773 research outputs found
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Collisionless electron heating in inductively coupled discharges
A kinetic theory of collisionless electron heating is developed for inductively coupled discharges with a finite height L. The novel effect associated with the finite-length system is the resonance between the bounce motion of the electrons and the wave frequency, leading to enhanced heating. The theory is in agreement with results of particle simulations
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First-principles calculations and experimental studies of: XYZ 2 thermoelectric compounds: Detailed analysis of van der Waals interactions
First-principles calculations can accelerate the search for novel high-performance thermoelectric materials. However, the prediction of the thermoelectric properties is strongly dependent on the approximations used for the calculations. Here, thermoelectric properties were calculated with different computational approximations (i.e., PBE-GGA, HSE06, spin-orbit coupling and DFT-D3) for three layered XYZ2 compounds (TmAgTe2, YAgTe2, and YCuTe2). In addition to the computations, the structural, electrical and thermal properties of these compounds were measured experimentally and compared to the computations. An enhanced prediction of the crystal structure and heat capacity was achieved with the inclusion of van der Waals interactions due to more accurate modeling of the interatomic forces. In particular, a large shift of the acoustic phonons and low-frequency optical phonons to lower frequencies was observed from the dispersion-optimized structure. From the phonon dispersion curves of these compounds, the ultralow thermal conductivity in the investigated XYZ2 compounds could be described by a recent developed minimum thermal conductivity model. For the prediction of the electrical conductivity, a temperature-dependent relaxation time was used, and it was limited by acoustic phonons. While HSE06 has only a small influence on the electrical properties due to a computed band gap energy of >0.25 eV, the inclusion of both van der Waals interactions and spin-orbit coupling leads to a more accurate band structure, resulting in better prediction of electrical properties. Furthermore, the experimental thermoelectric properties of YAgTe2, TmAg0.95Zn0.05Te2 and TmAg0.95Mg0.05Te2 were measured, showing an increase in zT of TmAg0.95Zn0.05Te2 by more than 35% (zT = 0.47 ± 0.12) compared to TmAgTe2
Critical Behavior of a Three-State Potts Model on a Voronoi Lattice
We use the single-histogram technique to study the critical behavior of the
three-state Potts model on a (random) Voronoi-Delaunay lattice with size
ranging from 250 to 8000 sites. We consider the effect of an exponential decay
of the interactions with the distance,, with , and
observe that this system seems to have critical exponents and
which are different from the respective exponents of the three-state Potts
model on a regular square lattice. However, the ratio remains
essentially the same. We find numerical evidences (although not conclusive, due
to the small range of system size) that the specific heat on this random system
behaves as a power-law for and as a logarithmic divergence for
and Comment: 3 pages, 5 figure
Safety and clinical activity of atacicept in the long-term extension of the Phase IIb ADDRESS II study in systemic lupus erythematosus
Objectives:
Atacicept reduced SLE disease activity in the Phase IIb ADDRESS II study, particularly in patients with high disease activity (HDA; SLEDAI-2K ≥10) at screening. We assessed long-term safety and efficacy of atacicept in the long-term extension (LTE) of ADDRESS II.
Methods:
In the 24-week, randomised, double-blind, placebo-controlled ADDRESS II study, patients received weekly atacicept (75 or 150 mg) or placebo. Atacicept was continued at the same dose in atacicept-treated patients in the LTE; placebo-treated patients switched to atacicept 150 mg. Long-term safety was the primary end point. Secondary endpoints included SLE responder index (SRI)-4 and SRI-6 response rates and flares.
Results:
253 patients entered the ADDRESS II LTE; 88 received atacicept 150 mg, 82 atacicept 75 mg and 83 placebo/atacicept 150 mg. Median active treatment duration in the LTE was 83.8 weeks. Frequencies of treatment-emergent adverse events (TEAEs) were similar across groups (90.4–93.2%). 12.5%, 14.6% and 21.7% of patients in the atacicept 150 mg, atacicept 75 mg and placebo/atacicept 150 mg groups reported serious TEAEs during the treatment period. The proportions of patients with TEAEs leading to discontinuation were 5.7%, 4.9% and 10.8%, respectively. SRI-4 and SRI-6 response rates were maintained with atacicept in the modified intent-to-treat and HDA populations and those on continuous 150 mg had a reduced risk of first severe flare and longer time to first severe flare vs those who initially received placebo.
