RADAR: Content, Metadata, Submission and Preservation Guidelines

These guidelines are aimed at depositors to RADAR, the Glasgow School of Art's research repository, which makes information publically available about a wide range of research outputs, from books and journal articles to exhibitions and artefacts. The guidelines cover content (including output types, formats and open access), metadata requirements and discoverability, submission policies, terms and conditions, and preservation

Review of Child Neglect in Scotland

Neglect is damaging to children in the short and long term. Neglect is associated with some of the poorest outcomes. It affects children in the early years, but teenage neglect, often overlooked, is also damaging. Formulating an effective response to neglect still poses national and local challenges

Longitudinal Case Study of a Learning Resource Center: Math Lab for Academically Disadvantaged Students 1983-1991

Occupational and Adult Educatio

Intervenors before the Supreme Court of Canada, 1997--1999: A content analysis.

The increased appearance of intervenors at the Supreme Court of Canada has received much attention since the advent of the Canadian Charter of Rights and Freedoms. Political scientists have studied the quantitative increase in cases with intervenor presence, but have yet to take the next logical step. The next step is to analyse the influence of intervenors at the Supreme Court and this requires that a new method of data analysis be utilized. This thesis investigates the influence of intervenors before the Supreme Court of Canada and poses the following research questions: (1) do intervenors attract the attention of the Supreme Court Justices within the Justices\u27 written decisions? and (2) if the jurists are found to acknowledge the intervenors in their decisions, what is the form of this acknowledgement? In other words, is the intervenor acknowledged independently or is the intervenor linked to the arguments put forth by the appellant or the respondent? (Abstract shortened by UMI.)Dept. of History, Philosophy, and Political Science. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2000 .B86. Source: Masters Abstracts International, Volume: 40-03, page: 0598. Adviser: Howard Pawley. Thesis (M.A.)--University of Windsor (Canada), 2000

Genetically raised serum bilirubin levels and lung cancer: a cohort study and Mendelian randomisation using UK Biobank.

BACKGROUND: Moderately raised serum bilirubin levels are associated with lower rates of lung cancer, particularly among smokers. It is not known whether these relationships reflect antioxidant properties or residual confounding. OBJECTIVE: This study aimed to investigate potential causal relationships between serum total bilirubin and lung cancer incidence using one-sample Mendelian randomisation (MR) and UK Biobank. METHODS: We instrumented serum total bilirubin level using two variants (rs887829 and rs4149056) that together explain ~40% of population-level variability and are linked to mild hereditary hyperbilirubinaemia. Lung cancer events occurring after recruitment were identified from national cancer registries. Observational and genetically instrumented incidence rate ratios (IRRs) and rate differences per 10 000 person-years (PYs) by smoking status were estimated. RESULTS: We included 377 294 participants (median bilirubin 8.1 μmol/L (IQR 6.4-10.4)) and 2002 lung cancer events in the MR analysis. Each 5 μmol/L increase in observed bilirubin levels was associated with 1.2/10 000 PY decrease (95% CI 0.7 to 1.8) in lung cancer incidence. The corresponding MR estimate was a decrease of 0.8/10 000 PY (95% CI 0.1 to 1.4). The strongest associations were in current smokers where a 5 μmol/L increase in observed bilirubin levels was associated with a decrease in lung cancer incidence of 10.2/10 000 PY (95% CI 5.5 to 15.0) and an MR estimate of 6.4/10 000 PY (95% CI 1.4 to 11.5). For heavy smokers (≥20/day), the MR estimate was an incidence decrease of 23.1/10 000 PY (95% CI 7.3 to 38.9). There was no association in never smokers and no mediation by respiratory function. CONCLUSION: Genetically raised serum bilirubin, common across human populations, may protect people exposed to high levels of smoke oxidants against lung cancers

The state of child neglect in the UK - An Annual Review by Action for Children in Partnership with the University of Stirling

First paragraph: Over the last decade awareness of the extent of child neglect has grown and there is now a significant evidence base about the severe impact of neglect upon children's well-being and development (Farmer and Lutman, 2012; Stevenson, 2007). There is emerging evidence about the factors associated with effective early intervention and the difference that therapeutic support for children and their families can make (Long et al. 2012)

Pronounced genetic structure and low genetic diversity in European red-billed chough (Pyrrhocorax pyrrhocorax) populations

Conservation Genetics August 2015, Volume 16, Issue 4, pp 1011–1012 Erratum to: Pronounced genetic structure and low genetic diversity in European red-billed chough (Pyrrhocorax pyrrhocorax) populations Erratum to: Conserv Genet (2012) 13:1213–1230 DOI 10.1007/s10592-012-0366-6 In the original publication, Tables 3 and 6 were published with incorrect estimates of population heterozygosities. All other diversity statistics were correct as originally presented. Updated versions of Tables 3 and 6 with corrected heterozygosity estimates confirmed using Arlequin 3.5 (Excoffier and Lischer 2010) as in Dávila et al. (2014) are provided in this erratum. Discrepancies were minor for populations on the British Isles. The correct estimates for Spain are slightly larger than those reported for La Palma by Dávila et al. (2014), but this does not necessarily affect their interpretation that choughs on La Palma may have originated from multiple migration events. The original conclusion that chough populations on the British Isles have low genetic diversity compared to continental European populations remains and is now, in fact, strengthened.Peer reviewedPostprin

