COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Innovative green-technology SMEs as an opportunity to promote financial de-risking

International audienceThe authors recommend that the G20 target innovative green-technology SMEs as an opportunity to promote financial de-risking while addressing Paris Agreement commitments and UN Sustainable Development Goals. This should be achieved by creating signals for private investors through: (1) a reporting system that can help monitor the scale-up of green-technology SMEs; (2) the use of public funds to signal innovative green-technology SMEs to investors; and (3) the inclusion of SMEs in the design of green finance platforms. By implementing these recommendations, the G20 will ensure that innovative, low-carbon SMEs become attractive, low(er)-risk investment opportunities for the private sector.Les auteurs recommandent que le G20 cible les PME innovantes en matière de technologies vertes comme une opportunité de promouvoir la réduction des risques financiers tout en respectant les engagements de l'Accord de Paris et les objectifs de développement durable des Nations Unies. Ceci devrait être réalisé en créant des signaux pour les investisseurs privés à travers: (1) un système de reporting qui peut aider à suivre l'expansion des PME de technologies vertes; (2) l'utilisation de fonds publics pour signaler les PME innovantes en technologies vertes aux investisseurs; et (3) l'inclusion des PME dans la conception de plateformes de financement vert. En mettant en œuvre ces recommandations, le G20 veillera à ce que les PME innovantes et à faibles émissions de carbone deviennent des opportunités d'investissement attrayantes et à faible risque pour le secteur privé

L’art de la ville

Les textes rassemblés dans ce numéro ont été présentés lors du colloque international « L'art de la ville » qui s'est tenu à l'Université Toulouse-le Mirail (6-8 novembre 2008). Les auteurs s'intéressent à la manière dont l'art (la littérature, l'architecture, la peinture, la photographie, le cinéma...), à travers toutes les époques, aborde la ville. Sans vouloir cadastrer, archiver ou comprendre un lieu qui demeure dans le mouvement, ils envisagent le renouvellement de la démarche artistique au contact du paysage urbain - « circumambulate the city », disait Melville. Conscient de ses limites, l'art se réinvente pour approcher un lieu où l'évidence du concret se mêle aux dérives imaginaires. Il n'évoque pas seulement la ville en termes de cadre, de construction sociale ou symbolique, ou de surface sémiotique, saturée de textes et d'images, mais il accorde ses doutes et ses modulations avec les traces et les transmutations urbaines. Il semble ainsi esquisser une « poéthique » (M. Deguy) de la ville. This collection of papers was presented at the International Conference "The Art of the City" organized at the University of Toulouse-le Mirail (6-8 November 2008). The authors explore the treatment of the city in the arts (literature, architecture, painting, photography, cinema...). Without wishing to plot the constant movement of the city into predetermined patterns, they consider the renewal of art in contact with the elusive urban landscape - "circumambulate the city", Melville said. Confronted with its own limitations, art reinvents language and form in order to evoke a space where brutal materiality meets dreamlike abstractions. It not only represents the city as a frame, a social or symbolic construct, or as a semiotic surface saturated with signs and images, but attunes its doubts and modulations to the urban traces and transmutations. It then seems to delineate a "poethics" (M. Deguy) of the city