296 research outputs found
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Study of External Kink Modes in Shaped HBT-EP Plasmas
The first study of magnetohydrodynamic (MHD) equilibria and external kink modes in shaped plasmas on the High Beta Tokamak - Extended Pulse (HBT-EP) is described. A new poloidal field coil and high-current, low-voltage capacitive power supply was designed and installed. The new coil significantly modifies the shape of the plasma cross section and provides a new research tool for the study of kink mode structure and control. When fully energized, the coil creates a magnetic separatrix, which defines the boundary between confined and unconfined plasma. The separatrix is set by a poloidal field null called an “X-point”, which is on the inboard side of the torus, above the midplane. Several arrays of magnetic sensors observe and characterize the plasma equilibrium and the MHD fluctuations from kink modes. Free-boundary plasma equilibria are reconstructed using standard methods that minimize the mean-square error between the numerically reconstructed equilibria and various measurements. Reconstructions of shaped plasma equilibria show the creation of fully diverted plasmas with shaped outer boundaries. The reconstructions are confirmed by direct measurements using arrays of magnetic sensors and a moveable Langmuir probe to measure the outermost closed flux surface. Measurements of individual kink modes are obtained from the magnetic fluctuations using a technique known as biorthogonal decomposition. External kink modes that naturally arise in shaped plasmas are observed and described. The poloidal structure of modes in shaped plasmas are found to be similar to those that arise in circular plasmas, except near the X-point. The magnetic signature of kink modes on the surface of the plasma are calculated using the ideal MHD code DCON. For plasmas with an X-point, DCON shows a short-wavelength, low amplitude structure near the X-point. The code VALEN is used to calculate the perturbed magnetic field measured at the sensors due to the DCON mode at the plasma surface. VALEN includes the effects of sensor/plasma separation and eddy currents induced in conducting structures by rotation of the modes. Good agreement is found between the measured mode structures and the ideal kink mode structures calculated at the sensors by VALEN. A distributed array of forty active control coils was used to perturb the plasma equilibria, and for both shaped and circular equilibria, the structure of the response to the perturbation was found to be the same as the that of the dominant naturally occurring mode in that equilibrium. Finally, the magnitude of the plasma’s response to applied magnetic perturbations was found to be comparable between shaped and unshaped plasmas, even though separation between the sensors and the boundary of the shaped plasmas increases relative to circular plasmas with the same plasma current and radial positions. In addition to demonstrating a new research tool for study of kink modes on HBT-EP, this research demonstrates the importance of accurate electromagnetic calculations, including eddy currents, when comparing measured and predicted mode structure
Gas Seal Failures Caused by Axial Vibrations
Case StudyThis case study describes the root cause investigation of 12 dry gas seal failures in three integrally geared centrifugal compressors over a period of 12 years. These compressors are in fuel gas booster service, supplying a 500 MW gas turbine combined cycle power plant.
The root cause investigation determined that the dry gas seal failures were the result of a design integration problem in which the rotor-bearing system exposed the dry gas seals to both excessive axial displacement and excessive axial vibrations.
These problems were resolved by redesigning the rotor-bearing system to incorporate thrust bearings on the pinion
Gas Seal Failures Caused by Axial Vibrations
Case StudyThis case study describes the root cause investigation of 12 dry gas seal failures in three integrally geared centrifugal compressors over a period of 12 years. These compressors are in fuel gas booster service, supplying a 500 MW gas turbine combined cycle power plant.
The root cause investigation determined that the dry gas seal failures were the result of a design integration problem in which the rotor-bearing system exposed the dry gas seals to both excessive axial displacement and excessive axial vibrations.
These problems were resolved by redesigning the rotor-bearing system to incorporate thrust bearings on the pinion
The use of three-dimensional conjugate CFD to enhance understanding of, and to verify, multi-modal heat transfer in dynamic laboratory test walls
This work describes the use of conjugate computational fluid dynamics (C-CFD) to simulate controlled laboratory based dynamic heat transfer tests on building components. This study proposes that conjugate CFD simulation can be used to evaluate the influence of combined convective and conductive heat transfer in multi-state building components. To this end, a solid wall and cavity wall were tested with a Calibrated Hotbox and subject to variable temperature conditions leading to combined convective and conductive heat transfer. The varying temperature of the heat source was monitored and used as the input boundary condition in the simulation model, which included a computational domain which encompassed the hot-side air chamber and the wall, including cavity when applicable. It was found acceptable accuracy could be realized with a simplified constant surface heat transfer coefficient with fixed air temperature on the cold air side, which greatly reduced computational effort. The experimental results revealed that the cavity wall experienced a phase lag, peak displacement of 2.9 times higher and decrement factor 1.6 times lower compared with that of the solid wall
Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells.
Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal of mammalian cells. With site-specific integration for gene correction in cellular therapeutics, use of the OCT4 promoter may have advantages when expressing a suicide gene if pluripotency remains. However, the human OCT4 promoter region is 4 kb in size, limiting the capacity of therapeutic genes and other regulatory components for viral vectors, and decreasing the efficiency of homologous recombination. The purpose of this investigation was to characterize the functionality of a novel 967bp OCT4-short response element during pluripotency and to examine the OCT4 titer-dependent response during differentiation to human derivatives not expressing OCT4. Our findings demonstrate that the OCT4-short response element is active in pluripotency and this activity is in high correlation with transgene expression in vitro, and the OCT4-short response element is inactivated when pluripotent cells differentiate. These studies demonstrate that this shortened OCT4 regulatory element is functional and may be useful as part of an optimized safety component in a site-specific gene transferring system that could be used as an efficient and clinically applicable safety platform for gene transfer in cellular therapeutics
PFAS River Export Analysis Highlights the Urgent Need for Catchment-Scale Mass Loading Data
Source apportionment of per-and polyfluoroalkyl substances (PFAS) requires an understanding of the mass loading of these compounds in river basins. However, there is a lack of temporally variable and catchment-scale mass loading data, meaning identification and prioritization of sources of PFAS to rivers for management interventions can be difficult. Here, we analyze PFAS concentrations and loads in the River Mersey to provide the first temporally robust estimates of PFAS export for a European river system and the first estimates of the contribution of wastewater treatment works (WwTWs) to total river PFAS export. We estimate an annual PFAS export of 68.1 kg for the River Mersey and report that the yield of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in the catchment is among the highest recorded globally. Analysis of river and WwTW loads indicates approximately one-third of PFOA emitted from WwTWs is potentially stored in the catchment and approximately half of PFOS transported by the River Mersey may not originate from WwTWs. As governments move toward regulation of PFAS in WwTW effluents, our findings highlight the complexity of PFAS source apportionment and the need for catchment-scale mass loading data. This study indicates that strategies for reducing PFAS loading that focus solely on WwTW effluents may not achieve river water quality targets
Characterisation of road-dust sediment in urban systems: a review of a global challenge
From Springer Nature via Jisc Publications RouterHistory: received 2020-04-14, accepted 2020-10-08, registration 2020-10-09, pub-electronic 2020-10-21, online 2020-10-21, pub-print 2020-12Publication status: PublishedFunder: University of ManchesterAbstract: Purpose: The proportion of people living in urbanised areas is predicted to rise to > 65% by 2050, and therefore, more humans than ever will be exposed to urban environmental pollution. Accumulation of organic and inorganic substances on street and road surfaces is a major global challenge requiring scientifically robust methods of establishing risk that inform management strategies. This aim of this contribution is to critically review the global literature on urban road–deposited sediment contamination with a specific focus on variability in sampling and analytical methods. Materials and methods: In order to assess the concentration of contaminants in global road-deposited sediment (RDS), a comprehensive search of published RDS studies was completed. We review methodological approaches used in RDS studies to highlight the variability in datasets as a result of sampling technique, grain size fractionation, geochemical and mineralogical characterisation methods and establishing the influence of local geology on contaminant concentrations. We also consider emerging contaminants in RDS, and we provide a workflow diagram which promotes a standardised sampling and analysis regime that we believe can reduce data variability and promote collaboration when it comes to tackling the important issue of RDS contamination. Results and discussion: Across the literature, Asia (except China) and Africa are underrepresented in RDS studies despite these continents having the largest and fastest growing populations, respectively. The removal of tetraethyl lead from gasoline produced a noticeable decrease in lead concentrations in global RDS, and platinum group element (PGE) concentrations in RDS were consistent with catalytic converter usage. Research into the impact of electric vehicles on non-exhaust emissions suggests other contaminants such as zinc may become more prominent in the future. Most RDS studies consider grain size fractions larger than > 20 μm due to sampling constraints despite RDS < 20 μm being most relevant to human health. The use of chemical extraction methods to establish contaminant geochemistry is popular; however, most extraction procedures are not relevant or specific to minerals identified in RDS through microscopic and spectroscopic investigations. Conclusions: This review highlights considerable variability in sampling and analytical approach which makes it difficult to identify broad global patterns in RDS contamination. To remove this variability from future RDS research, this review suggests a workflow plan which attempts to improve the comparability between RDS studies. Such comparability is crucial in identifying more discrete RDS trends and informing future emission policy
Safer bio-based solvents to replace toluene and tetrahydrofuran for the biocatalyzed synthesis of polyesters
With increased awareness of environmental issues caused by traditional petrochemical processes, both academia and industry are making enormous efforts towards the development of sustainable practices using renewable biomass as a feedstock. In this work, the biocatalyzed synthesis of polyesters derived from renewable monomers was performed in safer, bio-derivable organic solvents. Candida antarctica lipase B (CaLB), an enzyme belonging to the Ser-hydrolase family (adsorbed on methacrylic resin, also known as Novozym 435) was tested for its performance in the synthesis of adipate- and furandicarboxylate-based polyesters. In addition, the traditional solvents toluene and tetrahydrofuran were compared with a series of green solvents, 2,2,5,5-tetramethyloxolane, 2-methyltetrahydrofuran, 2,5-dimethyltetrahydrofuran and pinacolone for the enzymatic polymerizations. We can conclude that the monomer conversions and molecular masses of the obtained polyesters in all the tested alternative solvents were suitable, and in some cases superior, with CaLB immobilized via physisorption on acrylic resin being the optimal biocatalyst for all reactions. Strikingly, it was found that for the majority of the new solvents, lower reaction temperatures gave comparable monomer conversions and polymers with similar molecular weights whilst pinacolone yielded better polymers with Mn > 2000 Da and conversions of over 80%
Degradation of electroless Ni(P) under-bump metallization in Sn3.5Ag and Sn37Pb solders during high-temperature storage
The interfacial reaction between electroless Ni(P) under-bump metallization (UBM) and solders is studied. A P-rich layer forms in the UBM along the solder side after reflow and thermal aging. Crack formation inside the P-rich layer can sometimes penetrate throughout the entire UBM layer structure. The Ni(P) UBM degradation occurs earlier in the Sn3.5Ag solder than in Sn37Pb because of its higher reflow temperature. Despite the formation of a P-rich layer and cracks inside the UBM, it still keeps its original function within the high-temperature storage period in this study. Explanations for the formation of the P-rich layer and cracks in the UBM are outlined along with explanations for the Ni(P) UBM degradation process
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