A new type of slumping-induced soft-sediment deformation structure: the envelope structure

The sediments of the Cretaceous Gyeokpori Formation in south-western South Korea accumulated in a lake in which mainly siliciclastic rocks were deposited, with some interbedded volcaniclastics. The nearby volcanic activity resulted in unstable lake margins inducing a dominance of gravity-flow deposits. The high sedimentation rate facilitated soft-sediment deformation on the sloping margin. The deposition of numerous gravity-flow deposits resulted in a vertically heterolithic stratification. The slumps are composed of different lithologies, which is expressed in different types of deformation due to the difference in cohesion between sandy and mussy layers within the slumps. Coarser-grained (cohesionless) slumps tend to show more chaotic deformation of their lamination or layering. The difference in slumping behaviour of the cohesive and non-cohesive examples is explained and modelled. A unique soft-sediment deformation structure is recognized. This structure has not been described before, and we call it ‘envelope structure’. It consists of a conglomerate mass that has become entirely embedded in fine-grained sediment because slope failure took place and the fine-grained material slumped down with the conglomerate ‘at its back’. The cohesive laminated mudstone formed locally slump folds that embedded the non-cohesive overlying conglomerate unit, possibly partly due to the bulldozing effect of the latter. This structure presumably can develop when the density contrast with the underlying and overlying deposits is exceptionally high. The envelope structure should be regarded as a special – and rare – type of a slumping-induced deformation structure

Sublingual Immunization with M2-Based Vaccine Induces Broad Protective Immunity against Influenza

The ectodomain of matrix protein 2 (M2e) of influenza A virus is a rationale target antigen candidate for the development of a universal vaccine against influenza as M2e undergoes little sequence variation amongst human influenza A strains. Vaccine-induced M2e-specific antibodies (Abs) have been shown to display significant cross-protective activity in animal models. M2e-based vaccine constructs have been shown to be more protective when administered by the intranasal (i.n.) route than after parenteral injection. However, i.n. administration of vaccines poses rare but serious safety issues associated with retrograde passage of inhaled antigens and adjuvants through the olfactory epithelium. In this study, we examined whether the sublingual (s.l.) route could serve as a safe and effective alternative mucosal delivery route for administering a prototype M2e-based vaccine. The mechanism whereby s.l. immunization with M2e vaccine candidate induces broad protection against infection with different influenza virus subtypes was explored.A recombinant M2 protein with three tandem copies of the M2e (3M2eC) was expressed in Escherichia coli. Parenteral immunizations of mice with 3M2eC induced high levels of M2e-specific serum Abs but failed to provide complete protection against lethal challenge with influenza virus. In contrast, s.l. immunization with 3M2eC was superior for inducing protection in mice. In the latter animals, protection was associated with specific Ab responses in the lungs.The results demonstrate that s.l. immunization with 3M2eC vaccine induced airway mucosal immune responses along with broad cross-protective immunity to influenza. These findings may contribute to the understanding of the M2-based vaccine approach to control epidemic and pandemic influenza infections

Intrastratal flow in the Cretaceous Gyeokpori Formation (SW South Korea)

Intrastratal flow is a process that is still poorly understood, rarely described and difficult to interpret in ancient rocks. Sediments in the Cretaceous lacustrine Gyeokpori Formation of southwestern South Korea contain some chaotically deformed sandstone layers with deformed mudstone clasts that are ascribed to this process. The interpretation is based on the fact that these layers cannot be explained as a result of subaqueous debris flows or mass transport, whereas the sedimentary context, including the presence of other soft-sediment deformation structures, indicates that intrastratal flow must have been physically possible. The sedimentary setting was a lake in which mainly siliciclastic rocks were deposited, with some interbedded volcaniclastics. The nearby volcanic activity caused seismic shocks that affected the unstable lake margins resulting in the dominance of gravity-flow deposits, but also in a high sedimentation rate that facilitated soft-sediment deformation partly caused by intrastratal flow. This must have happened fairly frequently during a probably limited time-span, as several layers showing traces of intrastratal flow are present within a succession of only <1 m thick. The combined data on the geological setting and our findings regarding the origin of the various soft-sediment deformation structures may help to recognize the traces left by intrastratal flow elsewhere in the geological record

A new type of slumping-induced soft-sediment deformation structure: the envelope structure