The biological properties of Shiga-like toxin I

Shiga toxin and the Escherichia coli Shiga-like toxins (SLTs) are type 2 ribosome inactivating proteins (RIPs), exhibiting a specific RNA N-glycosidase activity comparable to that of the plant toxin ricin (Endo et al. 1988). Not only do they possess the same enzymatic activity as a plant toxin, but on examination at the molecular level, they may be seen to be classic bipartite toxins. The present study examines in detail the RNA N-glycosidase activity of Shiga-like toxin I (SLT I) ie, the ribosomes susceptibility to the toxin, of a range the exact of different eukaryotic site of SLT I-catalysed depurination of yeast ribosomal RNA and the kinetics of such depurination. The cytotoxic effect of SLT I on Vero cells is also examined. In addition to its characterisation and subsequent comparison to ricin, an attempt has been made to correlate certain structure - function aspects of SLT I. By structural comparison with other bacterial toxins it has been proposed that proteolytic cleavage with thin an arginine rich, trypsin sensitive, disulphide-bonded loop structure is essential for expression of cytotoxicity. Examination of the enzymatic activity and cytotoxicity of a 'protease insensitive' mutant SLT I A subunit (SLT lA) generated in the present study has led to the conclusion tha t proteolytic processing wi thin this disulphide-bonded loop is not essential, but that processing may occur at alternative sites within SLT lA to compensate for loss cleavage at the proposed target sites

Rhyolite volcanism at Öræfajökull volcano, S.E. Iceland : a window on Quaternary climate change

Öræfajökull is an ice-capped stratovolcano situated in the south east of Iceland which has developed throughout the mid to late Quaternary. It has erupted basaltic and rhyolitic lavas during interglacial and glacial periods, many of which display strong physical evidence of volcano-ice interaction. This makes Öræfajökull an ideal location to reconstruct terrestrial palaeo-environments. The area of Goðafjall and Hrútsfjall is one of a small number of rhyolitic depositional centres situated on the south west flanks of the volcano and is the first rhyolitic area of Öræfajökull to be mapped in detail.The relatively high K content of the rhyolitic units make them good candidates for 40Ar/39Ar dating, yielding eruption ages that provide a temporal constraint on the development of the stratovolcano. 40Ar/39Ar dating of young rocks (<1 My) is challenging and many of the samples were found to contain both excess and atmospheric argon. A small number exhibited a fractionated argon source with a sub-atmospheric 40Ar/36Ar ratio that could not be explained by a single episode of mass fractionation. Soret thermal diffusion has been suggested as a possible mechanism for fractionation, although further investigation is required.Two dominant rhyolite eruptions have been identified by detailed field mapping supported by the geochemical application of chemostratigraphy. The stratigraphically lower group of lavas outcrop between 100 to 380 m.a.s.l. and were erupted subaerially into a relatively ice-free environment at the base of the edifice. A 40Ar/39Ar age of 202 ± 9 ka implies that eruption occurred during the interglacial MIS 7. Conversely the upper group of lavas show strong evidence of volcano-ice interaction, suggesting that they were erupted subglacially and confined by ice with a minimum ice surface elevation of at least 800 m.a.s.l. These lavas yield a 40Ar/39Ar age of 116 ± 14 ka, which implies that eruption occurred during the transitional period between the MIS5e interglacial and colder sub-stages prior to MIS 4.At least two further glacial advances have occurred since the emplacement of the subglacial rhyolite unit. In addition, an ice confined trachydacite flow from the Vatnafjall ridge situated 20 km north east of Goðafjall has also been dated yielding a 40Ar/39Ar age of 95 ± 7 k. This lava was emplaced at an elevation of over 700 m in the presence of an adjacent valley fill glacier was at least 700 m thick.Ice thickness has varied dramatically throughout the evolution of Öræfajökull and glacial erosion has played an important role in its topographic development.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Preventing child neglect in the UK: what makes services accessible to children and families? An annual review by Action for Children in partnership with the University of Stirling

First paragraph: Neglect remains the most common form of child mistreatment in the UK. It is the most common reason for a child being subject to child protection measures. The majority of professionals surveyed in the online survey said they had come across child neglect in their role. A quarter of the UK adults surveyed have felt very or quite worried about the safety of a child living in their area. Nearly three-quarters of the children and young people had known a child or children who have shown signs of neglect and three in 10 children stated explicitly that they have been worried about whether a child is being looked after properly