also through the induction of a successful anti-tumor vaccination that improves patient survival

Co-design of designers and artisans, valorisation and communication of the partnership - a reflection for sustainable fashion design

Inserted in this movement of ethical responsibility, valorization of culture, as well as the positive impact generated for society as we craved, this paper proposes to reflect on the partnership between designers and artisans in the development of the fashion product, considering that in most cases the role of the artisan in the works of co-design is perceived as secondary in relation to the designer. Therefore, the objective of this work is to promote the valorization of the artisan's work, in a meritocratic way, exposing the problem of co-authorship of design products and how these can be communicated in a transparent and fairway. For this, the methodology of the case study was used to present examples of co-design partnerships in the creation of design products, in which the artisan has the same protagonism of the designer in the co-authorship of the product. The fashion designer in a similar way should consider developing collections that are committed to the environment and to social development, contributing to better promotion of social responsibility and the valorization of local communities.This work is supported by FEDER funds through the Competitivity Factors Operational Programme - COMPETE and by national funds through FCT – Foundation for Science and Technology within the scope of the project POCI-01-0145-FEDER-007136. The first author would also like to gratefully acknowledge the support from the Federal University of Technology, especially, the Fashion Design Department and the Office of Research and Graduate Studies

Expressão dos genes nodC, nodW e nopP em Bradyrhizobium japonicum estirpe CPAC 15 avaliada por RT-qPCR.

Resumo O objetivo deste trabalho foi avaliar a expressão, por RT-qPCR, dos genes de nodulação nodC e nodW e do gene nopP da estirpe CPAC 15, que provavelmente atuam na infecção das raízes da soja. Foram realizados dois experimentos. No primeiro, a expressão dos genes foi avaliada nas células após a incubação com genisteína por 15 min, 1, 4 e 8 horas. Os resultados revelaram que os três genes apresentaram maior expressão imediatamente após o contato com o indutor (15 min). No segundo experimento, a bactéria foi cultivada na presença de indutores (genisteína ou exsudatos de sementes de soja) por 48 horas. A expressão dos três genes foi maior na presença de genisteína, com valores de expressão para nodC, nodW e nopP superiores ao controle. Os resultados obtidos confirmam a funcionalidade dos três genes na estirpe CPAC 15, com ênfase para o nopP, cuja funcionalidade em Bradyrhizobium japonicum foi descrita pela primeira vez. Termos para indexação: Glycine max, flavonoides, genes de nodulação, sistema de secreção tipo III

The Dynamics of the Innovation System for Functional Foods in South Brazil

 This study aims at identifying the dynamics of the innovation system for functional foods (FF) in Rio Grande do Sul, Brazil. Functional food is any healthy food claimed to have a health-promoting or disease-preventing property beyond the basic function of supplying nutrients. Health has been named as the most significant trend and innovation driver in the global food and drinks market. Brazil is one of the leading countries in food production and consumption, and the market for functional foods have been growing 10% per year, three times more than the market for conventional foods. Although this food category is considered mature in some developed markets (such as in Japan, in the Nordic countries and in the U.S), it is still unknown for many consumers, especially those located in developing countries. On the other hand, functional foods has been attracting the attention of multinationals and local food industries, since innovation can significantly impact on their competitive advantages. Therefore, in this study, first we are going to investigate consumers’ motivations, attitudes and intention to buy functional foods, since the market demands a better understanding of this trend. A survey with 450 consumers was conducted and provided quantitative insights. Secondly, we identified the availability of functional food products in the local retail market, through observation techniques. Our aim was to confront consumers’ needs with local food companies’ market supply. In a further stage, we are going to analyse the functioning of this innovation system, describing the agents involved in this context and their relations through in-depth interviews with local representatives (stakeholders). Innovation system is here understood as the set of distinct institutions which jointly and individually contribute to the development and diffusion of new technologies and which provides the framework within which governments form and implement policies to influence the innovation process. As such "it is a system of interconnected institutions to create, store and transfer the knowledge, skills and artefacts which define new technologies." (Metcalfe, 1995). Hence, we are investigating issues such as: Are local food companies ready to innovate in such a competitive and dynamic scenario? How can this system respond to consumers’ demands? Are there conditions for an innovative food network in South Brazil? Our contributions help to shed light into these questions. Preliminary results indicate that the innovation system for functional foods in Rio Grande do Sul is incipient, but it is developing fast. Stronger governance and co-ordination strategies are needed. There are few local functional food products in the market, but those are attractive to consumers and indicate promising opportunities. The survey shows that interviewed consumers presented positive attitudes towards functional foods and enough purchasing power to buy it. Nutritionists and other health professionals have high credibility and could help inform consumers about the benefits of particular categories of functional foods. Food industry itself is not regarded as the most trustworthy source. Finally, this study shows that the understanding of Brazilian consumers is fundamental to help food companies define their strategies. To map the most accepted categories of functional foods is also important, aiming to avoid the "tentative and error" approach

Carbon footprint in different beef production systems on a southern Brazilian farm: a case study.

