Self-degradation of heat shock proteins

The 70-kDa heat shock protein of Drosophila decays in vivo at a much faster rate than other abundantly labeled proteins. Degradation also occurs in vitro, even during electrophoresis. It appears that this degradation is not mediated by a general protease and that the 70-kDa heat shock protein has a slow proteolytic action upon itself. Heat-induced proteins in CHO cells and a mouse cell line also degrade spontaneously in vitro, as do certain non-heat shock proteins from Drosophila tissues as well as the cell lines

The Import and Content of Luther\u27s Exegetical Lectures on the Epistle to the Hebrews

It has been abundantly proved that, when Luther nailed the famous Ninety-five Theses to the door of the Castle Church In Wittenberg, he had no thought of disrupting the Church. The tenor of the theses shows very clearly that he had in mind only to uphold the honor and the integrity of the Church he loved and to keep his fellow human beings from being defrauded financially as well as spiritually. His theses likewise show that he wanted to be and remain a faithful subject of the Pontiff at Rome. He took for granted that the Pope would heartily disapprove of the tactics and practices of Tetzel. He not only nailed his theses to the door of the Castle Church, but also very obediently sent a copy to his archbishop

Die politischen Ergebnisse der Kommunalwahlen in Moskau

Die Kommunalwahlen in Moskau vom 10. September endeten erwartungsgemäß mit einem überwältigenden Sieg der Partei "Einiges Russland". Drei von vier zukünftigen Abgeordneten in den Kommunalvertretungen gehören der Regierungspartei an. Und dennoch waren die Wahlen ein Erfolg für die Opposition: Weit über 200 oppositionell gesinnten Kandidaten gelang der Einzug in die Kommunalvertretungen. Ein großer Teil von ihnen hat sich zu einer informellen Koalition um den ehemaligen Duma-Abgeordneten Dmitrij Gudkow zusammengeschlossen. Ob sie diesem allerdings zu einer Kandidatur bei der Bürgermeisterwahl in Moskau 2018 verhelfen können, ist fraglich. Denn zur Überwindung des "kommunalen Filters" - einem administrativen Instrument zur Einschränkung von Kandidaturen - wäre der Einzug in noch mehr Kommunalräte notwendig gewesen. Daher bleibt nur die Hoffnung auf eine Wahlrechtsreform - und darauf, dass die partizipatorische Arbeit in der lokalen Selbstverwaltung Moskaus zum Vorbild im ganzen Land wird

Control of the colossal magnetoresistance by strain effect in Nd0.5_{0.5}Ca0.5_{0.5}MnO3_{3} thin films

Thin films of Nd$_{0.5}$Ca$_{0.5}$MnO$_{3}$ manganites with colossal magnetoresistance (CMR) properties have been synthesized by the Pulsed Laser Deposition technique on (100)-SrTiO$_{3}$. The lattice parameters of these manganites and correlatively their CMR properties can be controlled by the substrate temperature $T_{S}$. The maximum CMR effect at 75K, calculated as the ratio $\rho (H=0T)/\rho (H=7T)$ is 10$^4$ for a deposition temperature of $T_{S}=680$ degC. Structural studies show that the Nd$_{0.5}$Ca$_{0.5}$MnO$_{3}$ film is single phase, [010]-oriented and has a pseudocubic symmetry of the perovskite subcell with a=3.77$\AA$ at room temperature. We suggest that correlation between lattice parameters, CMR and substrate temperature $T_{S}$ result mainly from substrate-induced strains which can weaken the charge-ordered state at low temperature.Comment: 9 pages, 4 figures. To be published in Applied Physics Letter

Stress deformations and structural quenching in Sm0.5Ca0.5MnO3 thin films allow a huge decrease of the charge order melting magnetic field

Thin films of Sm0.5Ca0.5MnO3 manganites with charge ordering (CO) properties and colossal magnetoresistance were synthesized by pulsed laser deposition technique on (100)-SrTiO3 and (100)-LaAlO3 substrates. We first compare the structural modifications as function of the substrate and film thickness. Secondly, measuring transport properties in magnetic fields up to 24T, we establish the temperature-field phase diagram describing the stability of the CO state and compare it to bulk material. We show that some structural modification induced by the substrate occurs and that the CO melting magnetic field is greatly reduced. Moreover, with the temperature decrease, no modification of the lattice parameters is observed. We then propose an explanation based on the quenching of the unit cell of the film that adopts the in-plane lattice parameters of the substrate and thus, prevents the complete growth of the CO state at low temperature.Comment: to be published in Journal of Applied Physic

Nach der Perestroika - Die Evolution der Wahlen in Russland

Die Institution Wahlen, die 1997 in Russland einen europäischen Standard erreicht hatte, ist in den letzten Jahren mehr und mehr verfallen. Das zeigt eine Untersuchung des Abstimmungsvorganges. Dabei werden zwei Faktoren analysiert: die Abhängigkeit der Stimmergebnisse von der Wahlbeteiligung und die Verteilung der Wahlkommissionen nach Wahlbeteiligung. Die statistische Untersuchung ergibt, dass in vielen Fällen die Ergebnisse der Wahlen zwischen 2007 und 2011 offensichtlich "handgemacht" - also gefälscht oder verfälscht - waren

Электоральная дифференциация Украины на выборах президента в 2014 г.

