Orientation in Friedel-Crafts Acetylation of Nerolineand Its 6-Alkyl Homologues

The Friedel-Crafts acetylation of neroline in nitrobenzene medium is shown to result predominantly either in 1- or in 6-substitution,depending on the experimental conditions; as a byproduct, 1,6-diacetyl-2-methoxynaphthalene is obtained. Further,it is shown that 6-alkylated nerolines such as 6-propyl-2-methoxynaphthalene, are acetylated in position 1, even in nitrobenzene medium, and that 1,6-dialkylated nerolines such as 6-ethyl-2- methoxy-1-methylnaphthalene, can also be acetylated, whilst 1,6-dialkyl-2-naphthols are unable to undergo Nencki acylation reactions. In the course of this work, certain errors in the literature have been corrected

Hydrox:ycetones possedant une activite protectricecontre les effets des radiations lethales

On a etudie la preparation au moyen de la methode de Nencki, de plusieurs acides superieurs aliphatiques ou alicycliques, avec le pyrogallol et l\u27a-naphtol; on obtien ainsi des cetones o-hydroxylees douees d\u27activite protectrice contre des doses lethales de rayons X. Il est en outre montre que la reaction de Nencki peut etre appliquee au 1,6-dihydroxynaphtalene, lequel a donne avec l\u27acide caprylique le 1,6- dihydroxy-2-octanoylnaphtalene

[2,6-Bis(6-methyl­quinolin-2-yl)pyridine-κ3 N,N′,N′′]dichloridomanganese(II)

In the mol­ecule of the title compound, [MnCl2(C25H19N3)], the three N atoms span the axial–equatorial–axial sites of the trigonal-bipyramidal coordination polyhedron; the geometry of the MnII atom is 34% distorted from trigonal-bipyramidal (towards square-pyramidal along the Berry pseudorotation pathway). One of the Cl atoms is disordered over two positions in a 0.82 (3):0.18 (3) ratio. Weak inter­molecular C—H⋯Cl hydrogen bonding occurs in the crystal structure

[2,6-Bis(6-methyl­quinolin-2-yl)pyridine-κ3 N,N′,N′′]dichloridoiron(II)

In the mol­ecule of the title compound, [FeCl2(C25H19N3)], the three N atoms span the axial–equatorial–axial sites of the trigonal-bipyramidal coordination polyhedron; the geometry of the FeII atom is 32% distorted from trigonal-bipyramidal (towards square-pyramidal along the Berry pseudorotation pathway). One of the Cl atoms is disordered over two positions in a 0.938 (11):0.062 (11) ratio. Inter­molecular C—H⋯Cl hydrogen bonding occurs in the crystal structure

Nosocomial Outbreaks Caused by Leuconostoc mesenteroides subsp. mesenteroides

From July 2003 through October 2004, 42 patients became infected by strains of Leuconostoc mesenteroides subsp. mesenteroides (genotype 1) in different departments of Juan Canalejo Hospital in northwest Spain. During 2006, 6 inpatients, also in different departments of the hospital, became infected (genotypes 2–4). Parenteral nutrition was the likely source

Curbing methicillin-resistant Staphylococcus aureus in 38 French hospitals through a 15-year institutional control program

BACKGROUND: The Assistance Publique-Hôpitaux de Paris (AP-HP) institution administers 38 teaching hospitals (23 acute care and 15 rehabilitation and long-term care hospitals; total, 23 000 beds) scattered across Paris and surrounding suburbs in France. In the late 1980s, the proportion of methicillin resistance among clinical strains of Staphylococcus aureus (MRSA) reached approximately 40% at AP-HP.METHODS: A program aimed at curbing the MRSA burden was launched in 1993, based on passive and active surveillance, barrier precautions, training, and feedback. This program, supported by the strong commitment of the institution, was reinforced in 2001 by a campaign promoting the use of alcohol-based hand-rub solutions. An observational study on MRSA rate was prospectively carried out from 1993 onwards. RESULTS: There was a significant progressive decrease in MRSA burden (-35%) from 1993 to 2007, whether recorded as the proportion (expressed as percentage) of MRSA among S aureus strains (41.0% down to 26.6% overall; 45.3% to 24.2% in blood cultures) or incidence of MRSA cases (0.86 down to 0.56 per 1000 hospital days). The MRSA burden decreased more markedly in intensive care units (-59%) than in surgical (-44%) and medical (-32%) wards. The use of ABHR solutions (in liters per 1000 hospital days) increased steadily from 2 L to 21 L (to 26 L in acute care hospitals and to 10 L in rehabilitation and long-term care hospitals) following the campaign. CONCLUSION: A sustained reduction of MRSA burden can be obtained at the scale of a large hospital institution with high endemic MRSA rates, providing that an intensive program is maintained for a long period

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

The National Institute on Aging's Interventions Testing Program was established to evaluate agents that are purported to increase lifespan and delay the appearance of age-related disease in genetically heterogeneous mice. Up to five compounds are added to the study each year and each compound is tested at three test sites (The Jackson Laboratory, University of Michigan, and University of Texas Health Science Center at San Antonio). Mice in the first cohort were exposed to one of four agents: aspirin, nitroflurbiprofen, 4-OH-Α-phenyl-N-tert-butyl nitrone, or nordihydroguaiaretic acid (NDGA). Sample size was sufficient to detect a 10% difference in lifespan in either sex, with 80% power, using data from two of the three sites. Pooling data from all three sites, a log-rank test showed that both NDGA ( p  = 0.0006) and aspirin ( p  = 0.01) led to increased lifespan of male mice. Comparison of the proportion of live mice at the age of 90% mortality was used as a surrogate for measurement of maximum lifespan; neither NDGA ( p  = 0.12) nor aspirin ( p  = 0.16) had a significant effect in this test. Measures of blood levels of NDGA or aspirin and its salicylic acid metabolite suggest that the observed lack of effects of NDGA or aspirin on lifespan in females could be related to gender differences in drug disposition or metabolism. Further studies are warranted to find whether NDGA or aspirin, over a range of doses, might prove to postpone death and various age-related outcomes reproducibly in mice.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72117/1/j.1474-9726.2008.00414.x.pd