Disorders of the immune status in patients with chronic cerebral ischemia; differentiated pharmacological correction

The objective of the study is to establish the immune disorder patterns in patients with CCI I-II associated with arterial hypertension and to develop differentiated pharmacological methods for their correctio

Learning analytics in massive open online courses as a tool for predicting learner performance

Learning analytics in MOOCs can be used to predict learner performance, which is critical as higher education is moving towards adaptive learning. Interdisciplinary methods used in the article allow for interpreting empirical qualitative data on performance in specific types of course assignments to predict learner performance and improve the quality of MOOCs. Learning analytics results make it possible to take the most from the data regarding the ways learners engage with information and their level of skills at entry. The article presents the results of applying the proposed learning analytics algorithm to analyze learner performance in specific MOOCs developed by Ural Federal University and offered through the National Open Education Platform. © 2018, National Research University Higher School of Economics.This study was support- ed by financial assis- tance provided under the Resolution of the Government of the Rus sian Federation No. 211, Contract No. 02. A03.21.0006. Translated from Russian by I. Zhuchkova

Speech Organization of Development Program as Strategic Planning Document

The article is devoted to the study of speech organization of the text of the development program as a strategic planning document. The factors determining features of the text of this genre are revealed. The analysis is carried out from the standpoint of communicative genre approach used in the works of modern researchers. The attempt is made to give a complete characteristics of the text in terms of genre. Parameters caused by both linguistic and extralinguistic factors are taken into account. Basic elements of the genre are described: “communicative purpose,” “image of the author,” “image of the addressee,” “image of the past,” “image of the future,” “dictum contents,” “linguistic embodiment of the genre.” Means of their speech representation in the document of this variety are considered. The analysis of the material at the lexical and grammatical levels reveals the features of the document text. It is established that the function of planning (target setting, forecasting), which is the main for Development Program, determines the updating of genre elements “communicative goal” and “image of the future,” forming a special category of futurality. It is shown that lexical features of journalistic text are present in the texts of development programs. The author explains this feature by the orientation of the document to a wide addressee. The expediency of application of communicative and genre approach to the description of speech organization of documents of strategic planning of other types is shown

Bacterial Carriage of Pathogenic Antibiotic-resistant Staphylococci Among Conditionally Healthy Infants and Preschool-age Children

Staphylococci are related to opportunistic microorganisms and are part of normal human microflora. However, there are varieties that can cause pyoinflammatory diseases in organisms with weakened immune status. In the event of an inadequate therapeutic approach, they are preserved in the body, and the person becomes a bacterial carrier and a source of dissemination of pathogenic microorganisms. The formation of antibiotic resistance also plays a significant role in the emergence of bacterial carriage. The situation is especially serious in organized children’s groups, where children are in close contact with one another. Thus, the study of the prevalence rate of antibiotic resistance among pathogenic strains of staphylococci in children’s groups is topical and worthy of attention. The purpose of this work is to identify carriers of pathogenic and antibiotic resistant staphylococci isolated from the microflora of the oral cavity of preschool children considered healthy. The results of the research can prove useful in practical healthcare and, particularly, in pediatric practice. Keywords: staphylococci, pathogenic cocci, bacterial carriage, antibiotic resistance, infant morbidity rat

Educational project on the formation of business and entrepreneurial skills in secondary and high school students

The project activity of pupils at formation of business entrepreneurial skills in the educational project “in business”Рассматривается проектная деятельность школьников при формировании деловых предпринимательских навыков в образовательном проекте «В деле

Pharmacological correction of L-NAME-induced oxide deficiency with derivatives of 3-(2,2,2-trimethylhydrazinium) propionate

This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivative

CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT

Determination of interrelationships between impairments of laboratory parameters of immune and metabolic status in patients with chronic cerebral ischemia of I-II stages was carried out. The study included 104 patients, of which 76 were female and 28 males, with CCI on the background of II degree hypertension, of which 52 patients were with stage I and 52 with stage II at the age of 50 ± 5 years. Also, clinical and laboratory parameters were studied in 22 healthy donors of the same age. Evaluation of clinical and laboratory data was carried out at the beginning of treatment and 2 weeks after its end. The sorption capacity of erythrocytes and the sorption capacity of the glycocalyx (SEG), the activity of lipid peroxidation processes, the state of the antioxidant system were determined in blood plasma and erythrocytes, the level of stable metabolites of nitric oxide (SMNO), neopterin, C-reactive protein, cytokines (TNFα, IL- 1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA), complement system components (C3, C4, C5, C5А), the phagocytic and oxygen-dependent activity of polymorphonuclear blood leukocytes. Comparative assessment of the results of correlation, factorial and cluster analyzes for assessing the parameters of the immune and metabolic status in patients with stage I CCI revealed the most significant laboratory parameters necessary for determination in the clinic for objective assessment of the severity of immune and metabolic disorders: TNFα, IL-8, IL-10, SMNO and NEG. In patients with CCI stage II, to objectively assess the severity of immune and metabolic disorders, TNFα, IL-8, IL-17, IL-10, the phagocytic number of neutrophils and SEG are recommended

The organization of the rating system for assessing the quality of university students training

In spite the universities use the rating system of assessing for a quite long time, this issue is still not fully considered. The article is based on the position of insufficient state of knowledge of the multifunctionality of the students rating. The rating helps to reveal the potential of students. It is mentioned that the rating system of assessment is a tool that will improve the quality of training and provide the required level of motivation. During the research, the following methods were used: analysis, synthesis, induction, deduction. As a result, the principles of the rating assessment system were revealed, a definition of the term "Rating" was given, its goals were indicated. As an example of the organization of the rating system of assessment, the Nyzhnii Novhorod State Pedagogical University and its "Regulations on the rating system for assessing the quality of student training" were used. It is noted that the rating includes: current check, midterm and final examinations. Further, all possible conditions under which the student receives points were identified and considered. On the example of the NSPU named after Kozma Minin transferring of the rating points into a five-point grading rating system is presented. Also, the types of violations for which points are discarded, are considered. As the study showed, comprehensive planned system yields productive results for students and the university.peer-reviewe

Calcium Signaling Initiated by Agonists in Mesenchymal Stromal Cells from the Human Adipose Tissue

Mesenchymal stromal cells (MSCs) from different sources represent a heterogeneous population of proliferating non-differentiated cells that contain multipotent stem cells capable of originating a variety of mesenchymal cell lineages. By using Ca2+ imaging and the Ca2+ dye Fluo-4, we studied MSCs from the human adipose tissue and examined Ca2+ signaling initiated by a variety of GPCR ligands, focusing primarily on adrenergic and purinergic agonists. Being characterized by a relative change of Fluo-4 fluorescence, agonist-induced Ca2+ responses were generated in an “all-or-nothing” fashion. Specifically, at relatively low doses, agonists elicited undetectable responses but initiated quite similar Ca2+ transients at all concentrations above the threshold. The inhibitory analysis and Ca2+/IP3 uncaging pointed at the phosphoinositide cascade as a pivotal pathway responsible for agonist transduction and implicated Ca2+-induced Ca2+ release (CICR) in shaping agonists-dependent Ca2+ signals. Altogether, our data suggest that agonist transduction in MSCs includes two fundamentally different stages: an agonist initially triggers a local, gradual, and relatively small Ca2+ signal, which next stimulates CICR to accomplish transduction with a large and global Ca2+ transient. By involving the trigger-like mechanism CICR, a cell is capable of generating Ca2+ responses of virtually universal shape and magnitude at different agonist concentrations above the threshold