The article investigates the electoral statistics of Ukrainian Presidential Elections 25 May 2014. Conventional division of Ukraine into three parts - the eastern, central and western - shows significant differences both political preferences and voting activity. The correlation between these two indicators exclude the possibility of a study by the Sobyanin-Soukhovolsky criterium. However, in separate parts of Ukraine there is more uniformity. Distribution of election commissions on turnout for Ukraine as a whole and for most regions indicates the absence of “ballot stuffing”.В статье исследована статистика голосования на выборах Президента Украины 25 мая 2014 г. Условное деление Украины на три части - восточную, центральную и западную - показывает значительные различия как по политическим предпочтениям, так и по активности участия в голосовании. Корреляция между этими двумя показателями исключает возможность исследования по критерию Собянина-Суховольского. Однако внутри частей Украины наблюдается большая однородность. Распределение участковых комиссий по явке для Украины в целом и для большинства областей свидетельствует об отсутствии «вбросов бюллетеней»

Suporte ventilatório em UTI neonatal, prognósticos e desfechos clínicos

Orientadora: Profª. Me. Sonia Mara de AndradeCoorientador: João Pedro Pontes CamaraMonografia (graduação) - Universidade Federal do Paraná (Campus Toledo), Curso de Graduação em Medicina.Inclui referênciasResumo: Objetivo: O objetivo deste estudo é traçar o perfil clínico-epidemiológico, prognóstico e desfecho dos RN que necessitam ou não de suporte ventilatório em UTI neonatal. Métodos: Estudo observacional analítico, longitudinal prospectivo, de abordagem quantitativa, realizado em uma UTI neonatal no oeste paranaense. Foram incluídos os RN hospitalizados no período de julho a novembro de 2021, sendo categorizados de acordo com o suporte ventilatório utilizado: grupo invasivo (GI), não-invasivo (GNI) e sem suporte (GSS). A análise foi realizada calculando-se médias de frequência simples e teste exato de Fisher para comparar as variáveis de avaliação clínica em relação ao suporte invasivo e não-invasivo. Resultados: Dos 56 RN, 53,6% são do sexo masculino, 64,3% brancos, 69,6% das mães entre 19 a 35 anos e 62,5% casadas. Entre os que utilizaram suporte ventilatório, no GNI 35% são a termo e 45% baixo peso, no GI 28,6% são pré-termo moderado e 42,9% baixo peso. Do GI, 57,1% apresentaram piora após suporte ventilatório e 100% do GNI melhora. Em relação ao desfecho, 100% GNI teve alta e 57,1% do GI óbito. Conclusões: Neonatos do sexo feminino, idade gestacional a termo, filhos de mães entre 19 a 35 anos, negras e pardas e com risco gestacional alto caracterizam o GNI e que tiveram melhores prognósticos e desfechos. O suporte ventilatório invasivo foi necessário em neonatos de extrema prematuridade e extremo baixo peso, houve prevalência de sepse e óbitos neste grup

Concerns como componentes reutilizáveis em simulações baseadas em agentes de software

A modelagem e simulação baseada em agentes, ou Agent-based Modeling and Simulation (ABMS), é um paradigma de simulação que usa agentes simulados para reproduzir e estudar eventos específicos. A partir deste modelo, é possível observar o comportamento de um agente inserido em um conjunto de indivíduos autônomos. Entre as áreas de aplicação pode-se citar desastres, gerenciamento ambiental, mobilidade e transporte. Apesar do seu potencial, muitas ferramentas disponíveis atualmente que suportam ABMS não possuem recursos para facilitar o reuso dos elementos de uma simulação. Há uma abordagem de desenvolvimento dirigida a modelos focada em ABMS com potencial para o reuso. Esta abordagem inclui uma linguagem específica de domínio chamada ABStractLang e a ferramenta que implementa a linguagem, denominada ABStractme. Esta monografia propõe a extensão desta abordagem, a partir do refinamento de um conceito previamente definido -concern - para a modularização de simulações. Este refinamento visa o reuso de concerns desenvolvidos em diversas simulações, a partir da definição de sua interface. Por fim, a ferramenta ABStractme, que dá suporte à abordagem dirigida a modelos, foi evoluída para incorporar a extensão proposta.Agent-based modeling and simulation (ABMS) is a simulation paradigm where simulated agents are used to reproduce specific events so that they can be studied. With this model it is possible to observe the behavior of an agent inserted in a set of autonomous individuals. Areas of application include disasters, environmental management, mobility and transportation. Despite its potential, most tools currently available that support ABMS do not have the capabilities to facilitate the reuse of the elements of a simulation. There is a model-driven approach to development focused on ABMS with potential for reuse. This approach includes a domain-specific language called ABStractLang and the tool that implements the language, called ABStractme. This monograph proposes the extension of this approach with the refinement of a previously defined concept - emph concern - for the modularization of simulations. This refinement aims at the reuse of emph concerns developed in several simulations, from the definition of its interface. Also, the tool ABStractme that supports the model-driven approach has evolved to incorporate the extension proposed