The sediments of the Cretaceous Gyeokpori Formation in south-western South Korea accumulated in a lake in which mainly siliciclastic rocks were deposited, with some interbedded volcaniclastics. The nearby volcanic activity resulted in unstable lake margins inducing a dominance of gravity-flow deposits. The high sedimentation rate facilitated soft-sediment deformation on the sloping margin. The deposition of numerous gravity-flow deposits resulted in a vertically heterolithic stratification. The slumps are composed of different lithologies, which is expressed in different types of deformation due to the difference in cohesion between sandy and mussy layers within the slumps. Coarser-grained (cohesionless) slumps tend to show more chaotic deformation of their lamination or layering. The difference in slumping behaviour of the cohesive and non-cohesive examples is explained and modelled. A unique soft-sediment deformation structure is recognized. This structure has not been described before, and we call it ‘envelope structure’. It consists of a conglomerate mass that has become entirely embedded in fine-grained sediment because slope failure took place and the fine-grained material slumped down with the conglomerate ‘at its back’. The cohesive laminated mudstone formed locally slump folds that embedded the non-cohesive overlying conglomerate unit, possibly partly due to the bulldozing effect of the latter. This structure presumably can develop when the density contrast with the underlying and overlying deposits is exceptionally high. The envelope structure should be regarded as a special – and rare – type of a slumping-induced deformation structure

A new type of slumping-induced soft-sediment deformation structure: the envelope structure

The sediments of the Cretaceous Gyeokpori Formation in south-western South Korea accumulated in a lake in which mainly siliciclastic rocks were deposited, with some interbedded volcaniclastics. The nearby volcanic activity resulted in unstable lake margins inducing a dominance of gravity-flow deposits. The high sedimentation rate facilitated soft-sediment deformation on the sloping margin. The deposition of numerous gravity-flow deposits resulted in a vertically heterolithic stratification. The slumps are composed of different lithologies, which is expressed in different types of deformation due to the difference in cohesion between sandy and mussy layers within the slumps. Coarser-grained (cohesionless) slumps tend to show more chaotic deformation of their lamination or layering. The difference in slumping behaviour of the cohesive and non-cohesive examples is explained and modelled

A Molecular Signature Determines the Prognostic and Therapeutic Subtype of Non-Muscle-Invasive Bladder Cancer Responsive to Intravesical Bacillus Calmette-Guérin Therapy

Non-muscle-invasive bladder cancer (NMIBC) is clinically heterogeneous; thus, many patients fail to respond to treatment and relapse. Here, we identified a molecular signature that is both prognostic and predictive for NMIBC heterogeneity and responses to Bacillus Calmette-Guérin (BCG) therapy. Transcriptomic profiling of 948 NMIBC patients identified a signature-based subtype predictor, MSP888, along with three distinct molecular subtypes: DP.BCG+ (related to progression and response to BCG treatment), REC.BCG+ (related to recurrence and response to BCG treatment), and EP (equivocal prognosis). Patients with the DP.BCG+ subtype showed worse progression-free survival but responded to BCG treatment, whereas those with the REC.BCG+ subtype showed worse recurrence-free survival but responded to BCG treatment. Multivariate analyses revealed that MSP888 showed independent clinical utility for predicting NMIBC prognosis (each p = 0.001 for progression and recurrence, respectively). Comparative analysis of this classifier and previously established molecular subtypes (i.e., Lund taxonomy and UROMOL class) revealed that a great proportion of patients were similar between subtypes; however, the MSP888 predictor better differentiated biological activity or responsiveness to BCG treatment. Our data increase our understanding of the mechanisms underlying the poor prognosis of NMIBC and the effectiveness of BCG therapy, which should improve clinical practice and complement other diagnostic tools

A Molecular Signature Determines the Prognostic and Therapeutic Subtype of Non-Muscle-Invasive Bladder Cancer Responsive to Intravesical Bacillus Calmette-Guérin Therapy

Non-muscle-invasive bladder cancer (NMIBC) is clinically heterogeneous; thus, many patients fail to respond to treatment and relapse. Here, we identified a molecular signature that is both prognostic and predictive for NMIBC heterogeneity and responses to Bacillus Calmette-Guérin (BCG) therapy. Transcriptomic profiling of 948 NMIBC patients identified a signature-based subtype predictor, MSP888, along with three distinct molecular subtypes: DP.BCG+ (related to progression and response to BCG treatment), REC.BCG+ (related to recurrence and response to BCG treatment), and EP (equivocal prognosis). Patients with the DP.BCG+ subtype showed worse progression-free survival but responded to BCG treatment, whereas those with the REC.BCG+ subtype showed worse recurrence-free survival but responded to BCG treatment. Multivariate analyses revealed that MSP888 showed independent clinical utility for predicting NMIBC prognosis (each p = 0.001 for progression and recurrence, respectively). Comparative analysis of this classifier and previously established molecular subtypes (i.e., Lund taxonomy and UROMOL class) revealed that a great proportion of patients were similar between subtypes; however, the MSP888 predictor better differentiated biological activity or responsiveness to BCG treatment. Our data increase our understanding of the mechanisms underlying the poor prognosis of NMIBC and the effectiveness of BCG therapy, which should improve clinical practice and complement other diagnostic tools

Comparison of M2e sequences used in the present study.

<p>M2e sequences were aligned with PR8-M2e sequence as a reference. The different amino acids from M2e sequence of PR8 virus are in bold.</p