Large-area submillimeter resolution CdZnTe strip detector for astronomy

We report the first performance measurements of a sub-millimeter CdZnTe strip detector developed as a prototype for space-borne astronomical instruments. Strip detector arrays can be used to provide two-dimensional position resolution with fewer electronic channels than pixellated arrays. Arrays of this type and other candidate technologies are under investigation for the position-sensitive backplane detector for a coded-aperture telescope operating in the range of 30 - 300 keV. The prototype is a 1.4 mm thick, 64 multiplied by 64 stripe CdZnTe array of 0.375 mm pitch in both dimensions, approximately one square inch of sensitive area. Pulse height spectra in both single and orthogonal stripe coincidence mode were recorded at several energies. The results are compared to slab- and pixel-geometry detector spectra. The room-temperature energy resolution is less than 10 keV (FWHM) for 122 keV photons with a peak-to-valley ratio greater than 5:1. The response to photons with energies up to 662 keV appears to be considerably improved relative to that of previously reported slab and pixel detectors. We also show that strip detectors can yield spatial and energy resolutions similar to those of pixellated arrays with the same dimensions. Electrostatic effects on the pulse heights, read-out circuit complexity, and issues related to design of space borne instruments are also discussed

NEW DIRECTIONS IN ONLINE COMMUNITY RESEARCH

Information Systems researchers have studied multiple forms of online communities for decades. Significant progress has been made in addressing research questions such as how and when individuals are motivated to contribute knowledge in online settings. Yet, not only are important questions unanswered—such as why online communities succeed or fail—but also there still remains disagreement on the basic definition of online community. Furthermore, as the diversity of users and uses of online media continues to increase, IS researchers can now ask and answer different questions. For example, advances in social computing, mobile computing, and social media support new forms of online communities. In this panel we will propose and debate the direction of an online community research agenda for the next decade and beyond

Gut inflammation provides a respiratory electron acceptor for Salmonella.

Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation react with endogenous, luminal sulphur compounds (thiosulphate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to use tetrathionate as an electron acceptor produce a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen

Cretaceous-Cenozoic growth of the Patagonian broken foreland basin, Argentina: Chronostratigraphic framework and provenance variations during transitions in Andean subduction dynamics

The Cretaceous-Cenozoic evolution of the Patagonian broken foreland basin system at 42–43°S in the northern Chubut province of Argentina is associated with variable retroarc phases of fold-thrust belt shortening, extension, and basement uplift during changes in the dynamics of oceanic slab subduction. Basement inheritance and progressive shallowing of an east-dipping subducting slab are important mechanisms of foreland partitioning, as dictated by the preexisting (pre-Andean) structural architecture and forelandward (eastward) advance of Late Cretaceous arc magmatism. Previously recognized growth strata help define the timing of fold-thrust belt shortening and retroarc basement-involved uplift, but the precise consequences for sediment routing remain poorly understood, with uncertainties in patterns of basin evolution before, during, and after shallowing and resteepening of the subducting slab. In this study, distinctive sediment source regions and magmatic histories enable evaluation of the stratigraphic and tectonic evolution of the retroarc foreland basin using new provenance results, maximum depositional ages, and isotopic signatures from detrital zircon U-Pb geochronology and Lu-Hf geochemical analyses. A compilation of published bedrock crystallization ages and distributions of metamorphic and igneous basement rocks identify: a western source region defined by the Andean magmatic arc and associated pre-Andean basement; and an eastern source region consisting of intraplate magmatic units and the North Patagonian Massif. We demonstrate that Aptian-Cenomanian retroarc basin fill was derived principally from the basement massif and intraplate volcanic units to the east, followed by a Late Cretaceous (Campanian-Maastrichtian) reversal in sedimentary polarity and subsequent exclusive derivation from the Andean arc and orogenic belt to the west. Late Cretaceous-Paleocene slab shallowing and arc cessation was succeeded by late Eocene–earliest Miocene extension during slab rollback and renewal of arc magmatism. Thereafter, Miocene sedimentation was closely linked to shortening in the Andean fold-thrust belt. Within the retroarc succession, new U-Pb ages provide estimates of depositional ages for Lower Cretaceous through Miocene stratigraphic units. Finally, in addition to U-Pb provenance and chronostratigraphic constraints, zircon Hf isotopic signatures from the detrital record provide confirmation of a Cretaceous-Cenozoic history involving: (1) initial establishment of a continental magmatic arc; (2) transition from a neutral to compressive tectonic regime; (3) shallowing of the subducting slab and arc cessation during retroarc basement partitioning; (4) arc retreat and foreland basin abandonment during slab rollback (with modest extension and crustal thinning); and (5) final renewed shortening during arc rejuvenation.Fil: Butler, Kristina L.. University of Texas at Austin; Estados UnidosFil: Horton, Brian K.. University of Texas at Austin; Estados UnidosFil: Echaurren Gonzalez, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Fuentes, Facundo. YPF - Tecnología; Argentin