The carbon footprint (CF) of beef production is one of the most widely discussed environmental issues within the current agricultural community due to its association with climate change. Because of these relevant and serious concerns, the beef cattle industry is under increasing pressure to reduce production or implement technological changes with significant consequences in terms of beef marketing. The goals of this study were to evaluate the CF per 1 kg of live weight gain (LWG) at the farm gate for different beef production systems in the southern part of Brazil. Aberdeen Angus beef-bred cattle were assigned to one of seven categories: natural grass; improved natural grass; natural grass plus ryegrass; improved natural grass plus sorghum; cultivated ryegrass and sorghum; natural grass supplemented with protein mineralised salt; and natural grass supplemented with protein-energetic mineralised salt. Monte Carlo analysis was employed to analyse the effect of variations of dry matter intake digestibility (DMID), total digestible nutrients (TDN) and crude protein (CP) parameters in methane (CH4) enteric, CH4 manure, nitrous oxide (N2O) manure and N2O N-fertiliser. The method used was a comparative life cycle assessment (LCA) centred on the CF. The CF varied from 18.3 kg CO2 equivalent/kg LWG for the ryegrass and sorghum pasture system to 42.6 kg CO2 equivalent/kg LWG for the natural grass system, including the contributions of cows, calves and steers. Among all grassland-based cattle farms, production systems with DMID from 52 to 59% achieved the lowest CO2 emissions and the highest feed conversion rate, thereby generating lower CH4 and N2O emissions per production system. Because the feed intake and feed conversion rate are one of the most important production parameters in beef cattle production with an obvious risk of data uncertainty, accurate feed data, which include quantity and quality, are important in estimates of CF for LWG. The choice of adequate feeding strategies to mitigate greenhouse gas (GHG) emissions may result in better environmental advantages

Genomic and evolutionary comparisons of diazotrophic and pathogenic bacteria of the order Rhizobiales

<p>Abstract</p> <p>Background</p> <p>Species belonging to the Rhizobiales are intriguing and extensively researched for including both bacteria with the ability to fix nitrogen when in symbiosis with leguminous plants and pathogenic bacteria to animals and plants. Similarities between the strategies adopted by pathogenic and symbiotic Rhizobiales have been described, as well as high variability related to events of horizontal gene transfer. Although it is well known that chromosomal rearrangements, mutations and horizontal gene transfer influence the dynamics of bacterial genomes, in Rhizobiales, the scenario that determine pathogenic or symbiotic lifestyle are not clear and there are very few studies of comparative genomic between these classes of prokaryotic microorganisms trying to delineate the evolutionary characterization of symbiosis and pathogenesis.</p> <p>Results</p> <p>Non-symbiotic nitrogen-fixing bacteria and bacteria involved in bioremediation closer to symbionts and pathogens in study may assist in the origin and ancestry genes and the gene flow occurring in Rhizobiales. The genomic comparisons of 19 species of Rhizobiales, including nitrogen-fixing, bioremediators and pathogens resulted in 33 common clusters to biological nitrogen fixation and pathogenesis, 15 clusters exclusive to all nitrogen-fixing bacteria and bacteria involved in bioremediation, 13 clusters found in only some nitrogen-fixing and bioremediation bacteria, 01 cluster exclusive to some symbionts, and 01 cluster found only in some pathogens analyzed. In BBH performed to all strains studied, 77 common genes were obtained, 17 of which were related to biological nitrogen fixation and pathogenesis. Phylogenetic reconstructions for Fix, Nif, Nod, Vir, and Trb showed possible horizontal gene transfer events, grouping species of different phenotypes.</p> <p>Conclusions</p> <p>The presence of symbiotic and virulence genes in both pathogens and symbionts does not seem to be the only determinant factor for lifestyle evolution in these microorganisms, although they may act in common stages of host infection. The phylogenetic analysis for many distinct operons involved in these processes emphasizes the relevance of horizontal gene transfer events in the symbiotic and pathogenic similarity.</p

Urbanizaçâo, impactos ambientais e governança no complexo regional Centro-Sul

A palavra governança vem servindo para designar diferentes formas de governar, particularmente aquelas mais sensíveis às demandas da população e que estimulem a inserção dos movimentos sociais nos processos decisórios. No Brasil, “governança ambiental” é usado, em geral, para se referir a processos de exercício de poder que, na área do meio ambiente, estejam ampliando os espaços de participação dos diversos segmentos da sociedade civil organizada. Este artigo analisa aspectos da governança ambiental no contexto do complexo regional Centro-Sul a partir dos resultados obtidos em pesquisa do Instituto Brasileiro de Geografia e Estatística (IBGE). Examinou-se a relação porventura existente entre os problemas ambientais detectados e as medidas que, em nível local, vinham sendo tomadas pelo gestor. O estudo considerou duas faixas diferenciadas de urbanização dos municípios do Centro-Sul e, como indicadores clássicos, o IDH e o PIB. O objetivo foi identificar diferenças com relação à inserção da participação popular na gestão ambiental, mediante a análise de algumas variáveis específicas, como participação em Comitês de bacia, existência e composição do Conselho Municipal de Meio Ambiente e do Fórum da Agenda 21 local.governança ambiental; impactos ambientais; urbanização; PIB; IDH