16 research outputs found
LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer
SummarySignaling crosstalk between tumor cells and fibroblasts confers proinvasive properties to the tumor microenvironment. Here, we identify leukemia inhibitory factor (LIF) as a tumor promoter that mediates proinvasive activation of stromal fibroblasts independent of alpha-smooth muscle actin (α-SMA) expression. We demonstrate that a pulse of transforming growth factor β (TGF-β) establishes stable proinvasive fibroblast activation by inducing LIF production in both fibroblasts and tumor cells. In fibroblasts, LIF mediates TGF-β-dependent actomyosin contractility and extracellular matrix remodeling, which results in collective carcinoma cell invasion in vitro and in vivo. Accordingly, carcinomas from multiple origins and melanomas display strong LIF upregulation, which correlates with dense collagen fiber organization, cancer cell collective invasion, and poor clinical outcome. Blockade of JAK activity by Ruxolitinib (JAK inhibitor) counteracts fibroblast-dependent carcinoma cell invasion in vitro and in vivo. These findings establish LIF as a proinvasive fibroblast producer independent of α-SMA and may open novel therapeutic perspectives for patients with aggressive primary tumors
Responses of an avian predator to variations in prey density at a temperate latitude.
International audienc
Responses of an avian predator to variations in prey density at a temperate latitude.
International audienc
Changements d'usage des terres et réseaux trophiques prédateurs-proies. Exemple des petits mammifères et des rapaces diurnes sur un gradient paysager en zone bocagère.
Poste
Conséquences des changements d'usage des terres dans les bocages de l'ouest sur la disponibilité des petits mammifères et l'abondance de deux rapaces diurnes
Response of two diurnal raptors, the common buzzard (Buteo buteo) and the eurasian Kestrel (Falco tinnunculus) to agricultural intensity in three landscape units of western France
communication oral
Conséquences des changements d'usage des terres en zone agricole sur l'architecture d'un réseau trophique prédateurs-proies (rapaces/petits mammifères)
International audienc
Conséquences des changements d'usage des terres en zone agricole sur l'architecture d'un réseau trophique prédateurs-proies (rapaces/petits mammifères)
International audienc
Projet Hy-Light « Hyperspectral Imagery for urban night Lights mapping »
National audienc