In Situ Characterisation of Permanent Magnetic Quadrupoles for focussing proton beams

High intensity laser driven proton beams are at present receiving much attention. The reasons for this are many but high on the list is the potential to produce compact accelerators. However two of the limitations of this technology is that unlike conventional nuclear RF accelerators lasers produce diverging beams with an exponential energy distribution. A number of different approaches have been attempted to monochromise these beams but it has become obvious that magnetic spectrometer technology developed over many years by nuclear physicists to transport and focus proton beams could play an important role for this purpose. This paper deals with the design and characterisation of a magnetic quadrupole system which will attempt to focus and transport laser-accelerated proton beams.Comment: 20 pages, 42 figure

Incidence and time course of everolimus-related adverse events in postmenopausal women with hormone receptor-positive advanced breast cancer: insights from BOLERO-2.

BackgroundIn the BOLERO-2 trial, everolimus (EVE), an inhibitor of mammalian target of rapamycin, demonstrated significant clinical benefit with an acceptable safety profile when administered with exemestane (EXE) in postmenopausal women with hormone receptor-positive (HR(+)) advanced breast cancer. We report on the incidence, time course, severity, and resolution of treatment-emergent adverse events (AEs) as well as incidence of dose modifications during the extended follow-up of this study.Patients and methodsPatients were randomized (2:1) to receive EVE 10 mg/day or placebo (PBO), with open-label EXE 25 mg/day (n = 724). The primary end point was progression-free survival. Secondary end points included overall survival, objective response rate, and safety. Safety evaluations included recording of AEs, laboratory values, dose interruptions/adjustments, and study drug discontinuations.ResultsThe safety population comprised 720 patients (EVE + EXE, 482; PBO + EXE, 238). The median follow-up was 18 months. Class-effect toxicities, including stomatitis, pneumonitis, and hyperglycemia, were generally of mild or moderate severity and occurred relatively early after treatment initiation (except pneumonitis); incidence tapered off thereafter. EVE dose reduction and interruption (360 and 705 events, respectively) required for AE management were independent of patient age. The median duration of dose interruption was 7 days. Discontinuation of both study drugs because of AEs was higher with EVE + EXE (9%) versus PBO + EXE (3%).ConclusionsMost EVE-associated AEs occur soon after initiation of therapy, are typically of mild or moderate severity, and are generally manageable with dose reduction and interruption. Discontinuation due to toxicity was uncommon. Understanding the time course of class-effect AEs will help inform preventive and monitoring strategies as well as patient education.Trial registration numberNCT00863655

Social Determinants of Disease: HIV and COVID-19 Experiences

Purpose of Review: The differential impact of the COVID-19 and HIV pandemics on marginalized communities has renewed calls for more robust and deeper investigation into structural and social causes of health inequities contributing to these infections, including underlying factors related to systematic racism. Using the Social Determinants of Health (SDOH) framework, we analyzed parallel and divergent factors associated with COVID-19 and HIV/AIDS and the prevalence of disparate disease in diverse communities. We utilized PRISMA guidelines to identify relevant literature (N = 210 articles) that resulted in a review of 125 articles included in our synthesis. Recent Findings: With racial health inequities as a core contributor to disease vulnerability, we also identified other factors such as economic stability, social and community support, the neighborhood and built environment, healthcare access and quality, and education access and quality as important socioecological considerations toward achieving health equity. Our review identifies structural and systematic factors that drive HIV and COVID-19 transmission. Summary: Our review highlights the importance of not solely focusing on biomedical interventions as solutions to ending HIV and COVID-19, but rather call for building a more just public health and social service safety net that meets the needs of people at the intersection of multiple vulnerabilities

Neutron-Capture Elements in the Early Galaxy: Insights from a Large Sample of Metal-Poor Giants

New abundances for neutron-capture (n-capture) elements in a large sample of metal-poor giants from the Bond survey are presented. The spectra were acquired with the KPNO 4-m echelle and coude feed spectrographs, and have been analyzed using LTE fine-analysis techniques with both line analysis and spectral synthesis. Abundances of eight n-capture elements (Sr, Y, Zr, Ba, La, Nd, Eu, Dy) in 43 stars have been derived from blue (lambda = 4070--4710, R~20,000, S/N ratio~100-200) echelle spectra and red (lambda = 6100--6180, R~22,000, S/N ratio~100-200) coude spectra, and the abundance of Ba only has been derived from the red spectra for an additional 27 stars. Overall, the abundances show clear evidence for a large star-to-star dispersion in the heavy element-to-iron ratios. The new data also confirm that at metallicities [Fe/H] <~ --2.4, the abundance pattern of the heavy (Z >= 56) n-capture elements in most giants is well-matched to a scaled Solar System r-process nucleosynthesis pattern. The onset of the main r-process can be seen at [Fe/H] ~ --2.9. Contributions from the s-process can first be seen in some stars with metallicities as low as [Fe/H] ~ --2.75, and are present in most stars with metallicities [Fe/H] > --2.3. The lighter n-capture elements (Sr-Y-Zr) are enhanced relative to the heavier r-process element abundances. Their production cannot be attributed solely to any combination of the Solar System r- and main s-processes, but requires a mixture of material from the r-process and from an additional n-capture process which can operate at early Galactic time.Comment: Text + 5 Tables and 11 Figures: Submitted to the Astrophysical Journa