Development of an orthogonal-stripe CdZnTe gamma radiation imaging spectrometer

We report performance measurements of a sub-millimeter resolution CdZnTe strip detector developed as a prototype for astronomical instruments operating with good efficiency in the 30-300 keV photon energy range. The prototype is a 1.4 mm thick, 64×64 contact stripe CdZnTe array of 0.375 mm pitch in both dimensions. Pulse height spectra were recorded in orthogonal-stripe coincidence mode which demonstrate room-temperature energy resolution \u3c10 keV (FWHM) for 122 keV photons with a peak-to-valley ratio \u3e5:1. Good response is also demonstrated at higher energies using a coplanar grid readout configuration. Spatial resolution capabilities finer than the stripe pitch are demonstrated. We present the image of a 133Ba source viewed through a collimator slit produced by a 4×4 stripe detector segment. Charge signals from electron and hole collecting contacts are also discussed

EFFECTS OF STATIC STRETCHING ON MAXIMAL ISOKINETIC TORQUE

The effects of 20 seconds of agonist (AGO), antagonist (ANT) or no (NO) pre-exercise stretch on concentric (CON) and eccentric (ECC) maximal isokinetic torque produced at the knee were examined. Twelve male semi-pro rugby players performed dominant isokinetic knee extension following the specified stretch protocol. One-way Repeated Measures ANOVA revealed AGO to be significantly less (p < 0.05) than the other protocols for both CON (270 28 Nm) and ECC (309 42 Nm) torque. There was no difference between the ANT or NO for either CON (303 35 Nm and 304 38 Nm, respectively) or ECC (341 40 Nm and 33644 Nm). The results support the theory that pre-exercise agonist stretching may lead to performance decrements in maximal concentric torque production

CLINICAL AND BIOMECHANICAL COMPARISONS BETWEEN YOUTH PITCHERS WITH AND WITHOUT A HISTORY OF THROWING ARM PAIN OR INJUR

This study aimed to determine if there are clinical and kinematic differences in youth pitchers with a self-reported history of throwing arm pain or injury (PI) to those without (NPI). Forty male baseball pitchers ages 9 to 14 years old were divided into a PI group (n=20) and a NPI group (n=20). Injury history, pitching exposure, subject demographics, range of motion, and strength measurements were collected, along with throwing arm kinematics via a motion capture system. When comparing PI and NPI, significant physical differences were observed, with a greater presence of axillary hair, increased forearm length and decreased shoulder internal rotation strength in PI. No significant differences of upper limb motion during pitching were reported. When considering youth pitchers, evidence of physical maturity, arm length, and strength could be important factors in developing pain or injury

Intratumoral Gold Nanoparticle-Enhanced CT Imaging: An in Vivo Investigation of Biodistribution and Retention

This study aims to evaluate the in vivo distribution of Gold Nanoparticles (GNPs) at different time points after intratumoral (IT) injection, exploiting their properties as contrast agents for Computed Tomography (CT). GNPs approximately 40 nm in diameter were synthesized with a surface plasmon peak at ~530 nm, capped with Bovine Serum Albumin (BSA) to improve colloidal stability, and characterized with standard methods. CT phantom imaging was performed to quantify X-ray attenuation as a function of GNP concentration and surface functionalization and to determine the appropriate particle dose for in vivo studies. Concentrated GNPs were intratumorally (IT) injected into Lewis Lung Carcinoma (LLC) solid tumors grown on the right flank of 6-week old female C57BL/6 mice. Ten days post-injection, follow up CT imaging was performed to assess the distribution and retention of the particles in the tumor. Using the CT attenuation quantification, images for each timepoint were segmented, and 3D volumes rendered, to conduct biodistribution analyses. The successful retention and permanence of the GNPs into the solid tumor after ten days suggests the significance of GNPs as a potential theranostic agent