Conclusion:
Long-term treatment with atacicept 150 mg in SLE patients had an acceptable safety profile, with durable efficacy
The effect of polar lipids on tear film dynamics
In this paper we present a mathematical model describing the effect of polar lipids on the evolution of a precorneal tear film, with the aim of explaining the interesting experimentally observed phenomenon that the tear film continues to move upwards even after the upper eyelid has become stationary. The polar lipid is an insoluble surface species that locally alters the surface tension of the tear film. In the lubrication limit, the model reduces to two coupled nonlinear partial differential equations for the film thickness and the concentration of lipid. We solve the system numerically and observe that the presence of the lipid causes an increase in flow of liquid up the eye. We further exploit the size of the parameters in the problem to explain the initial evolution of the system
Mechanized Metatheory for the Masses: The \u3cb\u3ePOPLMARK\u3c/b\u3e Challenge
How close are we to a world where every paper on programming languages is accompanied by an electronic appendix with machinechecked proofs?
We propose an initial set of benchmarks for measuring progress in this area. Based on the metatheory of System F, a typed lambda-calculus with second-order polymorphism, subtyping, and records, these benchmarks embody many aspects of programming languages that are challenging to formalize: variable binding at both the term and type levels, syntactic forms with variable numbers of components (including binders), and proofs demanding complex induction principles. We hope that these benchmarks will help clarify the current state of the art, provide a basis for comparing competing technologies, and motivate further research
A survey of spectral models of gravity coupled to matter
This is a survey of the historical development of the Spectral Standard Model
and beyond, starting with the ground breaking paper of Alain Connes in 1988
where he observed that there is a link between Higgs fields and finite
noncommutative spaces. We present the important contributions that helped in
the search and identification of the noncommutative space that characterizes
the fine structure of space-time. The nature and properties of the
noncommutative space are arrived at by independent routes and show the
uniqueness of the Spectral Standard Model at low energies and the Pati-Salam
unification model at high energies.Comment: An appendix is added to include scalar potential analysis for a
Pati-Salam model. 58 Page
Meanings of epilepsy in its sociocultural context and implications for stigma: Findings from ethnographic studies in local communities in China and Vietnam
We investigated beliefs about the causes, course, and treatment of epilepsy and its impact on quality of life (QOL) in key target groups, using “mini-ethnographies” involving 141 in-depth interviews and 12 focus groups in China, and 84 in-depth interviews and 16 focus groups in Vietnam. Data were analyzed thematically, using a qualitative data analysis package. In both countries, beliefs about causes and triggers of epilepsy and seizures were a complex interweaving of Western, traditional, and folk medicine concepts. Epilepsy was understood to be chronic, not curable, but controllable, and was seen as enormously socially disruptive, with wide-ranging impact on QOL. Our findings suggest a more “embodied” and benign set of theories about epilepsy than in some other cultural contexts; nonetheless, people with epilepsy are still seen as having low social value and face social rejection. By exploring meanings attached to epilepsy in these two cultural contexts, we have clarified reasons behind previously documented negative attitudes and foci for future intervention studies
A Cordial Sync: Going Beyond Marginal Policies for Multi-Agent Embodied Tasks
Autonomous agents must learn to collaborate. It is not scalable to develop a
new centralized agent every time a task's difficulty outpaces a single agent's
abilities. While multi-agent collaboration research has flourished in
gridworld-like environments, relatively little work has considered visually
rich domains. Addressing this, we introduce the novel task FurnMove in which
agents work together to move a piece of furniture through a living room to a
goal. Unlike existing tasks, FurnMove requires agents to coordinate at every
timestep. We identify two challenges when training agents to complete FurnMove:
existing decentralized action sampling procedures do not permit expressive
joint action policies and, in tasks requiring close coordination, the number of
failed actions dominates successful actions. To confront these challenges we
introduce SYNC-policies (synchronize your actions coherently) and CORDIAL
(coordination loss). Using SYNC-policies and CORDIAL, our agents achieve a 58%
completion rate on FurnMove, an impressive absolute gain of 25 percentage
points over competitive decentralized baselines. Our dataset, code, and
pretrained models are available at https://unnat.github.io/cordial-sync .Comment: Accepted to ECCV 2020 (spotlight); Project page:
https://unnat.github.io/cordial-syn
Modulation of Sn concentration in ZnO nanorod array: intensification on the conductivity and humidity sensing properties
Tin (Sn)-doped zinc oxide (ZnO) nanorod arrays (TZO) were synthesized onto aluminum-doped ZnO-coated glass substrate via a facile sonicated sol–gel immersion method for humidity sensor applications. These nanorod arrays were grown at different Sn concentrations ranging from 0.6 to 3 at.%. X-ray diffraction patterns showed that the deposited TZO arrays exhibited a wurtzite structure. The stress/strain condition of the ZnO film metamorphosed from tensile strain/compressive stress to compressive strain/tensile stress when the Sn concentrations increased. Results indicated that 1 at.% Sn doping of TZO, which has the lowest tensile stress of 0.14 GPa, generated the highest conductivity of 1.31 S cm− 1. In addition, 1 at.% Sn doping of TZO possessed superior sensitivity to a humidity of 3.36. These results revealed that the optimum performance of a humidity-sensing device can be obtained mainly by controlling the amount of extrinsic element in a ZnO film
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