Comparison of high-latitude line-of-sight ozone column density with derived ozone fields and the effects of horizontal inhomogeneity

International audienceExtensive ozone measurements were made during the second SAGE III Ozone Loss and Validation Experiment (SOLVE II). We compare high-latitude line-of-sight (LOS) slant column ozone measurements from the NASA DC-8 to ozone simulated by forward integration of measurement-derived ozone fields constructed both with and without the assumption of horizontal homogeneity. The average bias and rms error of the simulations assuming homogeneity are relatively small (?6 and 10%, respectively) in comparison to the LOS measurements. The comparison improves significantly (?2% bias; 8% rms error) using forward integrations of three-dimensional proxy ozone fields reconstructed from potential vorticity-O3 correlations. The comparisons provide additional verification of the proxy fields and quantify the influence of large-scale ozone inhomogeneity. The spatial inhomogeneity of the atmosphere is a source of error in the retrieval of trace gas vertical profiles and column abundance from LOS measurements, as well as a complicating factor in intercomparisons that include LOS measurements at large solar zenith angles

Chemical Engineering Division waste management programs. Quarterly report, January--March 1975

Development work on the study of consolidation techniques for Zircaloy fuel-cladding hulls included scouting tests on volatility schemes for separating the zirconium as the volatile tetrachloride and ignition tests on several Zircaloy materials to further characterize the pyrophoric behavior of Zircaloy. All tests were with nonirradiated metal pending acquisition of irradiated samples. Installation is nearly complete of a glovebox facility for studies on the salvage of alpha-contaminated metals by pyrochemical methods. Disposal of a major portion of fission product tritium formed in light water reactor fuels by deep- well injection of the low-level aqueous waste from plants reprocessing such fuels is being evaluated. The question of siting is a very important factor in determining the feasibility of this particular disposal option. A review is given of the status of information for U. S. sedimentary basins, the areas most likely to be generally suitable for siting of waste wells. Work on the reliability of high-level-waste canisters included an examination of creep, shot- peening, and subcooling of the filler canister below storage temperatures, as methods of relieving stresses induced in canisters due to differential contraction of canister and glass during cooling. A method was investigated for relieving stresses in calcine-filled canisters. Properties of fission product oxides were examined to elucidate possible adverse corrosive effects at the canister-waste interface. (LK

Comparative analysis between condom use clusters and risk behaviours among portuguese university students

The research on condom use has been focused on high-risk individuals, paying less attention to those who have moderate risk or safe sexual conducts. In order to design accurate interventions, potential differences among the condom use behavior groups must be considered. The goal was to assess possible differences in individuals presenting different types of risk behavior. 140 heterosexual university students answered a self-reported questionnaire about their sexual history, condom use habits, sexual self-esteem, sexual satisfaction, sexual control, attitudes towards condoms, self-efficacy to condom use, and emotions and feelings during sexual intercourse. A cluster analysis was conducted using the results about condom use and risk behaviors. Three groups with different risk levels emerged, presenting differences over sexual self-efficacy, attitudes towards condoms, socio-demographic variables, and sexual history. The results suggest the condom use inconsistency is highly associated with other risk behaviors but the contrary does not necessarily happens. Condom use consistent users also presented risk behaviors as smoking and drinking. The group differences suggest the risks were more affected by the combination of lack of skills with a negative attitude toward condoms than by contextual or personal variables. These differences sustain the need of an intervention adjusted to the individual's risk levels, since they differ on skills and beliefs that may hinder or promote the adoption of health behaviors.Foundation for Science and Technology/Fundacao para a Ciencia e Tecnologia (Portugal)info:eu-repo/semantics/publishedVersio

Nominal Logic with Equations Only

Many formal systems, particularly in computer science, may be captured by equations modulated by side conditions asserting the "freshness of names"; these can be reasoned about with Nominal Equational Logic (NEL). Like most logics of this sort NEL employs this notion of freshness as a first class logical connective. However, this can become inconvenient when attempting to translate results from standard equational logic to the nominal setting. This paper presents proof rules for a logic whose only connectives are equations, which we call Nominal Equation-only Logic (NEoL). We prove that NEoL is just as expressive as NEL. We then give a simple description of equality in the empty NEoL-theory, then extend that result to describe freshness in the empty NEL-theory.Comment: In Proceedings LFMTP 2011, arXiv:1110.668

Emerging Strategies for Healthy Urban Governance

Urban health promotion is not simply a matter of the right interventions, or even the necessary resources. Urban (and indeed global) health depends to an important extent on governance, the institutions and processes through which societies manage the course of events. This paper describes the concept of governance, distinguishing between reforms aimed at improving how government works and innovations that more fundamentally reinvent governance by developing new institutions and processes of local stakeholder control. The paper highlights strategies urban governors can use to maximize their influence on the national and international decisions that structure urban life. It concludes with some observations on the limitations of local governance strategies and the importance of establishing a “virtuous circuit” of governance through which urban dwellers play a greater role in the formation and implementation of policy at the national and global levels