35,512 research outputs found
NE3 THE IMPORTANCE OF MODIFYING THE COURSE OF ALZHEIMER'S DISEASE: OLDER AMERICANS' RISK-BENEFIT PREFERENCES FOR NEW TREATMENTS
Psychometric validation of the Turkish nine-item Internet Gaming Disorder ScaleâShort Form (IGDS9-SF)
The main aims of the current study were to test the factor structure, reliability and validity of the nine-item Internet Gaming Disorder Scale-Short Form (IGDS9- SF), a standardized measure to assess symptoms and prevalence of Internet Gaming Disorder (IGD). In the present study participants were assessed with the IGDS9-SF, nine-item Internet Gaming Disorder Scale (IGDS) and the Young's Internet Addiction Test-Short Form (YIAT-SF). Confirmatory factor analyses demonstrated that the factor structure (i.e., the dimensional structure) of the IGDS9-SF was satisfactory. The scale was also reliable (i.e., internally consistent with a Cronbach's alpha of 0.89) and showed adequate convergent and criterion-related validity, as indicated by statistically significant positive correlations between average time daily spent playing games during last year, IGDS and YIAT-SF scores. By applying the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) threshold for diagnosing IGD (e.g., endorsing at least five criteria), it was found that the prevalence of disordered gamers ranged from 0.96% (whole sample) to 2.57% (e-sports players). These findings support the Turkish version of the IGDS9-SF as a valid and reliable tool for determining the extent of IGD-related problems among young adults and for the purposes of early IGD diagnosis in clinical settings and similar research
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The Psy-Security-Curriculum ensemble: British Values curriculum policy in English schools
Framed as being in response to terrorist attacks and concerns about religious bias in some English schools, âBritish Valuesâ (BV) curriculum policy forms part of the British Governmentâs Counter-Terrorism and Security Act, 2015. This includes a Duty on teachers in England to actively promote British Values to deter students from radicalisation. This paper, first, traces the history of Britishness in the curriculum to reveal a prevalence of nationalistic, colonial values. Next, an ensemble of recent policies and speeches focusing on British Values is analysed, using a psycho-political approach informed by anti-colonial scholarship. Finally, we interrogate two key critiques of the British Values curriculum discourse: the universality of British Values globally, and concerns over the securitisation of education. Findings indicate that the constitution of white British supremacist subjectivities operate through curriculum as a defence mechanism against perceived threats to white privilege, by normalising a racialised state-controlled social order. The focus is on âBritishâ values, but the analytic framework and findings have wider global significance
The Benefits of B ---> K* l+ l- Decays at Low Recoil
Using the heavy quark effective theory framework put forward by Grinstein and
Pirjol we work out predictions for B -> K* l+ l-, l = (e, mu), decays for a
softly recoiling K*, i.e., for large dilepton masses sqrt{q^2} of the order of
the b-quark mass m_b. We work to lowest order in Lambda/Q, where Q = (m_b,
sqrt{q^2}) and include the next-to-leading order corrections from the charm
quark mass m_c and the strong coupling at O(m_c^2/Q^2, alpha_s). The leading
Lambda/m_b corrections are parametrically suppressed. The improved Isgur-Wise
form factor relations correlate the B -> K* l+ l- transversity amplitudes,
which simplifies the description of the various decay observables and provides
opportunities for the extraction of the electroweak short distance couplings.
We propose new angular observables which have very small hadronic
uncertainties. We exploit existing data on B -> K* l+ l- distributions and show
that the low recoil region provides powerful additional information to the
large recoil one. We find disjoint best-fit solutions, which include the
Standard Model, but also beyond-the-Standard Model ones. This ambiguity can be
accessed with future precision measurements.Comment: 31 pages, 8 figures; Instability near minimal recoil from numerics
removed, Fig. 1 replaced and minor shifts in short distance uncertainties in
SM predictions; typos corrected and references added; main results and
conclusions unchange
Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress
In recent years evolutionary ecologists have become increasingly interested in the effects of reactive
oxygen species (ROS) on the life-histories of animals. ROS levels have mostly been inferred indirectly
due to the limitations of estimating ROS from in vitro methods. However, measuring ROS (hydrogen
peroxide, H2O2) content in vivo is now possible using the MitoB probe. Here, we extend and refine
the MitoB method to make it suitable for ecological studies of oxidative stress using the brown trout
Salmo trutta as model. The MitoB method allows an evaluation of H2O2 levels in living organisms over
a timescale from hours to days. The method is flexible with regard to the duration of exposure and
initial concentration of the MitoB probe, and there is no transfer of the MitoB probe between fish. H2O2
levels were consistent across subsamples of the same liver but differed between muscle subsamples
and between tissues of the same animal. The MitoB method provides a convenient method for
measuring ROS levels in living animals over a significant period of time. Given its wide range of possible
applications, it opens the opportunity to study the role of ROS in mediating life history trade-offs in
ecological settings
Constraints on dark matter and the shape of the Milky Way dark halo from the 511 keV line
About one year ago, it was speculated that decaying or annihilating Light
Dark Matter (LDM) particles could explain the flux and extension of the 511 keV
line emission in the galactic centre. Here we present a thorough comparison
between theoretical expectations of the galactic positron distribution within
the LDM scenario and observational data from INTEGRAL/SPI. Unlike previous
analyses, there is now enough statistical evidence to put tight constraints on
the shape of the dark matter halo of our galaxy, if the galactic positrons
originate from dark matter. For annihilating candidates, the best fit to the
