453 research outputs found

    Eucapnic Voluntary Hyperpnea: Gold Standard for Diagnosing Exercise-Induced Bronchoconstriction in Athletes?

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    In athletes, a secure diagnos is of exercise-induced bronchoconstriction (EIB) is dependent on objective testing. Evaluating spirometric indices of airflow before and following an exercise bout is intuitively the optimal means for the diagnosis; however, this approach is recognized as having several key limitations. Accordingly, alternative indirect bronchoprovocation tests have been recommended as surrogate means for obtaining a diagnosis of EIB. Of these tests, it is often argued that the eucapnic voluntary hyperpnea (EVH) challenge represents the ‘gold standard’. This article provides a state-of-the-art review of EVH, including an overview of the test methodology and its interpretation. We also address the performance of EVH against the other functional and clinical approaches commonly adopted for the diagnosis of EIB. The published evidence supports a key role for EVH in the diagnostic algorithm for EIB testing in athletes. However, its wide sensitivity and specificity and poor repeatability preclude EVH from being termed a ‘gold standard’ test for EIB

    Deep Thermoacoustic Imaging Using Scanning Electron Acoustic Microscopy

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    There has developed over the past few years some controversy [1] over the meaning and use of terms such as “thermal wave imaging” vs. “thermoacoustic imaging” or “Thermal Wave Microscopy” as opposed to “Scanning Electron Acostic Microscopy” (SEAM). The issue in question is the extent of the role played by acoustics directly on the imaging. In the present work, SEAM studies of a prepared test standard are presented which show that macroscopic elastic properties can play an important role in imaging. The SEAM technique uses Coordinate Modulation (CM) of the electron beam [2] rather than the more commonly used intensity modulation via beam blanking. Defects as deep as 26 thermal diffusion lengths in stainless steel have been clearly imaged with this technique. This work strongly supports the Jackson -Amer thermal bending model [3] for low frequency (up to approximately 100kHz in small specimens) acoustic detection in the solid as compared to the theory of Opsal and Rosencwaig [4] which does not incorporate total specimen response to the thermal source. This problem has more recently been theoretically investigated by Favro [5,6], who has developed a more general theory encompasing both the Opsal-Rosencwaig short wavelength limit and the Jackson-Amer long wavelength limit. Favro’s theory also accounts for features in the image shown
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