observed 511 keV emission is provided by a radial density profile with inner
logarithmic slope gamma=1.03+-0.04. In contrast, decaying dark matter requires
a much steeper density profile, gamma>1.5, rather disfavoured by both
observations and numerical simulations. Within the annihilating LDM scenario, a
velocity-independent cross-section would be consistent with the observational
data while a cross-section purely proportional to v^2 can be rejected at a high
confidence level. Assuming the most simplistic model where the galactic
positrons are produced as primaries, we show that the LDM candidate should be a
scalar rather than a spin-1/2 particle and obtain a very stringent constraint
on the value of the positron production cross-section to explain the 511 keV
emission. One consequence is that the value of the fine structure constant
should differ from that recommended in the CODATA. This is a very strong test
for the LDM scenario and an additional motivation in favour of experiments
measuring alpha directly. Our results finally indicate that an accurate
measurement of the shape of the dark halo profile could have a tremendous
impact on the determination of the origin of the 511 keV line and vice versa.Comment: 11 pages, 4 figures, submitted to MNRA
Intraspecfic variation in cold-temperature metabolic phenotypes of Arabidopsis lyrata ssp petraea
Atmospheric temperature is a key factor in determining the distribution of a plant species. Alongside this, plant populations growing at the margin of their range may exhibit traits that indicate genetic differentiation and adaptation to their local abiotic environment. We investigated whether geographically separated marginal populations of Arabidopsis lyrata ssp. petraea have distinct metabolic phenotypes associated with exposure to cold temperatures. Seeds of A. petraea were obtained from populations along a latitudinal gradient, namely Wales, Sweden and Iceland and grown in a controlled cabinet environment. Mannose, glucose, fructose, sucrose and raffinose concentrations were different between cold treatments and populations, especially in the Welsh population, but polyhydric alcohol concentrations were not. The free amino acid compositions were population specific, with fold differences in most amino acids, especially in the Icelandic populations, with gross changes in amino acids, particularly those associated with glutamine metabolism. Metabolic fingerprints and profiles were obtained. Principal component analysis (PCA) of metabolite fingerprints revealed metabolic characteristic phenotypes for each population and temperature. It is suggested that amino acids and carbohydrates were responsible for discriminating populations within the PCA. Metabolite fingerprinting and profiling has proved to be sufficiently sensitive to identify metabolic differences between plant populations at different atmospheric temperatures. These findings show that there is significant natural variation in cold metabolism among populations of A. l. petraea which may signify plant adaptation to local climates
â20 tins of Stella for a fiverâ: The making of class through Labour and Coalition government alcohol policy
Alcohol use in the UK has been a key concern to both the Labour and Coalition governments, and commands considerable attention in the media and academic discussions. This article analyses how recent government policy discussions have defined particular forms of drinking as problematic, and how these definitions and associated policy initiatives can be seen as part of a wider symbolic economy through which people come to be valued differently, incorporating ideas of economic, cultural and social capital. Therefore, I argue that government policies and discussions of drinking are a key way in which class is constituted in contemporary Britain
Tackling concentrated worklessness: integrating governance and policy across and within spatial scales
Spatial concentrations of worklessness remained a key characteristic of labour markets in advanced industrial economies, even during the period of decline in aggregate levels of unemployment and economic inactivity evident from the late 1990s to the economic downturn in 2008. The failure of certain localities to benefit from wider improvements in regional and national labour markets points to a lack of effectiveness in adopted policy approaches, not least in relation to the governance arrangements and policy delivery mechanisms that seek to integrate residents of deprived areas into wider local labour markets. Through analysis of practice in the British context, we explore the difficulties of integrating economic and social policy agendas within and across spatial scales to tackle problems of concentrated worklessness. We present analysis of a number of selected case studies aimed at reducing localised worklessness and identify the possibilities and constraints for effective action given existing governance arrangements and policy priorities to promote economic competitiveness and inclusion
The design-by-adaptation approach to universal access: learning from videogame technology
This paper proposes an alternative approach to the design of universally accessible interfaces to that provided by formal design frameworks applied ab initio to the development of new software. This approach, design-byadaptation, involves the transfer of interface technology and/or design principles from one application domain to another, in situations where the recipient domain is similar to the host domain in terms of modelled systems, tasks and users. Using the example of interaction in 3D virtual environments, the paper explores how principles underlying the design of videogame interfaces may be applied to a broad family of visualization and analysis software which handles geographical data (virtual geographic environments, or VGEs). One of the motivations behind the current study is that VGE technology lags some way behind videogame technology in the modelling of 3D environments, and has a less-developed track record in providing the variety of interaction methods needed to undertake varied tasks in 3D virtual worlds by users with varied levels of experience. The current analysis extracted a set of interaction principles from videogames which were used to devise a set of 3D task interfaces that have been implemented in a prototype VGE for formal evaluation
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